83 Publications (Page 1 of 4)
2021
Biomimetic stiffening of cell-laden hydrogels via sequential thiol-ene and hydrazone click reactions
Acta Biomaterialia. | Journal Article
 
Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours
Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Rhodes, Steven D⋅Rhodes, Steven D⋅Rhodes, Steven D⋅Rhodes, Steven D⋅Babb, Olivia⋅Babb, Olivia⋅Babb, Olivia⋅Babb, Olivia⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Calver, Brian⋅Calver, Brian⋅Calver, Brian⋅Calver, Brian⋅Ren-Yuan, Bai⋅Ren-Yuan, Bai⋅Ren-Yuan, Bai⋅Ren-Yuan, Bai⋅Hulsey, Emily L⋅Hulsey, Emily L⋅Hulsey, Emily L⋅Hulsey, Emily L⋅Reza, Saadatzadeh M⋅Reza, Saadatzadeh M⋅Reza, Saadatzadeh M⋅Reza, Saadatzadeh M⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Tong, Yan⋅Tong, Yan⋅Tong, Yan⋅Tong, Yan⋅Smith, Abbi E⋅Smith, Abbi E⋅Smith, Abbi E⋅Smith, Abbi E⋅Wade, Clapp D⋅Wade, Clapp D⋅Wade, Clapp D⋅Wade, Clapp D⋅Tee, Andrew R⋅Tee, Andrew R⋅Tee, Andrew R⋅Tee, Andrew R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L and Fishel, Melissa L
The British Journal of Cancer, vol. 124, (no. 9), pp. 1566-1580, Apr 2021. | Journal Article
 
Hypoxia signaling: Challenges and opportunities for cancer therapy
Seminars in Cancer Biology. | Journal Article
2020
Long-Term Gemcitabine Treatment Reshapes the Pancreatic Tumor Microenvironment and Sensitizes Murine Carcinoma to Combination Immunotherapy
Principe, Daniel R⋅Narbutis, Matthew⋅Kumar, Sandeep⋅Park, Alex⋅Viswakarma, Navin⋅Dorman, Matthew J⋅Kamath, Suneel D⋅Grippo, Paul J⋅Fishel, Melissa L⋅Hwang, Rosa F⋅Thummuri, Dinesh⋅Underwood, Patrick W⋅Munshi, Hidayatullah G⋅Trevino, Jose G and Rana, Ajay
Cancer research, pp. canres.2959.2019, 2020-Apr-01. | Journal Article
 
Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data
Xu, David⋅Xu, David⋅Xu, David⋅Xu, David⋅Xu, David⋅Xu, David⋅Zhou, Donghui⋅Zhou, Donghui⋅Zhou, Donghui⋅Zhou, Donghui⋅Zhou, Donghui⋅Zhou, Donghui⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Bailey, Barbara J⋅Sishtla, Kamakshi⋅Sishtla, Kamakshi⋅Sishtla, Kamakshi⋅Sishtla, Kamakshi⋅Sishtla, Kamakshi⋅Sishtla, Kamakshi⋅Liu, Sheng⋅Liu, Sheng⋅Liu, Sheng⋅Liu, Sheng⋅Liu, Sheng⋅Liu, Sheng⋅Wan, Jun⋅Wan, Jun⋅Wan, Jun⋅Wan, Jun⋅Wan, Jun⋅Wan, Jun⋅Aryal, Uma K⋅Aryal, Uma K⋅Aryal, Uma K⋅Aryal, Uma K⋅Aryal, Uma K⋅Aryal, Uma K⋅Lee, Jonathan A⋅Lee, Jonathan A⋅Lee, Jonathan A⋅Lee, Jonathan A⋅Lee, Jonathan A⋅Lee, Jonathan A⋅Wells, Clark D⋅Wells, Clark D⋅Wells, Clark D⋅Wells, Clark D⋅Wells, Clark D⋅Wells, Clark D⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Corson, Timothy W⋅Corson, Timothy W⋅Corson, Timothy W⋅Corson, Timothy W⋅Corson, Timothy W⋅Corson, Timothy W⋅Pollok, Karen⋅Pollok, Karen⋅Pollok, Karen E⋅Pollok, Karen⋅Pollok, Karen⋅Pollok, Karen⋅Meroueh, Samy O⋅Meroueh, Samy O⋅Meroueh, Samy O⋅Meroueh, Samy O⋅Meroueh, Samy O and Meroueh, Samy O
ACS chemical biology, 2020-Apr-03. | Journal Article
 
The multifunctional APE1 DNA repair–redox signaling protein as a drug target in human disease
Drug Discovery Today. | Journal Article
2019
Anti-tumor activity and mechanistic characterization of APE1/Ref-1 inhibitors in bladder cancer
Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Xia, Hanyu⋅Xia, Hanyu⋅Xia, Hanyu⋅Xia, Hanyu⋅Xia, Hanyu⋅Xia, Hanyu⋅Xia, Hanyu⋅Xia, Hanyu⋅McGeown, Jack⋅McGeown, Jack⋅McGeown, Jack⋅McGeown, Jack⋅McGeown, Jack⋅McGeown, Jack⋅McGeown, Jack⋅McGeown, Jack⋅McIlwain, David W⋅McIlwain, David W⋅McIlwain, David W⋅McIlwain, David W⋅McIlwain, David W⋅McIlwain, David W⋅McIlwain, David W⋅McIlwain, David W⋅Elbanna, May⋅Elbanna, May⋅Elbanna, May⋅Elbanna, May⋅Elbanna, May⋅Elbanna, May⋅Elbanna, May⋅Elbanna, May⋅Craft, Ariel A⋅Craft, Ariel A⋅Craft, Ariel A⋅Craft, Ariel A⋅Craft, Ariel A⋅Craft, Ariel A⋅Craft, Ariel A⋅Craft, Ariel A⋅Kaimakliotis, Hristos Z⋅Kaimakliotis, Hristos Z⋅Kaimakliotis, Hristos Z⋅Kaimakliotis, Hristos Z⋅Kaimakliotis, Hristos Z⋅Kaimakliotis, Hristos Z⋅Kaimakliotis, Hristos Z⋅Kaimakliotis, Hristos Z⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Pili, Roberto⋅Pili, Roberto⋅Pili, Roberto⋅Pili, Roberto⋅Pili, Roberto⋅Pili, Roberto⋅Pili, Roberto⋅Pili, Roberto⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Jerde, Travis J⋅Jerde, Travis J⋅Jerde, Travis J⋅Jerde, Travis J⋅Jerde, Travis J⋅Jerde, Travis J⋅Jerde, Travis J and Jerde, Travis J
Molecular cancer therapeutics, vol. 18, (no. 11), pp. 1960, 20191100. | Journal Article
 
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer
Shouksmith, Andrew E⋅Shouksmith, Andrew E⋅Shah, Fenil⋅Shah, Fenil⋅Grimard, Michelle L⋅Grimard, Michelle L⋅Gawel, Justyna M⋅Gawel, Justyna M⋅Raouf, Yasir S⋅Raouf, Yasir S⋅Geletu, Mulu⋅Geletu, Mulu⋅Berger-Becvar, Angelika⋅Berger-Becvar, Angelika⋅de Araujo, Elvin D⋅de Araujo, Elvin D⋅Luchman, H Artee⋅Luchman, H Artee⋅Heaton, William L⋅Heaton, William L⋅Bakhshinyan, David⋅Bakhshinyan, David⋅Adile, Ashley A⋅Adile, Ashley A⋅Venugopal, Chitra⋅Venugopal, Chitra⋅O'Hare, Thomas⋅O'Hare, Thomas⋅Deininger, Michael W⋅Deininger, Michael W⋅Singh, Sheila K⋅Singh, Sheila K⋅Konieczny, Stephen F⋅Konieczny, Stephen F⋅Weiss, Samuel⋅Weiss, Samuel⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Gunning, Patrick T and Gunning, Patrick T
Journal of medicinal chemistry, vol. 62, (no. 5), pp. 2665, 2019-03-14. | Journal Article
 
LTMG: a novel statistical modeling of transcriptional expression states in single-cell RNA-Seq data
Wan, Changlin⋅Wan, Changlin⋅Wan, Changlin⋅C, Wan⋅Chang, Wennan⋅W, Chang⋅Chang, Wennan⋅Chang, Wennan⋅Y, Zhang⋅Zhang, Yu⋅Zhang, Yu⋅Zhang, Yu⋅F, Shah⋅Shah, Fenil⋅Shah, Fenil⋅Shah, Fenil⋅Lu, Xiaoyu⋅Lu, Xiaoyu⋅X, Lu⋅Lu, Xiaoyu⋅Zang, Yong⋅Zang, Yong⋅Zang, Yong⋅Y, Zang⋅Zhang, Anru⋅Zhang, Anru⋅A, Zhang⋅Zhang, Anru⋅Cao, Sha⋅Cao, Sha⋅Cao, Sha⋅S, Cao⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅ML, Fishel⋅Ma, Qin⋅Ma, Qin⋅Ma, Qin⋅Q, Ma⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi and C, Zhang
Nucleic Acids Research, vol. 47, (no. 18), pp. e111, 20191010. | Journal Article
2018
Abstract 2941: APE1/Ref-1 redox signaling regulates HIF1a-mediated CA9 expression in hypoxic pancreatic cancer cells: Combination treatment in patient-derived pancreatic tumor models
Logsdon, Derek⋅Logsdon, Derek⋅Shah, Fenil⋅Shah, Fenil⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Supuran, Claudiu⋅Supuran, Claudiu⋅Fishel, Melissa⋅Fishel, Melissa⋅Kelley, Mark R and Kelley, Mark R
Cancer Research, vol. 78, (no. 13 Supplement), pp. 2941, 2018-07-01. | Journal Article
 
Abstract 4802: Combination therapy in PDAC involving blockade of the APE1/Ref-1 signaling pathway: An investigation into drug synthetic lethality and anti-neuropathy therapeutic approach
Shah, Fenil L⋅Shah, Fenil L⋅Shah, Fenil L⋅Atallah, Nadia⋅Atallah, Nadia⋅Atallah, Nadia⋅Grimard, Michelle⋅Grimard, Michelle⋅Grimard, Michelle⋅Guo, Chunlu⋅Guo, Chunlu⋅Guo, Chunlu⋅Zhang, Chi⋅Zhang, Chi⋅Zhang, Chi⋅Fehrenbacher, Jill⋅Fehrenbacher, Jill⋅Fehrenbacher, Jill⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Fishel, Melissa⋅Fishel, Melissa and Fishel, Melissa
Cancer Research, vol. 78, (no. 13 Supplement), pp. 4802, 2018-07-01. | Journal Article
 
APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells
McIlwain, David W⋅McIlwain, David W⋅McIlwain, David W⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Boos, Alexander⋅Boos, Alexander⋅Boos, Alexander⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Jerde, Travis J⋅Jerde, Travis J and Jerde, Travis J
Oncotarget, vol. 9, (no. 13), pp. 10977, 2018-Feb-16. | Journal Article
 
Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival
Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Logsdon, Derek P⋅Shah, Fenil⋅Shah, Fenil⋅Shah, Fenil⋅Shah, Fenil⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Carta, Fabrizio⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Supuran, Claudiu T⋅Kamocka, Malgorzata⋅Kamocka, Malgorzata⋅Kamocka, Malgorzata⋅Kamocka, Malgorzata⋅Jacobsen, Max H⋅Jacobsen, Max H⋅Jacobsen, Max H⋅Jacobsen, Max H⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Kelley, Mark R⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L and Fishel, Melissa L
Scientific reports, vol. 8, (no. 1), pp. 14, 2018-Sep-13. | Journal Article
 
Development of a Novel 3D Tumor-tissue Invasion Model for High-throughput, High-content Phenotypic Drug Screening
Puls, T J⋅Puls, T J⋅Tan, Xiaohong⋅Tan, Xiaohong⋅Husain, Mahera⋅Husain, Mahera⋅Whittington, Catherine F⋅Whittington, Catherine F⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Voytik-Harbin, Sherry L and Voytik-Harbin, Sherry L
Scientific reports, vol. 8, (no. 1), pp. 14, 2018-Aug-29. | Journal Article
 
Presence of stromal cells in a bioengineered tumor microenvironment alters glioblastoma migration and response to STAT3 inhibition
Herrera-Perez, R Marisol⋅Herrera-Perez, R Marisol⋅Herrera-Perez, R Marisol⋅Voytik-Harbin, Sherry L⋅Voytik-Harbin, Sherry L⋅Voytik-Harbin, Sherry L⋅Sarkaria, Jann N⋅Sarkaria, Jann N⋅Sarkaria, Jann N⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Rickus, Jenna L⋅Rickus, Jenna L and Rickus, Jenna L
PloS one, vol. 13, (no. 3), pp. e0194183, 2018-00-00. | Journal Article
 
PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma
Zeleniak, Ann E⋅Zeleniak, Ann E⋅Huang, Wei⋅Huang, Wei⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Hill, Reginald and Hill, Reginald
Neoplasia, vol. 20, (no. 1), pp. 24, January 2018. | Journal Article
 
PTEN-Dependent Stabilization of MTSS1 Inhibits Metastatic Phenotype in Pancreatic Ductal Adenocarcinoma
Zeleniak, Ann⋅Zeleniak, Ann E⋅Huang, Wei⋅Huang, Wei⋅Fishel, Melissa⋅Fishel, Melissa L⋅Hill, Reginald and Hill, Reginald
Neoplasia, vol. 20, (no. 1), pp. 12, 20180101. | Journal Article
 
Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization
Sardar Pasha, Sheik Pran Babu⋅Sardar Pasha, Sheik Pran Babu⋅Sishtla, Kamakshi⋅Sishtla, Kamakshi⋅Sulaiman, Rania S⋅Sulaiman, Rania S⋅Park, Bomina⋅Park, Bomina⋅Shetty, Trupti⋅Shetty, Trupti⋅Shah, Fenil⋅Shah, Fenil⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Wikel, James H⋅Wikel, James H⋅Kelley, Mark R⋅Kelley, Mark R⋅Corson, Timothy W and Corson, Timothy W
The Journal of pharmacology and experimental therapeutics, vol. 367, (no. 1), pp. 118, 2018-Oct. | Journal Article
2017
Abstract 5783:In vitromodeling of patient derived bladder cancer cell lines in 3D culture systems
Elbanna, May⋅Chintala, Sreenivasulu⋅Ciamporcero, Eric⋅Adelayie, Remi⋅Orillion, Ashley⋅Arisa, Sreevani⋅Damayanti, Nur⋅Grimard, Michelle⋅Puls, TJ⋅Harbin, Sherry⋅Fishel, Melissa and Pili, Roberto
Cancer Research, vol. 77, (no. 13 Supplement), pp. 5783, 2017-07-01. | Journal Article
 
Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers
Prabhu, Lakshmi⋅Prabhu, Lakshmi⋅Wei, Han⋅Wei, Han⋅Chen, Lan⋅Chen, Lan⋅Demir, Özlem⋅Demir, Özlem⋅Sandusky, George⋅Sandusky, George⋅Sun, Emily⋅Sun, Emily⋅Wang, John⋅Wang, John⋅Mo, Jessica⋅Mo, Jessica⋅Zeng, Lifan⋅Zeng, Lifan⋅Fishel, Melissa⋅Fishel, Melissa⋅Safa, Ahmad⋅Safa, Ahmad⋅Amaro, Rommie⋅Amaro, Rommie⋅Korc, Murray⋅Korc, Murray⋅Zhang, Zhong Yin⋅Zhang, Zhong-Yin⋅Lu, Tao and Lu, Tao
Oncotarget, vol. 8, (no. 25), pp. 39977, 2017-Jun-20. | Journal Article
 
APE1/Ref‐1 knockdown in pancreatic ductal adenocarcinoma – characterizing gene expression changes and identifying novel pathways using single‐cell RNA sequencing
Shah, Fenil⋅Shah, Fenil⋅Goossens, Emery⋅Goossens, Emery⋅Atallah, Nadia M⋅Atallah, Nadia M⋅Grimard, Michelle⋅Grimard, Michelle⋅Kelley, Mark R⋅Kelley, Mark R⋅Fishel, Melissa L and Fishel, Melissa L
Molecular Oncology, vol. 11, (no. 12), pp. 1732, December 2017. | Journal Article
 
Cancer-associated fibroblast exosomes regulate survival and proliferation of pancreatic cancer cells
Richards, K E⋅Richards, K.E.⋅Zeleniak, A E⋅Zeleniak, A.E.⋅Fishel, M L⋅Fishel, M.L.⋅Wu, J⋅Wu, J.⋅Littlepage, L E⋅Littlepage, L.E.⋅Hill, R and Hill, R.
Oncogene, vol. 36, pp. 1770-1778. | Journal Article
 
Exploiting the Ref-1-APE1 node in cancer signaling and other diseases: from bench to clinic
Shah, Fenil⋅Shah, Fenil⋅Logsdon, Derek⋅Logsdon, Derek⋅Messmann, Richard A⋅Messmann, Richard A⋅Fehrenbacher, Jill C⋅Fehrenbacher, Jill C⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Kelley, Mark R and Kelley, Mark R
NPJ precision oncology, vol. 1, (no. 1), 2017-00-00. | Journal Article
 
Loss of MTSS1 results in increased metastatic potential in pancreatic cancer
Zeleniak, Ann E⋅Zeleniak, Ann E⋅Huang, Wei⋅Huang, Wei⋅Brinkman, Mary K⋅Brinkman, Mary K⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Hill, Reginald and Hill, Reginald
Oncotarget, vol. 8, (no. 10), pp. 16487, 2017-Mar-07. | Journal Article
 
Ref-1/APE1 as a Transcriptional Regulator and Novel Therapeutic Target in Pediatric T-cell Leukemia
Ding, Jixin⋅Ding, Jixin⋅Ding, Jixin⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Fishel, Melissa L⋅Reed, April M⋅Reed, April M⋅Reed, April M⋅McAdams, Erin⋅McAdams, Erin⋅McAdams, Erin⋅Czader, Magdalena⋅Czader, Magdalena B⋅Czader, Magdalena B⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Kelley, Mark R⋅Kelley, Mark R and Kelley, Mark R
Molecular cancer therapeutics, vol. 16, (no. 7), pp. 1411, 2017-Jul. | Journal Article