183 Publications (Page 1 of 8)
2023
Adenylyl cyclases (ACs) in GtoPdb v.2023.1
Dessauer, Carmen W.Ostrom, RennoldsSeifert, Roland and Watts, Val J.
IUPHAR/BPS Guide to Pharmacology CITE, vol. 2023, (no. 1), 2023-04-26. | Journal Article
 
Isoform Specific Regulation of Adenylyl Cyclase 5 by Gβγ
Yen, Yu-ChenYen, Yu-ChenLi, YongLi, YongChen, Chun-LiangChen, Chun-LiangKlose, ThomasKlose, ThomasWatts, Val JWatts, Val JDessauer, Carmen WDessauer, Carmen WTesmer, John J G and Tesmer, John J G
bioRxiv : the preprint server for biology, 2023-May-02. | Journal Article
2022
Editorial: Adenylyl cyclase isoforms as potential drug targets
Brust, Tarsis FOstrom, Rennolds S and Watts, Val J
Frontiers in pharmacology, vol. 13, pp. 1098240, 2022-12-09. | Journal Article
 
Halogen‐Dance‐Based Synthesis of Phosphonomethoxyethyl (PME) Substituted 2‐Aminothiazoles as Potent Inhibitors of Bacterial Adenylate Cyclases
Česnek, MichalŠafránek, MichalDračínský, MartinTloušťová, EvaMertlíková‐Kaiserová, HelenaHayes, Michael P.Watts, Val J. and Janeba, Zlatko
ChemMedChem, vol. 17, (no. 1), pp. n/a, January 5, 2022. | Journal Article
 
Optimization of a Pyrimidinone Series for Selective Inhibition of Ca2+/Calmodulin-Stimulated Adenylyl Cyclase 1 Activity for the Treatment of Chronic Pain
Scott, Jason A.Scott, Jason ASoto-Velasquez, MonicaSoto-Velasquez, MonicaHayes, Michael PHayes, Michael P.LaVigne, Justin E.LaVigne, Justin EMiller, Heath R.Miller, Heath RKaur, JatinderKaur, JatinderEjendal, Karin F. K.Ejendal, Karin F. KWatts, Val J.Watts, Val JFlaherty, Daniel P and Flaherty, Daniel P.
Journal of medicinal chemistry, vol. 65, (no. 6), pp. 4686, 20220324. | Journal Article
 
Physiological roles of mammalian transmembrane adenylyl cyclase isoforms
Ostrom, Katrina FLaVigne, Justin EBrust, Tarsis FSeifert, RolandDessauer, Carmen WWatts, Val J and Ostrom, Rennolds S
Physiological reviews, vol. 102, (no. 2), pp. 857, 2022-04-01. | Journal Article
 
Protein-protein interaction-based high throughput screening for adenylyl cyclase 1 inhibitors: Design, implementation, and discovery of a novel chemotype
Dwyer, Tiffany S.Dwyer, Tiffany S.O’Brien, Joseph B.O’Brien, Joseph B.Ptak, Christopher P.Ptak, Christopher P.LaVigne, Justin E.LaVigne, Justin E.Flaherty, Daniel P.Flaherty, Daniel P.Watts, Val J.Watts, Val J.Roman, David L. and Roman, David L.
Frontiers in pharmacology, vol. 13, pp. 977742, 2022-09-06. | Journal Article
 
Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice
Johnson, KaylaDoucette, AlexisEdwards, AlexisVerdi, AleeyaMcFarland, RyanHulke, ShelbyFowler, AmandaWatts, Val J and Klein, Amanda H
Frontiers in pharmacology, vol. 13, pp. 937741, 2022-09-02. | Journal Article
2021
Acyclic nucleoside phosphonates with 2-aminothiazole base as inhibitors of bacterial and mammalian adenylate cyclases
Břehová, PetraChaloupecká, EmaČesnek, MichalSkácel, JanDračínský, MartinTloušťová, EvaMertlíková-Kaiserová, HelenaSoto-Velasquez, Monica P.Watts, Val J. and Janeba, Zlatko
European journal of medicinal chemistry, vol. 222, pp. 113581, 2021-10-15. | Journal Article
 
AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca 2+ Channels
Kar, PulakBarak, PradeepZerio, AnnaLin, Yu-PingParekh, Amy JWatts, Val JCooper, Dermot M FZaccolo, ManuelaKramer, Holger and Parekh, Anant B
Function (Oxford, England), vol. 2, (no. 5), pp. zqab036, 2021-00-00. | Journal Article
 
AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels
Kar, PulakBarak, PradeepZerio, AnnaLin, Yu-PingParekh, Amy JWatts, Val JCooper, Dermot M FZaccolo, ManuelaKramer, Holger and Parekh, Anant B
Function (Oxford, England), vol. 2, (no. 5), pp. zqab036, 2021-01-01. | Journal Article
 
Intrathecal Knockdown of Adenylyl Cyclase 1 Attenuates Morphine Tolerance and Withdrawal in Mice
Doucette, AlexisJohnson, KaylaWatts, Val and Klein, Amanda
The journal of pain, vol. 22, (no. 5), pp. 579, May 2021. | Journal Article
 
The CUL3/neddylation inhibitor MLN4924 reduces ethanol-induced locomotor sensitization and inflammatory pain allodynia in mice
Ding, ZhongDing, ZhongDing, ZhongKnipp, Gregory T.Knipp, Gregory T.Knipp, Gregory T.van Rijn, Richard M.van Rijn, Richard M.van Rijn, Richard M.Chester, Julia A.Chester, Julia A.Chester, Julia A.Watts, Val J.Watts, Val J. and Watts, Val J.
Behavioural brain research, vol. 399, pp. 113051, 2021-02-05. | Journal Article
2020
Approaches to Targeting Adenylyl Cyclase 1 for Novel Pain Therapeutics
O’Brien, JosephHayes, MichaelWatts, Val and Roman, David
The FASEB journal, vol. 34, (no. S1), pp. 1, 2020-04-00. | Journal Article
 
A Selective AC1 Inhibitor as Non‐GPCR‐ or Ion Channel‐Dependent Approach for the Treatment of Pain
Giacoletti, GiannaPrice, TatumMsdi, Abdulwhab ShremoCook, RyanHayes, MichaelVazquez-Falto, KaterinaGonzales, AlexandraChapman, SumerSantini, EdwinNornoo, AdwoaWatts, Val and Brust, Tarsis
The FASEB journal, vol. 34, (no. S1), pp. 1, April 2020. | Journal Article
 
Focused Library Screening for Isoform Selective Adenylyl Cyclase 1 Inhibitors as Non‐Opioid Alternatives for Chronic and Inflammatory Pain
Hayes, Michael PWiernicki, Todd RMartinez-Grau, Maria AngelesBurris, Kevin D and Watts, Val J
The FASEB Journal, vol. 34, (no. S1), pp. 1, April 2020. | Journal Article
 
Genome-Wide Small Interfering RNA Screening Reveals a Role for Cullin3-Really Interesting New Gene Ligase Signaling in Heterologous Sensitization of Adenylyl Cyclase
Ding, ZhongEjendal, Karin F KSoto-Velasquez, MonicaHayes, Michael PSantoro, NicholasLarsen, Martha J and Watts, Val J
The Journal of pharmacology and experimental therapeutics, vol. 372, (no. 3), pp. 276, 2020-Mar. | Journal Article
2019
Adenylyl cyclases (ACs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Dessauer, Carmen WDessauer, Carmen W.Ostrom, RennoldsOstrom, RennoldsSeifert, RolandSeifert, RolandWatts, Val J. and Watts, Val J
IUPHAR/BPS Guide to Pharmacology CITE, vol. 2019, (no. 4), 2019-09-16. | Journal Article
 
Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D 1 and D 2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening
Doyle, Trevor BMuntean, Brian SEjendal, Karin FHayes, Michael PSoto-Velasquez, MonicaMartemyanov, Kirill ADessauer, Carmen WHu, Chang-Deng and Watts, Val J
Cells, vol. 8, (no. 11), 2019-11-19. | Journal Article
 
Identification of Novel Adenylyl Cyclase 5 (AC5) Signaling Networks in D1 and D2 Medium Spiny Neurons using Bimolecular Fluorescence Complementation Screening
Doyle, Trevor BMuntean, Brian SEjendal, Karin FHayes, Michael PSoto-Velasquez, MonicaMartemyanov, Kirill ADessauer, Carmen WHu, Chang-Deng and Watts, Val J
Cells, vol. 8, (no. 11), pp. 1468, 2019-11-19. | Journal Article
 
Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9
Baldwin, Tanya ALi, YongBrand, Cameron SWatts, Val J and Dessauer, Carmen W
Molecular pharmacology, vol. 95, (no. 4), pp. 360, 2019-04-00. | Journal Article
 
Optimization of a 1,3,4-oxadiazole series for inhibition of Ca 2+ /calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain
Kaur, JatinderKaur, JatinderKaur, JatinderKaur, JatinderSoto-Velasquez, MonicaSoto-Velasquez, MonicaSoto-Velasquez, MonicaSoto-Velasquez, MonicaDing, ZhongDing, ZhongDing, ZhongDing, ZhongGhanbarpour, AhmadrezaGhanbarpour, AhmadrezaGhanbarpour, AhmadrezaGhanbarpour, AhmadrezaLill, Markus ALill, Markus ALill, Markus ALill, Markus Avan Rijn, Richard Mvan Rijn, Richard Mvan Rijn, Richard Mvan Rijn, Richard MWatts, Val JWatts, Val JWatts, Val JWatts, Val JFlaherty, Daniel PFlaherty, Daniel PFlaherty, Daniel P and Flaherty, Daniel P
European journal of medicinal chemistry, vol. 162, pp. 568, 2019-Jan-15. | Journal Article
 
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes
Alexander, Stephen PHAlexander, Stephen PHFabbro, DorianoFabbro, DorianoKelly, EamonnKelly, EamonnMathie, AlistairMathie, AlistairPeters, John APeters, John AVeale, Emma LVeale, Emma LArmstrong, Jane FArmstrong, Jane FFaccenda, ElenaFaccenda, ElenaHarding, Simon DHarding, Simon DPawson, Adam JPawson, Adam JSharman, Joanna LSharman, Joanna LSouthan, ChristopherSouthan, ChristopherDavies, Jamie ADavies, Jamie ABeuve, AnnieBeuve, AnnieBoison, DetlevBoison, DetlevBrouckaert, PeterBrouckaert, PeterBurnett, John CBurnett, John CBurns, KathrynBurns, KathrynDessauer, CarmenDessauer, CarmenFriebe, AndreasFriebe, AndreasGarthwaite, JohnGarthwaite, JohnGertsch, JürgGertsch, JürgHelsby, NualaHelsby, NualaIzzo, Angelo AIzzo, Angelo AKoesling, DorisKoesling, DorisKuhn, MichaelaKuhn, MichaelaOstrom, RennoldsOstrom, RennoldsPapapetropoulos, AndreasPapapetropoulos, AndreasPotter, Lincoln RPotter, Lincoln RPyne, Nigel JPyne, Nigel JPyne, SusanPyne, SusanRusswurm, MichaelRusswurm, MichaelSchmidt, Harald HHWSchmidt, Harald HHWSeifert, RolandSeifert, RolandStasch, Johannes‐PeterStasch, Johannes‐PeterSzabo, CsabaSzabo, Csabavan der Stelt, Mariovan der Stelt, Mariovan der Vliet, Albertvan der Vliet, AlbertWatts, Val and Watts, Val
British Journal of Pharmacology, vol. 176, (no. S1), pp. S396, December 2019. | Journal Article
 
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein-coupled receptors
Alexander, S.P.H.Alexander, Stephen P HAlexander, S.P.H.Alexander, Stephen P HChristopoulos, A.Christopoulos, ArthurChristopoulos, A.Christopoulos, ArthurDavenport, Anthony PDavenport, A.P.Davenport, A.P.Davenport, Anthony PKelly, EamonnKelly, E.Kelly, EamonnKelly, EamonnKelly, E.Mathie, A.Mathie, A.Mathie, AlistairMathie, AlistairPeters, John APeters, J.A.Peters, John APeters, JohnPeters, J.A.Veale, Emma LVeale, E.L.Veale, E.L.Veale, Emma LArmstrong, J.F.Armstrong, Jane FArmstrong, JaneArmstrong, Jane FArmstrong, J.F.Faccenda, ElenaFaccenda, E.Faccenda, E.Faccenda, ElenaHarding, S.D.Harding, Simon DHarding, SimonHarding, S.D.Harding, Simon DPawson, A.J.Pawson, A.J.Pawson, Adam JPawson, Adam JSharman, J.L.Sharman, JoannaSharman, Joanna LSharman, J.L.Sharman, Joanna LSouthan, ChristopherSouthan, ChristopherSouthan, C.Southan, C.Davies, Jamie ADavies, Jamie ADavies, J.A.Davies, J.A.Abbracchio, Maria PCGTP CollaboratorsAbbracchio, M.P.Abbracchio, M.P.Alexander, WayneAlexander, W.Bennett, AndrewAlexander, W.Sjogren, BenitaAl-hosaini, K.Al-hosaini, K.Al-hosaini, KhaledBäck, M.Sobey, ChristopherBäck, MagnusBäck, M.Beaulieu, Jean-MartinBeaulieu, J.-M.Beaulieu, J.-M.Bernstein, K.E.Bernstein, Kenneth E.Abbracchio, MariaBernstein, K.E.Bettler, BernhardBettler, B.Bettler, B.Birdsall, Nigel JMBirdsall, N.J.M.Birdsall, N.J.M.Blaho, VictoriaBlaho, V.Blaho, V.Back, MagnusBousquet, CorinneBousquet, C.Bousquet, C.Bräuner-Osborne, HansBräuner-Osborne, H.Bräuner-Osborne, H.Burnstock, G.Bettler, BernhardBurnstock, G.Burnstock, GeoffreyCaló, G.Caló, GirolamoCaló, G.Castaño, J.P.Castaño, Justo PCastaño, J.P.Catt, K.J.Catt, K.J.Catt, Kevin JCeruti, S.Brauner-Osborne, HansCeruti, S.Ceruti, StefaniaChazot, P.Chazot, P.Chazot, PaulChiang, N.Chiang, NanChiang, N.Chun, J.Castano, JustoChun, J.Chun, JeroldCianciulli, AntoniaCianciulli, A.Cianciulli, A.Clapp, L.H.Clapp, L.H.Clapp, Lucie HCouture, R.Couture, R.Couture, RéjeanCsaba, Z.Csaba, Z.Csaba, ZsoltDent, G.Dent, GordonDent, G.Singh, K.D.Singh, K.D.Singh, Khuraijam DhanachandraDouglas, S.D.Douglas, Steven DDouglas, S.D.Dournaud, PascalDournaud, P.Dournaud, P.Eguchi, SatoruEguchi, S.Eguchi, S.Csaba, ZsoltEscher, EmanuelEscher, E.Escher, E.Filardo, EdwardFilardo, E.Singh, KhuraijamFilardo, E.Fong, T.M.Douglas, StevenFong, T.M.Fong, Tung MFumagalli, M.Fumagalli, MartaFumagalli, M.Gainetdinov, R.R.Gainetdinov, R.R.Gainetdinov, Raul RGasparo, MarcEscher, EmanuelGasparo, M.D.Gasparo, M.D.Gershengorn, MarvinGershengorn, M.Filardo, EdwardGershengorn, M.Gobeil, F.Gobeil, F.Gobeil, FernandGoodfriend, T.L.Goodfriend, Theodore LFumagalli, MartaGoodfriend, T.L.Goudet, C.Goudet, CyrilGoudet, C.Gregory, K.J.Gasparo, MarcGregory, Karen JGregory, K.J.Gundlach, Andrew LGundlach, A.L.Gundlach, A.L.Gershengorn, MarvinGobeil, FernandHamann, J.Hamann, J.Hamann, JörgHanson, J.Hanson, JulienHanson, J.Goodfriend, TheodoreHauger, R.L.Hauger, Richard LHauger, R.L.Hay, D.Gregory, KarenHay, DebbieHay, D.Heinemann, A.Heinemann, AkosHeinemann, A.Gundlach, AndrewHollenberg, Morley DHamann, JorgHollenberg, M.D.Hollenberg, M.D.Holliday, Nicholas DHolliday, N.D.Holliday, N.D.Horiuchi, M.Horiuchi, M.Horiuchi, MastguguHoyer, DanielHoyer, D.Hoyer, D.Hunyady, L.Hunyady, LászlóHunyady, L.Heinemann, AkosHusain, A.Husain, AhsanHusain, A.Ijzerman, Adriaan PIjzerman, A.P.Ijzerman, A.P.Horiuchi, MastguguInagami, TadashiInagami, T.Inagami, T.Jacobson, K.A.Jacobson, Kenneth AJacobson, K.A.Hoyer, DanielJensen, Robert TJensen, R.T.Jensen, R.T.Hunyady, LaszloJockers, R.Jockers, RalfJockers, R.Jonnalagadda, DeepaJonnalagadda, D.Jonnalagadda, D.Karnik, S.Karnik, S.Karnik, SadashivaKaupmann, K.Kaupmann, KlemensKaupmann, K.Kemp, J.Kemp, J.Kemp, JacquelineKennedy, CharlesKennedy, C.Kennedy, C.Jonnalagadda, DeepaKihara, Y.Kihara, Y.Kihara, YasuyukiKozielewicz, P.Kozielewicz, P.Kozielewicz, PawełKreienkamp, Hans-JürgenKreienkamp, H.-J.Kreienkamp, H.-J.Kukkonen, J.P.Kemp, JacquelineKukkonen, Jyrki PKukkonen, J.P.Langenhan, T.Langenhan, T.Langenhan, TobiasKihara, YasuyukiLeach, K.Leach, K.Leach, KatieLecca, DavideLecca, D.Kozielewicz, PawelLecca, D.Lee, J.D.Lee, John DLee, J.D.Kukkonen, JyrkiLeeman, S.E.Leeman, Susan ELeeman, S.E.Leprince, JérômeLeprince, J.Leprince, J.Lolait, S.J.Lolait, Stephen JLolait, S.J.Lupp, AmelieLupp, A.Lupp, A.Lecca, DavideMacrae, R.Lee, JohnMacrae, RobynMacrae, R.Leeman, SusanMaguire, J.Maguire, J.Maguire, JanetMazella, J.Mazella, JeanMazella, J.Lolait, StephenMcArdle, Craig AMcArdle, C.A.McArdle, C.A.Melmed, S.Melmed, S.Melmed, ShlomoMichel, M.C.Michel, Martin CMichel, M.C.Miller, L.Miller, L.Miller, LaurenceMitolo, V.Mitolo, VincenzoMitolo, V.Mazella, JeanMouillac, B.Mouillac, BernardMouillac, B.Murphy, P.M.Murphy, Philip MMelmed, ShlomoMurphy, P.M.Nahon, J.-L.Nahon, Jean-LouisNahon, J.-L.Miller, LaurenceNorel, XavierNorel, X.Norel, X.Nyimanu, D.Nyimanu, DuuameneNyimanu, D.O’Carroll, Anne-MarieO’Carroll, A.-M.Mouillac, BernardO’Carroll, A.-M.Offermanns, S.Offermanns, S.Offermanns, StefanPanaro, M.A.Panaro, Maria APanaro, M.A.Pertwee, R.G.Pertwee, R.G.Pertwee, Roger GNyimanu, DuuamenePin, J.-P.Pin, J.-P.Pin, Jean-PhilippeProssnitz, E.Prossnitz, E.Prossnitz, EricRamachandran, R.Ramachandran, RithwikRamachandran, R.Reinscheid, R.K.Reinscheid, R.K.Reinscheid, Rainer KPanaro, MariaRondard, PhilippeRondard, P.Rondard, P.Rovati, G.E.Rovati, G.E.Rovati, G EnricoRuzza, C.Ruzza, ChiaraRuzza, C.Sanger, G.Sanger, G.Sanger, GarethSchöneberg, T.Schöneberg, T.Schöneberg, TorstenSchulte, G.Schulte, GunnarSchulte, G.Rondard, PhilippeSchulz, S.Schulz, S.Schulz, StefanSegaloff, D.L.Segaloff, Deborah LRuzza, ChiaraSegaloff, D.L.Serhan, C.N.Sanger, GarethSerhan, Charles NSerhan, C.N.Stoddart, L.A.Stoddart, L.A.Stoddart, Leigh ASugimoto, YukihikoSugimoto, Y.Sugimoto, Y.Summers, R.Summers, R.Summers, RogerTan, ValerieTan, V.Tan, V.Thomas, W.Serhan, CharlesThomas, W.Thomas, WalterStoddart, LeighTimmermans, Pieter BMWMTimmermans, P.B.M.W.M.Timmermans, P.B.M.W.M.Tirupula, K.Tirupula, K.Tirupula, KalyanTulipano, G.Tulipano, GiovanniTulipano, G.Summers, RogerUnal, HamiyetTan, ValerieUnal, H.Unal, H.Unger, ThomasUnger, T.Unger, T.Vanderheyden, P.Vanderheyden, P.Vanderheyden, PatrickTimmermans, PieterVaudry, DavidTirupula, KalyanVaudry, D.Vaudry, D.Vaudry, H.Tulipano, GiovanniVaudry, HubertVaudry, H.Vilardaga, J.-P.Vilardaga, J.-P.Vilardaga, Jean-PierreWalker, Christopher SWalker, C.S.Unger, ThomasWalker, C.S.Ward, D.T.Ward, Donald TWard, D.T.Wester, H.-J.Wester, Hans-JürgenWester, H.-J.Vaudry, DavidWillars, Gary BWillars, G.B.Willars, G.B.Williams, Tom LloydWilliams, T.L.Williams, T.L.Walker, ChristopherWoodruff, Trent MWoodruff, T.M.Woodruff, T.M.Yao, C.and, Chengcan YaoWard, DonaldYao, C.Williams, TomWoodruff, TrentYao, ChengcanConner, AlexDavies, PaulDelling, MarkusFalzoni, SimonettaGrissmer, StephanHanukoglu, IsraelJarvis, MikeKaczmarek, LeonardPlant, LeighRen, DejianSmart, TrevorSnutch, TerranceTian, JinbinEynde, CharlotteWei, AguanWinn, BrendaFuller, PeterKorach, KennethBryant, ClareFarndale, RichardJarvis, GavinMacEwan, DavidBrouckaert, PeterBurnett, JohnDessauer, CarmenFriebe, AndreasGarthwaite, JohnIzzo, AngeloKuhn, MichaelaSzabo, CsabaWatts, ValAnderson, CatrionaDawson, PaulHammond, JamesHancox, JulesKanai, YoshikatsuKemp, Stephan and Thwaites, David
2019-12-01. | Journal Article
2018
A Novel CRISPR/Cas9-Based Cellular Model to Explore Adenylyl Cyclase and Cyclic AMP Signaling.
Soto-Velasquez, MonicaHayes, Michael PAlpsoy, AktanDykhuizen, Emily C and Watts, Val J
Molecular pharmacology, June 27, 2018. | Journal Article