203 Publications (Page 2 of 9)
2017
Ref-1/APE1 as Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia.
Ding, Jixin⋅Ding, Jixin⋅Ding, Jixin⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Reed, April M⋅Reed, April M⋅Reed, April M⋅McAdams, Erin⋅McAdams, Erin⋅McAdams, Erin⋅Czader, Magdalena⋅Czader, Magdalena B⋅Czader, Magdalena B⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Kelley, Mark R⋅Kelley, Mark R and Kelley, Mark R
Molecular cancer therapeutics, April 26, 2017. | Journal Article
2016
Abstract 1246: Development of STAT3 dual-targeting strategies for the treatment of pancreatic cancer
Fishel, Melissa L⋅Fishel, Melissa L⋅Grimard, Michelle L⋅Grimard, Michelle L⋅Kelley, Mark R⋅Kelley, Mark R⋅Rosa, David A⋅Rosa, David A⋅Shouksmith, Andrew⋅Shouksmith, Andrew⋅Tin, Gary⋅Tin, Gary⋅Park, Ji⋅Park, Ji⋅Gunning, Patrick T and Gunning, Patrick T
Cancer Research, vol. 76, (no. 14 Supplement), pp. 1246, 2016-07-15. | Journal Article
 
Abstract 4740: Targeting Ref-1/APE1 pathway inhibition in pancreatic cancer using APX3330 for clinical trials
Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Grimard, Michelle L⋅Grimard, Michelle L⋅Grimard, Michelle L⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Shah, Fenil⋅Shah, Fenil and Shah, Fenil
Cancer Research, vol. 76, (no. 14 Supplement), pp. 4740, 2016-07-15. | Journal Article
 
Abstract 5183: Efficacy study of APX3330, a Ref-1 redox inhibitor, and Gemcitabine in a mouse pancreatic ductal adenocarcinoma model
McElyea, Kyle C⋅McElyea, Kyle C⋅McElyea, Kyle C⋅McElyea, Kyle C⋅Jacobsen, Max H⋅Jacobsen, Max H⋅Jacobsen, Max H⋅Jacobsen, Max H⋅Schmidt, Max⋅Schmidt, Max⋅Schmidt, Max⋅Schmidt, Max⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L and Fishel, Melissa L
Cancer Research, vol. 76, (no. 14 Supplement), pp. 5183, 2016-07-15. | Journal Article
 
Abstract B51: Regulation of HIF1α under hypoxia by APE1/Ref-1 impacts CA9 expression: Dual-targeting in patient-derived 3D pancreatic cancer models
Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L and Fishel, Melissa L
Cancer Research, vol. 76, (no. 24 Supplement), pp. B51, 2016-12-15. | Journal Article
 
Abstract B88: Clinical trials targeting APE1/Ref-1 in pancreatic cancer with APX3330
Kelley, Mark R⋅Kelley, Mark R⋅Shahda, Safi⋅Shahda, Safi⋅O'Neil, Bert H⋅O'Neil, Bert H⋅Pearce, Homer⋅Pearce, Homer⋅Walling, Jackie and Walling, Jackie
Cancer Research, vol. 76, (no. 24 Supplement), pp. B88, 2016-12-15. | Journal Article
 
Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy.
Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Wikel, James H⋅Wikel, James H⋅Wikel, James H⋅Guo, Chunlu⋅Guo, Chunlu⋅Guo, Chunlu⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Wireman, Randy⋅Wireman, Randy⋅Wireman, Randy⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Vasko, Michael R⋅Vasko, Michael R and Vasko, Michael R
The Journal of pharmacology and experimental therapeutics, vol. 359, (no. 2), pp. 300-309, November 2016. | Journal Article
 
Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual-Targeting in Patient-Derived 3D Pancreatic Cancer Models.
Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Tong, Yan⋅Tong, Yan⋅Tong, Yan⋅Tong, Yan⋅Tong, Yan⋅Tong, Yan⋅Tong, Yan⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L and Fishel, Melissa L
Molecular cancer therapeutics, August 17, 2016. | Journal Article
 
Small molecule activation of apurinic/apyrimidinic endonuclease 1 reduces DNA damage induced by cisplatin in cultured sensory neurons.
Georgiadis, Millie M⋅Georgiadis, Millie M⋅Chen, Qiujia⋅Chen, Qiujia⋅Meng, Jingwei⋅Meng, Jingwei⋅Guo, Chunlu⋅Guo, Chunlu⋅Wireman, Randall⋅Wireman, Randall⋅Reed, April⋅Reed, April⋅Vasko, Michael R⋅Vasko, Michael R⋅Kelley, Mark R and Kelley, Mark R
DNA repair, vol. 41, pp. 32-41, May 2016. | Journal Article
2015
Abstract B158: Targeting APE1/Ref-1 results in inhibition of hypoxia signaling genes
Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Luo, Meihua⋅Luo, Meihua⋅Luo, Meihua⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Hao, Yangyang⋅Hao, Yangyang⋅Hao, Yangyang⋅Tong, Yan⋅Tong, Yan⋅Tong, Yan⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Zyromski, Nicholas⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Schipani, Ernestina⋅Liu, Yunlong⋅Liu, Yunlong⋅Liu, Yunlong⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Fishel, Melissa L⋅Fishel, Melissa L and Fishel, Melissa L
Molecular Cancer Therapeutics, vol. 14, (no. 12 Supplement 2), pp. B158, 2015-12-00. | Journal Article
 
Abstract B167: APX3330 drug development for clinical trials targeting APE1/Ref-1 in pancreatic cancer
Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Shahda, Safi⋅Shahda, Safi⋅Shahda, Safi⋅Kelley, Mark R⋅Kelley, Mark R and Kelley, Mark R
Molecular Cancer Therapeutics, vol. 14, (no. 12 Supplement 2), pp. B167, 2015-12-00. | Journal Article
 
Abstract B19: Redox factor 1 (Ref-1) signaling in the interaction between pancreatic tumor cells and cancer-associated fibroblasts
Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Cheng, Huiwen⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Kelley, Mark R⋅Kelley, Mark R and Kelley, Mark R
Cancer Research, vol. 75, (no. 13 Supplement), pp. B19, 2015-07-01. | Journal Article
 
APE1, the DNA base excision repair protein, regulates the removal of platinum adducts in sensory neuronal cultures by NER.
Kim, Hyun-Suk⋅Guo, Chunlu⋅Thompson, Eric L⋅Jiang, Yanlin⋅Kelley, Mark R⋅Vasko, Michael R and Lee, Suk Hee
Mutation research, vol. 779, pp. 96-104, September 2015. | Journal Article
 
Apurinic/apyrimidinic endonuclease/redox factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.
Fishel, Melissa L⋅Fishel, Melissa L⋅Wu, Xue⋅Wu, Xue⋅Devlin, Cecilia M⋅Devlin, Cecilia M⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Jiang, Yanlin⋅Jiang, Yanlin⋅Luo, Meihua⋅Luo, Meihua⋅He, Ying⋅He, Ying⋅Yu, Zhangsheng⋅Yu, Zhangsheng⋅Tong, Yan⋅Tong, Yan⋅Lipking, Kelsey P⋅Lipking, Kelsey P⋅Maitra, Anirban⋅Maitra, Anirban⋅Rajeshkumar, N V⋅Rajeshkumar, N V⋅Scandura, Glenda⋅Scandura, Glenda⋅Kelley, Mark R⋅Kelley, Mark R⋅Ivan, Mircea and Ivan, Mircea
The Journal of biological chemistry, vol. 290, (no. 5), pp. 3057-3068, January 30, 2015. | Journal Article
 
Longitudinal Bioluminescence Imaging of Primary Versus Abdominal Metastatic Tumor Growth in Orthotopic Pancreatic Tumor Models in NSG Mice
Shannon, Harlan E⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Xie, Jingwu⋅Xie, Jingwu⋅Xie, Jingwu⋅Xie, Jingwu⋅Xie, Jingwu⋅Xie, Jingwu⋅Gu, Dongsheng⋅Gu, Dongsheng⋅Gu, Dongsheng⋅Gu, Dongsheng⋅Gu, Dongsheng⋅Gu, Dongsheng⋅McCarthy, Brian P⋅McCarthy, Brian P⋅McCarthy, Brian P⋅McCarthy, Brian P⋅McCarthy, Brian P⋅McCarthy, Brian P⋅Riley, Amanda A⋅Riley, Amanda A⋅Riley, Amanda A⋅Riley, Amanda A⋅Riley, Amanda A⋅Riley, Amanda A⋅Sinn, Anthony L⋅Sinn, Anthony L⋅Sinn, Anthony L⋅Sinn, Anthony L⋅Sinn, Anthony L⋅Sinn, Anthony L⋅Silver, Jayne M⋅Silver, Jayne M⋅Silver, Jayne M⋅Silver, Jayne M⋅Silver, Jayne M⋅Silver, Jayne M⋅Peterman, Kacie⋅Peterman, Kacie⋅Peterman, Kacie⋅Peterman, Kacie⋅Peterman, Kacie⋅Peterman, Kacie⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Territo, Paul R⋅Territo, Paul R⋅Territo, Paul R⋅Territo, Paul R⋅Territo, Paul R and Territo, Paul R
Pancreas, vol. 44, (no. 1), pp. 75, 2015-Jan. | Journal Article
2014
Abstract 4961: Longitudinal bioluminescence imaging of primary versus abdominal metastatic tumor growth in orthotopic pancreatic tumor models in NOD/SCIDγ(-/-) mice
Shannon, Harlan E⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Shannon, Harlan E⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Xie, Jingwu⋅Xie, Jingwu⋅Xie, Jingwu⋅Xie, Jingwu⋅Gu, Dongsheng⋅Gu, Dongsheng⋅Gu, Dongsheng⋅Gu, Dongsheng⋅McCarthy, Brian P⋅McCarthy, Brian P⋅McCarthy, Brian P⋅McCarthy, Brian P⋅Riley, Amanda A⋅Riley, Amanda A⋅Riley, Amanda A⋅Riley, Amanda A⋅Sinn, Anthony L⋅Sinn, Anthony L⋅Sinn, Anthony L⋅Sinn, Anthony L⋅Silver, Jayne M⋅Silver, Jayne M⋅Silver, Jayne M⋅Silver, Jayne M⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Territo, Paul R⋅Territo, Paul R⋅Territo, Paul R and Territo, Paul R
Cancer Research, vol. 74, (no. 19 Supplement), pp. 4961, 2014-10-01. | Journal Article
 
Abstract B32: First-in-class Ref-1 redox inhibitors for the multipathway targeting of survival signals for relapsed childhood acute lymphoblastic leukemia
Cardoso, Angelo A⋅Wikel, James H⋅Ding, Jixin⋅Reed, April M⋅Luo, Meihua and Kelley, Mark R
Cancer Research, vol. 74, (no. 20 Supplement), pp. B32, 2014-10-15. | Journal Article
 
Inhibition of APE1/Ref-1 redox activity rescues human retinal pigment epithelial cells from oxidative stress and reduces choroidal neovascularization.
Li, Y⋅Liu, X⋅Zhou, T⋅Kelley, M R⋅Edwards, P⋅Gao, H and Qiao, X
Redox biology, vol. 2, pp. 485-494, 2014. | Journal Article
 
Role of the DNA base excision repair protein, APE1 in cisplatin, oxaliplatin, or carboplatin induced sensory neuropathy.
Kelley, Mark R⋅Jiang, Yanlin⋅Guo, Chunlu⋅Reed, April⋅Meng, Hongdi and Vasko, Michael R
PloS one, vol. 9, (no. 9), pp. e106485, 2014. | Journal Article
 
Suppression of choroidal neovascularization through inhibition of APE1/Ref-1 redox activity.
Li, Yue⋅Liu, Xiuli⋅Zhou, Tongrong⋅Kelley, Mark R⋅Edwards, Paul A⋅Gao, Hua and Qiao, Xiaoxi
Investigative ophthalmology & visual science, vol. 55, (no. 7), pp. 4461-4469, June 26, 2014. | Journal Article
 
Targeting DNA repair pathways for cancer treatment: what's new?
Kelley, Mark R⋅Kelley, Mark R⋅Logsdon, Derek⋅Logsdon, Derek⋅Fishel, Melissa L and Fishel, Melissa L
Future oncology (London, England), vol. 10, (no. 7), pp. 1215-1237, May 2014. | Journal Article
 
The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.
Domenis, Rossana⋅Bergamin, Natascha⋅Gianfranceschi, Giuseppe⋅Vascotto, Carlo⋅Romanello, Milena⋅Rigo, Silvia⋅Vagnarelli, Giovanna⋅Faggiani, Massimo⋅Parodi, Piercamillo⋅Kelley, Mark⋅Beltrami, Carlo A⋅Cesselli, Daniela⋅Tell, Gianluca and Beltrami, Antonio P
PloS one, vol. 9, (no. 2), pp. e89232, 2014. | Journal Article
2013
Correction: Specific Inhibition of the Redox Activity of Ape1/Ref-1 by E3330 Blocks Tnf-Α-Induced Activation of Il-8 Production in Liver Cancer Cell Lines
Vascotto, Carlo⋅Cesaratto, Laura⋅Codarin, Erika⋅Vascotto, Carlo⋅Leonardi, Antonio⋅Kelley, Mark R⋅Tiribelli, Claudio and Tell, Gianluca
PLoS ONE, vol. 8, (no. 8), 2013-08-22. | Journal Article
 
Inhibition of apurinic/apyrimidinic endonuclease I's redox activity revisited.
Zhang, Jun⋅Zhang, Jun⋅Luo, Meihua⋅Luo, Meihua⋅Marasco, Daniela⋅Marasco, Daniela⋅Logsdon, Derek⋅Logsdon, Derek⋅La Favers, Kaice A⋅Lafavers, Kaice A⋅Chen, Qiujia⋅Chen, Qiujia⋅Reed, April⋅Reed, April⋅Kelley, Mark⋅Kelley, Mark R⋅Gross, Michael L⋅Gross, Michael L⋅Georgiadis, Millie M and Georgiadis, Millie M
Biochemistry, vol. 52, (no. 17), pp. 2955-66, 2013/Apr/30. | Journal Article
 
Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines.
Cesaratto, Laura⋅Codarin, Erika⋅Vascotto, Carlo⋅Leonardi, Antonio⋅Kelley, Mark⋅Tiribelli, Claudio and Tell, Gianluca
PloS one, vol. 8, (no. 8), pp. e70909, 2013. | Journal Article