185 Publications (Page 2 of 8)
2018
Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia
Rivero-Gutierrez, B.⋅Rivero-Gutierrez, B.⋅B, Rivero-Gutierrez⋅Rivero-Gutierrez, Belen⋅Rivero-Gutierrez, Belen⋅Haller, April⋅A, Haller⋅Haller, A.⋅Haller, A.⋅Haller, April⋅Holland, Jenna⋅Holland, Jenna⋅J, Holland⋅Holland, J.⋅Holland, J.⋅Yates, E.⋅Yates, E.⋅Yates, Emily⋅E, Yates⋅Yates, Emily⋅Khrisna, Radha⋅R, Khrisna⋅Khrisna, R.⋅Khrisna, Radha⋅Khrisna, R.⋅K, Habegger⋅Habegger, Kirk⋅Habegger, Kirk⋅Habegger, K.⋅Habegger, K.⋅Dimarchi, Richard⋅R, Dimarchi⋅Dimarchi, R.⋅Dimarchi, Richard⋅Dimarchi, R.⋅D'Alessio, David⋅D’Alessio, D.⋅D'Alessio, David⋅D, D’Alessio⋅D’Alessio, D.⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, D.⋅Perez-Tilve, D. and D, Perez-Tilve
Molecular Metabolism, vol. 17, pp. 38, November 2018. | Journal Article
 
Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases.
Clemmensen, Christoffer⋅Finan, Brian⋅Müller, Timo D⋅Di Marchi, Richard D⋅Tschöp, Matthias H and Hofmann, Susanna M
Nature reviews. Endocrinology, November 16, 2018. | Journal Article
 
Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21
Kim, T.⋅Kim, Teayoun⋅Kim, T.⋅Kim, Teayoun⋅Kim, Teayoun⋅Kim, Teayoun⋅Kim, T.⋅Nason, S.⋅Nason, Shelly⋅Nason, S.⋅Nason, S.⋅Nason, Shelly⋅Nason, Shelly⋅Nason, Shelly⋅Holleman, Cassie⋅Holleman, C.⋅Holleman, Cassie⋅Holleman, Cassie⋅Holleman, C.⋅Holleman, C.⋅Holleman, Cassie⋅Pepin, M.⋅Pepin, M.⋅Pepin, Mark⋅Pepin, Mark⋅Pepin, M.⋅Pepin, Mark⋅Pepin, Mark⋅Wilson, L.⋅Wilson, L.⋅Wilson, Landon⋅Wilson, Landon⋅Wilson, L.⋅Wilson, Landon⋅Wilson, Landon⋅Berryhill, Taylor F⋅Berryhill, Taylor F⋅Berryhill, T.F.⋅Berryhill, Taylor F⋅Berryhill, T.F.⋅Berryhill, Taylor F⋅Berryhill, T.F.⋅Wende, Adam R⋅Wende, Adam R⋅Wende, A.R.⋅Wende, Adam R⋅Wende, A.R.⋅Wende, A.R.⋅Wende, Adam R⋅Steele, Chad⋅Steele, Chad⋅Steele, Chad⋅Steele, Chad⋅Steele, C.⋅Steele, C.⋅Steele, C.⋅Young, Martin E⋅Young, Martin E⋅Young, Martin E⋅Young, Martin E⋅Young, M.E.⋅Young, M.E.⋅Young, M.E.⋅Barnes, S.⋅Barnes, Stephen⋅Barnes, S.⋅Barnes, Stephen⋅Barnes, Stephen⋅Barnes, S.⋅Barnes, Stephen⋅Drucker, D.J.⋅Drucker, Daniel J⋅Drucker, D.J.⋅Drucker, Daniel J⋅Drucker, Daniel J⋅Drucker, D.J.⋅Drucker, Daniel J⋅Finan, Brian⋅Finan, B.⋅Finan, Brian⋅Finan, B.⋅Finan, Brian⋅Finan, Brian⋅Finan, B.⋅DiMarchi, Richard⋅DiMarchi, Richard⋅DiMarchi, Richard⋅DiMarchi, R.⋅DiMarchi, R.⋅DiMarchi, R.⋅Di Marchi, Richard⋅Perez-Tilve, D.⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, D.⋅Perez-Tilve, D.⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Tschöp, Matthias⋅Tschöp, Matthias⋅Tschöp, Matthias⋅Tschöp, M.⋅Tschoep, Matthias⋅Tschöp, M.⋅Tschöp, M.⋅Habegger, K.M.⋅Habegger, K.M.⋅Habegger, Kirk M⋅Habegger, Kirk M⋅Habegger, Kirk M⋅Habegger, K.M. and Habegger, Kirk M
Diabetes, vol. 67, (no. 9), pp. 1782, 2018-09-00. | Journal Article
 
Glucagon-Receptor Signaling Regulates Mitochondrial Bioenergetics via Hepatic Farnesol X Receptor
KIM, TEAYOUN⋅NASON, SHELLY⋅ANTIPENKO, JESSICA P⋅VESTRI, CATHERINA S⋅SMITH-JOHNSTON, KELLEY⋅PEPIN, MARK E⋅WENDE, ADAM R⋅FINAN, BRIAN⋅Dimarchi, Richard⋅PEREZ-TILVE, DIEGO⋅MOELLERING, DOUGLAS R and HABEGGER, KIRK M
Diabetes, vol. 67, (no. Supplement 1), pp. 1978, 2018-05-00. | Journal Article
 
Glucagon Regulates Energy Balance via FGF-21 Signaling in the Brain
NASON, SHELLY⋅KIM, TEAYOUN⋅ANTIPENKO, JESSICA P⋅PAUL, JODI⋅FINAN, BRIAN⋅Dimarchi, Richard and HABEGGER, KIRK M
Diabetes, vol. 67, (no. Supplement 1), pp. 1806, 2018-05-00. | Journal Article
 
Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents
Kim, Teayoun⋅Kim, T.⋅Kim, T.⋅Kim, Teayoun⋅Kim, Teayoun⋅Holleman, Cassie L⋅Holleman, Cassie L⋅Holleman, C.L.⋅Holleman, Cassie L⋅Holleman, C.L.⋅Nason, Shelly⋅Nason, Shelly⋅Nason, S.⋅Nason, Shelly⋅Nason, S.⋅Arble, Deanna M⋅Arble, Deanna M⋅Arble, D.M.⋅Arble, D.M.⋅Arble, Deanna M⋅Ottaway, Nickki⋅Ottaway, Nickki⋅Ottaway, Nickki⋅Ottaway, N.⋅Ottaway, N.⋅Chabenne, Joseph⋅Chabenne, Joseph⋅Chabenne, Joseph⋅Chabenne, J.⋅Chabenne, J.⋅Loyd, Christine⋅Loyd, C.⋅Loyd, Christine⋅Loyd, C.⋅Loyd, Christine⋅Kim, Jeong-A⋅Kim, J.-A.⋅Kim, Jeong-A⋅Kim, J.-A.⋅Kim, Jeong-A⋅Sandoval, Darleen⋅Sandoval, Darleen⋅Sandoval, D.⋅Sandoval, Darleen⋅Sandoval, D.⋅Drucker, D.J.⋅Drucker, Daniel J⋅Drucker, Daniel J⋅Drucker, Daniel J⋅Drucker, D.J.⋅DiMarchi, R.⋅DiMarchi, Richard⋅Di Marchi, Richard⋅DiMarchi, R.⋅DiMarchi, Richard⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, D.⋅Perez-Tilve, D.⋅Habegger, Kirk M⋅Habegger, Kirk M⋅Habegger, K.M.⋅Habegger, Kirk M and Habegger, K.M.
Diabetes, vol. 67, (no. 11), pp. 2166, 2018-11-00. | Journal Article
 
High-Yield Synthesis of Human Insulin-Like Peptide 5 Employing a Nonconventional Strategy.
Zaykov, Alexander N⋅Zaykov, Alexander N⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Liu, Fa⋅Liu, Fa⋅DiMarchi, Richard D and Di Marchi, Richard D
Organic letters, vol. 20, (no. 12), pp. 3695-3699, June 15, 2018. | Journal Article
 
"Let's Stay Together"; GIP and GLP-1 dual agonism in the treatment of metabolic disease.
Di Marchi, Richard D
Molecular metabolism, October 12, 2018. | Journal Article
 
Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs
Renner, Simone⋅Blutke, Andreas⋅Dobenecker, Britta⋅Dhom, Georg⋅Müller, Timo D⋅Finan, Brian⋅Clemmensen, Christoffer⋅Bernau, Maren⋅Novak, Istvan⋅Rathkolb, Birgit⋅Senf, Steffanie⋅Zöls, Susanne⋅Roth, Mirjam⋅Götz, Anna⋅Hofmann, Susanna M⋅Hrabĕ de Angelis, Martin⋅Wanke, Rüdiger⋅Kienzle, Ellen⋅Scholz, Armin M⋅Di Marchi, Richard⋅Ritzmann, Mathias⋅Tschöp, Matthias H and Wolf, Eckhard
Molecular Metabolism, vol. 16, pp. 190, October 2018. | Journal Article
 
Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
Agrawal, Archita⋅Agrawal, Archita⋅Agrawal, Archita⋅Parlee, Sebastian⋅Parlee, Sebastian⋅Parlee, Sebastian⋅Parlee, Sebastian⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Li, Pengyun⋅Li, Pengyun⋅Li, Pengyun⋅Li, Pengyun⋅Pan, Jia⋅Pan, Jia⋅Pan, Jia⋅Pan, Jia⋅Mroz, Piotr A⋅Mroz, Piotr A⋅Mroz, Piotr A⋅Mroz, Piotr A⋅Kruse Hansen, Ann Maria⋅Kruse Hansen, Ann Maria⋅Kruse Hansen, Ann Maria⋅Kruse Hansen, Ann M⋅Andersen, Birgitte⋅Andersen, Birgitte⋅Andersen, Birgitte⋅Andersen, Birgitte⋅Finan, Brian⋅Finan, Brian⋅Finan, Brian⋅Finan, Brian⋅Kharitonenkov, Alexei⋅Kharitonenkov, Alexei⋅Kharitonenkov, Alexei⋅Kharitonenkov, Alexei⋅Di Marchi, Richard D⋅DiMarchi, Richard D⋅DiMarchi, Richard D and DiMarchi, Richard D
Molecular Metabolism, vol. 13, pp. 55, July 2018. | Journal Article
 
Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism.
Mroz, Piotr A⋅Mroz, Piotr A⋅Mroz, Piotr A⋅Finan, Brian⋅Finan, Brian⋅Finan, Brian⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Yang, Bin⋅Yang, Bin⋅Yang, Bin⋅Tschöp, Matthias H⋅Tschöp, Matthias H⋅Tschöp, Matthias H⋅Di Marchi, Richard D⋅DiMarchi, Richard D⋅DiMarchi, Richard D⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego and Perez-Tilve, Diego
Molecular metabolism, December 5, 2018. | Journal Article
 
Structurally Constrained Insulin Analogs by Directed Stepwise Crosslinking
Zhang, Fa⋅Zhang, Fa⋅Zhang, Fa⋅Mayer, John⋅Mayer, John⋅Mayer, John⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Liu, Fa⋅Liu, Fa⋅Liu, Fa⋅DiMarchi, Richard⋅DiMarchi, Richard and Di Marchi, Richard
Protein & Peptide Letters, vol. 25, (no. 12), pp. 1154, 20180000. | Journal Article
 
Synthesis and Characterization of the R27S Genetic Variant of Insulin‐like Peptide 5
Zaykov, Alexander N⋅Zaykov, Alexander N⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Liu, Fa⋅Liu, Fa⋅DiMarchi, Richard D and Di Marchi, Richard D
ChemMedChem, vol. 13, (no. 8), pp. 859, April 23, 2018. | Journal Article
 
Synthesis of disulfide-rich heterodimeric peptides through an auxiliary N, N-crosslink
Thalluri, Kishore⋅Thalluri, Kishore⋅Thalluri, Kishore⋅Mayer, John P⋅Mayer, John P⋅Mayer, John P⋅Chabenne, Joseph R⋅Chabenne, Joseph R⋅Chabenne, Joseph R⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅DiMarchi, Richard D⋅Di Marchi, Richard D and DiMarchi, Richard D
Communications Chemistry, vol. 1, (no. 1), pp. 7, 2018-12-00. | Journal Article
 
Targeting the Incretin/Glucagon System with Triagonists to Treat Diabetes.
Capozzi, Megan E⋅Di Marchi, Richard D⋅Tschöp, Matthias H⋅Finan, Brian and Campbell, Jonathan E
Endocrine reviews, June 13, 2018. | Journal Article
 
Targeting the Incretin/Glucagon System With Triagonists to Treat Diabetes
Capozzi, Megan E⋅Capozzi, Megan E⋅Di Marchi, Richard D⋅DiMarchi, Richard D⋅Tschöp, Matthias H⋅Tschöp, Matthias H⋅Finan, Brian⋅Finan, Brian⋅Campbell, Jonathan E and Campbell, Jonathan E
Endocrine Reviews, vol. 39, (no. 5), pp. 738, 2018-October. | Journal Article
 
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions
Altindis, Emrah⋅Altindis, Emrah⋅Altindis, Emrah⋅Cai, Weikang⋅Cai, Weikang⋅Cai, Weikang⋅Sakaguchi, Masaji⋅Sakaguchi, Masaji⋅Sakaguchi, Masaji⋅Zhang, Fa⋅Zhang, Fa⋅Zhang, Fa⋅GuoXiao, Wang⋅GuoXiao, Wang⋅GuoXiao, Wang⋅Liu, Fa⋅Liu, Fa⋅Liu, Fa⋅De Meyts, Pierre⋅De Meyts, Pierre⋅Mey, Pierre⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Pan, Hui⋅Pan, Hui⋅Di Marchi, Richard⋅DiMarchi, Richard⋅Kahn, C Ronald and Kahn, C Ronald
Proceedings of the National Academy of Sciences of the United States of America, vol. 115, (no. 10), pp. 2466, 2018-03-06. | Journal Article
2017
Biomimetic Synthesis of Insulin Enabled by Oxime Ligation and Traceless “C-Peptide” Chemical Excision
Thalluri, Kishore⋅Thalluri, Kishore⋅Thalluri, Kishore⋅Thalluri, Kishore⋅Kou, Binbin⋅Kou, Binbin⋅Kou, Binbin⋅Kou, Binbin⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Mayer, John P⋅Mayer, John P⋅Mayer, John P⋅Mayer, John P⋅Liu, Fa⋅Liu, Fa⋅Liu, Fa⋅Liu, Fa⋅DiMarchi, Richard D⋅DiMarchi, Richard D⋅DiMarchi, Richard D and Di Marchi, Richard D
Organic Letters, vol. 19, (no. 3), pp. 709, 2017-02-03. | Journal Article
 
Emerging Poly-Agonists for Obesity and Type 2 Diabetes
Kleinert, Maximilian⋅Clemmensen, Christoffer⋅Stemmer, Kerstin⋅Müller, Timo D⋅Di Marchi, Richard D and Tschöp, Matthias H
Obesity, vol. 25, (no. 10), pp. 1649, 2017-10-00. | Journal Article
 
GLP-1 based multi-agonists-induced signaling includes profound TRP channel involvement in insulin secretion
Khajavi, Noushafarin⋅Finan, Brian⋅Kluth, Oliver⋅Mergler, Stefan⋅Muller, Timo⋅Kleinau, Gunnar⋅Schurmann, Annette⋅Tschop, Matthias H⋅Di Marchi, Richard⋅Krude, Heiko and Biebermann, Heike
Endocrine Abstracts, 2017-05-03. | Journal Article
 
GLP-1/glucagon receptor co-agonism for treatment of obesity.
Sánchez-Garrido, Miguel A⋅Brandt, Sara J⋅Clemmensen, Christoffer⋅Müller, Timo D⋅Di Marchi, Richard D and Tschöp, Matthias H
Diabetologia, July 21, 2017. | Journal Article
 
Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment
Girada, Shravan Babu⋅Kuna, Ramya S⋅Bele, Shilpak⋅Zhu, Zhimeng⋅Chakravarthi, N.R⋅Di Marchi, Richard D and Mitra, Prasenjit
Molecular Metabolism, vol. 6, (no. 10), pp. 1185, October 2017. | Journal Article
 
Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity
Quarta, Carmelo⋅Quarta, C.⋅Quarta, Carmelo⋅Clemmensen, C.⋅Clemmensen, Christoffer⋅Clemmensen, Christoffer⋅Zhu, Zhimeng⋅Zhu, Z.⋅Zhu, Zhimeng⋅Yang, Bin⋅Yang, B.⋅Yang, Bin⋅Joseph, Sini S⋅Joseph, S.S.⋅Joseph, Sini S⋅Lutter, Dominik⋅Lutter, D.⋅Lutter, Dominik⋅Yi, Chun-Xia⋅Yi, C.-X.⋅Yi, Chun-Xia⋅Graf, E.⋅Graf, Elisabeth⋅Graf, Elisabeth⋅García-Cáceres, Cristina⋅García-Cáceres, Cristina⋅García-Cáceres, C.⋅Legutko, Beata⋅Legutko, Beata⋅Legutko, B.⋅Fischer, Katrin⋅Fischer, Katrin⋅Fischer, K.⋅Brommage, Robert⋅Brommage, Robert⋅Brommage, R.⋅Zizzari, Philippe⋅Zizzari, P.⋅Zizzari, Philippe⋅Franklin, B.S.⋅Franklin, Bernardo S⋅Franklin, Bernardo S⋅Krueger, M.⋅Krueger, Martin⋅Krueger, Martin⋅Koch, Marco⋅Koch, Marco⋅Koch, M.⋅Vettorazzi, Sabine⋅Vettorazzi, Sabine⋅Vettorazzi, S.⋅Li, Pengyun⋅Li, Pengyun⋅Li, P.⋅Hofmann, Susanna M⋅Hofmann, Susanna M⋅Hofmann, S.M.⋅Bakhti, Mostafa⋅Bakhti, Mostafa⋅Bakhti, M.⋅Bastidas-Ponce, Aimée⋅Bastidas-Ponce, Aimée⋅Bastidas-Ponce, A.⋅Lickert, Heiko⋅Lickert, H.⋅Lickert, Heiko⋅Strom, Tim M⋅Strom, Tim M⋅Strom, T.M.⋅Gailus-Durner, V.⋅Gailus-Durner, Valerie⋅Gailus-Durner, Valerie⋅Bechmann, Ingo⋅Bechmann, Ingo⋅Bechmann, I.⋅Perez-Tilve, D.⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Tuckermann, Jan⋅Tuckermann, J.⋅Tuckermann, Jan⋅Hrabě de Angelis, Martin⋅Hrabě de Angelis, Martin⋅Angelis, M.⋅Sandoval, D.⋅Sandoval, Darleen⋅Sandoval, Darleen⋅Cota, Daniela⋅Cota, Daniela⋅Cota, D.⋅Latz, Eicke⋅Latz, Eicke⋅Latz, E.⋅Seeley, Randy J⋅Seeley, Randy J⋅Seeley, R.J.⋅Müller, Timo D⋅Müller, Timo D⋅Müller, T.D.⋅DiMarchi, R.D.⋅DiMarchi, Richard D⋅Di Marchi, Richard D⋅Finan, Brian⋅Finan, Brian⋅Finan, B.⋅Tschöp, M.H.⋅Tschöp, Matthias H and Tschöp, Matthias H
Cell Metabolism, vol. 26, (no. 4), pp. 632.e6, 2017-10-03. | Journal Article
 
Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice
Jall, Sigrid⋅Sachs, Stephan⋅Clemmensen, Christoffer⋅Finan, Brian⋅Neff, Frauke⋅Di Marchi, Richard⋅Tschöp, Matthias⋅Müller, Timo and Hofmann, Susanna
Molecular Metabolism, vol. 6, (no. 5), pp. 446, 2017. | Journal Article
 
Novel GLP-1R/GIPR co-agonist “twincretin” is neuroprotective in cell and rodent models of mild traumatic brain injury
Tamargo, Ian A⋅Bader, Miaad⋅Li, Yazhou⋅Yu, Seong-Jin⋅Wang, Yun⋅Talbot, Konrad⋅Di Marchi, Richard D⋅Pick, Chaim G and Greig, Nigel H
Experimental Neurology, vol. 288, pp. 186, February 2017. | Journal Article