My overall career goal is to integrate preclinical and clinical research to investigate the mechanisms of centrally regulated anxiety and panic-associated behavior that coincides with cardio-respiratory and thermoregulatory activity, and determine how these systems contribute to menopausal symptoms (e.g., hot flashes and anxiety) from loss of estrogen tone; neuropsychiatric disorders such as panic disorder and post traumatic stress disorder (PTSD); and respiratory disorders such as chronic obstructive pulmonary disorder (COPD).