Dr. Palam research interests include elucidating role of epigenetic factors and cooperating c-KIT mutations in myeloid malignancies. Briefly, epigenetic factors such as TET2, DNMT3a, and ASXL1 are shown to be frequently mutated in myeloid malignancies such asmyeloproliferative neoplasms (MPN), acute myeloid leukemia (AML), and myelodysplastic syndrome (MDS). Epigenetic alterations in hematopoietic stem and progenitor cells were shown to cause myeloid skewing and results in myeloid malignancies. Dr. Palam’s recent findings that loss of Tet2, a key regulator of genomic DNA methylation content, causes hyper proliferation of myeloid derived mast cells via aberrant activation of PI3K signaling and accumulated oncogenic c-Myc protein. Dr. Palam interested in mechanisms how loss of these epigenetic factors TET2, DNMT3a and ASXL1 drive hematopoietic dysregulation and myeloid malignancies.
- Hematologic Malignancies and Stem Cell Biology