217 Publications (Page 3 of 9)
2016
Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals In Early T Cell Progenitors.
Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Nabinger, Sarah C⋅Nabinger, Sarah⋅Nabinger, Sarah C⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Yoshimoto, Momoko⋅Yoshimoto, Momoko⋅Yoshimoto, Momoko⋅Gao, Rui⋅Gao, Rui⋅Gao, Rui⋅Chen, Sisi⋅Chen, Sisi⋅Chen, Sisi⋅Yao, Chonghua⋅Yao, Chonghua⋅Yao, Chonghua⋅Dong, Yuanshu⋅Dong, Yuanshu⋅Dong, Yuanshu⋅Zhang, Lujuan⋅Zhang, Lujuan⋅Zhang, Lujuan⋅Rodriguez, Sonia⋅Rodriguez, Sonia⋅Rodriguez, Sonia⋅Yashiro-Ohtani, Yumi⋅Yashiro-Ohtani, Yumi⋅Yashiro‐Ohtani, Yumi⋅Pear, Warren S⋅Pear, Warren S⋅Pear, Warren S⋅Carlesso, Nadia⋅Carlesso, Nadia⋅Carlesso, Nadia⋅Yoder, Mervin C⋅Yoder, Mervin C⋅Yoder, Mervin C⋅Kapur, Reuben⋅Kapur, Reuben⋅Kapur, Reuben⋅Kaplan, Mark H⋅Kaplan, Mark H⋅Kaplan, Mark H⋅Lacorazza, H Daniel⋅Daniel Lacorazza, Hugo⋅Daniel Lacorazza, Hugo⋅Zhang, Zhong-Yin⋅Zhang, Zhong‐Yin⋅Zhang, Zhong Yin⋅Liu, Yan⋅Liu, Yan and Liu, Yan
Stem cells (Dayton, Ohio), December 23, 2016. | Journal Article
2015
A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.
He, Yantao⋅Guo, Xing⋅Yu, Zhi-Hong⋅Wu, Li⋅Gunawan, Andrea M⋅Zhang, Yan⋅Dixon, Jack E and Zhang, Zhong Yin
Bioorganic & medicinal chemistry, vol. 23, (no. 12), pp. 2798-2809, June 15, 2015. | Journal Article
 
Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis.
He, Rongjun⋅Yu, Zhi-Hong⋅Zhang, Ruo-Yu⋅Wu, Li⋅Gunawan, Andrea M and Zhang, Zhong Yin
ACS medicinal chemistry letters, vol. 6, (no. 12), pp. 1231-1235, December 10, 2015. | Journal Article
 
Development and validation of a high-throughput cell-based screen to identify activators of a bacterial two-component signal transduction system.
van Rensburg, Julia J⋅van Rensburg, Julia J⋅Fortney, Kate R⋅Fortney, Kate R⋅Chen, Lan⋅Chen, Lan⋅Krieger, Andrew J⋅Krieger, Andrew J⋅Lima, Bruno P⋅Lima, Bruno P⋅Wolfe, Alan J⋅Wolfe, Alan J⋅Katz, Barry P⋅Katz, Barry P⋅Zhang, Zhong-Yin⋅Zhang, Zhong Yin⋅Spinola, Stanley M and Spinola, Stanley M
Antimicrobial agents and chemotherapy, vol. 59, (no. 7), pp. 3789-3799, July 2015. | Journal Article
 
Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors.
He, Rongjun⋅Yu, Zhi-Hong⋅Zhang, Ruo-Yu⋅Wu, Li⋅Gunawan, Andrea M⋅Lane, Brandon S⋅Shim, Joong S⋅Zeng, Li-Fan⋅He, Yantao⋅Chen, Lan⋅Wells, Clark D⋅Liu, Jun O and Zhang, Zhong Yin
ACS medicinal chemistry letters, vol. 6, (no. 7), pp. 782-786, July 9, 2015. | Journal Article
 
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis.
Bunda, Severa⋅Bunda, Severa⋅Burrell, Kelly⋅Burrell, Kelly⋅Heir, Pardeep⋅Heir, Pardeep⋅Zeng, Lifan⋅Zeng, Lifan⋅Alamsahebpour, Amir⋅Alamsahebpour, Amir⋅Kano, Yoshihito⋅Kano, Yoshihito⋅Raught, Brian⋅Raught, Brian⋅Zhang, Zhong Yin⋅Zhang, Zhong-yin⋅Zadeh, Gelareh⋅Zadeh, Gelareh⋅Ohh, Michael and Ohh, Michael
Nature communications, vol. 6, pp. 8859, 2015. | Journal Article
 
Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice.
Xi, Y.⋅Xi, Yannan⋅Liu, S.⋅Liu, Siming⋅Bettaieb, A.⋅Bettaieb, Ahmed⋅Matsuo, K.⋅Matsuo, Kosuke⋅Matsuo, Izumi⋅Matsuo, I.⋅Hosein, E.⋅Hosein, Ellen⋅Chahed, S.⋅Chahed, Samah⋅Wiede, F.⋅Wiede, Florian⋅Zhang, S.⋅Zhang, Sheng⋅Zhang, Z.-Y.⋅Zhang, Zhong Yin⋅Kulkarni, Rohit N⋅Kulkarni, R.N.⋅Tiganis, Tony⋅Tiganis, T.⋅Haj, Fawaz G and Haj, F.G.
Diabetologia, vol. 58, (no. 1), pp. 122-131, January 2015. | Journal Article
 
Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling.
Zhang, Z.-Y.⋅Zhang, Zhong Yin⋅Dodd, Garron T⋅Dodd, G.T.⋅Tiganis, T. and Tiganis, Tony
Trends in pharmacological sciences, vol. 36, (no. 10), pp. 661-674, October 2015. | Journal Article
 
Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.
Zhu, Helen He⋅Luo, Xiaolin⋅Zhang, Kaiqing⋅Cui, Jian⋅Zhao, Huifang⋅Ji, Zhongzhong⋅Zhou, Zhicheng⋅Yao, Jufang⋅Zeng, Lifan⋅Ji, Kaihong⋅Gao, Wei-Qiang⋅Zhang, Zhong Yin and Feng, Gen Sheng
Proceedings of the National Academy of Sciences of the United States of America, vol. 112, (no. 43), pp. 13342-13347, October 27, 2015. | Journal Article
2014
A new class of salicylic acid derivatives for inhibiting YopH of Yersinia pestis.
Paudyal, Mahesh P⋅Wu, Li⋅Zhang, Zhong Yin⋅Spilling, Christopher D and Wong, Chung F
Bioorganic & medicinal chemistry, vol. 22, (no. 24), pp. 6781-6788, December 15, 2014. | Journal Article
 
Diverse levels of sequence selectivity and catalytic efficiency of protein-tyrosine phosphatases.
Selner, Nicholas G⋅Luechapanichkul, Rinrada⋅Chen, Xianwen⋅Neel, Benjamin G⋅Zhang, Z. F⋅Knapp, Stefan⋅Bell, Charles E and Pei, Dehua
Biochemistry, vol. 53, (no. 2), pp. 397-412, 2014/Jan/21. | Journal Article
 
Diversity-Oriented Synthesis for Novel, Selective and Drug-like Inhibitors for a Phosphatase from Mycobacterium Tuberculosis.
He, Rongjun⋅He, Rongjun⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Yu, Zhi-Hong⋅Yu, Zhi-Hong⋅Wu, Li⋅Wu, Li⋅Gunawan, Andrea Michelle⋅Gunawan, Andrea Michelle⋅Zhang, Zhong Yin and Zhang, Zhong-Yin
MedChemComm, vol. 5, (no. 10), pp. 1496-1499, October 2014. | Journal Article
 
Hydroxyindole carboxylic Acid-based inhibitors for receptor-type protein tyrosine protein phosphatase Beta.
Zeng, Li-Fan⋅Zeng, Li-Fan⋅Zhang, Ruo-Yu⋅Zhang, Ruo-Yu⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Wu, Li⋅Wu, Li⋅Gunawan, Andrea M⋅Gunawan, Andrea M⋅Zhang, Z. F and Zhang, Zhong-Yin
Antioxidants & redox signaling, vol. 20, (no. 14), pp. 2130-40, 2014/May/10. | Journal Article
 
Integrin-mediated type II TGF-β receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
Chen, Xiwu⋅Wang, Hongtao⋅Liao, Hong-Jun⋅Hu, Wen⋅Gewin, Leslie⋅Mernaugh, Glenda⋅Zhang, Sheng⋅Zhang, Zhong Yin⋅Vega-Montoto, Lorenzo⋅Vanacore, Roberto M⋅Fässler, Reinhard⋅Zent, Roy and Pozzi, Ambra
The Journal of clinical investigation, vol. 124, (no. 8), pp. 3295-3310, August 2014. | Journal Article
 
Molecular basis of gain-of-function LEOPARD syndrome-associated SHP2 mutations.
Yu, Zhi-Hong⋅Zhang, Ruo-Yu⋅Walls, Chad D⋅Chen, Lan⋅Zhang, Sheng⋅Wu, Li⋅Liu, Sijiu and Zhang, Z. F
Biochemistry, vol. 53, (no. 25), pp. 4136-51, 2014/Jul/1. | Journal Article
 
Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice.
Sharma, Namit⋅Sharma, Namit⋅Everingham, Stephanie⋅Everingham, Stephanie⋅Zeng, Li-Fan⋅Zeng, Li-Fan⋅Zhang, Zhong-Yin⋅Zhang, Zhong Yin⋅Kapur, Reuben⋅Kapur, Reuben⋅Craig, Andrew W B and Craig, Andrew W.B
Oncotarget, vol. 5, (no. 15), pp. 6130-6141, August 15, 2014. | Journal Article
 
Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain
Liao, Jingling⋅Wu, Chun-Xiang⋅Burlak, Christopher⋅Zhang, Sheng⋅Sahm, Heather⋅Wang, Mu⋅Zhang, Zhong Yin⋅Vogel, Kurt W⋅Federici, Mark⋅Riddle, Steve M⋅Nichols, R. J⋅Liu, Dali⋅Cookson, Mark R⋅Stone, Todd A and Hoang, Quyen
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 11), Mar 18, 2014. | Journal Article
 
Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis.
Dong, Yuanshu⋅Dong, Yuanshu⋅Dong, Yuanshu⋅Zhang, Lujuan⋅Zhang, Lujuan⋅Zhang, Lujuan⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Zhou, Hong-Ming⋅Zhou, Hong-Ming⋅Zhou, Hong-Ming⋅Campbell, Amanda M.⋅Campbell, Amanda M⋅Campbell, Amanda M⋅Chen, Hanying⋅Chen, Hanying⋅Chen, Hanying⋅Yong, Weidong⋅Yong, Weidong⋅Yong, Weidong⋅Zhang, Wenjun⋅Zhang, Wenjun⋅Zhang, Wenjun⋅Zeng, Qi⋅Zeng, Qi⋅Zeng, Qi⋅Shou, Weinian⋅Shou, Weinian⋅Shou, Weinian⋅Zhang, Zhong-Yin⋅Zhang, Z. F and Zhang, Zhong-Yin
The Journal of biological chemistry, vol. 289, (no. 6), pp. 3799-810, 2014/Feb/7. | Journal Article
 
Phosphatase of regenerating liver: a novel target for cancer therapy.
Campbell, Amanda M and Zhang, Z. F
Expert opinion on therapeutic targets, vol. 18, (no. 5), pp. 555-69, 2014/May. | Journal Article
 
Phosphatase of regenerating liver in hematopoietic stem cells and hematological malignancies.
Kobayashi, Michihiro⋅Chen, Sisi⋅Gao, Rui⋅Bai, Yunpeng⋅Zhang, Zhong Yin and Liu, Yan
Cell cycle (Georgetown, Tex.), vol. 13, (no. 18), pp. 2827-2835, 2014. | Journal Article
 
PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal.
Kobayashi, Michihiro⋅Kobayashi, Michihiro⋅Bai, Yunpeng⋅Bai, Yunpeng⋅Dong, Yuanshu⋅Dong, Yuanshu⋅Yu, Hao⋅Yu, Hao⋅Chen, Sisi⋅Chen, Sisi⋅Gao, Rui⋅Gao, Rui⋅Zhang, Lujuan⋅Zhang, Lujuan⋅Yoder, Mervin C⋅Yoder, Mervin C⋅Kapur, Reuben⋅Kapur, Reuben⋅Zhang, Zhong‐Yin⋅Zhang, Zhong Yin⋅Liu, Yan and Liu, Yan
Stem cells (Dayton, Ohio), vol. 32, (no. 7), pp. 1956-1967, July 2014. | Journal Article
 
Protein tyrosine phosphatases as potential therapeutic targets
He, Rong-jun⋅Yu, Zhi-hong⋅Zhang, Ruo-yu and Zhang, Zhong Yin
Acta Pharmacologica Sinica, vol. 35, (no. 10), pp. 1227-46, Oct 2014. | Journal Article
 
Small molecule inhibitors target the tissue transglutaminase and fibronectin interaction.
Yakubov, Bakhtiyor⋅Yakubov, Bakhtiyor⋅Chen, Lan⋅Chen, Lan⋅Belkin, Alexey M⋅Belkin, Alexey M⋅Zhang, Sheng⋅Zhang, Sheng⋅Chelladurai, Bhadrani⋅Chelladurai, Bhadrani⋅Zhang, Zhong-Yin⋅Zhang, Z. F⋅Matei, Daniela and Matei, Daniela
PloS one, vol. 9, (no. 2), pp. e89285, 2014. | Journal Article
2013
A facile hydroxyindole carboxylic acid based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B.
Zeng, Li-Fan⋅Xu, Jie⋅He, Yantao⋅He, Rongjun⋅Wu, Li⋅Gunawan, Andrea M and Zhang, Z. F
ChemMedChem, vol. 8, (no. 6), pp. 904-8, 2013/Jun. | Journal Article
 
Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.
He, Yantao⋅Xu, Jie⋅Yu, Zhi-Hong⋅Gunawan, Andrea M⋅Wu, Li⋅Wang, Lina and Zhang, Z. F
Journal of medicinal chemistry, vol. 56, (no. 3), pp. 832-42, 2013/Feb/14. | Journal Article