185 Publications (Page 1 of 8)
2020
Addition of Sialic Acid to Insulin Confers Superior Physical Properties and Bioequivalence
Kabotso, Daniel⋅Kabotso, Daniel⋅Kabotso, Daniel⋅Smiley, David⋅Smiley, David⋅Smiley, David⋅Mayer, John Philip⋅Mayer, John Philip⋅Mayer, John Philip⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅DiMarchi, Richard D⋅DiMarchi, Richard D⋅DiMarchi, Richard D⋅Pohl, Nicola L B⋅Pohl, Nicola L B⋅Pohl, Nicola L B⋅Liu, Fa⋅Liu, Fa and Liu, Fa
Journal of medicinal chemistry, 2020-May-14. | Journal Article
 
Author Correction: Targeted pharmacological therapy restores β-cell function for diabetes remission
Sachs, Stephan⋅Bastidas-Ponce, Aimée⋅Tritschler, Sophie⋅Bakhti, Mostafa⋅Böttcher, Anika⋅Sánchez-Garrido, Miguel A⋅Tarquis-Medina, Marta⋅Kleinert, Maximilian⋅Fischer, Katrin⋅Jall, Sigrid⋅Harger, Alexandra⋅Bader, Erik⋅Roscioni, Sara⋅Ussar, Siegfried⋅Feuchtinger, Annette⋅Yesildag, Burcak⋅Neelakandhan, Aparna⋅Jensen, Christine B⋅Cornu, Marion⋅Yang, Bin⋅Finan, Brian⋅DiMarchi, Richard D⋅Tschöp, Matthias H⋅Theis, Fabian J⋅Hofmann, Susanna M⋅Müller, Timo D and Lickert, Heiko
Nature Metabolism, vol. 2, (no. 4), pp. 380, 2020-04-00. | Journal Article
 
Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression
Nason, Shelly R⋅Nason, Shelly R⋅Nason, Shelly R⋅Kim, Teayoun⋅Kim, Teayoun⋅Kim, Teayoun⋅Antipenko, Jessica P⋅Antipenko, Jessica P⋅Antipenko, Jessica P⋅Finan, Brian⋅Finan, Brian⋅Finan, Brian⋅DiMarchi, Richard⋅DiMarchi, Richard⋅DiMarchi, Richard⋅Hunter, Chad S⋅Hunter, Chad S⋅Hunter, Chad S⋅Habegger, Kirk M⋅Habegger, Kirk M and Habegger, Kirk M
Endocrinology, vol. 161, (no. 1), 2020-Jan-01. | Journal Article
 
Glucagon Regulates Energy Balance via FGF21 Signaling in the Brain
Presedo, Natalie⋅Kim, Teayoun⋅Nason, Shelly R⋅Antipenko, Jessica⋅Finan, Brian⋅DiMarchi, Richard and Habegger, Kirk
The FASEB Journal, vol. 34, (no. S1), pp. 1, 2020-04-00. | Journal Article
 
Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury
Bader, Miaad⋅Li, Yazhou⋅Tweedie, David⋅Shlobin, Nathan A⋅Bernstein, Adi⋅Rubovitch, Vardit⋅Tovar-y-Romo, Luis B⋅DiMarchi, Richard D⋅Hoffer, Barry J⋅Greig, Nigel H and Pick, Chaim G
Frontiers in Cell and Developmental Biology, vol. 7, pp. 356, 2020-01-10. | Journal Article
 
Neurotrophic and neuroprotective effects of a monomeric GLP-1/GIP/Gcg receptor triagonist in cellular and rodent models of mild traumatic brain injury
Li, Yazhou⋅Glotfelty, Elliot J⋅Namdar, Inbar⋅Tweedie, David⋅Olson, Lars⋅Hoffer, Barry J⋅DiMarchi, Richard D⋅Pick, Chagi G and Greig, Nigel H
Experimental Neurology, vol. 324, pp. 113113, February 2020. | Journal Article
 
Recent advances in the chemical synthesis of insulin and related peptides
Brunel, Florence M⋅Mayer, John P and DiMarchi, Richard D
Future medicinal chemistry, vol. 12, (no. 8), pp. 654, 20200101. | Journal Article
 
SAT-655 Bile Acid Sequestration Synergistically Accelerates Glucagon Receptor-Stimulated Body Weight Loss in Diet-Induced Obese Mice
Kim, Teayoun⋅Nason, Shelly R⋅Antipenko, Jessica⋅Presedo, Natalie⋅Finan, Brian⋅DiMarchi, Richard D and Habegger, Kirk M
Journal of the Endocrine Society, vol. 4, (no. Supplement_1), 2020-05-08. | Journal Article
 
Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors as drug candidates
Knerr, Patrick J⋅Mowery, Stephanie A⋅Finan, Brian⋅Perez-Tilve, Diego⋅Tschöp, Matthias H and DiMarchi, Richard D
Peptides, vol. 125, pp. 170225, March 2020. | Journal Article
 
Structural Refinement of Glucagon for Therapeutic Use
Chabenne, Joseph R⋅Chabenne, Joseph R⋅Mroz, Piotr A⋅Mroz, Piotr A⋅Mayer, John P⋅Mayer, John P⋅DiMarchi, Richard D and DiMarchi, Richard D
Journal of medicinal chemistry, vol. 63, (no. 7), pp. 3460, 2020-Apr-09. | Journal Article
2019
1870-P: Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression
NASON, SHELLY⋅KIM, TEAYOUN⋅ANTIPENKO, JESSICA P⋅FINAN, BRIAN⋅DIMARCHI, RICHARD and HABEGGER, KIRK M
Diabetes, vol. 68, (no. Supplement 1), pp. 1870, 2019-06-00. | Journal Article
 
1965-P: Glucagon Receptor Agonism Stimulates Body Weight Loss in Antibiotic Treatment in Obese Mice
KIM, TEAYOUN⋅ANTIPENKO, JESSICA P⋅NASON, SHELLY⋅PRESEDO, NATALIE⋅VAN DER POL, WILLIAM J⋅FINAN, BRIAN⋅DIMARCHI, RICHARD⋅MORROW, CASEY D and HABEGGER, KIRK M
Diabetes, vol. 68, (no. Supplement 1), pp. 1965, 2019-06-00. | Journal Article
 
A Brain-Melanocortin-Vagus Axis Mediates Adipose Tissue Expansion Independently of Energy Intake
Holland, Jenna⋅Sorrell, Joyce⋅Yates, Emily⋅Smith, Kathleen⋅Arbabi, Shahriar⋅Arnold, Myrtha⋅Rivir, Marita⋅Morano, Rachel⋅Chen, Jenny⋅Zhang, Xiang⋅Dimarchi, Richard⋅Woods, Stephen C⋅Sanchez-Gurmaches, Joan⋅Wohleb, Eric and Perez-Tilve, Diego
Cell Reports, vol. 27, (no. 8), pp. 2410.e6, 2019-05-21. | Journal Article
 
A disulfide-scan of insulin by [3+1] methodology exhibits site-specific influence on bioactivity
Brunel, Florence M⋅Brunel, Florence M⋅Mayer, John P⋅Mayer, John P⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Zaykov, Alexander N⋅Zaykov, Alexander N⋅Finan, Brian⋅Finan, Brian⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅DiMarchi, Richard D and DiMarchi, Richard D
ACS Chemical Biology, vol. 14, (no. 8), pp. 1835, 2019-07-25. | Journal Article
 
GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice
Décarie-Spain, Léa⋅Fisette, Alexandre⋅Zhu, Zhimeng⋅Yang, Bin⋅DiMarchi, Richard D⋅Tschöp, Matthias H⋅Finan, Brian⋅Fulton, Stephanie and Clemmensen, Christoffer
Neuropharmacology, vol. 151, pp. 63, June 2019. | Journal Article
 
Glucagon-like peptide 1 (GLP-1)
Müller, Timo⋅Finan, Brian⋅Bloom, S.R⋅D'Alessio, David⋅Drucker, Daniel⋅Flatt, P.R⋅Gribble, Fiona⋅Grill, Harvey⋅Habener, Joel⋅Holst, Jens⋅Langhans, Wolfgang⋅Meier, Juris⋅Nauck, Michael⋅Perez-Tilve, Diego⋅Pocai, A⋅Reimann, Frank⋅Sandoval, Darleen⋅Schwartz, Thue⋅Seeley, Randy⋅Stemmer, Kerstin⋅Tang-Christensen, Mads⋅Woods, Stephen⋅DiMarchi, Richard and Tschöp, Matthias
Molecular Metabolism, 2019-12. | Journal Article
 
Gut Peptide Agonism in the Treatment of Obesity and Diabetes
Grandl, Gerald⋅Novikoff, Aaron⋅DiMarchi, Richard⋅Tschöp, Matthias H and Müller, Timo D
Comprehensive Physiology, vol. 10, (no. 1), pp. 99, 2019-Dec-18. | Journal Article
 
Insulin-like peptide 5 fails to improve metabolism or body weight in obese mice
Zaykov, Alexander N⋅Zaykov, Alexander N⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Finan, Brian⋅Finan, Brian⋅DiMarchi, Richard D and DiMarchi, Richard D
Peptides, vol. 120, pp. 170116, October 2019. | Journal Article
 
Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway
Ratner, Cecilia⋅He, Zhenyan⋅Grunddal, Kaare V⋅Skov, Louise J⋅Hartmann, Bolette⋅Zhang, Fa⋅Feuchtinger, Annette⋅Bjerregaard, Anette⋅Christoffersen, Christina⋅Tschöp, Matthias H⋅Finan, Brian⋅DiMarchi, Richard D⋅Leinninger, Gina M⋅Williams, Kevin W⋅Clemmensen, Christoffer and Holst, Birgitte
Diabetes, vol. 68, (no. 6), pp. 1340, 2019-Jun. | Journal Article
 
Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain Injury
Bader, Miaad⋅Li, Yazhou⋅Tweedie, David⋅Shlobin, Nathan A⋅Bernstein, Adi⋅Rubovitch, Vardit⋅Tovar-Y-Romo, Luis B⋅DiMarchi, Richard D⋅Hoffer, Barry J⋅Greig, Nigel H and Pick, Chaim G
Frontiers in cell and developmental biology, vol. 7, pp. 356, 2019-00-00. | Journal Article
 
OR28-5 Bile Acid Sequestration Accelerates Glucagon Receptor-Mediated Body Weight Loss in Obese Mice
Kim, Teayoun⋅Nason, Shelly⋅Antipenko, Jessica⋅Presedo, Natalie⋅Finan, Brian⋅DiMarchi, Richard and Habegger, Kirk
Journal of the Endocrine Society, vol. 3, (no. Supplement_1), 2019-04-15. | Journal Article
 
Stereochemical inversion as a route to improved biophysical properties of therapeutic peptides exemplified by glucagon
Mroz, Piotr A⋅Mroz, Piotr A⋅Perez-Tilve, Diego⋅Perez-Tilve, Diego⋅Mayer, John P⋅Mayer, John P⋅DiMarchi, Richard D and DiMarchi, Richard D
Communications Chemistry, vol. 2, (no. 1), pp. 8, 2019-12-00. | Journal Article
 
The islet-expressed Lhx1 transcription factor interacts with Islet-1 and contributes to glucose homeostasis
Bethea, Maigen⋅Bethea, Maigen⋅Bethea, Maigen⋅Liu, Yanping⋅Liu, Yanping⋅Liu, Yanping⋅Wade, Alexa K⋅Wade, Alexa K⋅Wade, Alexa K⋅Mullen, Rachel⋅Mullen, Rachel⋅Mullen, Rachel⋅Gupta, Rajesh⋅Gupta, Rajesh⋅Gupta, Rajesh⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅Gelfanov, Vasily⋅DiMarchi, Richard⋅DiMarchi, Richard⋅DiMarchi, Richard⋅Bhatnagar, Sushant⋅Bhatnagar, Sushant⋅Bhatnagar, Sushant⋅Behringer, Richard⋅Behringer, Richard⋅Behringer, Richard⋅Habegger, Kirk M⋅Habegger, Kirk M⋅Habegger, Kirk M⋅Hunter, Chad S⋅Hunter, Chad S and Hunter, Chad S
American journal of physiology. Endocrinology and metabolism, vol. 316, (no. 3), pp. E409, 2019-Mar-01. | Journal Article
2018
An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation.
Khajavi, Noushafarin⋅Finan, Brian⋅Kluth, Oliver⋅Müller, Timo D⋅Mergler, Stefan⋅Schulz, Angela⋅Kleinau, Gunnar⋅Scheerer, Patrick⋅Schürmann, Annette⋅Gudermann, Thomas⋅Tschöp, Matthias H⋅Krude, Heiko⋅DiMarchi, Richard D and Biebermann, Heike
Cellular signalling, vol. 51, pp. 13-22, July 25, 2018. | Journal Article
 
Controlled intramolecular antagonism as a regulator of insulin receptor maximal activity
Brandt, Sara J⋅Brandt, Sara J⋅Mayer, John P⋅Mayer, John P⋅Ford, James⋅Ford, James⋅Gelfanov, Vasily M⋅Gelfanov, Vasily M⋅DiMarchi, Richard D and DiMarchi, Richard D
Peptides, vol. 100, pp. 23, February 2018. | Journal Article