203 Publications (Page 1 of 9)
2023
APE1/Ref-1 as a Therapeutic Target for Inflammatory Bowel Disease
Sahakian, LaurenRobinson, Ainsley MSahakian, LindaStavely, RhianKelley, Mark RNurgali, Kulmira and Nurgali, Kulmira
Biomolecules, vol. 13, (no. 11), 2023. | Journal Article
2021
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
Zhang, ChiZhang, ChiZhang, ChiZhang, ChiRhodes, Steven DRhodes, Steven DRhodes, Steven DRhodes, Steven DBabb, OliviaBabb, OliviaBabb, OliviaBabb, OliviaGrimard, MichelleGrimard, MichelleGrimard, MichelleGrimard, MichelleCalver, BrianCalver, BrianCalver, BrianCalver, BrianRen-Yuan, BaiRen-Yuan, BaiRen-Yuan, BaiRen-Yuan, BaiHulsey, Emily LHulsey, Emily LHulsey, Emily LHulsey, Emily LReza, Saadatzadeh MReza, Saadatzadeh MReza, Saadatzadeh MReza, Saadatzadeh MPollok, Karen EPollok, Karen EPollok, Karen EPollok, Karen ETong, YanTong, YanTong, YanTong, YanSmith, Abbi ESmith, Abbi ESmith, Abbi ESmith, Abbi EWade, Clapp DWade, Clapp DWade, Clapp DWade, Clapp DTee, Andrew RTee, Andrew RTee, Andrew RTee, Andrew RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RFishel, Melissa LFishel, Melissa LFishel, Melissa L and Fishel, Melissa L
The British Journal of Cancer, vol. 124, (no. 9), pp. 1566-1580, Apr 2021. | Journal Article
 
Inhibition of APE1/Ref-1 for Neovascular Eye Diseases: From Biology to Therapy
Hartman, Gabriella DLambert-Cheatham, Nathan AKelley, Mark RCorson, Timothy W and Corson, Timothy W
International Journal of Molecular Sciences, vol. 22, (no. 19), 2021. | Journal Article
 
Ref-1 redox activity alters cancer cell metabolism in pancreatic cancer: exploiting this novel finding as a potential target
Gampala, SilpaGampala, SilpaGampala, SilpaShah, FenilShah, FenilShah, FenilLu, XiaoyuLu, XiaoyuLu, XiaoyuMoon, Hye-RanMoon, Hye-RanMoon, Hye-ranBabb, OliviaBabb, OliviaBabb, OliviaGanesh, Nikkitha UmeshNikkitha, Umesh GGanesh, Nikkitha UmeshSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeHulsey, EmilyHulsey, EmilyHulsey, EmilyArmstrong, LeeArmstrong, LeeArmstrong, LeeMosely, Amber LMosely, Amber LMosely, Amber LHan, BumsooHan, BumsooHan, BumsooIvan, MirceaIvan, MirceaYeh, Jing-Ruey JoannaYeh, Jing-Ruey JoannaJing-Ruey, Joanna YKelley, Mark RKelley, Mark RKelley, Mark RZhang, ChiZhang, ChiZhang, ChiFishel, Melissa LFishel, Melissa L and Fishel, Melissa L
Journal of Experimental and Clinical Cancer Research, vol. 40, pp. 1-24, 2021. | Journal Article
2019
Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer
Fishel, Melissa LFishel, Melissa LFishel, Melissa LFishel, Melissa LFishel, Melissa LFishel, Melissa LFishel, Melissa LFishel, Melissa LXia, HanyuXia, HanyuXia, HanyuXia, HanyuXia, HanyuXia, HanyuXia, HanyuXia, HanyuMcGeown, JackMcGeown, JackMcGeown, JackMcGeown, JackMcGeown, JackMcGeown, JackMcGeown, JackMcGeown, JackMcIlwain, David WMcIlwain, David WMcIlwain, David WMcIlwain, David WMcIlwain, David WMcIlwain, David WMcIlwain, David WMcIlwain, David WElbanna, MayElbanna, MayElbanna, MayElbanna, MayElbanna, MayElbanna, MayElbanna, MayElbanna, MayCraft, Ariel ACraft, Ariel ACraft, Ariel ACraft, Ariel ACraft, Ariel ACraft, Ariel ACraft, Ariel ACraft, Ariel AKaimakliotis, Hristos ZKaimakliotis, Hristos ZKaimakliotis, Hristos ZKaimakliotis, Hristos ZKaimakliotis, Hristos ZKaimakliotis, Hristos ZKaimakliotis, Hristos ZKaimakliotis, Hristos ZSandusky, George ESandusky, George ESandusky, George ESandusky, George ESandusky, George ESandusky, George ESandusky, George ESandusky, George EZhang, ChiZhang, ChiZhang, ChiZhang, ChiZhang, ChiZhang, ChiZhang, ChiZhang, ChiPili, RobertoPili, RobertoPili, RobertoPili, RobertoPili, RobertoPili, RobertoPili, RobertoPili, RobertoKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RJerde, Travis JJerde, Travis JJerde, Travis JJerde, Travis JJerde, Travis JJerde, Travis JJerde, Travis J and Jerde, Travis J
Molecular cancer therapeutics, vol. 18, (no. 11), pp. 1960, 20191100. | Journal Article
 
A phase I study of the APE1 protein inhibitor APX3330 in patients with advanced solid tumors
Shahda, SafiShahda, SafiShahda, SafiLakhani, Nehal JLakhani, Nehal JLakhani, Nehal JO'Neil, BertO'Neil, BertO'Neil, BertRasco, Drew WRasco, Drew WRasco, Drew WWan, JunWan, JunWan, JunMosley, Amber LMosley, Amber LMosley, Amber LLiu, HaoLiu, HaoLiu, HaoKelley, Mark RKelley, Mark RKelley, Mark RMessmann, Richard AdamMessmann, Richard Adam and Messmann, Richard Adam
Journal of Clinical Oncology, vol. 37, (no. 15_suppl), pp. 3097, 2019-05-20. | Journal Article
 
CTC enumeration and characterization as a pharmacodynamic marker in the phase I clinical study of APX3330, an APE1/Ref-1 inhibitor, in patients with advanced solid tumors
Chu, LincyAnderson, Amanda K. LLanders, Mark AndrewWang, YipengKelley, Mark R and Messmann, Richard Adam
Journal of Clinical Oncology, vol. 37, (no. 15_suppl), pp. e14531, 2019-05-20. | Journal Article
 
Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1
Trilles, RichardTrilles, RichardBeglov, DmitriBeglov, DmitriChen, QiujiaChen, QiujiaHe, HongzhenHe, HongzhenWireman, RandallWireman, RandallReed, AprilReed, AprilChennamadhavuni, SpandanChennamadhavuni, SpandanPanek, James SPanek, James SBrown, Lauren EBrown, Lauren EVajda, SandorVajda, SandorPorco, Jr, John APorco, Jr, John AKelley, Mark RKelley, Mark RGeorgiadis, Millie M and Georgiadis, Millie M
Journal of medicinal chemistry, vol. 62, (no. 4), pp. 1988, 2019-02-28. | Journal Article
 
Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination
Frossi, BarbaraFrossi, BarbaraFrossi, BarbaraFrossi, BarbaraFrossi, BarbaraAntoniali, GiuliaAntoniali, GiuliaAntoniali, GiuliaAntoniali, GiuliaAntoniali, GiuliaYu, KefeiYu, KefeiYu, KefeiYu, KefeiYu, KefeiAkhtar, NahidAkhtar, NahidAkhtar, NahidAkhtar, NahidAkhtar, NahidKaplan, Mark HKaplan, Mark HKaplan, Mark HKaplan, Mark HKaplan, Mark HKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RTell, GianlucaTell, GianlucaTell, GianlucaTell, GianlucaTell, GianlucaPucillo, Carlo E MPucillo, Carlo E MPucillo, Carlo E MPucillo, Carlo E M and Pucillo, Carlo E M
The Journal of biological chemistry, vol. 294, (no. 13), pp. 5207, 2019-03-29. | Journal Article
 
Inhibition of APE1-endonuclease activity affects cell metabolism in colon cancer cells via a p53-dependent pathway
Codrich, MartaComelli, MarinaMalfatti, Matilde ClarissaMio, CatiaAyyildiz, DilaraZhang, ChiKelley, Mark RTerrosu, GiovanniPucillo, Carlo E.M and Tell, Gianluca
DNA Repair, vol. 82, pp. 102675, October 2019. | Journal Article
2018
Abstract 2941: APE1/Ref-1 redox signaling regulates HIF1a-mediated CA9 expression in hypoxic pancreatic cancer cells: Combination treatment in patient-derived pancreatic tumor models
Logsdon, DerekLogsdon, DerekShah, FenilShah, FenilCarta, FabrizioCarta, FabrizioSupuran, ClaudiuSupuran, ClaudiuFishel, MelissaFishel, MelissaKelley, Mark R and Kelley, Mark R
Cancer Research, vol. 78, (no. 13 Supplement), pp. 2941, 2018-07-01. | Journal Article
 
Abstract 4802: Combination therapy in PDAC involving blockade of the APE1/Ref-1 signaling pathway: An investigation into drug synthetic lethality and anti-neuropathy therapeutic approach
Shah, Fenil LShah, Fenil LShah, Fenil LAtallah, NadiaAtallah, NadiaAtallah, NadiaGrimard, MichelleGrimard, MichelleGrimard, MichelleGuo, ChunluGuo, ChunluGuo, ChunluZhang, ChiZhang, ChiZhang, ChiFehrenbacher, JillFehrenbacher, JillFehrenbacher, JillKelley, Mark RKelley, Mark RKelley, Mark RFishel, MelissaFishel, Melissa and Fishel, Melissa
Cancer Research, vol. 78, (no. 13 Supplement), pp. 4802, 2018-07-01. | Journal Article
 
APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells
McIlwain, David WMcIlwain, David WMcIlwain, David WFishel, Melissa LFishel, Melissa LFishel, Melissa LBoos, AlexanderBoos, AlexanderBoos, AlexanderKelley, Mark RKelley, Mark RKelley, Mark RJerde, Travis JJerde, Travis J and Jerde, Travis J
Oncotarget, vol. 9, (no. 13), pp. 10977, 2018-Feb-16. | Journal Article
 
APX3330 Promotes Neurorestorative Effects after Stroke in Type One Diabetic Rats.
Yan, TaoVenkat, PoornimaChopp, MichaelZacharek, AlexYu, PengNing, RuizhuoQiao, XiaoxiKelley, Mark R and Chen, Jieli
Aging and disease, vol. 9, (no. 3), pp. 453-466, June 2018. | Journal Article
 
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival.
Logsdon, Derek PLogsdon, Derek PLogsdon, Derek PLogsdon, Derek PShah, FenilShah, FenilShah, FenilShah, FenilCarta, FabrizioCarta, FabrizioCarta, FabrizioCarta, FabrizioSupuran, Claudiu TSupuran, Claudiu TSupuran, Claudiu TSupuran, Claudiu TKamocka, MalgorzataKamocka, MalgorzataKamocka, MalgorzataKamocka, MalgorzataJacobsen, Max HJacobsen, Max HJacobsen, Max HJacobsen, Max HSandusky, George ESandusky, George ESandusky, George ESandusky, George EKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RFishel, Melissa LFishel, Melissa LFishel, Melissa L and Fishel, Melissa L
Scientific reports, vol. 8, (no. 1), pp. 13759, September 13, 2018. | Journal Article
 
Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis
Cai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangKotzin, JonathanKotzin, JonathanKotzin, JonathanKotzin, JonathanKotzin, JonathanRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiMali, RaghuveerMali, RaghuveerMali, RaghuveerMali, RaghuveerMali, RaghuveerLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeKapur, ReubenKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 132, (no. Supplement 1), pp. 1288, 2018-11-29. | Journal Article
 
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis.
Cai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
Cell stem cell, vol. 23, (no. 6), pp. 833-849.e5, December 6, 2018. | Journal Article
 
Novel first-in-class small molecule targeting APE1/Ref-1 to prevent and treat chemotherapy-induced peripheral neuropathy (CIPN)
Kelley, Mark RKelley, Mark RMessmann, Richard AdamMessmann, Richard AdamFehrenbacher, Jill and Fehrenbacher, Jill
Journal of Clinical Oncology, vol. 36, (no. 34_suppl), pp. 229, 2018-12-01. | Journal Article
 
Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization.
Sardar Pasha, Sheik Pran BabuSardar Pasha, Sheik Pran BabuSishtla, KamakshiSishtla, KamakshiSulaiman, Rania SSulaiman, Rania SPark, BominaPark, BominaShetty, TruptiShetty, TruptiShah, FenilShah, FenilFishel, Melissa LFishel, Melissa LWikel, James HWikel, James HKelley, Mark RKelley, Mark RCorson, Timothy W and Corson, Timothy W
The Journal of pharmacology and experimental therapeutics, August 3, 2018. | Journal Article
2017
APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing
Shah, FenilShah, FenilShah, FenilGoossens, EmeryGoossens, EmeryGoossens, EmeryAtallah, Nadia M.Atallah, Nadia MAtallah, Nadia MGrimard, MichelleGrimard, MichelleGrimard, MichelleKelley, Mark RKelley, Mark RKelley, Mark R.Fishel, Melissa L.Fishel, Melissa L and Fishel, Melissa L
Molecular Oncology, vol. 11, (no. 12), pp. 1732, December 2017. | Journal Article
 
Challenges and opportunities identifying therapeutic targets for chemotherapy-induced peripheral neuropathy resulting from oxidative DNA damage.
Kelley, Mark R and Fehrenbacher, Jill C
Neural regeneration research, vol. 12, (no. 1), pp. 72-74, January 2017. | Journal Article
 
Current Molecular Pharmacology: Meet Our Editorial Board Member
Kelley, Mark
Current Molecular Pharmacology, vol. 10, (no. 4), pp. 256, 2017-November. | Journal Article
 
DNA damage mediates changes in neuronal sensitivity induced by the inflammatory mediators, MCP-1 and LPS, and can be reversed by enhancing the DNA repair function of APE1
Fehrenbacher, Jill CFehrenbacher, Jill CGuo, ChunluGuo, ChunluKelley, Mark RKelley, Mark RVasko, Michael R and Vasko, Michael R
Neuroscience, vol. 366, pp. 35, 2017-12-16. | Journal Article
 
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic.
Shah, FenilShah, FenilLogsdon, DerekLogsdon, DerekMessmann, Richard AMessmann, Richard AFehrenbacher, Jill CFehrenbacher, Jill CFishel, Melissa LFishel, Melissa LKelley, Mark R and Kelley, Mark R
NPJ precision oncology, vol. 1, 2017. | Journal Article
 
Meet Our Editorial Board Member
Saykin, Andrew J and Kelley, Mark R
Current Molecular Pharmacology, vol. 10, (no. 4), 2017-10-04. | Journal Article