The laboratory focuses on mechanisms regulating proliferation, survival, self-renewal, metabolism, differentiation and homing/mobilization of hematopoietic, embryonic, and induced pluripotent stem cells at cellular, intracellular, and animal levels, as well as gene transfer, to influence these functions.
Dr. Broxmeyer's laboratory is interested in blood cell production (hematopoiesis) in the context of normal and abnormal cell regulation as assessed in vitro and in vivo.
Dr. Broxmeyer's research interests include:
- Study of the mechanisms regulating blood cell production (hematopoiesis) of normal and abnormal cell regulation as assessed in vitro and in vivo at the level of proliferation/self-enewal/differentiation/apoptosis and homing/migration of hematopoietic stem and progenitor cells, as well as regulation in the context of oxygen tension and the microenvironment, and generation of induced pluripotent stem cells.
