160 Publications (Page 1 of 7)
2020
Plaque-associated myeloid cells derive from resident microglia in an Alzheimer’s disease model
Reed-Geaghan, Erin G⋅Croxford, Andrew L⋅Becher, Burkhard and Landreth, Gary E
Journal of Experimental Medicine, vol. 217, (no. 4), 2020-04-06. | Journal Article
 
Three-dimensional nanoscopy of whole cells and tissues with in situ point spread function retrieval
Xu, Fan⋅Xu, Fan⋅Xu, Fan⋅Xu, Fan⋅Xu, Fan⋅Ma, Donghan⋅⋅⋅⋅⋅MacPherson, Kathryn P⋅MacPherson, Kathryn P⋅MacPherson, Kathryn P⋅MacPherson, Kathryn P⋅MacPherson, Kathryn P⋅Liu, Sheng⋅Liu, Sheng⋅Liu, Sheng⋅Liu, Sheng⋅Liu, Sheng⋅Bu, Ye⋅Wang, Yu⋅Wang, Yu⋅Wang, Yu⋅Wang, Yu⋅Wang, Yu⋅Tang, Yu⋅Tang, Yu⋅Tang, Yu⋅Tang, Yu⋅Tang, Yu⋅Bi, Cheng⋅Bi, Cheng⋅Bi, Cheng⋅Bi, Cheng⋅Bi, Cheng⋅Kwok, Tim⋅Kwok, Tim⋅Kwok, Tim⋅Kwok, Tim⋅Kwok, Tim⋅Chubykin, Alexander A⋅Chubykin, Alexander A⋅Chubykin, Alexander A⋅Chubykin, Alexander A⋅Chubykin, Alexander A⋅Yin, Peng⋅Yin, Peng⋅Yin, Peng⋅Yin, Peng⋅Yin, Peng⋅Calve, Sarah⋅Calve, Sarah⋅Calve, Sarah⋅Calve, Sarah⋅Calve, Sarah⋅Landreth, Gary E⋅Landreth, Gary E⋅Landreth, Gary E⋅Landreth, Gary E⋅Landreth, Gary E⋅Huang, Fang⋅Huang, Fang⋅Huang, Fang⋅Huang, Fang and Huang, Fang
Nature methods, vol. 17, (no. 5), pp. 540, 2020-May. | Journal Article
2019
PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux
Zhou, Ye⋅Zhou, Ye⋅Miles, Joshua R⋅Miles, Joshua R⋅Tavori, Hagai⋅Tavori, Hagai⋅Lin, Min⋅Lin, Min⋅Khoshbouei, Habibeh⋅Khoshbouei, Habibeh⋅Borchelt, David R⋅Borchelt, David R⋅Bazick, Hannah⋅Bazick, Hannah⋅Landreth, Gary E⋅Landreth, Gary E⋅Lee, Sooyeon⋅Lee, Sooyeon⋅Fazio, Sergio⋅Fazio, Sergio⋅Notterpek, Lucia and Notterpek, Lucia
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 39, (no. 27), pp. 5418, 2019-Jul-03. | Journal Article
2018
Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections.
Mlodzianoski, Michael J⋅Mlodzianoski, Michael J⋅Mlodzianoski, Michael J⋅Cheng-Hathaway, Paul J⋅Cheng-Hathaway, Paul J⋅Cheng-Hathaway, Paul J⋅Bemiller, Shane M⋅Bemiller, Shane M⋅Bemiller, Shane M⋅McCray, Tyler J⋅McCray, Tyler J⋅McCray, Tyler J⋅Liu, Sheng⋅Liu, Sheng⋅Liu, Sheng⋅Miller, David A⋅Miller, David A⋅Miller, David A⋅Lamb, Bruce T⋅Lamb, Bruce T⋅Lamb, Bruce T⋅Landreth, Gary E⋅Landreth, Gary E⋅Landreth, Gary E⋅Huang, Fang⋅Huang, Fang and Huang, Fang
Nature methods, vol. 15, (no. 8), pp. 583-586, August 2018. | Journal Article
 
ERK/MAPK signaling and autism spectrum disorders.
Vithayathil, Joseph⋅Pucilowska, Joanna and Landreth, Gary E
Progress in brain research, vol. 241, pp. 63-112, 2018. | Journal Article
 
Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer’s disease
Casali, Brad T⋅Reed-Geaghan, Erin G and Landreth, Gary E
Journal of Neuroinflammation, vol. 15, (no. 1), pp. 11, 2018-12-00. | Journal Article
 
Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation.
Moutinho, Miguel⋅Codocedo, Juan F⋅Puntambekar, Shweta S and Landreth, Gary E
Annual review of pharmacology and toxicology, September 12, 2018. | Journal Article
 
Pharmacological Inhibition of ERK Signaling Rescues Pathophysiology and Behavioral Phenotype Associated with 16p11.2 Chromosomal Deletion in Mice
Pucilowska, Joanna⋅Vithayathil, Joseph⋅Pagani, Marco⋅Kelly, Caitlin⋅Karlo, J Colleen⋅Robol, Camilla⋅Morella, Ilaria⋅Gozzi, Alessandro⋅Brambilla, Riccardo and Landreth, Gary E
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 38, (no. 30), pp. 6652, 2018-07-25. | Journal Article
 
The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.
Cheng-Hathaway, Paul J⋅Cheng-Hathaway, Paul J⋅Cheng-Hathaway, Paul J⋅Reed-Geaghan, Erin G⋅Reed-Geaghan, Erin G⋅Reed-Geaghan, Erin G⋅Jay, Taylor R⋅Jay, Taylor R⋅Jay, Taylor R⋅Casali, Brad T⋅Casali, Brad T⋅Casali, Brad T⋅Bemiller, Shane M⋅Bemiller, Shane M⋅Bemiller, Shane M⋅Puntambekar, Shweta S⋅Puntambekar, Shweta S⋅Puntambekar, Shweta S⋅von Saucken, Victoria E⋅von Saucken, Victoria E⋅von Saucken, Victoria E⋅Williams, Roxanne Y⋅Williams, Roxanne Y⋅Williams, Roxanne Y⋅Karlo, J. Colleen⋅Karlo, J Colleen⋅Karlo, J. Colleen⋅Moutinho, Miguel⋅Moutinho, Miguel⋅Moutinho, Miguel⋅Xu, Guixiang⋅Xu, Guixiang⋅Xu, Guixiang⋅Ransohoff, Richard M⋅Ransohoff, Richard M⋅Ransohoff, Richard M⋅Lamb, Bruce T⋅Lamb, Bruce T⋅Lamb, Bruce T⋅Landreth, Gary E⋅Landreth, Gary E and Landreth, Gary E
Molecular neurodegeneration, vol. 13, (no. 1), pp. 29, June 1, 2018. | Journal Article
2017
Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease
Mast, Natalia⋅Mast, Natalia⋅Saadane, Aicha⋅Saadane, Aicha⋅Valencia-Olvera, Ana⋅Valencia-Olvera, Ana⋅Constans, James⋅Constans, James⋅Maxfield, Erin⋅Maxfield, Erin⋅Arakawa, Hiroyuki⋅Arakawa, Hiroyuki⋅Li, Young⋅Li, Young⋅Landreth, Gary⋅Landreth, Gary⋅Pikuleva, Irina A and Pikuleva, Irina A
Neuropharmacology, vol. 123, pp. 476, 2017-09-01. | Journal Article
 
Chronic impairment of ERK signaling in glutamatergic neurons of the forebrain does not affect spatial memory retention and LTP in the same manner as acute blockade of the ERK pathway
Vithayathil, Joseph⋅Pucilowska, Joanna⋅Friel, David and Landreth, Gary E
Hippocampus, vol. 27, (no. 12), pp. 1249, December 2017. | Journal Article
 
Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease.
Jay, Taylor R⋅Jay, Taylor R.⋅Hirsch, Anna M.⋅Hirsch, Anna M⋅Broihier, Margaret L⋅Broihier, Margaret L.⋅Miller, Crystal M.⋅Miller, Crystal M⋅Neilson, Lee E⋅Neilson, Lee E.⋅Ransohoff, Richard M⋅Ransohoff, Richard M.⋅Lamb, Bruce T.⋅Lamb, Bruce T⋅Landreth, Gary E. and Landreth, Gary E
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 37, (no. 3), pp. 637-647, January 18, 2017. | Journal Article
 
Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system
Garcia-Mesa, Yoelvis⋅Garcia-Mesa, Yoelvis⋅Jay, Taylor⋅Jay, Taylor⋅Checkley, Mary⋅Checkley, Mary⋅Luttge, Benjamin⋅Luttge, Benjamin⋅Dobrowolski, Curtis⋅Dobrowolski, Curtis⋅Valadkhan, Saba⋅Valadkhan, Saba⋅Landreth, Gary⋅Landreth, Gary⋅Karn, Jonathan⋅Karn, Jonathan⋅Alvarez-Carbonell, David and Alvarez-Carbonell, David
Journal of NeuroVirology, vol. 23, (no. 1), pp. 66, 20170200. | Journal Article
 
Psychosocial stress on neuroinflammation and cognitive dysfunctions in Alzheimer's disease: the emerging role for microglia?
Piirainen, Sami⋅Youssef, Andrew⋅Song, Cai⋅Kalueff, Allan V⋅Landreth, Gary E⋅Malm, Tarja and Tian, Li
Neuroscience and Biobehavioral Reviews, vol. 77, pp. 164, June 2017. | Journal Article
 
Therapeutic potential of nuclear receptor agonists in Alzheimer’s disease
Moutinho, Miguel and Landreth, Gary E
Journal of Lipid Research, vol. 58, (no. 10), pp. 1949, 2017-10-00. | Journal Article
 
TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy
Bemiller, Shane M⋅Bemiller, Shane M⋅McCray, Tyler J⋅McCray, Tyler J⋅Allan, Kevin⋅Allan, Kevin⋅Formica, Shane V⋅Formica, Shane V⋅Xu, Guixiang⋅Xu, Guixiang⋅Wilson, Gina⋅Wilson, Gina⋅Kokiko-Cochran, Olga N⋅Kokiko-Cochran, Olga N⋅Crish, Samuel D⋅Crish, Samuel D⋅Lasagna-Reeves, Cristian A⋅Lasagna-Reeves, Cristian A⋅Ransohoff, Richard M⋅Ransohoff, Richard M⋅Landreth, Gary E⋅Landreth, Gary E⋅Lamb, Bruce T and Lamb, Bruce T
Molecular neurodegeneration, vol. 12, (no. 1), pp. 74, 2017-10-16. | Journal Article
 
TREM2 in Neurodegenerative Diseases
Jay, Taylor R⋅von Saucken, Victoria E and Landreth, Gary E
Molecular Neurodegeneration, vol. 12, 2017. | Journal Article
2016
ABCA1 is Necessary for Bexarotene-Mediated Clearance of Soluble Amyloid Beta from the Hippocampus of APP/PS1 Mice.
Corona, Angela W⋅Kodoma, Nathan⋅Casali, Brad T and Landreth, Gary E
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, vol. 11, (no. 1), pp. 61-72, March 2016. | Journal Article
 
ADVANCING THERAPEUTICS FOR NEUROINFLAMMATION IN ALZHEIMER'S DISEASE: CLINICAL DEVELOPMENT CONSIDERATIONS
Margolin, Richard⋅Schneider, Lon⋅Cutter, Gary⋅Breitner, John⋅Doody, Rachelle⋅Landreth, Gary and Chain, Daniel
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, vol. 12, (no. 7), pp. P822, 2016. | Journal Article
 
A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects.
Ghosal, Kaushik⋅Haag, Michael⋅Verghese, Philip B⋅West, Tim⋅Veenstra, Tim⋅Braunstein, Joel B⋅Bateman, Randall J⋅Holtzman, David M and Landreth, Gary E
Alzheimer's & dementia (New York, N. Y.), vol. 2, (no. 2), pp. 110-120, June 2016. | Journal Article
 
Bexarotene targets autophagy and is protective against thromboembolic stroke in aged mice with tauopathy
Huuskonen, Mikko T⋅Huuskonen, Mikko T⋅Huuskonen, Mikko⋅Huuskonen, Mikko T⋅Loppi, Sanna⋅Loppi, Sanna⋅Loppi, Sanna⋅Loppi, Sanna⋅Dhungana, Hiramani⋅Dhungana, Hiramani⋅Dhungana, Hiramani⋅Dhungana, Hiramani⋅Keksa-goldsteine, Velta⋅Keksa-goldsteine, Velta⋅Keksa-goldsteine, Velta⋅Keksa-goldsteine, Velta⋅Lemarchant, Sighild⋅Lemarchant, Sighild⋅Lemarchant, Sighild⋅Lemarchant, Sighild⋅Korhonen, Paula⋅Korhonen, Paula⋅Korhonen, Paula⋅Korhonen, Paula⋅Wojciechowski, Sara⋅Wojciechowski, Sara⋅Wojciechowski, Sara⋅Wojciechowski, Sara⋅Pollari, Eveliina⋅Pollari, Eveliina⋅Pollari, Eveliina⋅Pollari, Eveliina⋅Valonen, Piia⋅Valonen, Piia⋅Valonen, Piia⋅Valonen, Piia⋅Koponen, Juho⋅Koponen, Juho⋅Koponen, Juho⋅Koponen, Juho⋅Takashima, Akihiko⋅Takashima, Akihiko⋅Takashima, Akihiko⋅Takashima, Akihiko⋅Landreth, Gary⋅Landreth, Gary⋅Landreth, Gary⋅Landreth, Gary⋅Goldsteins, Gundars⋅Goldsteins, Gundars⋅Goldsteins, Gundars⋅Goldsteins, Gundars⋅Malm, Tarja⋅Malm, Tarja⋅Malm, Tarja⋅Malm, Tarja⋅Koistinaho, Jari⋅Koistinaho, Jari⋅Koistinaho, Jari⋅Koistinaho, Jari⋅Kanninen, Katja M⋅Kanninen, Katja M⋅Kanninen, Katja and Kanninen, Katja M
Scientific Reports (Nature Publisher Group), vol. 6, pp. 33176, Sep 2016. | Journal Article
 
Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease.
Jay, Taylor R⋅Hirsch, Anna M⋅Broihier, Margaret L⋅Miller, Crystal M⋅Neilson, Lee E⋅Ransohoff, Richard M⋅Lamb, Bruce T and Landreth, Gary E
The Journal of neuroscience : the official journal of the Society for Neuroscience, December 9, 2016. | Journal Article
 
Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system.
Garcia-Mesa, Yoelvis⋅Jay, Taylor R⋅Checkley, Mary Ann⋅Luttge, Benjamin⋅Dobrowolski, Curtis⋅Valadkhan, Saba⋅Landreth, Gary E⋅Karn, Jonathan and Alvarez-Carbonell, David
Journal of neurovirology, November 21, 2016. | Journal Article
 
LXR Regulation of Brain Cholesterol: From Development to Disease
Courtney, Rebecca and Landreth, Gary
Trends in Endocrinology & Metabolism, vol. 27, (no. 6), pp. 414, 2016. | Journal Article
 
Simvastatin inhibits protein isoprenylation in the brain
Ostrowski, Stephen M⋅Ostrowski, Stephen⋅Johnson, Kachael⋅Johnson, Kachael⋅Siefert, Matthew⋅Siefert, Matthew⋅Shank, Sam⋅Shank, Sam⋅Sironi, Luigi⋅Sironi, Luigi⋅Wolozin, Benjamin⋅Wolozin, Benjamin⋅Landreth, Gary E⋅Landreth, Gary⋅Ziady, Assem and Ziady, Assem G
Neuroscience, vol. 329, pp. 274, 2016. | Journal Article