185 Publications (Page 3 of 8)
Once Blind, Now We See GLP-1 Molecular Action
Mayer, John PTschöp, Matthias H and Di Marchi, Richard D
Cell Metabolism, vol. 26, (no. 2), pp. 291, 2017-08-01. | Journal Article
Pharmacodynamics, pharmacokinetics and safety of multiple ascending doses of the novel dual glucose‐dependent insulinotropic polypeptide/glucagon‐like peptide‐1 agonist RG7697 in people with type 2 diabetes mellitus
Schmitt, ChristophePortron, AgnèsJadidi, ShirinSarkar, Neena and Di Marchi, Richard
Diabetes, Obesity and Metabolism, vol. 19, (no. 10), pp. 1445, October 2017. | Journal Article
Pharmacodynamics, pharmacokinetics, safety and tolerability of the novel dual glucose‐dependent insulinotropic polypeptide/glucagon‐like peptide‐1 agonist RG7697 after single subcutaneous administration in healthy subjects
Portron, AgnèsJadidi, ShirinSarkar, NeenaDi Marchi, Richard and Schmitt, Christophe
Diabetes, Obesity and Metabolism, vol. 19, (no. 10), pp. 1453, October 2017. | Journal Article
Single-Molecule Combinatorial Therapeutics for Treating Obesity and Diabetes.
Tschöp, Matthias and Di Marchi, Richard
Diabetes, June 11, 2017. | Journal Article
Synthesis of Four-Disulfide Insulin Analogs via Sequential Disulfide Bond Formation.
Wu, FangzhouWu, FangzhouMayer, John PMayer, John PGelfanov, Vasily GGelfanov, Vasily MLiu, FaLiu, FaDiMarchi, Richard D and Di Marchi, Richard D
The Journal of organic chemistry, March 20, 2017. | Journal Article
Synthesis of relaxin‐2 and insulin‐like peptide 5 enabled by novel tethering and traceless chemical excision
Thalluri, KishoreThalluri, KishoreThalluri, KishoreThalluri, KishoreKou, BinbinKou, BinbinKou, BinbinKou, BinbinYang, XuYang, XuYang, XuYang, XuZaykov, Alexander NZaykov, Alexander NZaykov, Alexander NZaykov, Alexander NMayer, John PMayer, John PMayer, John PMayer, John PGelfanov, Vasily MGelfanov, Vasily MGelfanov, Vasily MGelfanov, Vasily MLiu, FaLiu, FaLiu, FaLiu, FaDi Marchi, Richard DDiMarchi, Richard DDiMarchi, Richard D and DiMarchi, Richard D
Journal of Peptide Science, vol. 23, (no. 6), pp. 465, June 2017. | Journal Article
Synthetic Advances in Insulin-like Peptides Enable Novel Bioactivity.
Liu, FaLiu, FaLiu, FaLi, PengyunLi, PengyunLi, PengyunGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyMayer, JohnMayer, JohnMayer, JohnDi Marchi, RichardDiMarchi, Richard and DiMarchi, Richard
Accounts of chemical research, August 3, 2017. | Journal Article
The Sustained Effects of a Dual GIP/GLP-1 Receptor Agonist, NNC0090-2746, in Patients with Type 2 Diabetes
Frias, Juan PabloBastyr, Edward JVignati, LouisTschöp, Matthias HSchmitt, ChristopheOwen, KlaraChristensen, Rune Haubo and Di Marchi, Richard D
Cell Metabolism, vol. 26, (no. 2), pp. 352.e2, 2017-08-01. | Journal Article
Treatment of Diabetes and Obesity by Rationally Designed Peptide Agonists Functioning at Multiple Metabolic Receptors
Khajavi, NoushafarinBiebermann, HeikeTschöp, Matthias and Di Marchi, Richard
Developmental Biology of Gastrointestinal Hormones, vol. 32, pp. 182, 20170800. | Journal Article
Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease
Finan, B.Finan, BrianFinan, BrianFinan, B.Clemmensen, ChristofferClemmensen, ChristofferClemmensen, C.Clemmensen, C.Zhu, Z.Zhu, Z.Zhu, ZhimengZhu, ZhimengStemmer, K.Stemmer, KerstinStemmer, K.Stemmer, KerstinGauthier, K.Gauthier, KarineGauthier, K.Gauthier, KarineMüller, L.Müller, Timo DMüller, LuisaMüller, L.Müller, LuisaMüller, Timo DDe Angelis, M.De Angelis, MeriDe Angelis, MeriDe Angelis, M.Moreth, K.Moreth, K.Moreth, KristinMoreth, KristinNeff, F.Neff, FraukeNeff, F.Neff, FraukePerez-Tilve, DiegoPerez-Tilve, D.Perez-Tilve, DiegoPerez-Tilve, D.Fischer, KatrinFischer, K.Fischer, KatrinFischer, K.Lutter, DominikLutter, D.Lutter, D.Lutter, DominikSánchez-Garrido, M.A.Sánchez-Garrido, Miguel ASánchez-Garrido, M.A.Sánchez-Garrido, Miguel ALiu, P.Liu, P.Liu, PengLiu, FaLiu, FaLiu, PengTuckermann, J.Tuckermann, JanTuckermann, JanTuckermann, J.Malehmir, M.Malehmir, MohsenMalehmir, M.Malehmir, MohsenHealy, Marc EHealy, M.E.Healy, M.E.Healy, Marc EWeber, A.Weber, AchimWeber, ChristianWeber, AchimWeber, A.Weber, ChristianHeikenwalder, M.Heikenwalder, MathiasHeikenwalder, MathiasHeikenwalder, M.Jastroch, MartinJastroch, MartinJastroch, M.Jastroch, M.Kleinert, M.Kleinert, MaximilianKleinert, M.Kleinert, MaximilianJall, S.Jall, S.Jall, SigridJall, SigridBrandt, S.Brandt, S.Brandt, SaraBrandt, SaraFlamant, F.Flamant, FrédéricFlamant, FrédéricFlamant, F.Schramm, Karl-WernerSchramm, Karl-WernerSchramm, K.-W.Schramm, K.-W.Biebermann, HeikeBiebermann, HeikeBiebermann, H.Biebermann, H.Döring, Y.Döring, YvonneDöring, YvonneDöring, Y.Weber, C.Weber, C.Habegger, K.M.Habegger, Kirk MHabegger, K.M.Habegger, Kirk MKeuper, MichaelaKeuper, M.Keuper, MichaelaKeuper, M.Gelfanov, VasilyGelfanov, VasilyGelfanov, V.Gelfanov, V.Liu, F.Liu, F.Köhrle, J.Köhrle, J.Köhrle, JosefKöhrle, JosefRozman, JanRozman, JanRozman, J.Rozman, J.Fuchs, H.Fuchs, HelmutFuchs, H.Fuchs, HelmutGailus-Durner, ValerieGailus-Durner, V.Gailus-Durner, V.Gailus-Durner, ValerieHrabě de Angelis, MartinHrabě de Angelis, MartinAngelis, M.Angelis, M.Hofmann, Susanna MHofmann, S.M.Hofmann, S.M.Hofmann, Susanna MYang, BinYang, B.Yang, BinYang, B.Tschöp, M.H.Tschöp, Matthias HTschöp, Matthias HTschöp, M.H.DiMarchi, RichardDiMarchi, R.Di Marchi, RichardDiMarchi, R.Müller, T.D. and Müller, T.D.
Cell, vol. 167, (no. 3), pp. 857.e14, 2016-10-20. | Journal Article
Chemical Synthesis of Human Insulin-Like Peptide-6.
Wu, FangzhouWu, FangzhouMayer, John PMayer, John PZaykov, Alexander NZaykov, Alexander NZhang, FaZhang, FaLiu, FaLiu, FaDiMarchi, Richard D and Di Marchi, Richard D
Chemistry (Weinheim an der Bergstrasse, Germany), vol. 22, (no. 28), pp. 9777-9783, July 4, 2016. | Journal Article
Fibroblast activation protein (FAP) as a novel metabolic target
Sánchez-Garrido, M.A.Sánchez-Garrido, MiguelSánchez-Garrido, MiguelSánchez-Garrido, M.A.Habegger, K.M.Habegger, K.M.Habegger, KirkHabegger, KirkClemmensen, ChristofferClemmensen, ChristofferClemmensen, C.Clemmensen, C.Holleman, C.Holleman, CassieHolleman, CassieHolleman, C.Müller, T.D.Müller, TimoMüller, T.D.Müller, TimoPerez-Tilve, D.Perez-Tilve, DiegoPerez-Tilve, DiegoPerez-Tilve, D.Li, PengyunLi, P.Li, PengyunLi, P.Agrawal, ArchitaAgrawal, A.S.Agrawal, A.S.Agrawal, ArchitaFinan, B.Finan, B.Finan, BrianFinan, BrianDrucker, DanielDrucker, D.J.Drucker, D.J.Drucker, DanielTschöp, MatthiasTschöp, M.H.Tschöp, MatthiasTschöp, M.H.DiMarchi, R.D.Di Marchi, RichardDiMarchi, RichardDiMarchi, R.D.Kharitonenkov, AlexeiKharitonenkov, AlexeiKharitonenkov, A. and Kharitonenkov, A.
Molecular Metabolism, vol. 5, (no. 10), pp. 1024, 2016. | Journal Article
GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight
Vogel, HeikeVogel, HeikeWolf, StefanieWolf, StefanieRabasa, CristinaRabasa, CristinaRodriguez-Pacheco, FranciscaRodriguez-Pacheco, FranciscaBabaei, Carina SBabaei, Carina SStöber, FranziskaStöber, FranziskaGoldschmidt, JürgenGoldschmidt, JürgenDiMarchi, Richard DDi Marchi, Richard DFinan, BrianFinan, BrianTschöp, Matthias HTschöp, Matthias HDickson, Suzanne LDickson, Suzanne LSchürmann, AnnetteSchürmann, AnnetteSkibicka, Karolina P and Skibicka, Karolina P
Neuropharmacology, vol. 110, (no. Pt A), pp. 406, November 2016. | Journal Article
GLP-1 directed delivery of dexamethasone ameliorates hypothalamic inflammation and reverses diet-induced obesity
Quarta, CarmeloClemmensen, ChristofferYang, BinZhu, ZhimengMuller, Timo DDi Marchi, Richard DFinan, Brian and Tschop, Matthias H
Endocrine Abstracts, 2016-05-13. | Journal Article
Native Design of Soluble, Aggregation-Resistant Bioactive Peptides: Chemical Evolution of Human Glucagon
Mroz, Piotr AMroz, Piotr APerez-Tilve, DiegoPerez-Tilve, DiegoLiu, FaLiu, FaMayer, John PMayer, John PDiMarchi, Richard D and Di Marchi, Richard D
ACS chemical biology, vol. 11, (no. 12), pp. 3420, 2016-12-16. | Journal Article
Pursuit of a perfect insulin
Zaykov, Alexander NMayer, John P and Di Marchi, Richard D
Nature reviews. Drug discovery, vol. 15, (no. 6), pp. 439, 2016-06-00. | Journal Article
Pyridyl-alanine as a Hydrophilic, Aromatic Element in Peptide Structural Optimization.
Mroz, Piotr AMroz, Piotr AMroz, Piotr APerez-Tilve, DiegoPerez-Tilve, DiegoPerez-Tilve, DiegoLiu, FaLiu, FaLiu, FaGelfanov, VasilyGelfanov, VasilyGelfanov, VasilyDiMarchi, Richard DDiMarchi, Richard DDi Marchi, Richard DMayer, John PMayer, John P and Mayer, John P
Journal of medicinal chemistry, vol. 59, (no. 17), pp. 8061-8067, September 8, 2016. | Journal Article
Synthetic Route to Human Relaxin-2 via Iodine-Free Sequential Disulfide Bond Formation
Yang, XuYang, XuGelfanov, VasilyGelfanov, VasilyLiu, FaLiu, FaDiMarchi, Richard and Di Marchi, Richard
Organic letters, vol. 18, (no. 21), pp. 5519, 2016-11-04. | Journal Article
A new quorum-sensing system (TprA/PhrA) forStreptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster
Hoover, Sharon EHoover, Sharon EHoover, Sharon EPerez, Amilcar JPerez, Amilcar JPerez, Amilcar JTsui, Ho‐Ching TTsui, Ho-Ching TTsui, Ho-Ching TSinha, DhritiSinha, DhritiSinha, DhritiSmiley, David LSmiley, David LSmiley, David LDiMarchi, Richard DDi Marchi, Richard DDiMarchi, Richard DWinkler, Malcolm EWinkler, Malcolm EWinkler, Malcolm ELazazzera, Beth ALazazzera, Beth A and Lazazzera, Beth A
Molecular Microbiology, vol. 97, (no. 2), pp. 243, 2015-07-00. | Journal Article
A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Finan, BrianFinan, BrianFinan, B.Finan, BrianFinan, BrianFinan, B.Finan, BrianYang, BinYang, BinYang, BinYang, B.Yang, BinYang, B.Yang, BinOttaway, N.Ottaway, N.Ottaway, NickkiOttaway, NickkiOttaway, NickkiOttaway, NickkiOttaway, NickkiSmiley, David LSmiley, David LSmiley, David LSmiley, D.L.Smiley, David LSmiley, David LSmiley, D.L.Ma, TaoMa, T.Ma, TaoMa, TaoMa, TaoMa, TaoMa, T.Clemmensen, ChristofferClemmensen, ChristofferClemmensen, ChristofferClemmensen, C.Clemmensen, C.Clemmensen, ChristofferClemmensen, ChristofferChabenne, JoeChabenne, JoeChabenne, JoeChabenne, J.Chabenne, JoeChabenne, J.Chabenne, JoeZhang, LianshanZhang, LianshanZhang, LianshanZhang, LianshanZhang, L.Zhang, L.Zhang, LianshanHabegger, Kirk MHabegger, Kirk MHabegger, Kirk MHabegger, K.M.Habegger, K.M.Habegger, Kirk MHabegger, Kirk MFischer, K.Fischer, KatrinFischer, KatrinFischer, K.Fischer, KatrinFischer, KatrinFischer, KatrinCampbell, J.E.Campbell, Jonathan ECampbell, Jonathan ECampbell, Jonathan ECampbell, J.E.Campbell, Jonathan ECampbell, Jonathan ESandoval, DarleenSandoval, D.Sandoval, DarleenSandoval, DarleenSandoval, D.Sandoval, DarleenSandoval, DarleenSeeley, Randy JSeeley, Randy JSeeley, R.J.Seeley, R.J.Seeley, Randy JSeeley, Randy JSeeley, Randy JBleicher, KonradBleicher, KonradBleicher, KonradBleicher, KonradBleicher, K.Bleicher, KonradBleicher, K.Uhles, S.Uhles, SabineUhles, SabineUhles, SabineUhles, S.Uhles, SabineUhles, SabineRiboulet, WilliamRiboulet, WilliamRiboulet, WilliamRiboulet, WilliamRiboulet, W.Riboulet, W.Riboulet, WilliamFunk, J.Funk, JürgenFunk, JürgenFunk, J.Funk, JürgenFunk, JürgenFunk, JürgenHertel, CorneliaHertel, CorneliaHertel, C.Hertel, CorneliaHertel, C.Hertel, CorneliaHertel, CorneliaBelli, SaraBelli, SaraBelli, SaraBelli, SaraBelli, SaraBelli, S.Belli, S.Sebokova, ElenaSebokova, E.Sebokova, ElenaSebokova, ElenaSebokova, ElenaSebokova, ElenaSebokova, E.Conde-knape, KarinConde-knape, KarinConde-Knape, K.Conde-Knape, KarinConde-Knape, KarinConde-Knape, K.Conde-Knape, KarinKonkar, AnishKonkar, AnishKonkar, A.Konkar, AnishKonkar, AnishKonkar, A.Konkar, AnishDrucker, Daniel JDrucker, Daniel JDrucker, Daniel JDrucker, D.J.Drucker, D.J.Drucker, Daniel JDrucker, Daniel JGelfanov, VasilyGelfanov, V.Gelfanov, VasilyGelfanov, VasilyGelfanov, V.Gelfanov, VasilyGelfanov, VasilyPfluger, Paul TPfluger, Paul TPfluger, Paul TPfluger, P.T.Pfluger, P.T.Pfluger, Paul TPfluger, Paul TMüller, Timo DMüller, T.D.Müller, Timo DMüller, T.D.Müller, Timo DMüller, Timo DMüller, Timo DPerez-Tilve, DiegoPerez-tilve, DiegoPerez-Tilve, D.Perez-Tilve, DiegoPerez-Tilve, DiegoPerez-tilve, DiegoPerez-Tilve, D.Dimarchi, Richard DDi Marchi, Richard DDimarchi, Richard DDiMarchi, R.D.DiMarchi, R.D.DiMarchi, Richard DDiMarchi, Richard DTschöp, M.H.Tschöp, Matthias HTschöp, Matthias HTschöp, Matthias HTschöp, Matthias HTschöp, M.H. and Tschöp, Matthias H
Nature medicine, vol. 21, (no. 1), pp. 36, 2015-Jan. | Journal Article
Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice
Heppner, KristyMarks, SarahHolland, JennaOttaway, NickkiSmiley, DavidDimarchi, Richard and Perez-Tilve, Diego
Diabetologia, vol. 58, (no. 9), pp. 2132, 20150900. | Journal Article
Effect of targeted estrogen delivery using glucagon-like peptide-1 on insulin secretion, insulin sensitivity and glucose homeostasis.
Tiano, Joseph PTate, Chandra RYang, Bin SDi Marchi, Richard and Mauvais-Jarvis, Franck
Scientific reports, vol. 5, pp. 10211, 2015. | Journal Article
FGF21: starvation hormone to a clinical drug?
Kharitonenkov, AlexeiKharitonenkov, AlexeiAgrawal, ArchitaAgrawal, ArchitaLi, PengyunLi, PengyunDiMarchi, RichardDi Marchi, RichardPerez-Tlive, Diego and Perez-Tlive, Diego
Endocrine Abstracts, 2015-10-12. | Journal Article
GLP-1–oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice
Schwenk, RobertBaumeier, ChristianFinan, BrianKluth, OliverBrauer, ChristineJoost, Hans-GeorgDi Marchi, RichardTschöp, Matthias and Schürmann, Annette
Diabetologia, vol. 58, (no. 3), pp. 614, 20150300. | Journal Article
Three-chain insulin analogs demonstrate the importance of insulin secondary structure to bioactivity.
Wu, FangzhouWu, FangzhouChabenne, Joseph RChabenne, Joseph RGelfanov, Vasily MGelfanov, Vasily MMayer, John PMayer, John PDiMarchi, Richard D and Di Marchi, Richard D
Journal of peptide science : an official publication of the European Peptide Society, vol. 21, (no. 3), pp. 223-230, March 2015. | Journal Article