144 Publications (Page 2 of 6)
2018
Temporal and Spatially Regulated Oncogenic KIT Expression and Loss of Dnmt3a Cooperate to Drive MPN Development: Role of PI3Kinase in Dnmt3a Loss Induced Hyperproliferation in Myeloid Cells
Palam, Lakshmi Reddy⋅Palam, Lakshmi Reddy⋅Palam, Lakshmi Reddy⋅Palam, Lakshmi Reddy⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Srivatsan, Sridhar reddy⋅Srivatsan, Sridhar reddy⋅Srivatsan, Sridhar reddy⋅Srivatsan, Sridhar reddy⋅Janga, Sarath Chandra⋅Janga, Sarath Chandra⋅Janga, Sarath Chandra⋅Janga, Sarath Chandra⋅Roers, Axel⋅Roers, Axel⋅Roers, Axel⋅Roers, Axel⋅Gerbaulet, Alexander⋅Gerbaulet, Alexander⋅Gerbaulet, Alexander⋅Gerbaulet, Alexander⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben and Kapur, Reuben
Blood, vol. 132, (no. Supplement 1), pp. 3055, 2018-11-29. | Journal Article
2017
DPP4 Truncated GM-CSF & IL-3 Manifest Distinct Receptor Binding & Regulatory Functions Compared to their Full Length Forms
O’leary, Heather Ann⋅O’leary, Heather Ann⋅O’leary, Heather Ann⋅O’Leary, H A⋅Capitano, M⋅Capitano, Maegan⋅Capitano, Maegan⋅Capitano, Maegan⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, S⋅Cooper, Scott⋅Mantel, Charlie⋅Mantel, Charlie⋅Mantel, C⋅Mantel, Charlie⋅Boswell, H. Scott⋅Boswell, H. Scott⋅Boswell, H S⋅Boswell, H. Scott⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, R⋅Ramdas, B⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Chan, Rebecca⋅Chan, R⋅Chan, Rebecca⋅Chan, Rebecca⋅Deng, Lisa⋅Deng, Lisa⋅Deng, Lisa⋅Deng, L⋅Qu, Cheng-Kui⋅Qu, Cheng-Kui⋅Qu, Cheng-Kui⋅Qu, C-K⋅Broxmeyer, H E⋅Broxmeyer, Hal E⋅Broxmeyer, Hal E and Broxmeyer, Hal E
Leukemia, vol. 31, (no. 11), pp. 2478, 2017-03-01. | Journal Article
 
Imipramine blue sensitively and selectively targets FLT3-ITD positive acute myeloid leukemia cells
Metts, Jonathan⋅Bradley, Heath L⋅Wang, Zhengqi⋅Shah, Neil P⋅Kapur, Reuben⋅Arbiser, Jack L and Bunting, Kevin D
Scientific reports, vol. 7, (no. 1), pp. 10, 2017-06-30. | Journal Article
 
p190-B RhoGAP and intracellular cytokine signals balance hematopoietic stem and progenitor cell self-renewal and differentiation
Hinge, Ashwini⋅Hinge, Ashwini⋅Xu, Juying⋅Xu, Juying⋅Javier, Jose⋅Javier, Jose⋅Mose, Eucabeth⋅Mose, Eucabeth⋅Kumar, Sachin⋅Kumar, Sachin⋅Kapur, Reuben⋅Kapur, Reuben⋅Srour, Edward F⋅Srour, Edward⋅Malik, Punam⋅Malik, Punam⋅Aronow, Bruce J⋅Aronow, Bruce⋅Filippi, Marie-Dominique and Filippi, Marie-dominique
Nature communications, vol. 8, (no. 1), pp. 14382, 2017-02-08. | Journal Article
 
Pharmacological inhibition of AKT activity in human CD34.sup.+ cells enhances their ability to engraft immunodeficient mice
Chen, Sisi⋅Gao, Rui⋅Kobayashi, Michihiro⋅Yu, Hao⋅Yao, Chonghua⋅Kapur, Reuben⋅Yoder, Mervin and Liu, Yan
Experimental Hematology, vol. 45, pp. 74, 20170101. | Journal Article
 
Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors
Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Nabinger, Sarah C⋅Nabinger, Sarah⋅Nabinger, Sarah C⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Yoshimoto, Momoko⋅Yoshimoto, Momoko⋅Yoshimoto, Momoko⋅Gao, Rui⋅Gao, Rui⋅Gao, Rui⋅Chen, Sisi⋅Chen, Sisi⋅Chen, Sisi⋅Yao, Chonghua⋅Yao, Chonghua⋅Yao, Chonghua⋅Dong, Yuanshu⋅Dong, Yuanshu⋅Dong, Yuanshu⋅Zhang, Lujuan⋅Zhang, Lujuan⋅Zhang, Lujuan⋅Rodriguez, Sonia⋅Rodriguez, Sonia⋅Rodriguez, Sonia⋅Yashiro-Ohtani, Yumi⋅Yashiro-Ohtani, Yumi⋅Yashiro‐Ohtani, Yumi⋅Pear, Warren S⋅Pear, Warren S⋅Pear, Warren S⋅Carlesso, Nadia⋅Carlesso, Nadia⋅Carlesso, Nadia⋅Yoder, Mervin C⋅Yoder, Mervin C⋅Yoder, Mervin C⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kaplan, Mark H⋅Kaplan, Mark H⋅Kaplan, Mark H⋅Lacorazza, H Daniel⋅Daniel Lacorazza, Hugo⋅Daniel Lacorazza, Hugo⋅Zhang, Zhong-Yin⋅Zhang, Zhong‐Yin⋅Zhang, Zhong Yin⋅Liu, Yan⋅Liu, Yan and Liu, Yan
STEM CELLS, vol. 35, (no. 4), pp. 1064, April 2017. | Journal Article
 
Role of mTORC1-S6K1 signaling pathway in regulation of hematopoietic stem cell and acute myeloid leukemia
Ghosh, Joydeep and Kapur, Reuben
Experimental Hematology, vol. 50, pp. 21, 2017. | Journal Article
2016
Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Maintenance by the PI3K-mTORC1 Pathway
Ghosh, Joydeep and Kapur, Reuben
Current Stem Cell Reports, vol. 2, (no. 4), pp. 378, 20161200. | Journal Article
 
ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells
Kapur, Reuben⋅Shi, Jianjian⋅Ghosh, Joydeep⋅Munugalavadla, Veerendra⋅Sims, Emily⋅Martin, Holly⋅Wei, Lei and Mali, Raghuveer Singh
Oncotarget, vol. 7, (no. 13), pp. 16947, 2016-Mar-29. | Journal Article
 
S6K1 regulates hematopoietic stem cell self-renewal and leukemia maintenance
Ghosh, Joydeep⋅Ghosh, Joydeep⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Chatterjee, Anindya⋅Chatterjee, Anindya⋅Ma, Peilin⋅Ma, Peilin⋅Mali, Raghuveer Singh⋅Mali, Raghuveer Singh⋅Carlesso, Nadia⋅Carlesso, Nadia⋅Liu, Yan⋅Liu, Yan⋅Plas, David R⋅Plas, David R⋅Chan, Rebecca J⋅Chan, Rebecca J⋅Kapur, Reuben and Kapur, Reuben
The Journal of clinical investigation, vol. 126, (no. 7), pp. 2625, 2016-07-01. | Journal Article
 
Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88
Zhang, Huajia⋅Rodriguez, Sonia⋅Wang, Lin⋅Wang, Soujuan⋅Serezani, Henrique⋅Kapur, Reuben⋅Cardoso, Angelo A and Carlesso, Nadia
Stem Cell Reports, vol. 6, (no. 6), pp. 956, 2016-06-14. | Journal Article
2015
Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock
Mantel, Charlie R⋅Mantel, Charlie R.⋅Mantel, Charlie R⋅Mantel, Charlie R⋅O’Leary, Heather A.⋅O'Leary, Heather A⋅O’Leary, Heather A⋅O’Leary, Heather A⋅Chitteti, Brahmananda R⋅Chitteti, Brahmananda R⋅Chitteti, Brahmananda R⋅Chitteti, Brahmananda R.⋅Huang, XinXin⋅Huang, Xin Xin⋅Huang, XinXin⋅Huang, XinXin⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, Scott⋅Hangoc, Giao⋅Hangoc, Giao⋅Hangoc, Giao⋅Hangoc, Giao⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Srour, Edward F⋅Srour, Edward F.⋅Srour, Edward F⋅Srour, Edward F⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Haas, David M⋅Haas, David M⋅Haas, David M.⋅Haas, David M⋅Falah, Nadia⋅Falah, Nadia⋅Falah, Nadia⋅Falah, Nadia⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Pelus, Louis M⋅Pelus, Louis M⋅Pelus, Louis M.⋅Pelus, Louis M⋅Bardeesy, Nabeel⋅Bardeesy, Nabeel⋅Bardeesy, Nabeel⋅Bardeesy, Nabeel⋅Fitamant, Julien⋅Fitamant, Julien⋅Fitamant, Julien⋅Fitamant, Julien⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Broxmeyer, Hal E⋅Broxmeyer, Hal E.⋅Broxmeyer, Hal E and Broxmeyer, Hal E
Cell, vol. 161, (no. 7), pp. 1565, 2015-06-18. | Journal Article
 
Imipramine Blue Sensitively and Selectively Targets FLT3 and c-Kit Mutant Acute Myeloid Leukemia
Metts, Jonathan L⋅Bradley, Heath L⋅Shah, Neil P⋅Kapur, Reuben⋅Arbiser, Jack L and Bunting, Kevin D
Blood, vol. 126, (no. 23), pp. 3688, 2015-12-03. | Journal Article
 
Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis
Onishi, Chie⋅Mori-Kimachi, Satomi⋅Hirade, Tomohiro⋅Abe, Mariko⋅Taketani, Takeshi⋅Suzumiya, Junji⋅Sugimoto, Toshitsugu⋅Yamaguchi, Seiji⋅Kapur, Reuben and Fukuda, Seiji
The Journal of biological chemistry, vol. 290, (no. 47), pp. 28356, 2015-Nov-20. | Journal Article
 
Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder
Chatterjee, Anindya⋅Ghosh, Joydeep and Kapur, Reuben
Oncotarget, vol. 6, (no. 21), pp. 18264, 2015-Jul-30. | Journal Article
 
Novel Functional Roles for Ten-Eleven-Translocation 2 (Tet2) in Normal and Leukemic Growth of Mast Cells
Mali, Raghuveer⋅Mali, Raghuveer⋅Mali, Raghuveer⋅Martin, Holly Rene⋅Martin, Holly Rene⋅Martin, Holly Rene⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Palam, Lakshmi⋅Palam, Lakshmi⋅Palam, Lakshmi⋅Visconte, Valeria⋅Visconte, Valeria⋅Visconte, Valeria⋅Ramon, Tiu⋅Ramon, Tiu⋅Ramon, Tiu⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Xu, Mingjiang⋅Xu, Mingjiang⋅Xu, Mingjiang⋅Kapur, Reuben⋅Kapur, Reuben and Kapur, Reuben
Blood, vol. 126, (no. 23), pp. 775, 2015-12-03. | Journal Article
 
Novel Mechanisms of Growth Inhibition By Histone Deacetylase Inhibitors in MPN
Pandey, Ruchi⋅Mali, Raghuveer⋅Ramdas, Baskar and Kapur, Reuben
Blood, vol. 126, (no. 23), pp. 1633, 2015-12-03. | Journal Article
 
Role of LIM Kinase in Oncogenic Signaling from FLT3 and KIT Receptors and Its Targeting in Myeloid Leukemia
Pandey, Ruchi⋅Pandey, Ruchi⋅Mali, Raghuveer⋅Mali, Raghuveer⋅Chatterjee, Anindya⋅Chatterjee, Anindya⋅Paublant, Fabrice⋅Paublant, Fabrice⋅Prudent, Renaud⋅Prudent, Renaud⋅Lafanechere, Laurence⋅Lafanechere, Laurence⋅Kapur, Reuben and Kapur, Reuben
Blood, vol. 126, (no. 23), pp. 1257, 2015-12-03. | Journal Article
 
S6K1 Regulates Self-Renewal of Leukemia Initiating Cells and Normal Hematopoietic Stem Cells
Ghosh, Joydeep⋅Ghosh, Joydeep⋅Chatterjee, Anindya⋅Chatterjee, Anindya⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Ma, Peilin⋅Ma, Peilin⋅Liu, Yan⋅Liu, Yan⋅Plas, David⋅Plas, David⋅Kapur, Reuben and Kapur, Reuben
Blood, vol. 126, (no. 23), pp. 442, 2015-12-03. | Journal Article
 
Targeting phosphatidylinositol-3-kinase pathway for the treatment of Philadelphia-negative myeloproliferative neoplasms
Pandey, Ruchi⋅Pandey, Ruchi⋅Kapur, Reuben and Kapur, Reuben
Molecular cancer, vol. 14, (no. 1), pp. 118, 2015-Jun-11. | Journal Article
2014
Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbf[Beta] for their development
Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Shelley, W⋅Shelley, W⋅Seo, Wooseok⋅Seo, Wooseok⋅Vemula, Sasidhar⋅Vemula, Sasidhar⋅Lin, Yang⋅Lin, Yang⋅Liu, Yan⋅Liu, Yan⋅Kapur, Reuben⋅Kapur, Reuben⋅Taniuchi, Ichiro⋅Taniuchi, Ichiro⋅Yoshimoto, Momoko and Yoshimoto, Momoko
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 33), pp. 12151, 20140819. | Journal Article
 
Functional B-1 progenitor cells are present in the hematopoietic stem cell-deficient embryo and depend on Cbfβ for their development
Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Shelley, W.⋅Shelley, W.⋅Shelley, W Christopher⋅Seo, Wooseok⋅Seo, Wooseok⋅Seo, Wooseok⋅Vemula, Sasidhar⋅Vemula, Sasidhar⋅Vemula, Sasidhar⋅Lin, Yang⋅Lin, Yang⋅Lin, Yang⋅Liu, Yan⋅Liu, Yan⋅Liu, Yan⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Taniuchi, Ichiro⋅Taniuchi, Ichiro⋅Taniuchi, Ichiro⋅Yoshimoto, Momoko⋅Yoshimoto, Momoko and Yoshimoto, Momoko
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 33), pp. 12156, 20140819. | Journal Article
 
Internal tandem duplication mutations in FLT3 gene augment chemotaxis to Cxcl12 protein by blocking the down-regulation of the Rho-associated kinase via the Cxcl12/Cxcr4 signaling axis
Onishi, Chie⋅Onish, Chie⋅Mori-Kimachi, Satomi⋅Hirade, Tomohiro⋅Abe, Mariko⋅Taketani, Takeshi⋅Suzumiya, Junji⋅Sugimoto, Toshitsugu⋅Yamaguchi, Seiji⋅Kapur, Reuben and Fukuda, Seiji
The Journal of biological chemistry, vol. 289, (no. 45), pp. 31065, 2014-Nov-07. | Journal Article
 
Mitigation of a Newly Discovered Phenomenon, Extra Physiologic Oxygen Shock/Stress (EPHOSS), Mediated By the Mitochondria Permeability Transition Pore, Greatly Improves Stem Cell Collection and Transplantation
Mantel, Charlie⋅Mantel, Charlie⋅Mantel, Charlie⋅Mantel, Charlie⋅Mantel, Charlie⋅Mantel, Charlie⋅O'Leary, Heather A⋅O'Leary, Heather A⋅O'Leary, Heather A⋅O'Leary, Heather A⋅O'Leary, Heather A⋅O'Leary, Heather A⋅Chitteti, Brahmananda Reddy⋅Chitteti, Brahmananda Reddy⋅Chitteti, Brahmananda Reddy⋅Chitteti, Brahmananda Reddy⋅Chitteti, Brahmananda Reddy⋅Chitteti, Brahmananda Reddy⋅Huang, Xinxin⋅Huang, Xinxin⋅Huang, Xinxin⋅Huang, Xinxin⋅Huang, Xinxin⋅Huang, Xinxin⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, Scott⋅Cooper, Scott⋅Hangoc, Giao⋅Hangoc, Giao⋅Hangoc, Giao⋅Hangoc, Giao⋅Hangoc, Giao⋅Hangoc, Giao⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Brustovetsky, Nickolay⋅Srour, Edward F⋅Srour, Edward F⋅Srour, Edward F⋅Srour, Edward F⋅Srour, Edward F⋅Srour, Edward F⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Lee, Man Ryul⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Messina-Graham, Steven⋅Falah, Nadia⋅Falah, Nadia⋅Falah, Nadia⋅Falah, Nadia⋅Falah, Nadia⋅Falah, Nadia⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Pelus, Louis M⋅Pelus, Louis M⋅Pelus, Louis M⋅Pelus, Louis M⋅Pelus, Louis M⋅Pelus, Louis M⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Ivan, Mircea⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Kim, Kye-Seong⋅Broxmeyer, Hal E⋅Broxmeyer, Hal E⋅Broxmeyer, Hal E⋅Broxmeyer, Hal E⋅Broxmeyer, Hal E and Broxmeyer, Hal E
Blood, vol. 124, (no. 21), pp. 2905, 2014-12-06. | Journal Article
 
Modulation in the expression of p70S6 kinase impairs the engraftment and self-renewal of hematopoietic stem cells
Ghosh, Joydeep⋅Ghosh, Joydeep⋅Ramdas, Baskar⋅Ramdas, Baskar⋅Chatterjee, Anindya⋅Chatterjee, Anindya⋅Ma, Peilin⋅Ma, Peilin⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Mali, Raghuveer⋅Mali, Raghuveer⋅Liu, Yan⋅Liu, Yan⋅Plas, David⋅Plas, David⋅Kapur, Reuben and Kapur, Reuben
Experimental Hematology, vol. 42, (no. 8), pp. S35, 2014. | Journal Article