Dr. Landreth’s work over the past 20 years has focused the principal genetic risk factors for Alzheimer’s disease. The laboratory has focused on the biology of ApoE, its role in amyloid homeostasis and the regulation of its expression by nuclear receptors. The laboratory has also investigated inflammatory mechanisms in Alzheimer’s disease and the biology of microglia.  Recent work has examined the mechanisms through which TREM2 influences disease pathogenesis. The laboratory maintains a focus on drug development for CNS disorders, including Alzheimer’s disease.

The Landreth lab investigates the roles of genetic risk factors in Alzheimer’s disease pathogenesis and employs state of the art genetic models to dissect the underlying disease mechanisms.

We are investigating the microglial gene, TREM2, which confers greatly elevated risk for the disease.

We are examining how disease affects microglia glucose utilization and gene expression and, in turn, how these cells influence neuronal activity and metabolism.

Subject Area:

  • Neuroscience


  • Neurodegenerative Disorders Research
Neuroscience, Human Anatomy, Cell Biology
PhD, University of Michigan, 1977
BA, University of Kansas, 1972