Three major research projects in Dr. Zhang's lab are:
- Understand the mechanism of resistance to L-asparaginase treatment in pediatric acute lymphoblastic leukemia (ALL). L-asparaginase is used to treat pediatric ALL patients
- Elucidate the interplay between oncogenic signaling and nutrient acquisition/utilization in lymphoid malignacies
- Explore the role of nonessential amino acid metabolism in normal hematopoiesis
Dr. Zhang's laboratory uses biochemical, cellular and molecular biology and mouse genetic approaches to understand the fundamental mechanisms that underlie tumor cells' response to various metabolic stresses.
My lab is interested in understanding the role of metabolic pathways in normal and malignant hematopoiesis.
