157 Publications (Page 3 of 7)
2013
The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control.
Joyce, Bradley R⋅Tampaki, Zoi⋅Kim, Kami⋅Wek, Ronald C and Sullivan, William J
Eukaryotic cell, vol. 12, (no. 7), pp. 979-89, 2013/Jul. | Journal Article
2012
Abstract LB-247: mTORC1 enhances bortezomib-induced death in TSC-null cells by a c-MYC-dependent induction of the unfolded protein response
Babcock, Justin T⋅Babcock, Justin T⋅Nguen, Hoa B⋅Nguen, Hoa B⋅He, Yujun⋅He, Yujun⋅Wek, Ronald C⋅Wek, Ronald C⋅Quilliam, Lawrence A and Quilliam, Lawrence A
Cancer Research, vol. 72, (no. 8 Supplement), pp. LB-247, 2012-04-15. | Journal Article
 
Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility.
Trinh, Mimi A⋅Kaphzan, Hanoch⋅Wek, Ronald C⋅Pierre, Philippe⋅Cavener, Douglas R and Klann, Eric
Cell reports, vol. 1, (no. 6), pp. 676-688, June 28, 2012. | Journal Article
 
Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism.
Baird, Thomas D and Wek, Ronald C
Advances in nutrition (Bethesda, Md.), vol. 3, (no. 3), pp. 307-21, 2012/May. | Journal Article
 
Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF.
Dai, Mu-Shui⋅Challagundla, Kishore B⋅Sun, Xiao-Xin⋅Palam, Lakshmi R⋅Zeng, Shelya X⋅Wek, Ronald C and Lu, Hua
The Journal of biological chemistry, vol. 287, (no. 21), pp. 17120-9, 2012/May/18. | Journal Article
 
Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response.
Dey, Souvik⋅Savant, Sudha⋅Teske, Brian F⋅Hatzoglou, Maria⋅Calkhoven, Cornelis F and Wek, Ronald C
The Journal of biological chemistry, vol. 287, (no. 26), pp. 21936-49, 2012/Jun/22. | Journal Article
 
TXNIP switches tracks toward a terminal UPR.
Anthony, Tracy G and Wek, Ronald C
Cell metabolism, vol. 16, (no. 2), pp. 135-7, 2012/Aug/8. | Journal Article
2011
A GCN2-like eukaryotic initiation factor 2 kinase increases the viability of extracellular Toxoplasma gondii parasites.
Konrad, Christian⋅Wek, Ronald C and Sullivan, William J
Eukaryotic cell, vol. 10, (no. 11), pp. 1403-12, 2011/Nov. | Journal Article
 
Mechanisms of translational regulation by a human eIF5-mimic protein.
Singh, C. R⋅Watanabe, Ryosuke⋅Zhou, Donghui⋅Jennings, Martin D⋅Fukao, Akira⋅Lee, Bumjun⋅Ikeda, Yuka⋅Chiorini, John A⋅Campbell, Susan G⋅Ashe, Mark P⋅Fujiwara, Toshinobu⋅Wek, Ronald C⋅Pavitt, Graham and Asano, Katsura
Nucleic acids research, vol. 39, (no. 19), pp. 8314-28, 2011/Oct. | Journal Article
 
Methods for analyzing eIF2 kinases and translational control in the unfolded protein response.
Teske, Brian F⋅Baird, Thomas D and Wek, Ronald C
Methods in enzymology, vol. 490, pp. 333-56, 2011. | Journal Article
 
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation.
Palam, Lakshmi R⋅Baird, Thomas D and Wek, Ronald C
The Journal of biological chemistry, vol. 286, (no. 13), pp. 10939-49, 2011/Apr/1. | Journal Article
 
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress.
Teske, Brian F⋅Teske, Brian F⋅Wek, Sheree A⋅Wek, Sheree A⋅Bunpo, Piyawan⋅Bunpo, Piyawan⋅Cundiff, Judy K⋅Cundiff, Judy K⋅McClintick, Jeanette N⋅McClintick, Jeanette N⋅Anthony, Tracy G⋅Anthony, Tracy G⋅Wek, Ronald C and Wek, Ronald C
Molecular biology of the cell, vol. 22, (no. 22), pp. 4390-405, 2011/Nov. | Journal Article
 
Translation control is critical during acute and chronic stages of toxoplasmosis infection.
Joyce, Bradley R⋅Konrad, Christian⋅Wek, Ronald C and Sullivan, William J
Expert review of anti-infective therapy, vol. 9, (no. 1), pp. 1-3, 2011/Jan. | Journal Article
2010
Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response.
Dey, Souvik⋅Dey, Souvik⋅Baird, Thomas D⋅Baird, Thomas D⋅Zhou, Donghui⋅Zhou, Donghui⋅Palam, Lakshmi R⋅Palam, Lakshmi Reddy⋅Spandau, Dan F⋅Spandau, Dan F⋅Wek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 285, (no. 43), pp. 33165-74, 2010/Oct/22. | Journal Article
 
How do tumours adapt to nutrient stress?
Wek, Ronald⋅Wek, R.C.⋅Staschke, Kirk A and Staschke, K.A.
EMBO Journal, vol. 29, (no. 12), pp. 1946-7, Jun 16, 2010. | Journal Article
 
Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast.
Staschke, Kirk A⋅Staschke, K.A.⋅Dey, S.⋅Dey, Souvik⋅Zaborske, John M⋅Zaborske, J.M.⋅Palam, L.R.⋅Palam, Lakshmi R⋅McClintick, Jeanette N⋅McClintick, J.N.⋅Pan, Tao⋅Pan, T.⋅Edenberg, H.J.⋅Edenberg, Howard J⋅Wek, R.C. and Wek, Ronald C
The Journal of biological chemistry, vol. 285, (no. 22), pp. 16893-911, 2010/May/28. | Journal Article
 
Obesity: stressing about unfolded proteins
Wek, Ronald⋅Wek, Ronald C⋅Anthony, Tracy G and Anthony, Tracy G
Nature Medicine, vol. 16, (no. 4), pp. 374-6, Apr 2010. | Journal Article
 
Obesity: stressing about unfolded proteins
Wek, Ronald C⋅Wek, Ronald⋅Anthony, Tracy G and Anthony, Tracy
Nature Medicine, vol. 16, (no. 5), pp. 607, May 2010. | Journal Article
 
Phosphorylation of eukaryotic initiation factor-2[alpha] promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii
Joyce, Bradley R⋅Queener, Sherry F⋅Wek, Ronald and Sullivan, William J
Proceedings of the National Academy of Sciences of the United States of America, vol. 107, (no. 40), Oct 5, 2010. | Journal Article
 
Phosphorylation of eukaryotic initiation factor-2a promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii
Joyce, Bradley R⋅Queener, Sherry F⋅Wek, Ronald and Sullivan, William J
Proceedings of the National Academy of Sciences, USA, vol. 107, (no. 40), pp. 17200-17205, 2010. | Journal Article
 
Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae.
Zaborske, John M⋅Wu, Xiaochen⋅Wek, Ronald C and Pan, Tao
BMC biochemistry, vol. 11, pp. 29, 2010. | Journal Article
 
The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase.
Bunpo, Piyawan⋅Bunpo, Piyawan⋅Cundiff, Judy⋅Cundiff, Judy K⋅Reinert, Rachel B⋅Reinert, Rachel⋅Wek, Ronald⋅Wek, Ronald C⋅Aldrich, Carla J⋅Aldrich, Carla⋅Anthony, Tracy and Anthony, Tracy G
The Journal of nutrition, vol. 140, (no. 11), pp. 2020-7, 2010/Nov. | Journal Article
 
The elF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase1-3
Bunpo, Piyawan⋅Cundiff, Judy K⋅Reinert, Rachel B⋅Wek, Ronald⋅Aldrich, Carla J and Anthony, Tracy G
The Journal of Nutrition, vol. 140, (no. 11), pp. 2020-2027, Nov 2010. | Journal Article
 
The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation.
Nemoto, Naoki⋅Udagawa, Tsuyoshi⋅Ohira, Takahiro⋅Jiang, Li⋅Hirota, Kouji⋅Wilkinson, Caroline R⋅Bähler, Jürg⋅Jones, Nic⋅Ohta, Kunihiro⋅Wek, Ronald C and Asano, Katsura
Journal of molecular biology, vol. 404, (no. 2), pp. 183-201, 2010/Nov/26. | Journal Article
2009
A Bifunctional Intronic Element Regulates the Expression of the Arginine/Lysine Transporter Cat-1 via Mechanisms Involving the Purine-rich Element Binding Protein A (Pur alpha )
Huang, Charlie C⋅Chiribau, Calin-Bogdan⋅Majumder, Mithu⋅Chiang, Cheng-Ming⋅Wek, Ronald⋅Kelm, Robert J⋅Khalili, Kamel⋅Snider, Martin D and Hatzoglou, Maria
Journal of Biological Chemistry, vol. 284, (no. 47), 2009. | Journal Article