185 Publications (Page 3 of 8)
2017
Once Blind, Now We See GLP-1 Molecular Action
Mayer, John P⋅Tschöp, Matthias H and Di Marchi, Richard D
Cell Metabolism, vol. 26, (no. 2), pp. 291, 2017-08-01. | Journal Article
 
Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose‐dependent insulinotropic polypeptide/glucagon‐like peptide‐1 agonist RG7697 in people with type 2 diabetes mellitus
Schmitt, Christophe⋅Portron, Agnès⋅Jadidi, Shirin⋅Sarkar, Neena and Di Marchi, Richard
Diabetes, Obesity and Metabolism, vol. 19, (no. 10), pp. 1445, October 2017. | Journal Article
 
Pharmacodynamics, pharmacokinetics, safety and tolerability of the novel dual glucose‐dependent insulinotropic polypeptide/glucagon‐like peptide‐1 agonist RG7697 after single subcutaneous administration in healthy subjects
Portron, Agnès⋅Jadidi, Shirin⋅Sarkar, Neena⋅Di Marchi, Richard and Schmitt, Christophe
Diabetes, Obesity and Metabolism, vol. 19, (no. 10), pp. 1453, October 2017. | Journal Article
 
Single-Molecule Combinatorial Therapeutics for Treating Obesity and Diabetes.
Tschöp, Matthias and Di Marchi, Richard
Diabetes, June 11, 2017. | Journal Article
 
Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.
Wu, Fangzhou⋅Wu, Fangzhou⋅Mayer, John P⋅Mayer, John P⋅Gelfanov, Vasily G⋅Gelfanov, Vasily M⋅Liu, Fa⋅Liu, Fa⋅DiMarchi, Richard D and Di Marchi, Richard D
The Journal of organic chemistry, March 20, 2017. | Journal Article
 
Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision
Thalluri, Kishore⋅Thalluri, Kishore⋅Thalluri, Kishore⋅Thalluri, Kishore⋅Kou, Binbin⋅Kou, Binbin⋅Kou, Binbin⋅Kou, Binbin⋅Yang, Xu⋅Yang, Xu⋅Yang, Xu⋅Yang, Xu⋅Zaykov, Alexander N⋅Zaykov, Alexander N⋅Zaykov, Alexander N⋅Zaykov, Alexander N⋅Mayer, John P⋅Mayer, John P⋅Mayer, John P⋅Mayer, John P⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Liu, Fa⋅Liu, Fa⋅Liu, Fa⋅Liu, Fa⋅Di Marchi, Richard D⋅DiMarchi, Richard D⋅DiMarchi, Richard D and DiMarchi, Richard D
Journal of Peptide Science, vol. 23, (no. 6), pp. 465, June 2017. | Journal Article
 
Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity.
Liu, Fa⋅Liu, Fa⋅Liu, Fa⋅Li, Pengyun⋅Li, Pengyun⋅Li, Pengyun⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Mayer, John⋅Mayer, John⋅Mayer, John⋅Di Marchi, Richard⋅DiMarchi, Richard and DiMarchi, Richard
Accounts of chemical research, August 3, 2017. | Journal Article
 
The Sustained Effects of a Dual GIP/GLP-1 Receptor Agonist, NNC0090-2746, in Patients with Type 2 Diabetes
Frias, Juan Pablo⋅Bastyr, Edward J⋅Vignati, Louis⋅Tschöp, Matthias H⋅Schmitt, Christophe⋅Owen, Klara⋅Christensen, Rune Haubo and Di Marchi, Richard D
Cell Metabolism, vol. 26, (no. 2), pp. 352.e2, 2017-08-01. | Journal Article
 
Treatment of Diabetes and Obesity by Rationally Designed Peptide Agonists Functioning at Multiple Metabolic Receptors
Khajavi, Noushafarin⋅Biebermann, Heike⋅Tschöp, Matthias and Di Marchi, Richard
Developmental Biology of Gastrointestinal Hormones, vol. 32, pp. 182, 20170800. | Journal Article
2016
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
Finan, B.⋅Finan, Brian⋅Finan, Brian⋅Finan, B.⋅Clemmensen, Christoffer⋅Clemmensen, Christoffer⋅Clemmensen, C.⋅Clemmensen, C.⋅Zhu, Z.⋅Zhu, Z.⋅Zhu, Zhimeng⋅Zhu, Zhimeng⋅Stemmer, K.⋅Stemmer, Kerstin⋅Stemmer, K.⋅Stemmer, Kerstin⋅Gauthier, K.⋅Gauthier, Karine⋅Gauthier, K.⋅Gauthier, Karine⋅Müller, L.⋅Müller, Timo D⋅Müller, Luisa⋅Müller, L.⋅Müller, Luisa⋅Müller, Timo D⋅De Angelis, M.⋅De Angelis, Meri⋅De Angelis, Meri⋅De Angelis, M.⋅Moreth, K.⋅Moreth, K.⋅Moreth, Kristin⋅Moreth, Kristin⋅Neff, F.⋅Neff, Frauke⋅Neff, F.⋅Neff, Frauke⋅Perez-Tilve, Diego⋅Perez-Tilve, D.⋅Perez-Tilve, Diego⋅Perez-Tilve, D.⋅Fischer, Katrin⋅Fischer, K.⋅Fischer, Katrin⋅Fischer, K.⋅Lutter, Dominik⋅Lutter, D.⋅Lutter, D.⋅Lutter, Dominik⋅Sánchez-Garrido, M.A.⋅Sánchez-Garrido, Miguel A⋅Sánchez-Garrido, M.A.⋅Sánchez-Garrido, Miguel A⋅Liu, P.⋅Liu, P.⋅Liu, Peng⋅Liu, Fa⋅Liu, Fa⋅Liu, Peng⋅Tuckermann, J.⋅Tuckermann, Jan⋅Tuckermann, Jan⋅Tuckermann, J.⋅Malehmir, M.⋅Malehmir, Mohsen⋅Malehmir, M.⋅Malehmir, Mohsen⋅Healy, Marc E⋅Healy, M.E.⋅Healy, M.E.⋅Healy, Marc E⋅Weber, A.⋅Weber, Achim⋅Weber, Christian⋅Weber, Achim⋅Weber, A.⋅Weber, Christian⋅Heikenwalder, M.⋅Heikenwalder, Mathias⋅Heikenwalder, Mathias⋅Heikenwalder, M.⋅Jastroch, Martin⋅Jastroch, Martin⋅Jastroch, M.⋅Jastroch, M.⋅Kleinert, M.⋅Kleinert, Maximilian⋅Kleinert, M.⋅Kleinert, Maximilian⋅Jall, S.⋅Jall, S.⋅Jall, Sigrid⋅Jall, Sigrid⋅Brandt, S.⋅Brandt, S.⋅Brandt, Sara⋅Brandt, Sara⋅Flamant, F.⋅Flamant, Frédéric⋅Flamant, Frédéric⋅Flamant, F.⋅Schramm, Karl-Werner⋅Schramm, Karl-Werner⋅Schramm, K.-W.⋅Schramm, K.-W.⋅Biebermann, Heike⋅Biebermann, Heike⋅Biebermann, H.⋅Biebermann, H.⋅Döring, Y.⋅Döring, Yvonne⋅Döring, Yvonne⋅Döring, Y.⋅Weber, C.⋅Weber, C.⋅Habegger, K.M.⋅Habegger, Kirk M⋅Habegger, K.M.⋅Habegger, Kirk M⋅Keuper, Michaela⋅Keuper, M.⋅Keuper, Michaela⋅Keuper, M.⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, V.⋅Gelfanov, V.⋅Liu, F.⋅Liu, F.⋅Köhrle, J.⋅Köhrle, J.⋅Köhrle, Josef⋅Köhrle, Josef⋅Rozman, Jan⋅Rozman, Jan⋅Rozman, J.⋅Rozman, J.⋅Fuchs, H.⋅Fuchs, Helmut⋅Fuchs, H.⋅Fuchs, Helmut⋅Gailus-Durner, Valerie⋅Gailus-Durner, V.⋅Gailus-Durner, V.⋅Gailus-Durner, Valerie⋅Hrabě de Angelis, Martin⋅Hrabě de Angelis, Martin⋅Angelis, M.⋅Angelis, M.⋅Hofmann, Susanna M⋅Hofmann, S.M.⋅Hofmann, S.M.⋅Hofmann, Susanna M⋅Yang, Bin⋅Yang, B.⋅Yang, Bin⋅Yang, B.⋅Tschöp, M.H.⋅Tschöp, Matthias H⋅Tschöp, Matthias H⋅Tschöp, M.H.⋅DiMarchi, Richard⋅DiMarchi, R.⋅Di Marchi, Richard⋅DiMarchi, R.⋅Müller, T.D. and Müller, T.D.
Cell, vol. 167, (no. 3), pp. 857.e14, 2016-10-20. | Journal Article
 
Chemical Synthesis of Human Insulin-Like Peptide-6.
Wu, Fangzhou⋅Wu, Fangzhou⋅Mayer, John P⋅Mayer, John P⋅Zaykov, Alexander N⋅Zaykov, Alexander N⋅Zhang, Fa⋅Zhang, Fa⋅Liu, Fa⋅Liu, Fa⋅DiMarchi, Richard D and Di Marchi, Richard D
Chemistry (Weinheim an der Bergstrasse, Germany), vol. 22, (no. 28), pp. 9777-9783, July 4, 2016. | Journal Article
 
Fibroblast activation protein (FAP) as a novel metabolic target
Sánchez-Garrido, M.A.⋅Sánchez-Garrido, Miguel⋅Sánchez-Garrido, Miguel⋅Sánchez-Garrido, M.A.⋅Habegger, K.M.⋅Habegger, K.M.⋅Habegger, Kirk⋅Habegger, Kirk⋅Clemmensen, Christoffer⋅Clemmensen, Christoffer⋅Clemmensen, C.⋅Clemmensen, C.⋅Holleman, C.⋅Holleman, Cassie⋅Holleman, Cassie⋅Holleman, C.⋅Müller, T.D.⋅Müller, Timo⋅Müller, T.D.⋅Müller, Timo⋅Perez-Tilve, D.⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, D.⋅Li, Pengyun⋅Li, P.⋅Li, Pengyun⋅Li, P.⋅Agrawal, Archita⋅Agrawal, A.S.⋅Agrawal, A.S.⋅Agrawal, Archita⋅Finan, B.⋅Finan, B.⋅Finan, Brian⋅Finan, Brian⋅Drucker, Daniel⋅Drucker, D.J.⋅Drucker, D.J.⋅Drucker, Daniel⋅Tschöp, Matthias⋅Tschöp, M.H.⋅Tschöp, Matthias⋅Tschöp, M.H.⋅DiMarchi, R.D.⋅Di Marchi, Richard⋅DiMarchi, Richard⋅DiMarchi, R.D.⋅Kharitonenkov, Alexei⋅Kharitonenkov, Alexei⋅Kharitonenkov, A. and Kharitonenkov, A.
Molecular Metabolism, vol. 5, (no. 10), pp. 1024, 2016. | Journal Article
 
GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight
Vogel, Heike⋅Vogel, Heike⋅Wolf, Stefanie⋅Wolf, Stefanie⋅Rabasa, Cristina⋅Rabasa, Cristina⋅Rodriguez-Pacheco, Francisca⋅Rodriguez-Pacheco, Francisca⋅Babaei, Carina S⋅Babaei, Carina S⋅Stöber, Franziska⋅Stöber, Franziska⋅Goldschmidt, Jürgen⋅Goldschmidt, Jürgen⋅DiMarchi, Richard D⋅Di Marchi, Richard D⋅Finan, Brian⋅Finan, Brian⋅Tschöp, Matthias H⋅Tschöp, Matthias H⋅Dickson, Suzanne L⋅Dickson, Suzanne L⋅Schürmann, Annette⋅Schürmann, Annette⋅Skibicka, Karolina P and Skibicka, Karolina P
Neuropharmacology, vol. 110, (no. Pt A), pp. 406, November 2016. | Journal Article
 
GLP-1 directed delivery of dexamethasone ameliorates hypothalamic inflammation and reverses diet-induced obesity
Quarta, Carmelo⋅Clemmensen, Christoffer⋅Yang, Bin⋅Zhu, Zhimeng⋅Muller, Timo D⋅Di Marchi, Richard D⋅Finan, Brian and Tschop, Matthias H
Endocrine Abstracts, 2016-05-13. | Journal Article
 
Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon
Mroz, Piotr A⋅Mroz, Piotr A⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Liu, Fa⋅Liu, Fa⋅Mayer, John P⋅Mayer, John P⋅DiMarchi, Richard D and Di Marchi, Richard D
ACS chemical biology, vol. 11, (no. 12), pp. 3420, 2016-12-16. | Journal Article
 
Pursuit of a perfect insulin
Zaykov, Alexander N⋅Mayer, John P and Di Marchi, Richard D
Nature reviews. Drug discovery, vol. 15, (no. 6), pp. 439, 2016-06-00. | Journal Article
 
Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.
Mroz, Piotr A⋅Mroz, Piotr A⋅Mroz, Piotr A⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Liu, Fa⋅Liu, Fa⋅Liu, Fa⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅DiMarchi, Richard D⋅DiMarchi, Richard D⋅Di Marchi, Richard D⋅Mayer, John P⋅Mayer, John P and Mayer, John P
Journal of medicinal chemistry, vol. 59, (no. 17), pp. 8061-8067, September 8, 2016. | Journal Article
 
Synthetic Route to Human Relaxin-2 via Iodine-Free Sequential Disulfide Bond Formation
Yang, Xu⋅Yang, Xu⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Liu, Fa⋅Liu, Fa⋅DiMarchi, Richard and Di Marchi, Richard
Organic letters, vol. 18, (no. 21), pp. 5519, 2016-11-04. | Journal Article
2015
A new quorum-sensing system (TprA/PhrA) forStreptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster
Hoover, Sharon E⋅Hoover, Sharon E⋅Hoover, Sharon E⋅Perez, Amilcar J⋅Perez, Amilcar J⋅Perez, Amilcar J⋅Tsui, Ho‐Ching T⋅Tsui, Ho-Ching T⋅Tsui, Ho-Ching T⋅Sinha, Dhriti⋅Sinha, Dhriti⋅Sinha, Dhriti⋅Smiley, David L⋅Smiley, David L⋅Smiley, David L⋅DiMarchi, Richard D⋅Di Marchi, Richard D⋅DiMarchi, Richard D⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Lazazzera, Beth A⋅Lazazzera, Beth A and Lazazzera, Beth A
Molecular Microbiology, vol. 97, (no. 2), pp. 243, 2015-07-00. | Journal Article
 
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, Brian⋅Finan, Brian⋅Finan, B.⋅Finan, Brian⋅Finan, Brian⋅Finan, B.⋅Finan, Brian⋅Yang, Bin⋅Yang, Bin⋅Yang, Bin⋅Yang, B.⋅Yang, Bin⋅Yang, B.⋅Yang, Bin⋅Ottaway, N.⋅Ottaway, N.⋅Ottaway, Nickki⋅Ottaway, Nickki⋅Ottaway, Nickki⋅Ottaway, Nickki⋅Ottaway, Nickki⋅Smiley, David L⋅Smiley, David L⋅Smiley, David L⋅Smiley, D.L.⋅Smiley, David L⋅Smiley, David L⋅Smiley, D.L.⋅Ma, Tao⋅Ma, T.⋅Ma, Tao⋅Ma, Tao⋅Ma, Tao⋅Ma, Tao⋅Ma, T.⋅Clemmensen, Christoffer⋅Clemmensen, Christoffer⋅Clemmensen, Christoffer⋅Clemmensen, C.⋅Clemmensen, C.⋅Clemmensen, Christoffer⋅Clemmensen, Christoffer⋅Chabenne, Joe⋅Chabenne, Joe⋅Chabenne, Joe⋅Chabenne, J.⋅Chabenne, Joe⋅Chabenne, J.⋅Chabenne, Joe⋅Zhang, Lianshan⋅Zhang, Lianshan⋅Zhang, Lianshan⋅Zhang, Lianshan⋅Zhang, L.⋅Zhang, L.⋅Zhang, Lianshan⋅Habegger, Kirk M⋅Habegger, Kirk M⋅Habegger, Kirk M⋅Habegger, K.M.⋅Habegger, K.M.⋅Habegger, Kirk M⋅Habegger, Kirk M⋅Fischer, K.⋅Fischer, Katrin⋅Fischer, Katrin⋅Fischer, K.⋅Fischer, Katrin⋅Fischer, Katrin⋅Fischer, Katrin⋅Campbell, J.E.⋅Campbell, Jonathan E⋅Campbell, Jonathan E⋅Campbell, Jonathan E⋅Campbell, J.E.⋅Campbell, Jonathan E⋅Campbell, Jonathan E⋅Sandoval, Darleen⋅Sandoval, D.⋅Sandoval, Darleen⋅Sandoval, Darleen⋅Sandoval, D.⋅Sandoval, Darleen⋅Sandoval, Darleen⋅Seeley, Randy J⋅Seeley, Randy J⋅Seeley, R.J.⋅Seeley, R.J.⋅Seeley, Randy J⋅Seeley, Randy J⋅Seeley, Randy J⋅Bleicher, Konrad⋅Bleicher, Konrad⋅Bleicher, Konrad⋅Bleicher, Konrad⋅Bleicher, K.⋅Bleicher, Konrad⋅Bleicher, K.⋅Uhles, S.⋅Uhles, Sabine⋅Uhles, Sabine⋅Uhles, Sabine⋅Uhles, S.⋅Uhles, Sabine⋅Uhles, Sabine⋅Riboulet, William⋅Riboulet, William⋅Riboulet, William⋅Riboulet, William⋅Riboulet, W.⋅Riboulet, W.⋅Riboulet, William⋅Funk, J.⋅Funk, Jürgen⋅Funk, Jürgen⋅Funk, J.⋅Funk, Jürgen⋅Funk, Jürgen⋅Funk, Jürgen⋅Hertel, Cornelia⋅Hertel, Cornelia⋅Hertel, C.⋅Hertel, Cornelia⋅Hertel, C.⋅Hertel, Cornelia⋅Hertel, Cornelia⋅Belli, Sara⋅Belli, Sara⋅Belli, Sara⋅Belli, Sara⋅Belli, Sara⋅Belli, S.⋅Belli, S.⋅Sebokova, Elena⋅Sebokova, E.⋅Sebokova, Elena⋅Sebokova, Elena⋅Sebokova, Elena⋅Sebokova, Elena⋅Sebokova, E.⋅Conde-knape, Karin⋅Conde-knape, Karin⋅Conde-Knape, K.⋅Conde-Knape, Karin⋅Conde-Knape, Karin⋅Conde-Knape, K.⋅Conde-Knape, Karin⋅Konkar, Anish⋅Konkar, Anish⋅Konkar, A.⋅Konkar, Anish⋅Konkar, Anish⋅Konkar, A.⋅Konkar, Anish⋅Drucker, Daniel J⋅Drucker, Daniel J⋅Drucker, Daniel J⋅Drucker, D.J.⋅Drucker, D.J.⋅Drucker, Daniel J⋅Drucker, Daniel J⋅Gelfanov, Vasily⋅Gelfanov, V.⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, V.⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Pfluger, Paul T⋅Pfluger, Paul T⋅Pfluger, Paul T⋅Pfluger, P.T.⋅Pfluger, P.T.⋅Pfluger, Paul T⋅Pfluger, Paul T⋅Müller, Timo D⋅Müller, T.D.⋅Müller, Timo D⋅Müller, T.D.⋅Müller, Timo D⋅Müller, Timo D⋅Müller, Timo D⋅Perez-Tilve, Diego⋅Perez-tilve, Diego⋅Perez-Tilve, D.⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-tilve, Diego⋅Perez-Tilve, D.⋅Dimarchi, Richard D⋅Di Marchi, Richard D⋅Dimarchi, Richard D⋅DiMarchi, R.D.⋅DiMarchi, R.D.⋅DiMarchi, Richard D⋅DiMarchi, Richard D⋅Tschöp, M.H.⋅Tschöp, Matthias H⋅Tschöp, Matthias H⋅Tschöp, Matthias H⋅Tschöp, Matthias H⋅Tschöp, M.H. and Tschöp, Matthias H
Nature medicine, vol. 21, (no. 1), pp. 36, 2015-Jan. | Journal Article
 
Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice
Heppner, Kristy⋅Marks, Sarah⋅Holland, Jenna⋅Ottaway, Nickki⋅Smiley, David⋅Dimarchi, Richard and Perez-Tilve, Diego
Diabetologia, vol. 58, (no. 9), pp. 2132, 20150900. | Journal Article
 
Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis.
Tiano, Joseph P⋅Tate, Chandra R⋅Yang, Bin S⋅Di Marchi, Richard and Mauvais-Jarvis, Franck
Scientific reports, vol. 5, pp. 10211, 2015. | Journal Article
 
FGF21: starvation hormone to a clinical drug?
Kharitonenkov, Alexei⋅Kharitonenkov, Alexei⋅Agrawal, Archita⋅Agrawal, Archita⋅Li, Pengyun⋅Li, Pengyun⋅DiMarchi, Richard⋅Di Marchi, Richard⋅Perez-Tlive, Diego and Perez-Tlive, Diego
Endocrine Abstracts, 2015-10-12. | Journal Article
 
GLP-1–oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice
Schwenk, Robert⋅Baumeier, Christian⋅Finan, Brian⋅Kluth, Oliver⋅Brauer, Christine⋅Joost, Hans-Georg⋅Di Marchi, Richard⋅Tschöp, Matthias and Schürmann, Annette
Diabetologia, vol. 58, (no. 3), pp. 614, 20150300. | Journal Article
 
Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity.
Wu, Fangzhou⋅Wu, Fangzhou⋅Chabenne, Joseph R⋅Chabenne, Joseph R⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Mayer, John P⋅Mayer, John P⋅DiMarchi, Richard D and Di Marchi, Richard D
Journal of peptide science : an official publication of the European Peptide Society, vol. 21, (no. 3), pp. 223-230, March 2015. | Journal Article