183 Publications (Page 2 of 8)
2018
A Novel CRISPR/Cas9‐Based Cellular Model to Explore Adenylyl Cyclase and Cyclic AMP Signaling
Soto‐Velasquez, Monica⋅Soto‐Velasquez, Monica⋅Alpsoy, Aktan⋅Alpsoy, Aktan⋅Dykhuizen, Emily C.⋅Dykhuizen, Emily C.⋅Watts, Val J. and Watts, Val J.
The FASEB journal, vol. 32, (no. S1), pp. 686.1, April 2018. | Journal Article
 
Genomics, GPCRs and new targets for the control of insect pests and vectors.
Hill, Catherine A⋅Hill, Catherine A⋅Sharan, Shruti⋅Sharan, Shruti⋅Watts, Val J and Watts, Val J
Current opinion in insect science, vol. 30, pp. 99-106, December 2018. | Journal Article
 
Identification of FDA-Approved Small Molecules Capable of Disrupting the Calmodulin–Adenylyl Cyclase 8 Interaction through Direct Binding to Calmodulin
Hayes, Michael P⋅Hayes, Michael P⋅Soto-Velasquez, Monica⋅Soto-Velasquez, Monica⋅Fowler, C Andrew⋅Fowler, C. Andrew⋅Watts, Val J⋅Watts, Val J⋅Roman, David L and Roman, David L
ACS Chemical Neuroscience, vol. 9, (no. 2), pp. 357, 20180221. | Journal Article
 
Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis.
Česnek, Michal⋅Skácel, Jan⋅Jansa, Petr⋅Dračínský, Martin⋅Šmídková, Markéta⋅Mertlíková-Kaiserová, Helena⋅Soto-Velasquez, Monica P⋅Watts, Val J and Janeba, Zlatko
ChemMedChem, July 3, 2018. | Journal Article
 
Optimization of a 1,3,4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain.
Kaur, Jatinder⋅Kaur, Jatinder⋅Soto-Velasquez, Monica⋅Soto-Velasquez, Monica⋅Ding, Zhong⋅Ding, Zhong⋅Ghanbarpour, Ahmadreza⋅Ghanbarpour, Ahmadreza⋅Lill, Markus A⋅Lill, Markus A⋅van Rijn, Richard M⋅van Rijn, Richard M⋅Watts, Val J⋅Watts, Val J⋅Flaherty, Daniel P and Flaherty, Daniel P
European journal of medicinal chemistry, vol. 162, pp. 568-585, November 16, 2018. | Journal Article
 
Selective Adenylyl Cyclase Type 1 Inhibitors as Potential Opioid Alternatives For Chronic Pain
Watts, Val J
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol. 43, (no. 1), pp. 216, 2018-01-00. | Journal Article
 
Synthesis of α‐Branched Acyclic Nucleoside Phosphonates as Potential Inhibitors of Bacterial Adenylate Cyclases
Frydrych, Jan⋅Skácel, Jan⋅Šmídková, Markéta⋅Mertlíková‐Kaiserová, Helena⋅Dračínský, Martin⋅Gnanasekaran, Ramachandran⋅Lepšík, Martin⋅Soto‐Velasquez, Monica⋅Watts, Val J and Janeba, Zlatko
ChemMedChem, vol. 13, (no. 2), pp. 206, January 22, 2018. | Journal Article
2017
Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties
Brust, Tarsis F⋅Brust, Tarsis F⋅Brust, Tarsis F⋅Alongkronrusmee, Doungkamol⋅Alongkronrusmee, Doungkamol⋅Alongkronrusmee, Doungkamol⋅Soto-Velasquez, Monica⋅Soto-Velasquez, Monica⋅Soto-Velasquez, Monica⋅Baldwin, Tanya A⋅Baldwin, Tanya A⋅Baldwin, Tanya A⋅Ye, Zhishi⋅Ye, Zhishi⋅Ye, Zhishi⋅Dai, Mingji⋅Dai, Mingji⋅Dai, Mingji⋅Dessauer, Carmen W⋅Dessauer, Carmen W⋅Dessauer, Carmen W⋅Van Rijn, Richard M⋅van Rijn, Richard M⋅van Rijn, Richard M⋅Watts, Val J⋅Watts, Val J and Watts, Val J
Science signaling, vol. 10, (no. 467), pp. eaah5381, 2017-Feb-21. | Journal Article
 
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases
Dessauer, Carmen W⋅Dessauer, Carmen W⋅Dessauer, C.W.⋅Watts, Val J⋅Watts, Val J⋅Watts, V.J.⋅Ostrom, Rennolds S⋅Ostrom, R.S.⋅Ostrom, Rennolds S⋅Conti, Marco⋅Conti, M.⋅Conti, Marco⋅Dove, Stefan⋅Dove, Stefan⋅Dove, S.⋅Seifert, R.⋅Seifert, Roland and Seifert, Roland
Pharmacological reviews, vol. 69, (no. 2), pp. 139, 2017-04-00. | Journal Article
 
Molecular Modeling Evaluation of the Enantiomers of a Novel Adenylyl Cyclase 2 Inhibitor.
Rana, Neha⋅Rana, Neha⋅Rana, Neha⋅Conley, Jason M⋅Conley, Jason M⋅Conley, Jason M⋅Soto-Velasquez, Monica⋅Soto-Velasquez, Monica⋅Soto-Velasquez, Monica⋅León, Francisco⋅León, Francisco⋅Leon, Francisco⋅Cutler, Stephen J⋅Cutler, Stephen J⋅Cutler, Stephen J⋅Watts, Val J⋅Watts, Val J⋅Watts, Val J⋅Lill, Markus A⋅Lill, Markus A and Lill, Markus A
Journal of chemical information and modeling, January 9, 2017. | Journal Article
2016
Comparative pharmacological characterization of D1-like dopamine receptors from Anopheles gambiae, Aedes aegypti and Culex quinquefasciatus suggests pleiotropic signaling in mosquito vector lineages
Hill, Catherine A⋅Hill, Catherine A⋅Hill, Catherine⋅Doyle, Trevor⋅Doyle, Trevor⋅Doyle, Trevor⋅Nuss, Andrew B⋅Nuss, Andrew B⋅Nuss, Andrew⋅Ejendal, Karin F⋅Ejendal, Karin F⋅Ejendal, Karin⋅Meyer, Jason M⋅Meyer, Jason M⋅Meyer, Jason⋅Watts, Val J⋅Watts, Val and Watts, Val J
Parasites & Vectors, vol. 9, 2016. | Journal Article
 
Design and Synthesis of Fluorescent Acyclic Nucleoside Phosphonates as Potent Inhibitors of Bacterial Adenylate Cyclases
Břehová, Petra⋅Šmídková, Markéta⋅Skácel, Jan⋅Dračínský, Martin⋅Mertlíková‐Kaiserová, Helena⋅Velasquez, Monica P. Soto⋅Watts, Val J and Janeba, Zlatko
ChemMedChem, vol. 11, (no. 22), pp. 2546, November 21, 2016. | Journal Article
 
[Research progress of Gα(i/o)-coupled receptor-mediated supersensitization of adenylyl cyclase].
Xu, Ru-qiang and Watts, Val J
Yao xue xue bao = Acta pharmaceutica Sinica, vol. 51, (no. 9), pp. 1349-1355, September 2016. | Journal Article
 
Research progress of Gα(i/o)-coupled receptor-mediated supersensitization of adenylyl cyclase
Xu, Ru-qiang and Watts, Val J
Yao hsüeh hsüeh pao, vol. 51, (no. 9), pp. 1355, 2016-09-00. | Journal Article
2015
Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathways.
Brust, Tarsis F⋅Hayes, Michael P⋅Roman, David L⋅Burris, Kevin D and Watts, Val J
The Journal of pharmacology and experimental therapeutics, vol. 352, (no. 3), pp. 480-493, March 2015. | Journal Article
 
Bisamidate Prodrugs of 2‐Substituted 9‐[2‐(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis
Česnek, Michal⋅Jansa, Petr⋅Šmídková, Markéta⋅Mertlíková‐Kaiserová, Helena⋅Dračínský, Martin⋅Brust, Tarsis F⋅Pávek, Petr⋅Trejtnar, František⋅Watts, Val J and Janeba, Zlatko
ChemMedChem, vol. 10, (no. 8), pp. 1364, August 2015. | Journal Article
 
Cover Picture: Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin fromBordetella pertussis(ChemMedChem 8/2015)
Česnek, Michal⋅Jansa, Petr⋅Šmídková, Markéta⋅Mertlíková-Kaiserová, Helena⋅Dračínský, Martin⋅Brust, Tarsis F⋅Pávek, Petr⋅Trejtnar, František⋅Watts, Val J and Janeba, Zlatko
ChemMedChem, vol. 10, (no. 8), pp. 1277, 2015-08-00. | Journal Article
 
Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors.
Nuss, Andrew B⋅Nuss, Andrew B⋅Ejendal, Karin F⋅Ejendal, Karin F K⋅Doyle, Trevor B⋅Doyle, Trevor B⋅Meyer, Jason M⋅Meyer, Jason M⋅Lang, Emma G⋅Lang, Emma G⋅Watts, Val J⋅Watts, Val J⋅Hill, Catherine A and Hill, Catherine A
PLoS neglected tropical diseases, vol. 9, (no. 3), pp. e0003515, March 2015. | Journal Article
 
Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
Conley, Jason M⋅Meyer, Jason M⋅Nuss, Andrew B⋅Doyle, Trevor B⋅Savinov, Sergey N⋅Hill, Catherine A and Watts, Val J
The Journal of pharmacology and experimental therapeutics, vol. 352, (no. 1), pp. 53-60, January 2015. | Journal Article
 
Gα(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years later.
Brust, Tarsis F⋅Conley, Jason M and Watts, Val J
European journal of pharmacology, vol. 763, pp. 223-232, September 15, 2015. | Journal Article
 
Identification of Small Molecule Inhibitors Selective for Type 1 Adenylyl Cyclase
Brust, Tarsis and Watts, Val
The FASEB journal, vol. 29, (no. S1), 2015-04-00. | Journal Article
 
New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling
Brust, Tarsis F⋅Brust, Tarsis F⋅Hayes, Michael P⋅Hayes, Michael P⋅Roman, David L⋅Roman, David L⋅Watts, Val J and Watts, Val J
Biochemical Pharmacology, vol. 93, (no. 1), pp. 91, 2015-01-01. | Journal Article
 
Palladium-Catalyzed Regio- and Stereo-Selective γ-Arylation of Tertiary Allylic Amines: Identification of Potent Adenylyl Cyclase Inhibitors
Ye, Zhishi⋅Ye, Zhishi⋅Brust, Tarsis F⋅Brust, Tarsis F⋅Watts, Val J⋅Watts, Val J⋅Dai, Mingji and Dai, Mingji
Organic letters, vol. 17, (no. 4), pp. 895, 2015-02-10. | Journal Article
 
Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and [beta]-arrestin-mediated signaling
Meade, Julie⋅Free, R.⋅Miller, Nicole⋅Chun, Lani⋅Doyle, Trevor⋅Moritz, Amy⋅Conroy, Jennie⋅Watts, Val and Sibley, David
Psychopharmacology, vol. 232, (no. 5), pp. 917, 20150301. | Journal Article
2014
Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience
Staffend, Nancy⋅Staffend, Nancy⋅Staffend, Nancy⋅Hedges, Valerie⋅Hedges, Valerie⋅Hedges, Valerie⋅Chemel, Benjamin⋅Chemel, Benjamin⋅Chemel, Benjamin⋅Watts, Val⋅Watts, Val⋅Watts, Val⋅Meisel, Robert⋅Meisel, Robert and Meisel, Robert
Brain Structure and Function, vol. 219, (no. 6), pp. 2081, 20141100. | Journal Article