240 Publications (Page 1 of 10)
2022
A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
 
A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer. Cancers
2020
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
B, Tang⋅MS, Frasinyuk⋅VM, Chikwana⋅KK, Mahalingan⋅CA, Morgan⋅DM, Segvich⋅SP, Bondarenko⋅GP, Mrug⋅P, Wyrebek⋅DS, Watt⋅AA, DePaoli-Roach⋅PJ, Roach and TD, Hurley
Journal of medicinal chemistry. | Journal Article
 
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
B, Tang⋅MS, Frasinyuk⋅VM, Chikwana⋅KK, Mahalingan⋅CA, Morgan⋅DM, Segvich⋅SP, Bondarenko⋅GP, Mrug⋅P, Wyrebek⋅DS, Watt⋅AA, DePaoli-Roach⋅PJ, Roach and TD, Hurley
 
Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies
Muralikrishnan, Vaishnavi⋅Hurley, Thomas D and Nephew, Kenneth P
Cancers. | Journal Article
 
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
MS, Gentry⋅Z, Afawi⋅DD, Armstrong⋅A, Delgado-Escueta⋅YP, Goldberg⋅TR, Grossman⋅JJ, Guinovart⋅F, Harris⋅TD, Hurley⋅R, Michelucci⋅BA, Minassian⋅P, Sanz and JM, Serratosa
 
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
MS, Gentry⋅Z, Afawi⋅DD, Armstrong⋅A, Delgado-Escueta⋅YP, Goldberg⋅TR, Grossman⋅JJ, Guinovart⋅F, Harris⋅TD, Hurley⋅R, Michelucci⋅BA, Minassian⋅P, Sanz and JM, Serratosa
Epilepsy & behavior : E&B. | Journal Article
2019
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
I, Chefetz⋅E, Grimley⋅K, Yang⋅L, Hong⋅EV, Vinogradova⋅R, Suciu⋅I, Kovalenko⋅D, Karnak⋅CA, Morgan⋅M, Chtcherbinine⋅C, Buchman⋅B, Huddle⋅S, Barraza and RJ, Buckanovich
Cell reports. | Journal Article
 
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
I, Chefetz⋅E, Grimley⋅K, Yang⋅L, Hong⋅EV, Vinogradova⋅R, Suciu⋅I, Kovalenko⋅D, Karnak⋅CA, Morgan⋅M, Chtcherbinine⋅C, Buchman⋅B, Huddle⋅S, Barraza and RJ, Buckanovich
2018
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH High Melanoma-Initiating Cells
Sarvi, Sana⋅Crispin, Richard⋅Lu, Yuting⋅Zeng, Lifan⋅Hurley, Thomas D⋅Houston, Douglas R⋅von Kriegsheim, Alex⋅Chen, Che-Hong⋅Mochly-Rosen, Daria⋅Ranzani, Marco⋅Mathers, Marie E⋅Xu, Xiaowei⋅Xu, Wei⋅Adams, David J⋅Carragher, Neil O⋅Fujita, Mayumi⋅Schuchter, Lynn⋅Unciti-Broceta, Asier⋅Brunton, Valerie G and Patton, E Elizabeth
Cell chemical biology, vol. 25, (no. 12), pp. 1456, 2018-12-20. | Journal Article
 
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
S, Sarvi⋅R, Crispin⋅Y, Lu⋅L, Zeng⋅TD, Hurley⋅DR, Houston⋅Kriegsheim A⋅CH, Chen⋅D, Mochly-Rosen⋅M, Ranzani⋅ME, Mathers⋅X, Xu⋅W, Xu⋅DJ, Adams and EE, Patton
 
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
Sarvi, Sana⋅Crispin, Richard⋅Lu, Yuting⋅Zeng, Lifan⋅Hurley, Thomas D⋅Houston, Douglas R⋅von Kriegsheim, Alex⋅Chen, Che-Hong⋅Mochly-Rosen, Daria⋅Ranzani, Marco⋅Mathers, Marie E⋅Xu, Xiaowei⋅Xu, Wei⋅Adams, David J⋅Carragher, Neil O⋅Fujita, Mayumi⋅Schuchter, Lynn⋅Unciti-Broceta, Asier⋅Brunton, Valerie G and Patton, E Elizabeth
Cell chemical biology, September 25, 2018. | Journal Article
 
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Huddle, Brandt C⋅BC, Huddle⋅E, Grimley⋅Grimley, Edward⋅Buchman, Cameron D⋅CD, Buchman⋅M, Chtcherbinine⋅Chtcherbinine, Mikhail⋅B, Debnath⋅Debnath, Bikash⋅P, Mehta⋅Mehta, Pooja⋅K, Yang⋅Yang, Kun⋅Morgan, Cynthia A⋅CA, Morgan⋅S, Li⋅Li, Siwei⋅Felton, Jeremy Antonio⋅J, Felton⋅D, Sun⋅Sun, Duxin⋅G, Mehta⋅Metha, Geeta⋅Neamati, Nouri⋅N, Neamati⋅Buckanovich, Ronald J⋅RJ, Buckanovich⋅SD, Larsen⋅Hurley, Thomas D and Larsen, Scott D
Journal of medicinal chemistry. | Journal Article
 
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
BC, Huddle⋅E, Grimley⋅CD, Buchman⋅M, Chtcherbinine⋅B, Debnath⋅P, Mehta⋅K, Yang⋅CA, Morgan⋅S, Li⋅J, Felton⋅D, Sun⋅G, Mehta⋅N, Neamati⋅RJ, Buckanovich and SD, Larsen
2017
Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
CD, Buchman and TD, Hurley
Journal of medicinal chemistry. | Journal Article
 
Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
CD, Buchman and TD, Hurley
2016
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.
CA, Maile⋅Maile, C A⋅Maile, C. A.⋅JR, Hingst⋅Hingst, J. R.⋅Hingst, J R⋅Mahalingan, K. K.⋅KK, Mahalingan⋅Mahalingan, K K⋅O’Reilly, A. O.⋅O'Reilly, A O⋅AO, O’Reilly⋅ME, Cleasby⋅Cleasby, M. E.⋅Cleasby, M E⋅JR, Mickelson⋅Mickelson, J R⋅Mickelson, J. R.⋅McCue, M E⋅ME, McCue⋅Mc Cue, M. E.⋅Anderson, S M⋅SM, Anderson⋅Anderson, S. M.⋅Hurley, T. D.⋅Hurley, T D⋅TD, Hurley⋅Wojtaszewski, J F P⋅Wojtaszewski, J. F.P.⋅JFP, Wojtaszewski⋅Piercy, R. J.⋅Piercy, R J and RJ, Piercy
Biochimica et biophysica acta. General subjects. | Journal Article
 
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.
CA, Maile⋅JR, Hingst⋅KK, Mahalingan⋅AO, O’Reilly⋅ME, Cleasby⋅JR, Mickelson⋅ME, McCue⋅SM, Anderson⋅TD, Hurley⋅JFP, Wojtaszewski and RJ, Piercy
 
Incorporation of phosphate into glycogen by glycogen synthase.
Contreras, Christopher J⋅Contreras, Christopher J⋅Segvich, Dyann M⋅Segvich, Dyann M⋅Mahalingan, Krishna⋅Mahalingan, Krishna⋅Chikwana, Vimbai M⋅Chikwana, Vimbai M⋅Kirley, Terence L⋅Kirley, Terence L⋅Hurley, Thomas D⋅Hurley, Thomas D⋅DePaoli-Roach, Anna A⋅DePaoli-Roach, Anna A⋅Roach, Peter J and Roach, Peter J
Archives of biochemistry and biophysics, vol. 597, pp. 21-29, May 1, 2016. | Journal Article
 
Incorporation of phosphate into glycogen by glycogen synthase.
CJ, Contreras⋅DM, Segvich⋅K, Mahalingan⋅VM, Chikwana⋅TL, Kirley⋅TD, Hurley⋅AA, DePaoli-Roach and PJ, Roach
 
Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.
J, Li⋅S, Condello⋅J, Thomes-Pepin⋅X, Ma⋅Y, Xia⋅TD, Hurley⋅D, Matei and JX, Cheng
 
Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells.
Li, Junjie⋅J, Li⋅Condello, Salvatore⋅S, Condello⋅Thomes-Pepin, Jessica⋅J, Thomes-Pepin⋅Ma, Xiaoxiao⋅X, Ma⋅Y, Xia⋅Xia, Yu⋅Hurley, Thomas D⋅TD, Hurley⋅Matei, Daniela⋅D, Matei⋅Cheng, Ji-Xin and JX, Cheng
Cell stem cell. | Journal Article
 
Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.
KK, Mahalingan⋅S, Baskaran⋅AA, DePaoli-Roach⋅PJ, Roach and TD, Hurley
 
Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation.
Mahalingan, Krishna K⋅Mahalingan, Krishna K⋅Baskaran, Sulochanadevi⋅Baskaran, Sulochanadevi⋅DePaoli-Roach, Anna A⋅DePaoli-Roach, Anna A⋅Roach, Peter J⋅Roach, Peter J⋅Hurley, Thomas D and Hurley, Thomas D
Biochemistry, December 20, 2016. | Journal Article
2015
Characterization of two distinct structural classes of selective aldehyde dehydrogenase 1A1 inhibitors.
Morgan, Cynthia A and Hurley, Thomas D
Journal of medicinal chemistry, vol. 58, (no. 4), pp. 1964-1975, February 26, 2015. | Journal Article