17 Publications
2019
Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
Garg, GarimaGarg, GarimaGarg, GarimaMuschaweckh, AndreasMuschaweckh, AndreasMuschaweckh, AndreasMoreno, HelenaMoreno, HelenaMoreno, HelenaVasanthakumar, AjithkumarVasanthakumar, AjithkumarVasanthakumar, AjithkumarFloess, StefanFloess, StefanFloess, StefanLepennetier, GildasLepennetier, GildasLepennetier, GildasOellinger, RupertOellinger, RupertOellinger, RupertZhan, YifanZhan, YifanZhan, YifanRegen, TommyRegen, TommyRegen, TommyHiltensperger, MichaelHiltensperger, MichaelHiltensperger, MichaelPeter, ChristianPeter, ChristianPeter, ChristianAly, LilianAly, LilianAly, LilianKnier, BenjaminKnier, BenjaminKnier, BenjaminPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyKapur, ReubenKapur, ReubenKapur, ReubenKaplan, Mark HKaplan, Mark HKaplan, Mark HWaisman, AriWaisman, AriWaisman, AriRad, RolandRad, RolandRad, RolandSchotta, GunnarSchotta, GunnarSchotta, GunnarHuehn, JochenHuehn, JochenHuehn, JochenKallies, AxelKallies, AxelKallies, AxelKorn, ThomasKorn, Thomas and Korn, Thomas
Cell Reports, vol. 26, (no. 7), pp. 1868.e5, 2019-02-12. | Journal Article
 
Combined Heterozygous Loss of Tet2 and Dnmt3a Along with Expression of Flt3ITD/WT results in Acute Myeloid Leukemia Which Responds to a Combination of FLT3 Inhibitor, APE1 Inhibitor and Decitabine
Ramdas, BaskarRamdas, BaskarRamdas, BaskarPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghCai, ZhigangCai, ZhigangCai, ZhigangPandey, RuchiPandey, RuchiPandey, RuchiKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 134, (no. Supplement_1), pp. 3754, 2019-11-13. | Journal Article
 
Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations
Rangaraju, SravantiRangaraju, SravantiRangaraju, SravantiRangaraju, SravantiRangaraju, SravantiMarino, SilviaMarino, SilviaMarino, SilviaMarino, SilviaMarino, SilviaRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidCripe, Larry DCripe, Larry DCripe, Larry DCripe, Larry DCripe, Larry DRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddySargent, Katie JSargent, Katie JSargent, Katie JSargent, Katie JSargent, Katie JSayar, HamidSayar, HamidSayar, HamidSayar, HamidSayar, HamidKonig, HeikoKonig, HeikoKonig, HeikoKonig, HeikoKonig, HeikoKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenBoswell, H. ScottBoswell, H. ScottBoswell, H. ScottBoswell, H. Scott and Boswell, H. Scott
Blood, vol. 134, (no. Supplement_1), pp. 5051, 2019-11-13. | Journal Article
 
Loss of Dnmt3a Dysregulates Hematopoietic Homeostasis and Myeloid Skewing Via the PI3Kinase Pathway: PI3Kα/β Inhibition Corrects Extramedullary Hematopoiesis and Myeloid Skewing Due to Loss of Dnmt3a
Palam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyRamdas, BaskarRamdas, BaskarRamdas, BaskarPickerell, KatelynPickerell, KatelynPickerell, KatelynKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 134, (no. Supplement_1), pp. 723, 2019-11-13. | Journal Article
2018
Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis
Cai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangKotzin, JonathanKotzin, JonathanKotzin, JonathanKotzin, JonathanKotzin, JonathanRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiMali, RaghuveerMali, RaghuveerMali, RaghuveerMali, RaghuveerMali, RaghuveerLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeKapur, ReubenKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 132, (no. Supplement 1), pp. 1288, 2018-11-29. | Journal Article
 
Identification of Beta-Catenin As a Novel Ubiquitin-Regulated Target of Combined Flβ3/Syk- and Proteasome Inhibitors for Interruption of LSC Signaling in Poor-Risk AML
Rangaraju, SravantiRangaraju, SravantiRangaraju, SravantiRangaraju, SravantiRangaraju, SravantiRangaraju, SravantiMarino, SilviaMarino, SilviaMarino, SilviaMarino, SilviaMarino, SilviaMarino, SilviaPetrusca, Daniela NicoletaPetrusca, Daniela NicoletaPetrusca, Daniela NicoletaPetrusca, Daniela NicoletaPetrusca, Daniela NicoletaPetrusca, Daniela NicoletaCripe, Larry DCripe, Larry DCripe, Larry DCripe, Larry DCripe, Larry DCripe, Larry DSargent, Katie JSargent, Katie JSargent, Katie JSargent, Katie JSargent, Katie JSargent, Katie JRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidSayar, HamidSayar, HamidSayar, HamidSayar, HamidSayar, HamidSayar, HamidRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyShanmugam, RajasubramaniamShanmugam, RajasubramaniamShanmugam, RajasubramaniamShanmugam, RajasubramaniamShanmugam, RajasubramaniamShanmugam, RajasubramaniamRogozea, AdrianaRogozea, AdrianaRogozea, AdrianaRogozea, AdrianaRogozea, AdrianaRogozea, AdrianaKonig, HeikoKonig, HeikoKonig, HeikoKonig, HeikoKonig, HeikoKonig, HeikoKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenBoswell, H. ScottBoswell, H. ScottBoswell, H. ScottBoswell, H. ScottBoswell, H. Scott and Boswell, H. Scott
Blood, vol. 132, (no. Supplement 1), pp. 3949, 2018-11-29. | Journal Article
 
Inhibition of Inflammatory Signaling in Tet2 Mutant Preleukemic Cells Mitigates Stress-Induced Abnormalities and Clonal Hematopoiesis
Cai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangCai, ZhigangKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JKotzin, Jonathan JRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiChen, SisiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiNelanuthala, SaiPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiPandey, RuchiMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanLiu, YanKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RKelley, Mark RSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeSandusky, GeorgeMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridMohseni, MorvaridWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamWilliams, AdamHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeHenao-Mejia, JorgeKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
Cell Stem Cell, vol. 23, (no. 6), pp. 849.e5, 2018-12-06. | Journal Article
 
Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway
Palam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghMali, Raghuveer SinghRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarSrivatsan, Sridhar NonavinkereSrivatsan, Sridhar NonavinkereSrivatsan, Sridhar NonavinkereSrivatsan, Sridhar NonavinkereSrivatsan, Sridhar NonavinkereVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaTiu, Ramon VTiu, Ramon VTiu, Ramon VTiu, Ramon VTiu, Ramon VVanhaesebroeck, BartVanhaesebroeck, BartVanhaesebroeck, BartVanhaesebroeck, BartVanhaesebroeck, BartRoers, AxelRoers, AxelRoers, AxelRoers, AxelRoers, AxelGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderXu, MingjiangXu, MingjiangXu, MingjiangXu, MingjiangXu, MingjiangJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraTakemoto, Clifford MTakemoto, Clifford MTakemoto, Clifford MTakemoto, Clifford MTakemoto, Clifford MPaczesny, SophiePaczesny, SophiePaczesny, SophiePaczesny, SophiePaczesny, SophieKapur, ReubenKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
JCI insight, vol. 3, (no. 4), 2018-02-22. | Journal Article
 
Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells
Palam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyPalam, Lakshmi ReddyRamdas, BaskarRamdas, BaskarRamdas, BaskarRamdas, BaskarSrivatsan, Sridhar reddySrivatsan, Sridhar reddySrivatsan, Sridhar reddySrivatsan, Sridhar reddyJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraJanga, Sarath ChandraRoers, AxelRoers, AxelRoers, AxelRoers, AxelGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderGerbaulet, AlexanderKapur, ReubenKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 132, (no. Supplement 1), pp. 3055, 2018-11-29. | Journal Article
2016
Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-[beta] to promote proliferation.(Corrigendum)(Correction notice)
Gore, A.Deitz, SamanthaPalam, LakshmiCraven, Kelly and Korc, Murray
Journal of Clinical Investigation, vol. 126, (no. 7), pp. 2774, 20160701. | Journal Article
 
Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation
Gore, A JesseGore, A JesseDeitz, Samantha LDeitz, Samantha LPalam, Lakshmi ReddyPalam, Lakshmi ReddyCraven, Kelly ECraven, Kelly EKorc, Murray and Korc, Murray
The Journal of clinical investigation, vol. 126, (no. 7), pp. 2774, 2016-07-01. | Journal Article
 
Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response
Young, Sara KYoung, Sara KPalam, Lakshmi ReddyPalam, Lakshmi ReddyWu, ChengWu, ChengSachs, Matthew SSachs, Matthew SWek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 291, (no. 12), pp. 6558, 2016-Mar-18. | Journal Article
2015
Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells
Mali, RaghuveerMali, RaghuveerMali, RaghuveerMartin, Holly ReneMartin, Holly ReneMartin, Holly ReneRamdas, BaskarRamdas, BaskarRamdas, BaskarPalam, LakshmiPalam, LakshmiPalam, LakshmiVisconte, ValeriaVisconte, ValeriaVisconte, ValeriaRamon, TiuRamon, TiuRamon, TiuHanenberg, HelmutHanenberg, HelmutHanenberg, HelmutXu, MingjiangXu, MingjiangXu, MingjiangKapur, ReubenKapur, Reuben and Kapur, Reuben
Blood, vol. 126, (no. 23), pp. 775, 2015-12-03. | Journal Article
2014
Pancreatic cancer-associated retinoblastoma 1 dysfunction enables TGF-[beta]to promote proliferation
Gore, AGore, JesseDeitz, SamanthaDeitz, SamanthaPalam, LakshmiPalam, LakshmiCraven, KellyCraven, KellyKorc, Murray and Korc, Murray
Journal of Clinical Investigation, vol. 124, (no. 1), pp. 338, 20140101. | Journal Article
 
Pancreatic cancer–associated retinoblastoma 1 dysfunction enables TGF-β to promote proliferation
Gore, A JesseGore, A JesseDeitz, Samantha LDeitz, Samantha LPalam, Lakshmi ReddyPalam, Lakshmi ReddyCraven, Kelly ECraven, Kelly EKorc, Murray and Korc, Murray
The Journal of clinical investigation, vol. 124, (no. 1), pp. 352, 2014-Jan. | Journal Article
2010
Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress Response
Dey, SouvikDey, SouvikBaird, Thomas DBaird, Thomas DZhou, DonghuiZhou, DonghuiPalam, Lakshmi RPalam, Lakshmi ReddySpandau, Dan FSpandau, Dan FWek, Ronald C and Wek, Ronald C
The Journal of biological chemistry, vol. 285, (no. 43), pp. 33174, 2010-Oct-22. | Journal Article
2009
DNA Methyltransferase Protein Synthesis Is Reduced in CXXC Finger Protein 1–Deficient Embryonic Stem Cells
Butler, JSButler, Jill SPalam, LRPalam, Lakshmi RTate, CMTate, Courtney MSanford, JeremySanford, Jeremy RWek, RonaldWek, Ronald CSkalnik, David G and Skalnik, David G
DNA and cell biology, vol. 28, (no. 5), pp. 231, 2009-May. | Journal Article