Research in my laboratory is centered on using three dimensional structure of proteins targets to design small molecules that modulate their function.
Our work currently focuses on the following classes of targets: urokinase-type plasminogen activator system, serine/threonine kinases, aldehyde dehydrogenases, and voltage-gated calcium channels. Compounds are identified through structure-based design that involves molecular docking and scoring.
I worked on understanding the mechanism by which β-lactamases hydrolyze β-lactam antibiotics.
Subject Area:
- Biochemistry & Molecular Biology.
Expertise:
- Pain Research
- Spinal Cord and Brain Injury Research
