49 Publications (Page 1 of 2)
2021
CRMP2 Is Involved in Regulation of Mitochondrial Morphology and Motility in Neurons.
Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay and Brustovetsky, Nickolay
Cells, vol. 10, (no. 10), October 17, 2021. | Journal Article
 
The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca2+-induced damage.
Hamilton, James⋅Brustovetsky, Tatiana and Brustovetsky, Nickolay
The Journal of biological chemistry, pp. 100669, April 14, 2021. | Journal Article
2020
Mutant huntingtin does not cross the mitochondrial outer membrane.
Hamilton, James⋅Hamilton, James⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Brustovetsky, Nickolay and Brustovetsky, Nickolay
Human molecular genetics, vol. 29, (no. 17), pp. 2962-2975, October 10, 2020. | Journal Article
 
The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition.
Brustovetsky, Nickolay
Cells, vol. 9, (no. 12), December 15, 2020. | Journal Article
2019
Mutant huntingtin fails to directly impair brain mitochondria.
Hamilton, James⋅Brustovetsky, Tatiana and Brustovetsky, Nickolay
Journal of neurochemistry, vol. 151, (no. 6), pp. 716-731, December 2019. | Journal Article
2017
Oxidative metabolism and Ca2+ handling in striatal mitochondria from YAC128 mice, a model of Huntington's disease.
Hamilton, James⋅Brustovetsky, Tatiana and Brustovetsky, Nickolay
Neurochemistry international, January 3, 2017. | Journal Article
2016
Mutant Huntingtin and Elusive Defects in Oxidative Metabolism and Mitochondrial Calcium Handling
Brustovetsky, Nickolay
(pp. 2944-2953). Jul 2016
 
Oxidative metabolism and Ca2+handling in isolated brain mitochondria and striatal neurons from R6/2 mice, a model of Huntington’s disease
Hamilton, James⋅Pellman, Jessica J⋅Brustovetsky, Tatiana⋅Harris, Robert A and Brustovetsky, Nickolay
Human Molecular Genetics, vol. 25, (no. 13), pp. 2775, 2016-04-30. | Journal Article
2015
Ca(2+) handling in isolated brain mitochondria and cultured neurons derived from the YAC128 mouse model of Huntington's disease.
Pellman, Jessica J⋅Hamilton, James⋅Brustovetsky, Tatiana and Brustovetsky, Nickolay
Journal of neurochemistry, vol. 134, (no. 4), pp. 652-667, August 2015. | Journal Article
 
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock.
Mantel, Charlie R⋅Mantel, Charlie R.⋅Mantel, Charlie R⋅Mantel, Charlie R⋅O’Leary, Heather A.⋅O'Leary, Heather A⋅O’Leary, Heather A⋅O’Leary, Heather A⋅Chitteti, Brahmananda R⋅Chitteti, Brahmananda R⋅Chitteti, Brahmananda R⋅Chitteti, Brahmananda R.⋅Huang, XinXin⋅Huang, Xin Xin⋅Huang, XinXin⋅Huang, XinXin⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, Scott⋅Hangoc, Giao⋅Hangoc, Giao⋅Hangoc, Giao⋅Hangoc, Giao⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Srour, Edward F⋅Srour, Edward F.⋅Srour, Edward F⋅Srour, Edward F⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Haas, David M⋅Haas, David M⋅Haas, David M.⋅Haas, David M⋅Falah, Nadia⋅Falah, Nadia⋅Falah, Nadia⋅Falah, Nadia⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Pelus, Louis M⋅Pelus, Louis M⋅Pelus, Louis M.⋅Pelus, Louis M⋅Bardeesy, Nabeel⋅Bardeesy, Nabeel⋅Bardeesy, Nabeel⋅Bardeesy, Nabeel⋅Fitamant, Julien⋅Fitamant, Julien⋅Fitamant, Julien⋅Fitamant, Julien⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Broxmeyer, Hal E⋅Broxmeyer, Hal E.⋅Broxmeyer, Hal E and Broxmeyer, Hal E
Cell, vol. 161, (no. 7), pp. 1553-1565, June 18, 2015. | Journal Article
 
Oxidative metabolism in YAC128 mouse model of Huntington's disease.
Hamilton, James⋅Pellman, Jessica J⋅Brustovetsky, Tatiana⋅Harris, Robert A and Brustovetsky, Nickolay
Human molecular genetics, vol. 24, (no. 17), pp. 4862-4878, September 1, 2015. | Journal Article
2014
Ferroxitosis: a cell death from modulation of oxidative phosphorylation and PKM2-dependent glycolysis in melanoma.
Lakhter, Alexander J⋅Lakhter, Alexander J⋅Lakhter, Alexander J⋅Lakhter, Alexander J⋅Lakhter, Alexander J⋅Hamilton, James⋅Hamilton, James⋅Hamilton, James⋅Hamilton, James⋅Hamilton, James⋅Dagher, Pierre C⋅Dagher, Pierre C⋅Dagher, Pierre C⋅Dagher, Pierre C⋅Dagher, Pierre C⋅Mukkamala, Suresh⋅Mukkamala, Suresh⋅Mukkamala, Suresh⋅Mukkamala, Suresh⋅Mukkamala, Suresh⋅Hato, Takashi⋅Hato, Takashi⋅Hato, Takashi⋅Hato, Takashi⋅Hato, Takashi⋅Dong, X. Charlie⋅Dong, X. Charlie⋅Dong, X. Charlie⋅Dong, X Charlie⋅Dong, X. Charlie⋅Mayo, Lindsey D⋅Mayo, Lindsey D⋅Mayo, Lindsey D⋅Mayo, Lindsey D⋅Mayo, Lindsey D⋅Harris, Robert A⋅Harris, Robert A⋅Harris, Robert A⋅Harris, Robert A⋅Harris, Robert A⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Naidu, Samisubbu R⋅Naidu, Samisubbu R⋅Naidu, Samisubbu R⋅Naidu, Samisubbu R and Naidu, Samisubbu R
Oncotarget, vol. 5, (no. 24), pp. 12694-12703, December 30, 2014. | Journal Article
2013
Loss of calcium/calmodulin-dependent protein kinase II activity in cortical astrocytes decreases glutamate uptake and induces neurotoxic release of ATP.
Ashpole, Nicole M⋅Ashpole, Nicole M⋅Chawla, Aarti R⋅Chawla, Aarti R⋅Martin, Matthew P⋅Martin, Matthew P⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Hudmon, Andy and Hudmon, Andy
The Journal of biological chemistry, vol. 288, (no. 20), pp. 14599-611, 2013/May/17. | Journal Article
2012
Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.
Ashpole, Nicole M⋅Ashpole, Nicole M⋅Song, Weihua⋅Song, Weihua⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Engleman, Eric A⋅Engleman, Eric A⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Hudmon, Andy and Hudmon, Andy
The Journal of biological chemistry, vol. 287, (no. 11), pp. 8495-506, 2012/Mar/9. | Journal Article
 
Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2 + exchanger
Brittain, Matthew K⋅Brittain, Matthew K⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Sheets, Patrick L⋅Sheets, Patrick L⋅Brittain, Joel M⋅Brittain, Joel M⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Brustovetsky, Nickolay and Brustovetsky, Nickolay
Neurobiology of Disease, vol. 46, (no. 1), pp. 109-117, 2012. | Journal Article
 
Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model.
Brittain, Joel M⋅Pan, Rui⋅You, Haitao⋅Brustovetsky, Tatiana⋅Brustovetsky, Nickolay⋅Zamponi, Gerald W⋅Lee, Wei-Hua and Khanna, Rajesh
Channels (Austin, Tex.), vol. 6, (no. 1), pp. 52-9, 2012 Jan-Feb. | Journal Article
 
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons.
Brittain, Matthew K⋅Brittain, Matthew K⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Brittain, Joel M⋅Brittain, Joel M⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Brustovetsky, Nickolay and Brustovetsky, Nickolay
Neuropharmacology, vol. 63, (no. 6), pp. 974-82, 2012/Nov. | Journal Article
2011
KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, blocks N-methyl-D-aspartate receptor and inhibits mitochondrial complex I
Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Brittain, Matthew K⋅Brittain, Matthew K⋅Sheets, Patrick L⋅Sheets, Patrick L⋅Cummins, Theodore R⋅Cummins, Theodore R⋅Pinelis, Vsevolod⋅Pinelis, Vsevolod⋅Brustovetsky, Nickolay and Brustovetsky, Nickolay
British Journal of Pharmacology, vol. 162, (no. 1), pp. 255-270, 2011. | Journal Article
 
Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex.
Brittain, Joel M⋅Brittain, Joel M⋅Brittain, Joel M⋅Brittain, J.M.⋅Brittain, Joel M⋅Brittain, Joel M⋅Duarte, D.B.⋅Duarte, Djane B⋅Duarte, Djane B⋅Duarte, Djane B⋅Duarte, Djane B⋅Duarte, Djane B⋅Wilson, Sarah M⋅Wilson, Sarah M⋅Wilson, Sarah M⋅Wilson, Sarah M⋅Wilson, S.M.⋅Wilson, Sarah M⋅Zhu, Weiguo⋅Zhu, Weiguo⋅Zhu, Weiguo⋅Zhu, Weiguo⋅Zhu, Weiguo⋅Zhu, W.⋅Ballard, Carrie⋅Ballard, Carrie⋅Ballard, Carrie⋅Ballard, Carrie⋅Ballard, Carrie⋅Ballard, C.⋅Johnson, Philip L⋅Johnson, P.L.⋅Johnson, Philip L⋅Johnson, Philip L⋅Johnson, Philip L⋅Johnson, Philip L⋅Liu, Naikui⋅Liu, Naikui⋅Liu, Naikui⋅Liu, Naikui⋅Liu, N.⋅Liu, Naikui⋅Xiong, Wenhui⋅Xiong, Wenhui⋅Xiong, Wenhui⋅Xiong, W.⋅Xiong, Wenhui⋅Xiong, Wenhui⋅Ripsch, Matthew S⋅Ripsch, Matthew S⋅Ripsch, Matthew S⋅Ripsch, M.S.⋅Ripsch, Matthew S⋅Ripsch, Matthew S⋅Wang, Yuying⋅Wang, Yuying⋅Wang, Yuying⋅Wang, Y.⋅Wang, Yuying⋅Wang, Yuying⋅Fehrenbacher, Jill C⋅Fehrenbacher, Jill C⋅Fehrenbacher, J.C.⋅Fehrenbacher, Jill C⋅Fehrenbacher, Jill C⋅Fehrenbacher, Jill C⋅Fitz, S.D.⋅Fitz, Stephanie D⋅Fitz, Stephanie D⋅Fitz, Stephanie D⋅Fitz, Stephanie D⋅Fitz, Stephanie D⋅Khanna, May⋅Khanna, May⋅Khanna, May⋅Khanna, May⋅Khanna, May⋅Khanna, M.⋅Park, C.-K.⋅Park, Chul-Kyu⋅Park, Chul-Kyu⋅Park, Chul-Kyu⋅Park, Chul-Kyu⋅Park, Chul-Kyu⋅Schmutzler, Brian S⋅Schmutzler, Brian S⋅Schmutzler, Brian S⋅Schmutzler, Brian S⋅Schmutzler, Brian S⋅Schmutzler, B.S.⋅Cheon, Bo M⋅Cheon, B.M.⋅Cheon, Bo Myung⋅Cheon, Bo Myung⋅Cheon, Bo Myung⋅Cheon, Bo Myung⋅Due, Michael R⋅Due, Michael R⋅Due, Michael R⋅Due, Michael R⋅Due, M.R.⋅Due, Michael R⋅Brustovetsky, T.⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Brustovetsky, Tatiana⋅Ashpole, Nicole M⋅Ashpole, Nicole M⋅Ashpole, N.M.⋅Ashpole, Nicole M⋅Ashpole, Nicole M⋅Ashpole, Nicole M⋅Hudmon, A.⋅Hudmon, Andy⋅Hudmon, Andy⋅Hudmon, Andy⋅Hudmon, Andy⋅Hudmon, Andy⋅Meroueh, Samy O⋅Meroueh, Samy O⋅Meroueh, S.O.⋅Meroueh, Samy⋅Meroueh, Samy O⋅Meroueh, Samy O⋅Hingtgen, Cynthia M⋅Hingtgen, Cynthia M⋅Hingtgen, Cynthia M⋅Hingtgen, Cynthia M⋅Hingtgen, Cynthia M⋅Hingtgen, C.M.⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, N.⋅Brustovetsky, Nickolay⋅Ji, Ru-Rong⋅Ji, Ru-Rong⋅Ji, Ru-Rong⋅Ji, Ru-Rong⋅Ji, R.-R.⋅Ji, Ru Rong⋅Hurley, Joyce H⋅Hurley, Joyce H⋅Hurley, Joyce H⋅Hurley, Joyce H⋅Hurley, J.H.⋅Hurley, Joyce H⋅Jin, Xiaoming⋅Jin, Xiaoming⋅Jin, Xiaoming⋅Jin, X.⋅Jin, Xiaoming⋅Jin, Xiaoming⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Shekhar, A.⋅Shekhar, Anantha⋅Shekhar, Anantha⋅Xu, Xiao-Ming⋅Xu, Xiao-Ming⋅Xu, Xiao-Ming⋅Xu, Xiao-Ming⋅Xu, Xiao-Ming⋅Xu, X. M.⋅Oxford, Gerry S⋅Oxford, Gerry S⋅Oxford, Gerry S⋅Oxford, Gerry S⋅Oxford, Gerry S⋅Oxford, G.S.⋅Vasko, Michael R⋅Vasko, Michael R⋅Vasko, Michael R⋅Vasko, M.R.⋅Vasko, Michael R⋅Vasko, Michael R⋅White, Fletcher A⋅White, F.A.⋅White, Fletcher A⋅White, Fletcher A⋅White, Fletcher A⋅White, Fletcher A⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Khanna, Rajesh⋅Khanna, R. and Khanna, Rajesh
Nature medicine, vol. 17, (no. 7), pp. 822-9, 2011/Jul. | Journal Article
2010
BAX insertion, oligomerization, and outer membrane permeabilization in brain mitochondria: role of permeability transition and SH-redox regulation.
Brustovetsky, Tatiana⋅Li, Tsyregma⋅Yang, Youyun⋅Zhang, Jiang Ting⋅Antonsson, Bruno and Brustovetsky, Nickolay
Biochimica et biophysica acta, vol. 1797, (no. 11), pp. 1795-806, 2010/Nov. | Journal Article
 
Calpain activation and Na+/Ca2+ exchanger degradation occur downstream of calcium deregulation in hippocampal neurons exposed to excitotoxic glutamate
Brustovetsky, Tatiana⋅Bolshakov, Alexey and Brustovetsky, Nickolay
Journal of Neuroscience Research, vol. 88, (no. 6), pp. 1317-1328, 2010. | Journal Article
 
Dissimilar mechanisms of cytochrome c release induced by octyl glucoside-activated BAX and by BAX activated with truncated BID.
Li, Tsyregma⋅Brustovetsky, Tatiana⋅Antonsson, Bruno and Brustovetsky, Nickolay
Biochimica et biophysica acta, vol. 1797, (no. 1), pp. 52-62, 2010/Jan. | Journal Article
 
Neuroprotective Effect of KB-R7943 Against Glutamate Excitotoxicity is Related to Mild Mitochondrial Depolarization
Storozhevykh, TP⋅Senilova, YaE⋅Brustovetsky, T.⋅Pinelis, VG and Brustovetsky, Nickolay
Neurochemical Research, vol. 35, (no. 2), pp. 323-335, 2010. | Journal Article
2009
Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death
Li, Viacheslav⋅Brustovetsky, Tatiana and Brustovetsky, Nickolay
Experimental Neurology, vol. 218, (no. 2), pp. 171-182, 2009. | Journal Article
 
Stimulation of glutamate receptors in cultured hippocampal neurons causes Ca2+-dependent mitochondrial contraction.
Brustovetsky, Tatiana⋅Li, Viacheslav and Brustovetsky, Nickolay
Cell calcium, vol. 46, (no. 1), pp. 18-29, 2009/Jul. | Journal Article