Expertise

Areas of Study:

  • Neuroscience

Research Interests:

  • Regulation of CB1 cannabinoid receptor signaling
  • Regulation of endocannabinoid production
  • Role of endocannabinoids in synaptic plasticity
  • Novel cannabinoid receptors

The Mackie lab examines the role and function of the endocannabinoid system by using a combination of electrophysiological, imaging, biochemical and immunological approaches.

Ken Mackie’s research program focuses on cannabinoid receptors, the cell surface receptors responsible for most of the psychoactive and therapeutic actions of cannabis.

Much of the current work in his lab centers on endogenous cannabinoids (endocannabinoids), compounds produced by the body that interact with cannabinoid receptors.


Subject Area:

  • Behavioral Neuroscience

Research interests: Regulation of CB1 cannabinoid receptor signaling, interactions among phytocannabinoids and terpenes, role of endocannabinoids in synaptic plasticity, novel cannabinoid receptors


Subject Area

  • Psychological and Brain Sciences
Past Affiliations

Assistant Professor, Department of Anesthesiology & Pain Medicine, School of Medicine, University of Washington (past)
1992 - 1998

Senior Fellow, University of Washington
1990 - 1992

Instructor, University of Washington
1990 - 1992

Resident, Department of Anesthesiology & Pain Medicine, School of Medicine, University of Washington (past)
1987 - 1990

Intern, Internal Medicine
1986 - 1987

Postdoctoral Fellow, Rockefeller University
1984 - 1986

Professor, Biochemistry Interdisciplinary Graduate Program, Molecular and Cellular Biochemistry Department, College of Arts and Sciences, Indiana University Bloomington

Adjunct Professor, Department of Physiology and Biophysics, School of Medicine, University of Washington (past)

Professor, Department of Physiology and Biophysics, School of Medicine, University of Washington (past)

Professor, Department of Anesthesiology & Pain Medicine, School of Medicine, University of Washington (past)

Professor, Neurobiology and Behavior Program, Graduate School, University of Washington (past)

Associate Professor, Biochemistry Interdisciplinary Graduate Program, Molecular and Cellular Biochemistry Department, College of Arts and Sciences, Indiana University Bloomington

Postdoctoral Fellow, Program in Neuroscience, College of Arts and Sciences, Indiana University Bloomington

Professor, Center for the Integrative Study of Animal Behavior, College of Arts and Sciences, Indiana University Bloomington

Communities
Biochemistry, Animal Science, Cellular Biochemistry, Neuroscience, Molecular Biochemistry, Psychology
Degrees
MD, Yale University, 1984
ScB, Brown University, Engineering, 1980
Keywords
drugs or drug abuse brain nervous system pharmacy & pharmacology neurotransmitters neurons recombinant dna anesthesiology neurobiology
Associations
American Society for Cell Biology
American Society of Anesthesiologists
International Cannabinoid Research Society
Society for Neuroscience