157 Publications (Page 1 of 7)
2024
Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions
2023
Activation of Gcn2 by small molecules designed to be inhibitors. Journal of Biological Chemistry
. | Journal Article
 
Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response. Antioxidants & Redox Signaling
Wek, Ronald C⋅Anthony, Tracy G and Staschke, Kirk A
. | Journal Article
 
The Role of the Integrated Stress Response in the Biologic Response of Keratinocytes to UVB Exposure. Proceedings of IMPRS
. | Journal Article
2022
Aminoacylation‐defective bi‐allelic mutations in human EPRS1 associated with psychomotor developmental delay, epilepsy, and deafness. Clinical Genetics
. | Journal Article
2021
Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
Misra, Jagannath⋅Holmes, Michael J⋅T. Mirek, Emily⋅Langevin, Michael⋅Kim, Hyeong-Geug⋅Carlson, Kenneth R⋅Watford, Malcolm⋅Dong, X Charlie⋅Anthony, Tracy G and Wek, Ronald C
Nucleic Acids Research, vol. 49, pp. 5726–5742. | Journal Article
 
Host sensing and signal transduction during Toxoplasma stage conversion
Augusto, Leonardo⋅Wek, Ronald C. and Sullivan, William J.
Molecular Microbiology, vol. 115, pp. 839–848. | Journal Article
2019
Adapting to cell stress from inside and out
Staschke, Kirk A⋅Staschke, Kirk A⋅Wek, Ronald C and Wek, Ronald C
Nature cell biology, vol. 21, (no. 7), pp. 800, 2019-07-00. | Journal Article
 
Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation
Martynowicz, Jennifer⋅Augusto, Leonardo⋅Wek, Ronald C⋅Boehm, 2nd, Stephen L and Sullivan, Jr, William J
mBio, vol. 10, (no. 2), pp. e00381-19, 2019-04-30. | Journal Article
 
Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality
Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Wichern, Emily⋅Wichern, Emily⋅Wichern, Emily⋅Wichern, Emily⋅Wichern, Emily⋅Wichern, Emily⋅Wichern, Emily⋅Childress, Paul J⋅Childress, Paul J⋅Childress, Paul J⋅Childress, Paul J⋅Childress, Paul J⋅Childress, Paul J⋅Childress, Paul J⋅Adaway, Michele⋅Adaway, Michele⋅Adaway, Michele⋅Adaway, Michele⋅Adaway, Michele⋅Adaway, Michele⋅Adaway, Michele⋅Misra, Jagannath⋅Misra, Jagannath⋅Misra, Jagannath⋅Misra, Jagannath⋅Misra, Jagannath⋅Misra, Jagannath⋅Misra, Jagannath⋅Klunk, Angela⋅Klunk, Angela⋅Klunk, Angela⋅Klunk, Angela⋅Klunk, Angela⋅Klunk, Angela⋅Klunk, Angela⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Liu, Yunlong⋅Liu, Yunlong⋅Liu, Yunlong⋅Liu, Yunlong⋅Liu, Yunlong⋅Liu, Yunlong⋅Liu, Yunlong⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Hamilton, James⋅Hamilton, James⋅Hamilton, James⋅Hamilton, James⋅Hamilton, James⋅Hamilton, James⋅Hamilton, James⋅Jacobs, Kylie⋅Jacobs, Kylie⋅Jacobs, Kylie⋅Jacobs, Kylie⋅Jacobs, Kylie⋅Jacobs, Kylie⋅Jacobs, Kylie⋅Vashishth, Deepak⋅Vashishth, Deepak⋅Vashishth, Deepak⋅Vashishth, Deepak⋅Vashishth, Deepak⋅Vashishth, Deepak⋅Vashishth, Deepak⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Wallace, Joseph M⋅Wallace, Joseph M⋅Wallace, Joseph M⋅Wallace, Joseph M⋅Wallace, Joseph M⋅Wallace, Joseph M⋅Wallace, Joseph M⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Bidwell, Joseph P and Bidwell, Joseph P
American journal of physiology. Endocrinology and metabolism, vol. 316, (no. 5), pp. E772, 2019-05-01. | Journal Article
 
Promoter demethylation of the asparagine synthetase gene is required for ATF4-dependent adaptation to asparagine depletion
Jiang, Jie⋅Jiang, Jie⋅Jiang, Jie⋅Jiang, Jie⋅Srivastava, Sankalp⋅Srivastava, Sankalp⋅Srivastava, Sankalp⋅Srivastava, Sankalp⋅Seim, Gretchen⋅Seim, Gretchen⋅Seim, Gretchen⋅Seim, Gretchen⋅Pavlova, Natalya N⋅Pavlova, Natalya N⋅Pavlova, Natalya N⋅Pavlova, Natalya N⋅King, Bryan⋅King, Bryan⋅King, Bryan⋅King, Bryan⋅Zou, Lihua⋅Zou, Lihua⋅Zou, Lihua⋅Zou, Lihua⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Zhong, Minghua⋅Zhong, Minghua⋅Zhong, Minghua⋅Zhong, Minghua⋅Feng, Hui⋅Feng, Hui⋅Feng, Hui⋅Feng, Hui⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Fan, Jing⋅Fan, Jing⋅Fan, Jing⋅Fan, Jing⋅Zhang, Ji⋅Zhang, Ji⋅Zhang, Ji and Zhang, Ji
The Journal of biological chemistry, vol. 294, (no. 49), pp. 18684, 2019-Dec-06. | Journal Article
 
Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii
Augusto, Leonardo⋅Augusto, Leonardo⋅Amin, Parth H⋅Amin, Parth H⋅Wek, Ronald C⋅Wek, Ronald C⋅Sullivan, William J and Sullivan, Jr, William J
PLoS pathogens, vol. 15, (no. 6), pp. e1007746, 2019-06-00. | Journal Article
 
Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii
Holmes, Michael J⋅Holmes, Michael J⋅Holmes, Michael J⋅Shah, Premal⋅Shah, Premal⋅Shah, Premal⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Sullivan, Jr, William J⋅Sullivan, William J and Sullivan, William J
mSphere, vol. 4, (no. 3), pp. e00292-19, 2019-06-05. | Journal Article
2018
Effects of PERK eIF2α kinase inhibitor against Toxoplasma gondii.
Augusto, Leonardo⋅Augusto, Leonardo⋅Martynowicz, Jennifer⋅Martynowicz, Jennifer⋅Staschke, Kirk A⋅Staschke, Kirk A⋅Wek, Ronald C⋅Wek, Ronald C⋅Sullivan, William J and Sullivan, Jr, William J
Antimicrobial agents and chemotherapy, September 4, 2018. | Journal Article
 
Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4
Ogbechi, Joy⋅Ogbechi, Joy⋅Hall, Belinda S⋅Hall, Belinda S⋅Sbarrato, Thomas⋅Sbarrato, Thomas⋅Taunton, Jack⋅Taunton, Jack⋅Willis, Anne E⋅Willis, Anne E⋅Wek, Ronald C⋅Wek, Ronald C⋅Simmonds, Rachel E and Simmonds, Rachel E
Cell death & disease, vol. 9, (no. 3), pp. 15, 2018-03-14. | Journal Article
 
Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress.
Wek, Ronald C
Cold Spring Harbor perspectives in biology, February 12, 2018. | Journal Article
 
Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver
Nikonorova, Inna A⋅Nikonorova, Inna A.⋅Nikonorova, Inna A.⋅Mirek, Emily T.⋅Mirek, Emily T⋅Mirek, Emily T.⋅Signore, Christina C⋅Signore, Christina C.⋅Signore, Christina C.⋅Goudie, Michael P⋅Goudie, Michael P.⋅Goudie, Michael P.⋅Wek, Ronald C.⋅Wek, Ronald C⋅Wek, Ronald C.⋅Anthony, Tracy G.⋅Anthony, Tracy G and Anthony, Tracy G.
The Journal of biological chemistry, vol. 293, (no. 14), pp. 5015, 2018-04-06. | Journal Article
 
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes
Collier, Ann E⋅Collier, Ann E⋅Spandau, Dan F⋅Spandau, Dan F⋅Wek, Ronald C and Wek, Ronald C
Molecular biology of the cell, vol. 29, (no. 1), pp. 41, 2018-01-01. | Journal Article
2017
Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice123
Pettit, Ashley P⋅Pettit, Ashley P⋅Pettit, Ashley P⋅Pettit, A.P.⋅Jonsson, William O⋅Jonsson, W.O.⋅Jonsson, William O⋅Jonsson, William O⋅Bargoud, Albert R⋅Bargoud, Albert R⋅Bargoud, A.R.⋅Bargoud, Albert R⋅Mirek, Emily T⋅Mirek, Emily T⋅Mirek, Emily T⋅Mirek, E.T.⋅Peelor, F.F.⋅Peelor, Frederick F⋅Peelor, Frederick F⋅Peelor, Frederick F⋅Wang, Y.⋅Wang, Yongping⋅Wang, Yongping⋅Wang, Yongping⋅Gettys, Thomas W⋅Gettys, Thomas W⋅Gettys, Thomas W⋅Gettys, T.W.⋅Kimball, Scot R⋅Kimball, Scot R⋅Kimball, S.R.⋅Kimball, Scot R⋅Miller, Benjamin F⋅Miller, Benjamin F⋅Miller, B.F.⋅Miller, Benjamin F⋅Hamilton, Karyn L⋅Hamilton, Karyn L⋅Hamilton, K.L.⋅Hamilton, Karyn L⋅Wek, Ronald C⋅Wek, R.C.⋅Wek, Ronald C⋅Wek, Ronald C⋅Anthony, T.G.⋅Anthony, Tracy G⋅Anthony, Tracy G and Anthony, Tracy G
The Journal of Nutrition, vol. 147, (no. 6), pp. 1040, 2017-04-26. | Journal Article
 
Function of inhibitor of Bruton's tyrosine kinase isoform α (IBTKα) in nonalcoholic steatohepatitis links autophagy and the unfolded protein response
Willy, Jeffrey A⋅Willy, Jeffrey A⋅Willy, Jeffrey A⋅Willy, Jeffrey A⋅Young, Sara K⋅Young, Sara K⋅Young, Sara K⋅Young, Sara K⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Mosley, Amber L⋅Gawrieh, Samer⋅Gawrieh, Samer⋅Gawrieh, Samer⋅Gawrieh, Samer⋅Stevens, James L⋅Stevens, James L⋅Stevens, James L⋅Stevens, James L⋅Masuoka, Howard C⋅Masuoka, Howard C⋅Masuoka, Howard C⋅Masuoka, Howard C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 292, (no. 34), pp. 14065, 2017-08-25. | Journal Article
 
Human keratinocyte differentiation requires translational control by the eIF2α kinase GCN2.
Collier, Ann E⋅Collier, Ann E⋅Wek, Ronald C⋅Wek, Ronald C⋅Spandau, Dan F and Spandau, Dan F
The Journal of investigative dermatology, May 17, 2017. | Journal Article
 
Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism
Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Shao, Yu⋅Hernandez-Buquer, Selene⋅Hernandez-Buquer, Selene⋅Hernandez-Buquer, Selene⋅Hernandez-Buquer, Selene⋅Hernandez-Buquer, Selene⋅Hernandez-Buquer, Selene⋅Hernandez-Buquer, Selene⋅Childress, Paul⋅Childress, Paul⋅Childress, Paul⋅Childress, Paul⋅Childress, Paul⋅Childress, Paul⋅Childress, Paul⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Stayrook, Keith R⋅Alvarez, Marta B⋅Alvarez, Marta B⋅Alvarez, Marta B⋅Alvarez, Marta B⋅Alvarez, Marta B⋅Alvarez, Marta B⋅Alvarez, Marta B⋅Davis, Hannah⋅Davis, Hannah⋅Davis, Hannah⋅Davis, Hannah⋅Davis, Hannah⋅Davis, Hannah⋅Davis, Hannah⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅He, Yongzheng⋅He, Yongzheng⋅He, Yongzheng⋅He, Yongzheng⋅He, Yongzheng⋅He, Yongzheng⋅He, Yongzheng⋅Condon, Keith W⋅Condon, Keith W⋅Condon, Keith W⋅Condon, Keith W⋅Condon, Keith W⋅Condon, Keith W⋅Condon, Keith W⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Burr, David B⋅Warden, Stuart J⋅Warden, Stuart J⋅Warden, Stuart J⋅Warden, Stuart J⋅Warden, Stuart J⋅Warden, Stuart J⋅Warden, Stuart J⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Robling, Alexander G⋅Yang, Feng-Chun⋅Yang, Feng-Chun⋅Yang, Feng-Chun⋅Yang, Feng-Chun⋅Yang, Feng-Chun⋅Yang, Feng Chun⋅Yang, Feng-Chun⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Allen, Matthew R⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Bidwell, Joseph P and Bidwell, Joseph P
Endocrinology, vol. 158, (no. 9), pp. 2740, 2017-09-01. | Journal Article
 
Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency
Zhang, Min⋅Zhang, Min⋅Gallego-Delgado, Julio⋅Gallego-Delgado, Julio⋅Fernandez-Arias, Cristina⋅Fernandez-Arias, Cristina⋅Waters, Norman C⋅Waters, Norman C⋅Rodriguez, Ana⋅Rodriguez, Ana⋅Tsuji, Moriya⋅Tsuji, Moriya⋅Wek, Ronald C⋅Wek, Ronald C⋅Nussenzweig, Victor⋅Nussenzweig, Victor⋅Sullivan, William J and Sullivan, William J
Cell Host & Microbe, vol. 22, (no. 6), pp. 776.e4, 2017-12-13. | Journal Article
 
Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice
Nikonorova, I.A.⋅Nikonorova, I.A.⋅Nikonorova, Inna A.⋅Nikonorova, Inna A⋅Al-Baghdadi, Rana J T⋅Al-Baghdadi, R.J.T.⋅Al-Baghdadi, R.J.T.⋅Al-Baghdadi, Rana J.T.⋅Mirek, Emily T.⋅Mirek, Emily T⋅Mirek, E.T.⋅Mirek, E.T.⋅Wang, Yongping⋅Wang, Yongping⋅Wang, Y.⋅Wang, Y.⋅Goudie, Michael P.⋅Goudie, Michael P⋅Goudie, M.P.⋅Goudie, M.P.⋅Wetstein, Berish B⋅Wetstein, Berish B.⋅Wetstein, B.B.⋅Wetstein, B.B.⋅Dixon, Joseph L.⋅Dixon, J.L.⋅Dixon, Joseph L⋅Dixon, J.L.⋅Hine, C.⋅Hine, Christopher⋅Hine, Christopher⋅Hine, C.⋅Mitchell, J.R.⋅Mitchell, J.R.⋅Mitchell, James R.⋅Mitchell, James R⋅Adams, C.M.⋅Adams, Christopher M.⋅Adams, C.M.⋅Adams, Christopher M⋅Wek, Ronald C⋅Wek, X.R.C.⋅Wek, X.R.C.⋅Wek, Ronald C.⋅Anthony, T.G.⋅Anthony, Tracy G⋅Anthony, Tracy G. and Anthony, T.G.
The Journal of biological chemistry, vol. 292, (no. 16), pp. 6798, 2017-04-21. | Journal Article
 
Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase.
Anthony, Tracy⋅Al-Baghdadi, Rana J T⋅Al-Baghdadi, Rana J T⋅Al-Baghdadi, Rana J T⋅Nikonorova, Inna A⋅Nikonorova, Inna A⋅Nikonorova, Inna A⋅Mirek, Emily T⋅Mirek, Emily T⋅Mirek, Emily T⋅Wang, Yongping⋅Wang, Yongping⋅Wang, Yongping⋅Park, Jinhee⋅Park, Jinhee⋅Park, Jinhee⋅Belden, William J⋅Belden, William J⋅Belden, William J⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Anthony, Tracy G⋅Anthony, Tracy G and Anthony, Tracy G
Scientific reports, vol. 7, (no. 1), pp. 1272, April 28, 2017. | Journal Article