246 Publications (Page 1 of 10)
2024
Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes. Chemico-Biological Interactions
. | Journal Article
 
Impaired malin expression and interaction with partner proteins in Lafora disease. Journal of Biological Chemistry
. | Journal Article
 
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders
Ullman, J.C.Mellem, K.T.Xi, Y.Ramanan, V.Merritt, H.Choy, R.Gujral, T.Young, L.E.A.Blake, K.Tep, S.Homburger, J.R.O?Regan, A.Ganesh, S.Wong, P.Satterfield, T.F.Lin, B.Situ, E.Yu, C.Espanol, B.Sarwaikar, R.Fastman, N.Tzitzilonis, C.Lee, P.Reiton, D.Morton, V.Santiago, P.Won, W.Powers, H.Cummings, B.B.Hoek, M.Graham, R.R.Chandriani, S.J.Bainer, R.DePaoli-Roach, A.A.Roach, P.J.Hurley, T.D.Sun, R.C.Gentry, M.S.Sinz, C.Dick, R.A.Noonberg, S.B.Beattie, D.T.Morgans, D.J. and Green, E.M.
Science Translational Medicine, vol. 16. | Journal Article
2022
A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
 
A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer. Cancers
 
The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex. Cell reports
. | Journal Article
2021
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation
Sun, R.C.Young, L.E.A.Bruntz, R.C.Markussen, K.H.Zhou, Z.Conroy, L.R.Hawkinson, T.R.Clarke, H.A.Stanback, A.E.Macedo, J.K.A.Emanuelle, S.Brewer, M.K.Rondon, A.L.Mestas, A.Sanders, W.C.Mahalingan, K.K.Tang, B.Chikwana, V.M.Segvich, D.M.Contreras, C.J.Allenger, E.J.Brainson, C.F.Johnson, L.A.Taylor, R.E.Armstrong, D.D.Shaffer, R.Waechter, C.J.Vander Kooi, C.W.DePaoli-Roach, A.A.Roach, P.J.Hurley, T.D.Drake, R.R. and Gentry, M.S.
Cell Metabolism, vol. 33, pp. 1404-1417.e9. | Journal Article
 
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy. European Journal of Medicinal Chemistry
. | Journal Article
2020
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
B, TangMS, FrasinyukVM, ChikwanaKK, MahalinganCA, MorganDM, SegvichSP, BondarenkoGP, MrugP, WyrebekDS, WattAA, DePaoli-RoachPJ, Roach and TD, Hurley
Journal of medicinal chemistry. | Journal Article
 
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
B, TangMS, FrasinyukVM, ChikwanaKK, MahalinganCA, MorganDM, SegvichSP, BondarenkoGP, MrugP, WyrebekDS, WattAA, DePaoli-RoachPJ, Roach and TD, Hurley
 
Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies
Muralikrishnan, VaishnaviHurley, Thomas D and Nephew, Kenneth P
Cancers. | Journal Article
 
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
MS, GentryZ, AfawiDD, ArmstrongA, Delgado-EscuetaYP, GoldbergTR, GrossmanJJ, GuinovartF, HarrisTD, HurleyR, MichelucciBA, MinassianP, Sanz and JM, Serratosa
Epilepsy & behavior : E&B. | Journal Article
 
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
MS, GentryZ, AfawiDD, ArmstrongA, Delgado-EscuetaYP, GoldbergTR, GrossmanJJ, GuinovartF, HarrisTD, HurleyR, MichelucciBA, MinassianP, Sanz and JM, Serratosa
2019
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
I, ChefetzE, GrimleyK, YangL, HongEV, VinogradovaR, SuciuI, KovalenkoD, KarnakCA, MorganM, ChtcherbinineC, BuchmanB, HuddleS, Barraza and RJ, Buckanovich
 
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Chefetz, IlanaI, ChefetzChefetz, IlanaChefetz, IlanaGrimley, EdwardGrimley, EdwardE, GrimleyGrimley, EdwardYang, KunYang, KunK, YangYang, KunHong, LindaL, HongHong, LindaHong, LindaVinogradova, Ekaterina VVinogradova, Ekaterina VVinogradova, Ekaterina VEV, VinogradovaR, SuciuSuciu, RaduSuciu, RaduSuciu, RaduKovalenko, IlyaKovalenko, IlyaI, KovalenkoKovalenko, IlyaKarnak, DavidKarnak, DavidKarnak, DavidD, KarnakMorgan, Cynthia AMorgan, Cynthia ACA, MorganMorgan, Cynthia AChtcherbinine, MikhailM, ChtcherbinineChtcherbinine, MikhailChtcherbinine, MikhailBuchman, CameronBuchman, CameronBuchman, CameronC, BuchmanB, HuddleHuddle, BrandtHuddle, BrandtHuddle, BrandtBarraza, ScottBarraza, ScottS, BarrazaBarraza, ScottMorgan, MeredithMorgan, MeredithMorgan, MeredithRJ, BuckanovichBernstein, Kara ABernstein, Kara ABernstein, Kara AYoon, EuisikYoon, EuisikYoon, EuisikLombard, David BLombard, David BLombard, David BBild, AndreaBild, AndreaBild, AndreaMehta, GeetaMehta, GeetaMehta, GeetaRomero, IrisRomero, IrisRomero, IrisChiang, Chun-YiChiang, Chun-YiChiang, Chun-YiLanden, CharlesLanden, CharlesLanden, CharlesCravatt, BenjaminCravatt, BenjaminCravatt, BenjaminHurley, Thomas DHurley, Thomas DHurley, Thomas DLarsen, Scott DLarsen, Scott DLarsen, Scott DBuckanovich, Ronald JBuckanovich, Ronald J and Buckanovich, Ronald J
Cell reports. | Journal Article
2018
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH High Melanoma-Initiating Cells
Sarvi, SanaCrispin, RichardLu, YutingZeng, LifanHurley, Thomas DHouston, Douglas Rvon Kriegsheim, AlexChen, Che-HongMochly-Rosen, DariaRanzani, MarcoMathers, Marie EXu, XiaoweiXu, WeiAdams, David JCarragher, Neil OFujita, MayumiSchuchter, LynnUnciti-Broceta, AsierBrunton, Valerie G and Patton, E Elizabeth
Cell chemical biology, vol. 25, (no. 12), pp. 1456, 2018-12-20. | Journal Article
 
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
Sarvi, SanaSarvi, SanaCrispin, RichardCrispin, RichardLu, YutingLu, YutingZeng, LifanZeng, LifanHurley, Thomas DHurley, Thomas D.Houston, Douglas R.Houston, Douglas Rvon Kriegsheim, AlexKriegsheim, AlexChen, Che-HongChen, Che-HongMochly-Rosen, DariaMochly Rosen, DariaRanzani, MarcoRanzani, Marcoal.Mathers, Marie EXu, XiaoweiXu, WeiAdams, David JCarragher, Neil OFujita, MayumiSchuchter, LynnUnciti-Broceta, AsierBrunton, Valerie G and Patton, E Elizabeth
Cell chemical biology, September 25, 2018. | Journal Article
 
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
S, SarviR, CrispinY, LuL, ZengTD, HurleyDR, HoustonKriegsheim ACH, ChenD, Mochly-RosenM, RanzaniME, MathersX, XuW, XuDJ, Adams and EE, Patton
 
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Huddle, Brandt CBC, HuddleE, GrimleyGrimley, EdwardCD, BuchmanBuchman, Cameron DChtcherbinine, MikhailM, ChtcherbinineDebnath, BikashB, DebnathP, MehtaMehta, PoojaK, YangYang, KunCA, MorganMorgan, Cynthia ALi, SiweiS, LiFelton, Jeremy AntonioJ, FeltonD, SunSun, DuxinG, MehtaMetha, GeetaNeamati, NouriN, NeamatiRJ, BuckanovichBuckanovich, Ronald JHurley, Thomas DSD, Larsen and Larsen, Scott D
Journal of medicinal chemistry. | Journal Article
 
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
BC, HuddleE, GrimleyCD, BuchmanM, ChtcherbinineB, DebnathP, MehtaK, YangCA, MorganS, LiJ, FeltonD, SunG, MehtaN, NeamatiRJ, Buckanovich and SD, Larsen
2017
Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
CD, Buchman and TD, Hurley
Journal of medicinal chemistry. | Journal Article
 
Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
CD, Buchman and TD, Hurley
2016
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.
CA, MaileJR, HingstKK, MahalinganAO, O’ReillyME, CleasbyJR, MickelsonME, McCueSM, AndersonTD, HurleyJFP, Wojtaszewski and RJ, Piercy
 
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.
Maile, C AMaile, C. A.CA, MaileJR, HingstHingst, J. R.Hingst, J RKK, MahalinganMahalingan, K. K.Mahalingan, K KO’Reilly, A. O.O'Reilly, A OAO, O’ReillyCleasby, M. E.Cleasby, M EME, CleasbyMickelson, J. R.JR, MickelsonMickelson, J RMc Cue, M. E.McCue, M EME, McCueAnderson, S MSM, AndersonAnderson, S. M.TD, HurleyHurley, T. D.Hurley, T DJFP, WojtaszewskiWojtaszewski, J. F.P.Wojtaszewski, J F PRJ, PiercyPiercy, R. J. and Piercy, R J
Biochimica et biophysica acta. General subjects. | Journal Article
 
Incorporation of phosphate into glycogen by glycogen synthase.
Contreras, Christopher JContreras, Christopher JSegvich, Dyann MSegvich, Dyann MMahalingan, KrishnaMahalingan, KrishnaChikwana, Vimbai MChikwana, Vimbai MKirley, Terence LKirley, Terence LHurley, Thomas DHurley, Thomas DDePaoli-Roach, Anna ADePaoli-Roach, Anna ARoach, Peter J and Roach, Peter J
Archives of biochemistry and biophysics, vol. 597, pp. 21-29, May 1, 2016. | Journal Article