Most of our current work focuses on the dynamics and mechanisms of peptidoglycan cell wall biosynthesis in S. pneumoniae mediated by gene control and protein interactions.

In particular, we are working to solve the “3 C Problem” of composition, chronology, and coordination of the protein molecular machines that synthesize and remodel peptidoglycan during cell division of bacteria in culture and in contact with host cells.

Research Areas:

  • Genomics and Bioinformatics
  • Microbial Cell Biology and Environmental Responses
  • Microbial Interactions and Pathogenesis

Research Interests:

  • physiology, molecular genetics, and pathogenesis of the bacterium Streptococcus pneumoniae (pneumococcus); genomics and bioinformatics, Microbial Cell Biology; environmental responses; microbial interactions and pathogenesis
Biochemistry, Molecular Biology, Biological Science, Cellular Biochemistry, Molecular Biochemistry
PhD, Johns Hopkins University, 1979