Our laboratory studies the tissue-level mechanisms responsible for musculoskeletal integrity in health and disease by utilizing numerous in vivo model systems that help investigators understand how disease and pharmaceutical intervention influence bone structure, cellular activity, tissue-level properties (such as mineralization, microdamage, collagen, hydration), and biomechanical properties.
The laboratory studies a range of diseases/conditions, including osteoporosis, chronic kidney disease, and disuse using techniques that include imaging (CT, DXA, X-ray), histology (static and dynamic histomorphometry, microdamage), and mechanical testing (bending, compression, fatigue loading).
Our work in this field is focused on gaining a greater understanding of the underlying skeletal schanges associated with CKD and finding a viable treatment for these changes.
Research Interests: Treating skeletal complications of chronic kidney disease
Subject area:
