240 Publications (Page 2 of 10)
2015
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
CA, Morgan and TD, Hurley
 
Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.
Morgan, Cynthia A and Hurley, Thomas D
Chemico-biological interactions, vol. 234, pp. 29-37, June 5, 2015. | Journal Article
 
Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.
CD, Buchman⋅KK, Mahalingan and TD, Hurley
Chemico-biological interactions. | Journal Article
 
Discovery of a series of aromatic lactones as ALDH1/2-directed inhibitors.
CD, Buchman⋅KK, Mahalingan and TD, Hurley
 
Hominids adapted to metabolize ethanol long before human-directed fermentation.
Carrigan, Matthew A⋅Uryasev, Oleg⋅Frye, Carole B⋅Eckman, Blair L⋅Myers, Candace R⋅Hurley, Thomas D and Benner, Steven A
Proceedings of the National Academy of Sciences of the United States of America, vol. 112, (no. 2), pp. 458-463, January 13, 2015. | Journal Article
 
N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.
Morgan, Cynthia A⋅Parajuli, Bibek⋅Buchman, Cameron D⋅Dria, Karl and Hurley, Thomas D
Chemico-biological interactions, vol. 234, pp. 18-28, June 5, 2015. | Journal Article
 
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
Condello, S⋅Morgan, C A⋅Nagdas, S⋅Cao, L⋅Turek, J⋅Hurley, T D and Matei, D
Oncogene, vol. 34, (no. 18), pp. 2297-2308, April 30, 2015. | Journal Article
2014
Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.
CA, Morgan and TD, Hurley
 
Development of a high-throughput in vitro assay to identify selective inhibitors for human ALDH1A1.
CA, Morgan and TD, Hurley
Chemico-biological interactions. | Journal Article
 
Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.
Kimble-Hill, Ann C⋅Kimble Hill, Ann C⋅Parajuli, Bibek⋅Parajuli, Bibek⋅Chen, Che-Hong⋅Chen, Che-Hong⋅Mochly-Rosen, Daria⋅Mochly Rosen, Daria D⋅Hurley, Thomas D and Hurley, Thomas D
Journal of medicinal chemistry, vol. 57, (no. 3), pp. 714-22, 2014/Feb/13. | Journal Article
 
Development of selective inhibitors for aldehyde dehydrogenases based on substituted indole-2,3-diones.
AC, Kimble-Hill⋅B, Parajuli⋅CH, Chen⋅D, Mochly-Rosen and TD, Hurley
 
Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.
Parajuli, Bibek⋅Parajuli, Bibek⋅Georgiadis, Taxiarchis M⋅Georgiadis, Taxiarchis M⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Hurley, Thomas D and Hurley, Thomas D
Chembiochem : a European journal of chemical biology, vol. 15, (no. 5), pp. 701-712, March 21, 2014. | Journal Article
 
Development of selective inhibitors for human aldehyde dehydrogenase 3A1 (ALDH3A1) for the enhancement of cyclophosphamide cytotoxicity.
B, Parajuli⋅TM, Georgiadis⋅ML, Fishel and TD, Hurley
 
Enrichment of chemical libraries docked to protein conformational ensembles and application to aldehyde dehydrogenase 2.
B, Wang⋅CD, Buchman⋅L, Li⋅TD, Hurley and SO, Meroueh
 
Enrichment of Chemical Libraries Docked to Protein Conformational Ensembles and Application to Aldehyde Dehydrogenase 2
Wang, Bo⋅Buchman, Cameron D⋅Li, Liwei⋅Hurley, Thomas D and Meroueh, Samy
Journal of Chemical Information and Modeling, vol. 54, (no. 7), Jul 28, 2014. | Journal Article
 
Hominids adapted to metabolize ethanol long before human-directed fermentation.
MA, Carrigan⋅O, Uryasev⋅CB, Frye⋅BL, Eckman⋅CR, Myers⋅TD, Hurley and SA, Benner
 
Hominids adapted to metabolize ethanol long before human-directed fermentation.
MA, Carrigan⋅O, Uryasev⋅CB, Frye⋅BL, Eckman⋅CR, Myers⋅TD, Hurley and SA, Benner
Proceedings of the National Academy of Sciences of the United States of America. | Journal Article
 
N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.
CA, Morgan⋅B, Parajuli⋅CD, Buchman⋅K, Dria and TD, Hurley
 
N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.
CA, Morgan⋅B, Parajuli⋅CD, Buchman⋅K, Dria and TD, Hurley
Chemico-biological interactions. | Journal Article
 
Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.
Parajuli, Bibek⋅Parajuli, Bibek⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Hurley, Thomas D and Hurley, Thomas D
Journal of medicinal chemistry, vol. 57, (no. 2), pp. 449-61, 2014/Jan/23. | Journal Article
 
Selective ALDH3A1 inhibition by benzimidazole analogues increase mafosfamide sensitivity in cancer cells.
B, Parajuli⋅ML, Fishel and TD, Hurley
 
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
S, Condello⋅CA, Morgan⋅S, Nagdas⋅L, Cao⋅J, Turek⋅TD, Hurley and D, Matei
Oncogene. | Journal Article
 
β-Catenin-regulated ALDH1A1 is a target in ovarian cancer spheroids.
S, Condello⋅CA, Morgan⋅S, Nagdas⋅L, Cao⋅J, Turek⋅TD, Hurley and D, Matei
2013
Catalytic contribution of threonine 244 in human ALDH2.
González-Segura, Lilian⋅Ho, K-K⋅Perez-Miller, Samantha⋅Weiner, Henry and Hurley, Thomas D
Chemico-biological interactions, vol. 202, (no. 1-3), pp. 32-40, 2013/Feb/25. | Journal Article
 
Catalytic contribution of threonine 244 in human ALDH2.
L, González-Segura⋅KK, Ho⋅S, Perez-Miller⋅H, Weiner and TD, Hurley