217 Publications (Page 8 of 9)
2000
Synthesis and characterization of a novel class of protein tyrosine phosphatase inhibitorsIbrahimi, O A⋅Ibrahimi, Omar A⋅Wu, Li⋅Wu, L⋅Zhao, K⋅Zhao, Kang⋅Zhang, Z. F and Zhang, Zhong YinBioorganic & Medicinal Chemistry Letters, vol. 10, (no. 5), pp. 460, 2000.
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Thermodynamic Study of Ligand Binding to Protein-tyrosine Phosphatase 1B and Its Substrate-trapping MutantsZhang, Yan-Ling⋅Zhang, Y L⋅Yao, Zhu-Jun⋅Yao, Z J⋅Sarmiento, Mauro⋅Sarmiento, M⋅Wu, L⋅Wu, Li⋅Burke, Terrence⋅Burke, Terrence R⋅Zhang, Zhong Yin and Zhang, Z. FJournal of Biological Chemistry, vol. 275, (no. 44), pp. 34212, 20001103.
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1999
A Phosphotyrosyl Mimetic Peptide Reverses Impairment of Insulin-Stimulated Translocation of GLUT4 Caused by Overexpression of PTP1B in Rat Adipose CellsChen, Hui⋅Chen, H⋅Cong, L N⋅Cong, Li-Na⋅Li, Y⋅Li, Yunhua⋅Yao, Zhu-Jun⋅Yao, Z J⋅Wu, L⋅Wu, Li⋅Zhang, Z Y⋅Zhang, Zhong Yin⋅Burke, Terrence R⋅Burke, Terrence R⋅Quon, M J and Quon, Michael JBiochemistry, vol. 38, (no. 1), pp. 389, 19990105.
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Impaired Transition State Complementarity in the Hydrolysis of O-Arylphosphorothioates by Protein-Tyrosine PhosphatasesZhang, Yan-Ling⋅Zhang, Y L⋅Hollfelder, Florian⋅Hollfelder, Florian⋅Gordon, Steven J⋅Gordon, S J⋅Chen, L⋅Chen, Li⋅Keng, Yen-Fang⋅Keng, Y F⋅Wu, L⋅Wu, Li⋅Herschlag, Daniel⋅Herschlag, Daniel⋅Zhang, Zhong Yin and Zhang, Z. FBiochemistry, vol. 38, (no. 37), pp. 12123, 19990914.
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Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2Zhou, B⋅Zhou, Bo⋅Zhang, Z. F and Zhang, Zhong YinJournal of Biological Chemistry, vol. 274, (no. 50), pp. 35534, 19991210.
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Potent and Highly Selective Inhibitors of the Protein Tyrosine Phosphatase 1BTaing, Meng⋅Keng, Yen-Fang⋅Shen, Kui⋅Wu, Li⋅Lawrence, David S and Zhang, Zhong YinBiochemistry, vol. 38, (no. 12), pp. 3803, 19990323.
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Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215Barrett, W C⋅Barrett, William C⋅DeGnore, J P⋅DeGnore, Jon P⋅König, S⋅König, Simone⋅Fales, Henry M⋅Fales, Henry M⋅Keng, Yen-Fang⋅Keng, Y F⋅Zhang, Zhong Yin⋅Zhang, Z. F⋅Yim, M B⋅Yim, Moon B⋅Chock, P. Boon and Chock, P BBiochemistry, vol. 38, (no. 20), pp. 6705, 19990518.
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Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1BBarrett, W C⋅Barrett, William⋅DeGnore, Jon⋅DeGnore, J P⋅Keng, Y F⋅Keng, Yen-Fang⋅Zhang, Z. F⋅Zhang, Zhong Yin⋅Yim, Moon⋅Yim, M B⋅Chock, P B and Chock, P.Journal of Biological Chemistry, vol. 274, (no. 49), pp. 34546, 19991203.
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1998
Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed ReactionZhao, Yu⋅Wu, Li⋅Noh, Seong⋅Guan, Kun-Liang and Zhang, Zhong YinJournal of Biological Chemistry, vol. 273, (no. 10), pp. 5484, 19980306.
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Conformational and Dynamic Changes of Yersinia Protein Tyrosine Phosphatase Induced by Ligand Binding and Active Site Mutation and Revealed by H/D Exchange and Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass SpectrometryWang, Fang⋅Wang, F⋅Li, W⋅Li, Weiqun⋅Emmett, Mark R⋅Emmett, Mark R⋅Hendrickson, Chris⋅Hendrickson, Christopher L⋅Marshall, Alan G⋅Marshall, Alan G⋅Zhang, Y L⋅Zhang, Yan-Ling⋅Wu, L⋅Wu, Li⋅Zhang, Zhong Yin and Zhang, Z. FBiochemistry, vol. 37, (no. 44), pp. 15299, 19981103.
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Enantioselective synthesis of nonphosphorus-containing phosphotyrosyl mimetics and their use in the preparation of tyrosine phosphatase inhibitory peptidesBurke, Terrence R⋅Yao, Zhu-Jun⋅Zhao, He⋅Milne, George W.A⋅Wu, Li⋅Zhang, Zhong Yin and Voigt, Johannes HTetrahedron, vol. 54, (no. 34), pp. 9994, 1998.
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Low-Affinity Binding Determined by Titration Calorimetry Using a High-Affinity Coupling Ligand: A Thermodynamic Study of Ligand Binding to Protein Tyrosine Phosphatase 1BZhang, Y L⋅Zhang, Yan-Ling⋅Zhang, Zhong Yin and Zhang, Z. FAnalytical Biochemistry, vol. 261, (no. 2), pp. 148, 1998-08-01.
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Molecular Basis for Substrate Specificity of Protein-tyrosine Phosphatase 1BSarmiento, M⋅Sarmiento, Mauro⋅Zhao, Yu⋅Zhao, Y⋅Gordon, S J⋅Gordon, Steven⋅Zhang, Zhong Yin and Zhang, Z. FJournal of Biological Chemistry, vol. 273, (no. 41), pp. 26374, 19981009.
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Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of CatalysisZhang, Zhong Yin and Zhang, Z. FCritical Reviews in Biochemistry and Molecular Biology, vol. 33, (no. 1), pp. 52, 19980000.
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Protein-tyrosine phosphatases: Structure, mechanism, and inhibitor discoveryBurke, Terrence R⋅Burke, Terrence⋅Zhang, Zhong Yin and Zhang, Zhong YinBIOPOLYM, vol. 47, (no. 3), pp. 241, 19980101.
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Suramin Is an Active Site-directed, Reversible, and Tight-binding Inhibitor of Protein-tyrosine PhosphatasesZhang, Y L⋅Zhang, Yan-Ling⋅Keng, Y F⋅Keng, Yen-Fang⋅Zhao, Y⋅Zhao, Yu⋅Wu, Li⋅Wu, L⋅Zhang, Z. F and Zhang, Zhong YinJournal of Biological Chemistry, vol. 273, (no. 20), pp. 12287, 19980515.
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Walden-Inversion-Enforced Transition-State Stabilization in a Protein Tyrosine PhosphataseAlhambra, Cristobal⋅Wu, Li⋅Zhang, Zhong Yin and Gao, JialiJournal of the American Chemical Society, vol. 120, (no. 16), pp. 3866, 19980429.
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1997
Identification of a Second Aryl Phosphate-Binding Site in Protein-Tyrosine Phosphatase 1B: A Paradigm for Inhibitor DesignPuius, Yoram A⋅Puius, Yoram⋅Zhao, Yu⋅Zhao, Yu⋅Sullivan, M.⋅Sullivan, Michael⋅Lawrence, David⋅Lawrence, David S⋅Almo, Steven C⋅Almo, Steven⋅Zhang, Zhong Yin and Zhang, Zhong YinProceedings of the National Academy of Sciences of the United States of America, vol. 94, (no. 25), pp. 13425, 19971209.
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Potent inhibition of protein-tyrosine phosphatase by phosphotyrosine-mimic containing cyclic peptidesAkamatsu, M⋅Akamatsu, Miki⋅Roller, Peter P⋅Roller, Peter P⋅Chen, L⋅Chen, Li⋅Zhang, Zhong Yin⋅Zhang, Z. F⋅Ye, B⋅Ye, Bin⋅Burke, Terrence R and Burke, Terrence RBioorganic & Medicinal Chemistry, vol. 5, (no. 1), pp. 163, January 1997.
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Rapid Loop Dynamics of Yersinia Protein Tyrosine PhosphatasesJuszczak, Laura J⋅Juszczak, L J⋅Zhang, Zhong Yin⋅Zhang, Z. F⋅Wu, Li⋅Wu, L⋅Gottfried, David S⋅Gottfried, David S⋅Eads, Daniel D and Eads, D DBiochemistry, vol. 36, (no. 8), pp. 2236, 19970225.
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Structure, Mechanism, and Specificity of Protein-Tyrosine PhosphatasesZhang, Z. F and Zhang, Zhong YinCurrent Topics in Cellular Regulation, vol. 35, pp. 68, 1997.
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The Single Sulfur to Oxygen Substitution in the Active Site Nucleophile of the Yersinia Protein-Tyrosine Phosphatase Leads to Substantial Structural and Functional PerturbationsZhang, Zhong Yin⋅Zhang, Z. F⋅Wu, L and Wu, LiBiochemistry, vol. 36, (no. 6), pp. 1369, 19970211.
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1996
Determinants of Substrate Recognition in the Protein-tyrosine Phosphatase, PTP1Zhang, Zhong Yin⋅Zhang, Zhong Yin⋅Walsh, AB⋅Walsh, Amy⋅Wu, Li⋅Wu, Li⋅McNamara, DJ⋅McNamara, Dennis⋅Dobrusin, EM⋅Dobrusin, Ellen⋅Miller, W. T and Miller, W.Journal of Biological Chemistry, vol. 271, (no. 10), pp. 5392, 19960308.
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Potent Low Molecular Weight Substrates for Protein-tyrosine PhosphataseMontserat, J⋅Montserat, Javier⋅Chen, Li⋅Chen, L⋅Lawrence, D S⋅Lawrence, David⋅Zhang, Zhong Yin and Zhang, Z. FJournal of Biological Chemistry, vol. 271, (no. 13), pp. 7872, 19960329.
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Probing the Function of Asp128 in the Low Molecular Weight Protein-Tyrosine Phosphatase-Catalyzed Reaction. A Pre-Steady-State and Steady-State Kinetic InvestigationWu, Li⋅Wu, Li⋅Zhang, Zhong Yin and Zhang, Zhong YinBiochemistry, vol. 35, (no. 17), pp. 5434, 19960430.
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