55 Publications (Page 1 of 3)
2020
Allosteric Cannabinoid Receptor 1 (CB1) Ligands Reduce Ocular Pain and Inflammation
Thapa, Dinesh⋅Cairns, Elizabeth A⋅Szczesniak, Anna-Maria⋅Kulkarni, Pushkar M⋅Straiker, Alex J⋅Thakur, Ganesh A and Kelly, Melanie E M
Molecules (Basel, Switzerland), vol. 25, (no. 2), pp. 417, 2020-Jan-20. | Journal Article
 
Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of Cannabinoid 1 Receptor Positive Allosteric Modulators
Garai, Sumanta⋅Garai, Sumanta⋅Kulkarni, Pushkar M⋅Kulkarni, Pushkar M⋅Schaffer, Peter C⋅Schaffer, Peter C⋅Leo, Luciana M⋅Leo, Luciana M⋅Brandt, Asher L⋅Brandt, Asher L⋅Zagzoog, Ayat⋅Zagzoog, Ayat⋅Black, Tallan⋅Black, Tallan⋅Lin, Xiaoyan⋅Lin, Xiaoyan⋅Hurst, Dow P⋅Hurst, Dow P⋅Janero, David R⋅Janero, David R⋅Abood, Mary E⋅Abood, Mary E⋅Zimmowitch, Anaelle⋅Zimmowitch, Anaelle⋅Straiker, Alex⋅Straiker, Alex⋅Pertwee, Roger G⋅Pertwee, Roger G⋅Kelly, Melanie⋅Kelly, Melanie⋅Szczesniak, Anna-Maria⋅Szczesniak, Anna-Maria⋅Denovan-Wright, Eileen M⋅Denovan-Wright, Eileen M⋅Mackie, Ken⋅Mackie, Ken⋅Hohmann, Andrea G⋅Hohmann, Andrea G⋅Reggio, Patricia H⋅Reggio, Patricia H⋅Laprairie, Robert B⋅Laprairie, Robert B⋅Thakur, Ganesh A and Thakur, Ganesh A
Journal of medicinal chemistry, vol. 63, (no. 2), pp. 568, 2020-Jan-23. | Journal Article
2019
Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing
Murataeva, Natalia⋅Murataeva, Natalia⋅Miller, Sally⋅Miller, Sally⋅Dhopeshwarkar, Amey⋅Dhopeshwarkar, Amey⋅Leishman, Emma⋅Leishman, Emma⋅Daily, Laura⋅Daily, Laura⋅Taylor, Xavier⋅Taylor, Xavier⋅Morton, Brian⋅Morton, Brian⋅Lashmet, Matthew⋅Lashmet, Matthew⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Hillard, Cecilia J⋅Hillard, Cecilia J⋅Romero, Julian⋅Romero, Julian⋅Straiker, Alex and Straiker, Alex
Experimental Eye Research, vol. 182, pp. 84, May 2019. | Journal Article
 
Cannabinoid Receptor-Mediated Modulation of Inhibitory Inputs to Mitral Cells in the Main Olfactory Bulb
Wang, Ze-Jun⋅Wang, Ze-Jun⋅Hu, Sherry Shu-Jung⋅Hu, Sherry Shu-Jung⋅Bradshaw, Heather B⋅Bradshaw, Heather B⋅Sun, Liqin⋅Sun, Liqin⋅Mackie, Ken⋅Mackie, Ken⋅Straiker, Alex⋅Straiker, Alex⋅Heinbockel, Thomas and Heinbockel, Thomas
Journal of neurophysiology, 2019-Jun-19. | Journal Article
 
Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea
Murataeva, Natalia⋅Daily, Laura⋅Taylor, Xavier⋅Dhopeshwarkar, Amey⋅Hu, Sherry⋅Miller, Sally⋅McHugh, Douglas⋅Oehler, Olivia⋅Li, Shimin⋅Bonanno, Joseph⋅Mackie, Ken and Straiker, Alex
Cornea, vol. 38, (no. 7), pp. 913, 2019-July. | Journal Article
 
What is currently known about cannabidiol and ocular pressure
Straiker, Alex
Expert Review of Ophthalmology, vol. 14, (no. 6), pp. 261, 11/2/2019. | Journal Article
2018
Cannabidiol Inhibits Endocannabinoid Signaling in Autaptic Hippocampal Neurons
Straiker, Alex⋅Dvorakova, Michaela⋅Zimmowitch, Anaelle and Mackie, Ken
Molecular pharmacology, vol. 94, (no. 1), pp. 748, 2018-07-00. | Journal Article
 
Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure
Miller, Sally⋅Miller, Sally⋅Kulkarni, Shashank⋅Kulkarni, Shashank⋅Ciesielski, Alex⋅Ciesielski, Alex⋅Nikas, Spyros P⋅Nikas, Spyros P⋅Mackie, Ken⋅Mackie, Ken⋅Makriyannis, Alexandros⋅Makriyannis, Alexandros⋅Straiker, Alex and Straiker, Alex
Pharmaceuticals (Basel, Switzerland), vol. 11, (no. 2), pp. 50, 2018-May-22. | Journal Article
 
Enantiomer-specific positive allosteric modulation of CB 1 signaling in autaptic hippocampal neurons
Mitjavila, Jose⋅Yin, Danielle⋅Kulkarni, Pushkar M⋅Zanato, Chiara⋅Thakur, Ganesh A⋅Ross, Ruth⋅Greig, Iain⋅Mackie, Ken and Straiker, Alex
Pharmacological research, vol. 129, pp. 481, 2018-03-00. | Journal Article
 
Revisiting cannabinoid receptor 2 expression and function in murine retina
Borowska-Fielding, Joanna⋅Borowska-Fielding, Joanna⋅Murataeva, Natalia⋅Murataeva, Natalia⋅Smith, Ben⋅Smith, Ben⋅Szczesniak, Anna-Maria⋅Szczesniak, Anna-Maria⋅Leishman, Emma⋅Leishman, Emma⋅Daily, Laura⋅Daily, Laura⋅Toguri, J. Thomas⋅Toguri, J. Thomas⋅Hillard, Cecelia J⋅Hillard, Cecelia J⋅Romero, Julian⋅Romero, Julian⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Kelly, Melanie E.M⋅Kelly, Melanie E.M⋅Straiker, Alex and Straiker, Alex
Neuropharmacology, vol. 141, pp. 31, October 2018. | Journal Article
 
Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure
Miller, Sally⋅Miller, Sally⋅Daily, Laura⋅Daily, Laura⋅Leishman, Emma⋅Leishman, Emma⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Straiker, Alex and Straiker, Alex
Investigative ophthalmology & visual science, vol. 59, (no. 15), pp. 5911, 2018-12-03. | Journal Article
2017
A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner
Miller, Sally⋅Miller, Sally⋅Miller, Sally⋅Hu, Sherry Shu-Jung⋅Hu, Sherry Shu-Jung⋅Hu, Sherry Shu-Jung⋅Leishman, Emma⋅Leishman, Emma⋅Leishman, Emma⋅Morgan, Dan⋅Morgan, Dan⋅Morgan, Dan⋅Wager-Miller, Jim⋅Wager Miller, Jim⋅Wager-Miller, Jim⋅Mackie, Ken⋅Mackie, Ken⋅Mackie, Ken⋅Bradshaw, Heather B⋅Bradshaw, Heather B⋅Bradshaw, Heather B⋅Straiker, Alex⋅Straiker, Alex and Straiker, Alex
Investigative ophthalmology & visual science, vol. 58, (no. 7), pp. 2938, 2017-06-01. | Journal Article
 
Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse.
Ruehle, Sabine⋅Wager-Miller, James⋅Straiker, Alex⋅Farnsworth, Jill⋅Murphy, Michelle N⋅Loch, Sebastian⋅Monory, Krisztina⋅Mackie, Ken and Lutz, Beat
Journal of neurochemistry, vol. 142, (no. 4), pp. 521-533, August 2017. | Journal Article
 
Discovery and characterization of two novel CB1 receptor splice variants with modified N‐termini in mouse
Ruehle, Sabine⋅Wager‐Miller, James⋅Straiker, Alex⋅Farnsworth, Jill⋅Murphy, Michelle N⋅Loch, Sebastian⋅Monory, Krisztina⋅Mackie, Ken and Lutz, Beat
Journal of Neurochemistry, vol. 142, (no. 4), pp. 533, August 2017. | Journal Article
 
The In Vivo Effects of the CB 1 -Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice
Cairns, Elizabeth A⋅Szczesniak, Anna-Maria⋅Straiker, Alex J⋅Kulkarni, Pushkar M⋅Pertwee, Roger G⋅Thakur, Ganesh A⋅Baldridge, William H and Kelly, Melanie E M
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, vol. 33, (no. 8), pp. 582, 2017-Oct. | Journal Article
 
The In Vivo Effects of the CB1-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice
Cairns, Elizabeth A⋅Szczesniak, Anna-Maria⋅Straiker, Alex J⋅Kulkarni, Pushkar M⋅Pertwee, Roger G⋅Thakur, Ganesh A⋅Baldridge, William H and Kelly, Melanie E.M
Journal of Ocular Pharmacology and Therapeutics, vol. 33, (no. 8), pp. 590, 2017-10-01. | Journal Article
 
Two Janus Cannabinoids That Are Both CB2 Agonists and CB1 Antagonists
Dhopeshwarkar, Amey⋅Dhopeshwarkar, Amey⋅Murataeva, Natalia⋅Murataeva, Natalia⋅Makriyannis, Alex⋅Makriyannis, Alex⋅Straiker, Alex⋅Straiker, Alex⋅Mackie, Ken and Mackie, Ken
The Journal of pharmacology and experimental therapeutics, vol. 360, (no. 2), pp. 311, 2017-Feb. | Journal Article
2016
Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain
Leishman, Emma⋅Leishman, Emma⋅Cornett, Ben⋅Cornett, Ben⋅Spork, Karl⋅Spork, Karl⋅Straiker, Alex⋅Straiker, Alex⋅Mackie, Ken⋅Mackie, Ken⋅Bradshaw, Heather B and Bradshaw, Heather B
Pharmacological Research, vol. 110, pp. 172, August 2016. | Journal Article
 
Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure
Miller, Sally⋅Miller, Sally⋅Miller, Sally⋅Leishman, Emma⋅Leishman, Emma⋅Leishman, Emma⋅Oehler, Olivia⋅Oehler, Olivia⋅Oehler, Olivia⋅Daily, Laura⋅Daily, Laura⋅Daily, Laura⋅Murataeva, Natalia⋅Murataeva, Natalia⋅Murataeva, Natalia⋅Wager Miller, Jim⋅Wager-Miller, Jim⋅Wager-Miller, Jim⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Straiker, Alex⋅Straiker, Alex and Straiker, Alex
Investigative ophthalmology & visual science, vol. 57, (no. 14), pp. 6426, 2016-11-01. | Journal Article
 
Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model
Miller, Sally⋅Miller, Sally⋅Leishman, Emma⋅Leishman, Emma⋅Hu, Sherry Shujung⋅Hu, Sherry Shujung⋅Elghouche, Alhasan⋅Elghouche, Alhasan⋅Daily, Laura⋅Daily, Laura⋅Murataeva, Natalia⋅Murataeva, Natalia⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Straiker, Alex and Straiker, Alex
Investigative ophthalmology & visual science, vol. 57, (no. 7), pp. 3296, 2016-Jun-01. | Journal Article
 
Where’s my entourage? The curious case of 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol
Murataeva, Natalia⋅Murataeva, Natalia⋅Murataeva, Natalia⋅Dhopeshwarkar, Amey⋅Dhopeshwarkar, Amey⋅Dhopeshwarkar, Amey⋅Yin, Danielle⋅Yin, Danielle⋅Yin, Danielle⋅Mitjavila, José⋅Mitjavila, José⋅Mitjavila, José⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Straiker, Alex⋅Straiker, Alex⋅Straiker, Alex⋅Mackie, Ken⋅Mackie, Ken and Mackie, Ken
Pharmacological Research, vol. 110, pp. 180, August 2016. | Journal Article
2015
Aiming for allosterism: Evaluation of allosteric modulators of CB.sub.1 in a neuronal model
Straiker, Alex⋅Mitjavila, Jose⋅Yin, Danielle⋅Gibson, Anne and Mackie, Ken
Pharmacological Research, vol. 99, pp. 370, 20150901. | Journal Article
 
Cannabinoid-induced chemotaxis in bovine corneal epithelial cells.
Murataeva, Natalia⋅Murataeva, Natalia⋅Murataeva, Natalia⋅Li, Shimin⋅Li, Shimin⋅Li, Shimin⋅Oehler, Olivia⋅Oehler, Olivia⋅Oehler, Olivia⋅Miller, Sally⋅Miller, Sally⋅Miller, Sally⋅Dhopeshwarkar, Amey⋅Dhopeshwarkar, Amey⋅Dhopeshwarkar, Amey⋅Hu, Sherry Shu-Jung⋅Hu, Sherry Shu-Jung⋅Hu, Sherry Shu-Jung⋅Bonanno, Joseph A⋅Bonanno, Joseph A⋅Bonanno, Joseph A⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Bradshaw, Heather⋅Mackie, Ken⋅Mackie, Ken⋅Mackie, Ken⋅McHugh, Douglas⋅McHugh, Douglas⋅McHugh, Douglas⋅Straiker, Alex⋅Straiker, Alex and Straiker, Alex
Investigative ophthalmology & visual science, vol. 56, (no. 5), pp. 3304-3313, May 2015. | Journal Article
 
Cannabinoid Receptor-Interacting Protein 1a Modulates CB1 Receptor Signaling and Regulation
Smith, Tricia H⋅Smith, Tricia H⋅Blume, Lawrence C⋅Blume, Lawrence C⋅Straiker, Alex⋅Straiker, Alex⋅Cox, Jordan O⋅Cox, Jordan O⋅David, Bethany G⋅David, Bethany G⋅McVoy, Julie R Secor⋅McVoy, Julie R Secor⋅Sayers, Katherine W⋅Sayers, Katherine W⋅Poklis, Justin L⋅Poklis, Justin L⋅Abdullah, Rehab A⋅Abdullah, Rehab A⋅Egertová, Michaela⋅Egertová, Michaela⋅Chen, Ching-Kang⋅Chen, Ching-Kang⋅Mackie, Ken⋅Mackie, Ken⋅Elphick, Maurice R⋅Elphick, Maurice R⋅Howlett, Allyn C⋅Howlett, Allyn C⋅Selley, Dana E and Selley, Dana E
Molecular pharmacology, vol. 87, (no. 4), pp. 765, 2015-Apr. | Journal Article
2014
Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice.
Morgan, Daniel J⋅Morgan, Daniel J⋅Davis, Brian J⋅Davis, Brian J⋅Kearn, Chris S⋅Kearn, Chris S⋅Marcus, David⋅Marcus, David⋅Cook, Alex J⋅Cook, Alex J⋅Wager Miller, Jim⋅Wager-Miller, Jim⋅Straiker, Alex⋅Straiker, Alex⋅Myoga, Michael H⋅Myoga, Michael H⋅Karduck, Jeffrey⋅Karduck, Jeffrey⋅Leishman, Emma⋅Leishman, Emma⋅Sim-Selley, Laura J⋅Sim-Selley, Laura J⋅Czyzyk, Traci A⋅Czyzyk, Traci A⋅Bradshaw, Heather B⋅Bradshaw, Heather B⋅Selley, Dana E⋅Selley, Dana E⋅Mackie, Kenneth P and Mackie, Ken
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 34, (no. 15), pp. 5152-63, 2014/Apr/9. | Journal Article