240 Publications (Page 1 of 10)
2022
A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
 
A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer. Cancers
2020
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
B, TangMS, FrasinyukVM, ChikwanaKK, MahalinganCA, MorganDM, SegvichSP, BondarenkoGP, MrugP, WyrebekDS, WattAA, DePaoli-RoachPJ, Roach and TD, Hurley
Journal of medicinal chemistry. | Journal Article
 
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
B, TangMS, FrasinyukVM, ChikwanaKK, MahalinganCA, MorganDM, SegvichSP, BondarenkoGP, MrugP, WyrebekDS, WattAA, DePaoli-RoachPJ, Roach and TD, Hurley
 
Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies
Muralikrishnan, VaishnaviHurley, Thomas D and Nephew, Kenneth P
Cancers. | Journal Article
 
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
MS, GentryZ, AfawiDD, ArmstrongA, Delgado-EscuetaYP, GoldbergTR, GrossmanJJ, GuinovartF, HarrisTD, HurleyR, MichelucciBA, MinassianP, Sanz and JM, Serratosa
 
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
MS, GentryZ, AfawiDD, ArmstrongA, Delgado-EscuetaYP, GoldbergTR, GrossmanJJ, GuinovartF, HarrisTD, HurleyR, MichelucciBA, MinassianP, Sanz and JM, Serratosa
Epilepsy & behavior : E&B. | Journal Article
2019
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
I, ChefetzE, GrimleyK, YangL, HongEV, VinogradovaR, SuciuI, KovalenkoD, KarnakCA, MorganM, ChtcherbinineC, BuchmanB, HuddleS, Barraza and RJ, Buckanovich
Cell reports. | Journal Article
 
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
I, ChefetzE, GrimleyK, YangL, HongEV, VinogradovaR, SuciuI, KovalenkoD, KarnakCA, MorganM, ChtcherbinineC, BuchmanB, HuddleS, Barraza and RJ, Buckanovich
2018
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH High Melanoma-Initiating Cells
Sarvi, SanaCrispin, RichardLu, YutingZeng, LifanHurley, Thomas DHouston, Douglas Rvon Kriegsheim, AlexChen, Che-HongMochly-Rosen, DariaRanzani, MarcoMathers, Marie EXu, XiaoweiXu, WeiAdams, David JCarragher, Neil OFujita, MayumiSchuchter, LynnUnciti-Broceta, AsierBrunton, Valerie G and Patton, E Elizabeth
Cell chemical biology, vol. 25, (no. 12), pp. 1456, 2018-12-20. | Journal Article
 
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
S, SarviR, CrispinY, LuL, ZengTD, HurleyDR, HoustonKriegsheim ACH, ChenD, Mochly-RosenM, RanzaniME, MathersX, XuW, XuDJ, Adams and EE, Patton
 
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
Sarvi, SanaCrispin, RichardLu, YutingZeng, LifanHurley, Thomas DHouston, Douglas Rvon Kriegsheim, AlexChen, Che-HongMochly-Rosen, DariaRanzani, MarcoMathers, Marie EXu, XiaoweiXu, WeiAdams, David JCarragher, Neil OFujita, MayumiSchuchter, LynnUnciti-Broceta, AsierBrunton, Valerie G and Patton, E Elizabeth
Cell chemical biology, September 25, 2018. | Journal Article
 
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Huddle, Brandt CBC, HuddleE, GrimleyGrimley, EdwardBuchman, Cameron DCD, BuchmanM, ChtcherbinineChtcherbinine, MikhailB, DebnathDebnath, BikashP, MehtaMehta, PoojaK, YangYang, KunMorgan, Cynthia ACA, MorganS, LiLi, SiweiFelton, Jeremy AntonioJ, FeltonD, SunSun, DuxinG, MehtaMetha, GeetaNeamati, NouriN, NeamatiBuckanovich, Ronald JRJ, BuckanovichSD, LarsenHurley, Thomas D and Larsen, Scott D
Journal of medicinal chemistry. | Journal Article
 
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
BC, HuddleE, GrimleyCD, BuchmanM, ChtcherbinineB, DebnathP, MehtaK, YangCA, MorganS, LiJ, FeltonD, SunG, MehtaN, NeamatiRJ, Buckanovich and SD, Larsen
2017
Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
CD, Buchman and TD, Hurley
Journal of medicinal chemistry. | Journal Article
 
Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
CD, Buchman and TD, Hurley
2016
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.
CA, MaileMaile, C AMaile, C. A.JR, HingstHingst, J. R.Hingst, J RMahalingan, K. K.KK, MahalinganMahalingan, K KO’Reilly, A. O.O'Reilly, A OAO, O’ReillyME, CleasbyCleasby, M. E.Cleasby, M EJR, MickelsonMickelson, J RMickelson, J. R.McCue, M EME, McCueMc Cue, M. E.Anderson, S MSM, AndersonAnderson, S. M.Hurley, T. D.Hurley, T DTD, HurleyWojtaszewski, J F PWojtaszewski, J. F.P.JFP, WojtaszewskiPiercy, R. J.Piercy, R J and RJ, Piercy
Biochimica et biophysica acta. General subjects. | Journal Article
 
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.
CA, MaileJR, HingstKK, MahalinganAO, O’ReillyME, CleasbyJR, MickelsonME, McCueSM, AndersonTD, HurleyJFP, Wojtaszewski and RJ, Piercy
 
Incorporation of phosphate into glycogen by glycogen synthase.
Contreras, Christopher JContreras, Christopher JSegvich, Dyann MSegvich, Dyann MMahalingan, KrishnaMahalingan, KrishnaChikwana, Vimbai MChikwana, Vimbai MKirley, Terence LKirley, Terence LHurley, Thomas DHurley, Thomas DDePaoli-Roach, Anna ADePaoli-Roach, Anna ARoach, Peter J and Roach, Peter J
Archives of biochemistry and biophysics, vol. 597, pp. 21-29, May 1, 2016. | Journal Article
 
Incorporation of phosphate into glycogen by glycogen synthase.
CJ, ContrerasDM, SegvichK, MahalinganVM, ChikwanaTL, KirleyTD, HurleyAA, DePaoli-Roach and PJ, Roach
 
Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.
J, LiS, CondelloJ, Thomes-PepinX, MaY, XiaTD, HurleyD, Matei and JX, Cheng
 
Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.
Li, JunjieJ, LiCondello, SalvatoreS, CondelloThomes-Pepin, JessicaJ, Thomes-PepinMa, XiaoxiaoX, MaY, XiaXia, YuHurley, Thomas DTD, HurleyMatei, DanielaD, MateiCheng, Ji-Xin and JX, Cheng
Cell stem cell. | Journal Article
 
Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.
KK, MahalinganS, BaskaranAA, DePaoli-RoachPJ, Roach and TD, Hurley
 
Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.
Mahalingan, Krishna KMahalingan, Krishna KBaskaran, SulochanadeviBaskaran, SulochanadeviDePaoli-Roach, Anna ADePaoli-Roach, Anna ARoach, Peter JRoach, Peter JHurley, Thomas D and Hurley, Thomas D
Biochemistry, December 20, 2016. | Journal Article
2015
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
Morgan, Cynthia A and Hurley, Thomas D
Journal of medicinal chemistry, vol. 58, (no. 4), pp. 1964-1975, February 26, 2015. | Journal Article