Current Research Interests: Mdm2 was initially described as an oncogene through its ability to transform cells. Clinically, Mdm2 is not detected in normal tissue but is detectable in 40-80% of various types of late stage cancers (adult and children). It remains unclear whether there are specific transcription factors that are necessary to elevate mdm2 gene expression in response to growth factors and cytokines, which are highly elevated in the tumor microenvironment. In addition, there are major voids in our understanding of how Mdm2 is regulated at the post-translational level to regulate proteins in tumor cells to promote metastasis in response to the growth factors and cytokines in the tumor microenvironment
His research focus was in Biochemistry and Molecular Biology focused on the regulation of Mdm2 oncogene.
