157 Publications (Page 2 of 7)
2017
Translational Control in the Latency of Apicomplexan Parasites
Holmes, Michael J⋅Holmes, Michael J⋅Augusto, Leonardo da Silva⋅Augusto, Leonardo da Silva⋅Zhang, Min⋅Zhang, Min⋅Wek, Ronald C⋅Wek, Ronald C⋅Sullivan, William J and Sullivan, William J
Trends in Parasitology, vol. 33, (no. 12), pp. 960, December 2017. | Journal Article
2016
ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis
Srivastava, Ritesh K⋅Li, Changzhao⋅Ahmad, Aftab⋅Abrams, Onika⋅Gorbatyuk, Marina S⋅Harrod, Kevin S⋅Wek, Ronald C⋅Afaq, Farrukh and Athar, Mohammad
Archives of Biochemistry and Biophysics, vol. 609, pp. 50, 2016-11-01. | Journal Article
 
General control nonderepressible 2 deletion predisposes to asparaginase-associated pancreatitis in mice.
Phillipson-Weiner, Lindsey⋅Phillipson-Weiner, Lindsey⋅Mirek, Emily T⋅Mirek, Emily T⋅Wang, Yongping⋅Wang, Yongping⋅McAuliffe, W Geoffrey⋅McAuliffe, W Geoffrey⋅Wek, Ronald C⋅Wek, Ronald C⋅Anthony, Tracy G and Anthony, Tracy G
American journal of physiology. Gastrointestinal and liver physiology, vol. 310, (no. 11), pp. G1061-G1070, June 1, 2016. | Journal Article
 
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential
Kwon, Jason J⋅Kwon, Jason J⋅Kwon, Jason J⋅Willy, Jeffrey A⋅Willy, Jeffrey A⋅Willy, Jeffrey A⋅Quirin, Kayla A⋅Quirin, Kayla A⋅Quirin, Kayla A⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Korc, Murray⋅Korc, Murray⋅Korc, Murray⋅Yin, Xiao-Ming⋅Yin, Xiao-Ming⋅Yin, Xiao Ming⋅Kota, Janaiah⋅Kota, Janaiah and Kota, Janaiah
Oncotarget, vol. 7, (no. 44), pp. 71650, 2016-11-01. | Journal Article
 
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
Young, Sara K⋅Young, Sara K⋅Shao, Yu⋅Shao, Yu⋅Bidwell, Joseph P⋅Bidwell, Joseph P⋅Wek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 26), pp. 13780-13788, June 24, 2016. | Journal Article
 
Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response.
Young, Sara K⋅Young, Sara K⋅Palam, Lakshmi Reddy⋅Palam, Lakshmi Reddy⋅Wu, Cheng⋅Wu, Cheng⋅Sachs, Matthew S⋅Sachs, Matthew S⋅Wek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 12), pp. 6546-6558, March 18, 2016. | Journal Article
 
Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver.
Fusakio, M.E.⋅Fusakio, Michael E⋅Fusakio, Michael E⋅Willy, J.A.⋅Willy, Jeffrey A⋅Willy, Jeffrey A⋅Wang, Yongping⋅Wang, Yongping⋅Wang, Y.⋅Mirek, Emily T⋅Mirek, E.T.⋅Mirek, Emily T⋅Baghdadi, R.J.T.A.⋅Baghdadi, R.J.T.A.⋅Al Baghdadi, Rana J T⋅Al Baghdadi, Rana J T⋅Adams, C.M.⋅Adams, Christopher M⋅Adams, Christopher M⋅Anthony, T.G.⋅Anthony, Tracy G⋅Anthony, Tracy G⋅Wek, Ronald C⋅Wek, Ronald C and Wek, R.C.
Molecular biology of the cell, vol. 27, (no. 9), pp. 1536-1551, May 1, 2016. | Journal Article
 
Translation Regulation of the Glutamyl-prolyl-tRNA Synthetase Gene EPRS through Bypass of Upstream Open Reading Frames with Noncanonical Initiation Codons.
Young, Sara K⋅Baird, Thomas D and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 20), pp. 10824-10835, May 13, 2016. | Journal Article
 
Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response.
Young, Sara K and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 33), pp. 16927-16935, August 12, 2016. | Journal Article
2015
Bmi1 promotes erythroid development through regulating ribosome biogenesis.
Gao, Rui⋅Gao, Rui⋅Chen, Sisi⋅Chen, Sisi⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Yu, Hao⋅Yu, Hao⋅Zhang, Yingchi⋅Zhang, Yingchi⋅Wan, Yang⋅Wan, Yang⋅Young, Sara K⋅Young, Sara K⋅Soltis, Anthony⋅Soltis, Anthony⋅Yu, Ming⋅Yu, Ming⋅Vemula, Sasidhar⋅Vemula, Sasidhar⋅Fraenkel, Ernest⋅Fraenkel, Ernest⋅Cantor, Alan⋅Cantor, Alan⋅Antipin, Yevgeniy⋅Antipin, Yevgeniy⋅Xu, Yang⋅Xu, Yang⋅Yoder, Mervin C⋅Yoder, Mervin C⋅Wek, Ronald C⋅Wek, Ronald C⋅Ellis, Steven R⋅Ellis, Steven R⋅Kapur, Reuben⋅Kapur, Reuben⋅Zhu, Xiaofan⋅Zhu, Xiaofan⋅Liu, Yan and Liu, Yan
Stem cells (Dayton, Ohio), vol. 33, (no. 3), pp. 925-938, March 2015. | Journal Article
 
CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis.
Willy, Jeffrey A⋅Young, Sara K⋅Stevens, James L⋅Masuoka, Howard C and Wek, Ronald C
Molecular biology of the cell, vol. 26, (no. 12), pp. 2190-2204, June 15, 2015. | Journal Article
 
GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment.
Wilson, Gabriel J⋅Wilson, Gabriel J⋅Wilson, Gabriel J⋅Wilson, Gabriel J⋅Lennox, Brittany A⋅Lennox, Brittany A⋅Lennox, Brittany A⋅Lennox, Brittany A⋅She, Pengxiang⋅She, Pengxiang⋅She, Pengxiang⋅She, Pengxiang⋅Mirek, Emily T⋅Mirek, Emily T⋅Mirek, Emily T⋅Mirek, Emily T⋅Al Baghdadi, Rana J T⋅Al Baghdadi, Rana J T⋅Al Baghdadi, Rana J T⋅Al Baghdadi, Rana J T⋅Fusakio, Michael E⋅Fusakio, Michael E⋅Fusakio, Michael E⋅Fusakio, Michael E⋅Dixon, Joseph L⋅Dixon, Joseph L⋅Dixon, Joseph L⋅Dixon, Joseph L⋅Henderson, Gregory C⋅Henderson, Gregory C⋅Henderson, Gregory C⋅Henderson, Gregory C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Wek, Ronald C⋅Anthony, Tracy G⋅Anthony, Tracy G⋅Anthony, Tracy G and Anthony, Tracy G
American journal of physiology. Endocrinology and metabolism, vol. 308, (no. 4), pp. E283-E293, February 15, 2015. | Journal Article
 
Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis.
Benmerzouga, Imaan⋅Checkley, Lisa A⋅Ferdig, Michael T⋅Arrizabalaga, Gustavo⋅Wek, Ronald C and Sullivan, William J
Antimicrobial agents and chemotherapy, vol. 59, (no. 11), pp. 6939-6945, November 2015. | Journal Article
 
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
Young, Sara K⋅Willy, Jeffrey A⋅Wu, Cheng⋅Sachs, Matthew S and Wek, Ronald C
The Journal of biological chemistry, vol. 290, (no. 47), pp. 28257-28271, November 20, 2015. | Journal Article
 
Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response.
Collier, Ann E⋅Collier, Ann E⋅Wek, Ronald C⋅Wek, Ronald C⋅Spandau, Dan F and Spandau, Dan F
The Journal of investigative dermatology, vol. 135, (no. 10), pp. 2502-2511, October 2015. | Journal Article
2014
Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals.
He, Hongzhen⋅He, Hongzhen⋅Singh, Isha⋅Singh, Isha⋅Wek, Sheree A⋅Wek, Sheree A⋅Dey, Souvik⋅Dey, Souvik⋅Baird, Thomas D⋅Baird, Thomas D⋅Wek, Ronald C⋅Wek, Ronald C⋅Georgiadis, Millie M and Georgiadis, Millie M
The Journal of biological chemistry, vol. 289, (no. 21), pp. 15023-34, 2014/May/23. | Journal Article
 
Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.
Cambiaghi, Tavane D⋅Pereira, Catia M⋅Shanmugam, Renuka⋅Bolech, Michael⋅Wek, Ronald C⋅Sattlegger, Evelyn and Castilho, Beatriz A
Biochemical and biophysical research communications, vol. 443, (no. 2), pp. 592-7, 2014/Jan/10. | Journal Article
 
GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii.
Konrad, Christian⋅Wek, Ronald C and Sullivan, William J
International journal for parasitology, vol. 44, (no. 2), pp. 139-46, 2014/Feb. | Journal Article
 
Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα
Baird, Thomas D⋅Baird, T.D.⋅Palam, Lakshmi Reddy⋅Palam, L.R.⋅Fusakio, M.E.⋅Fusakio, Michael E⋅Willy, Jeffrey A⋅Willy, J.A.⋅Davis, C.M.⋅Davis, Christopher M⋅McClintick, J.N.⋅McClintick, Jeanette N⋅Anthony, Tracy G⋅Anthony, T.G.⋅Wek, Ronald C and Wek, R.C.
Molecular Biology of the Cell, vol. 25, pp. 1666-1675. | Journal Article
2013
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis.
Teske, Brian F⋅Fusakio, Michael E⋅Zhou, Donghui⋅Shan, Jixiu⋅McClintick, Jeanette N⋅Kilberg, Michael S and Wek, Ronald C
Molecular biology of the cell, vol. 24, (no. 15), pp. 2477-90, 2013/Aug. | Journal Article
 
General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice.
She, Pengxiang⋅She, Pengxiang⋅Bunpo, Piyawan⋅Bunpo, Piyawan⋅Cundiff, Judy K⋅Cundiff, Judy K.⋅Wek, Ronald C⋅Wek, Ronald C.⋅Harris, Robert A.⋅Harris, Robert A⋅Anthony, Tracy G and Anthony, Tracy G.
The Journal of biological chemistry, vol. 288, (no. 43), pp. 31250-60, 2013/Oct/25. | Journal Article
 
Inhibitors of eIF2 alpha Dephosphorylation Slow Replication and Stabilize Latency in Toxoplasma gondii
Konrad, Christian⋅Queener, Sherry F⋅Wek, Ronald and Sullivan, William J
Antimicrobial Agents & Chemotherapy, vol. 57, (no. 4), pp. 1815-1822, 2013. | Journal Article
 
Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii.
Konrad, Christian⋅Queener, Sherry F⋅Wek, Ronald C and Sullivan, William J
Antimicrobial agents and chemotherapy, vol. 57, (no. 4), pp. 1815-22, 2013/Apr. | Journal Article
 
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
Babcock, Justin T⋅Nguyen, Hoa B⋅He, Yujun⋅Hendricks, Jeremiah W⋅Wek, Ronald C and Quilliam, Lawrence A
The Journal of biological chemistry, vol. 288, (no. 22), pp. 15687-98, 2013/May/31. | Journal Article
 
The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment
Wilson, Gabriel J⋅Wilson, Gabriel J⋅Bunpo, Piyawan⋅Bunpo, Piyawan⋅Cundiff, Judy K⋅Cundiff, Judy K⋅Wek, Ronald C⋅Wek, Ronald⋅Anthony, Tracy G and Anthony, Tracy G
American Journal of Physiology, vol. 305, (no. 9), Nov 1, 2013. | Journal Article