160 Publications (Page 2 of 7)
2016
THE R47H TREM2 VARIANT MODIFIES ALZHEIMER'S DISEASE PATHOLOGY AND NEUROINFLAMMATION IN A NOVEL KNOCK-IN MOUSE MODEL
Cheng-Hathaway, Paul⋅Cheng-Hathaway, Paul⋅Jay, Taylor⋅Jay, Taylor⋅Reed, Erin⋅Reed, Erin⋅Bemiller, Shane⋅Bemiller, Shane⋅Puntambekar, Shweta⋅Puntambekar, Shweta⋅Xu, Guixiang⋅Xu, Guixiang⋅Carlo, Colleen⋅Carlo, Colleen⋅Ransohoff, Richard⋅Ransohoff, Richard⋅Landreth, Gary⋅Landreth, Gary⋅Lamb, Bruce and Lamb, Bruce
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, vol. 12, (no. 7), pp. P243, 2016. | Journal Article
 
Trem2 deficiency is protective early but detrimental late in disease progression in an amyloid mouse model of Alzheimer's disease
Jay, Taylor⋅Hirsch, Anna⋅Broihier, Margaret and Landreth, Gary
Neurobiology of Aging, vol. 39, pp. S17, 2016. | Journal Article
2015
Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation
Malm, Tarja⋅Mariani, Monica⋅Donovan, Lauren J⋅Neilson, Lee and Landreth, Gary E
Journal of neuroinflammation, vol. 12, (no. 1), pp. 7, 2015-Jan-16. | Journal Article
 
Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice.
Skerrett, Rebecca⋅Pellegrino, Mateus P⋅Casali, Brad T⋅Taraboanta, Laura and Landreth, Gary E
The Journal of biological chemistry, vol. 290, (no. 35), pp. 21591-21602, August 28, 2015. | Journal Article
 
Dentate Gyrus Development Requires ERK Activity to Maintain Progenitor Population and MAPK Pathway Feedback Regulation.
Vithayathil, Joseph⋅Pucilowska, Joanna⋅Goodnough, L Henry⋅Atit, Radhika P and Landreth, Gary E
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 35, (no. 17), pp. 6836-6848, April 29, 2015. | Journal Article
 
ERK2 Alone Drives Inflammatory Pain But Cooperates with ERK1 in Sensory Neuron Survival.
O'Brien, Daniel E⋅Alter, Benedict J⋅Satomoto, Maiko⋅Morgan, Clinton D⋅Davidson, Steve⋅Vogt, Sherri K⋅Norman, Megan E⋅Gereau, Graydon B⋅Demaro, Joseph A⋅Landreth, Gary E⋅Golden, Judith P and Gereau, Robert W
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 35, (no. 25), pp. 9491-9507, June 24, 2015. | Journal Article
 
ERK Signaling Is Essential for Macrophage Development.
Richardson, Edward T⋅Richardson, Edward T⋅Richardson, Edward T⋅Shukla, Supriya⋅Shukla, Supriya⋅Shukla, Supriya⋅Nagy, Nancy⋅Nagy, Nancy⋅Nagy, Nancy⋅Boom, W H⋅Boom, W H⋅Boom, W Henry⋅Beck, Rose C⋅Beck, Rose C⋅Beck, Rose C⋅Zhou, Lan⋅Zhou, Lan⋅Zhou, Lan⋅Landreth, Gary E⋅Landreth, Gary E⋅Landreth, Gary E⋅Harding, Clifford V⋅Harding, Clifford V and Harding, Clifford V
PloS one, vol. 10, (no. 10), pp. e0140064, 2015. | Journal Article
 
Lipidated APOE has effects on cognitive function that are independent of amyloid-β pathology
Corona, Angela and Landreth, Gary
Brain : a journal of neurology, vol. 138, (no. Pt 12), pp. 3472, 2015-Dec. | Journal Article
 
Muscle-Derived Extracellular Signal-Regulated Kinases 1 and 2 Are Required for the Maintenance of Adult Myofibers and Their Neuromuscular Junctions
Seaberg, Bonnie⋅Seaberg, Bonnie⋅Henslee, Gabrielle⋅Henslee, Gabrielle⋅Wang, Shuo⋅Wang, Shuo⋅Paez-Colasante, Ximena⋅Paez-Colasante, Ximena⋅Landreth, Gary E⋅Landreth, Gary E⋅Rimer, Mendell and Rimer, Mendell
Molecular and cellular biology, vol. 35, (no. 7), pp. 1253, 2015-Apr. | Journal Article
 
Neuroinflammation in Alzheimer's disease.
Heneka, Michael T⋅Heneka, Michael T.⋅Carson, Monica J.⋅Carson, Monica J⋅El Khoury, Joseph⋅El Khoury, Joseph⋅Landreth, Gary E⋅Landreth, Gary E.⋅Brosseron, Frederic⋅Brosseron, Frederic⋅Feinstein, Douglas L⋅Feinstein, Douglas L.⋅Jacobs, Andreas H.⋅Jacobs, Andreas H⋅Wyss-Coray, Tony⋅Wyss Coray, Tony⋅Vitorica, Javier⋅Vitorica, Javier⋅Ransohoff, Richard M.⋅Ransohoff, Richard M⋅Herrup, Karl⋅al.⋅Frautschy, Sally A⋅Finsen, Bente⋅Brown, Guy C⋅Verkhratsky, Alexei⋅Yamanaka, Koji⋅Koistinaho, Jari⋅Latz, Eicke⋅Halle, Annett⋅Petzold, Gabor C⋅Town, Terrence⋅Morgan, Dave⋅Shinohara, Mari L⋅Perry, V Hugh⋅Holmes, Clive⋅Bazan, Nicolas G⋅Brooks, David J⋅Hunot, Stéphane⋅Joseph, Bertrand⋅Deigendesch, Nikolaus⋅Garaschuk, Olga⋅Boddeke, Erik⋅Dinarello, Charles A⋅Breitner, John C⋅Cole, Greg M⋅Golenbock, Douglas T and Kummer, Markus P
The Lancet. Neurology, vol. 14, (no. 4), pp. 388-405, April 2015. | Journal Article
 
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
Savage, Julie C⋅Jay, Taylor⋅Goduni, Elanda⋅Quigley, Caitlin⋅Mariani, Monica M⋅Malm, Tarja⋅Ransohoff, Richard M⋅Lamb, Bruce T and Landreth, Gary E
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 35, (no. 16), pp. 6532-6543, April 22, 2015. | Journal Article
 
Omega-3 Fatty Acids Augment the Actions of Nuclear Receptor Agonists in a Mouse Model of Alzheimer's Disease.
Casali, Brad T⋅Corona, Angela W⋅Mariani, Monica M⋅Karlo, J Colleen⋅Ghosal, Kaushik and Landreth, Gary E
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 35, (no. 24), pp. 9173-9181, June 17, 2015. | Journal Article
 
The 16p11.2 Deletion Mouse Model of Autism Exhibits Altered Cortical Progenitor Proliferation and Brain Cytoarchitecture Linked to the ERK MAPK Pathway
Pucilowska, Joanna⋅Vithayathil, Joseph⋅Tavares, Emmanuel J⋅Kelly, Caitlin⋅Karlo, J Colleen and Landreth, Gary E
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 35, (no. 7), pp. 3200, 2015-Feb-18. | Journal Article
 
The evolving biology of microglia in Alzheimer's disease
Malm, Tarja M⋅Malm, Tarja M⋅Jay, Taylor R⋅Jay, Taylor R⋅Landreth, Gary E and Landreth, Gary E
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, vol. 12, (no. 1), pp. 93, 2015-Jan. | Journal Article
 
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
Jay, Taylor R⋅Miller, Crystal M⋅Cheng, Paul J⋅Graham, Leah C⋅Bemiller, Shane⋅Broihier, Margaret L⋅Xu, Guixiang⋅Margevicius, Daniel⋅Karlo, J Colleen⋅Sousa, Gregory L⋅Cotleur, Anne C⋅Butovsky, Oleg⋅Bekris, Lynn⋅Staugaitis, Susan M⋅Leverenz, James B⋅Pimplikar, Sanjay W⋅Landreth, Gary E⋅Howell, Gareth R⋅Ransohoff, Richard M and Lamb, Bruce T
The Journal of experimental medicine, vol. 212, (no. 3), pp. 287-295, March 9, 2015. | Journal Article
2014
Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway
Lee, Sungho⋅Lee, Sungho⋅Xu, Guixiang⋅Xu, Guixiang⋅Jay, Taylor R⋅Jay, Taylor R⋅Bhatta, Sabina⋅Bhatta, Sabina⋅Kim, Ki-Wook⋅Kim, Ki-Wook⋅Jung, Steffen⋅Jung, Steffen⋅Landreth, Gary E⋅Landreth, Gary E⋅Ransohoff, Richard M⋅Ransohoff, Richard M⋅Lamb, Bruce T and Lamb, Bruce T
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 34, (no. 37), pp. 12546, 2014-Sep-10. | Journal Article
 
THE ROLE OF TREM2 EXPRESSION ON MYELOID CELLS IN ALZHEIMER'S DISEASE
Lamb, Bruce⋅Lamb, Bruce⋅Miller, Crystal⋅Miller, Crystal⋅Jay, Taylor⋅Jay, Taylor⋅Graham, Leah⋅Graham, Leah⋅Bemiller, Shane⋅Bemiller, Shane⋅Xu, Guixiang⋅Xu, Guixiang⋅Margevicius, Daniel⋅Margevicius, Daniel⋅Karlo, Colleen⋅Karlo, Colleen⋅Sousa, Gregory⋅Sousa, Gregory⋅Cotleur, Bunny⋅Cotleur, Bunny⋅Bekris, Lynn⋅Bekris, Lynn⋅Staugaitis, Susan⋅Staugaitis, Susan⋅Leverenz, James⋅Leverenz, James⋅Pimplikar, Sanjay⋅Pimplikar, Sanjay⋅Landreth, Gary⋅Landreth, Gary⋅Howell, Gareth⋅Howell, Gareth⋅Ransohoff, Richard and Ransohoff, Richard
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, vol. 10, (no. 4), pp. P877, 2014. | Journal Article
2013
Evidence for impaired amyloid [beta] clearance in Alzheimer's disease
Skerrett, Rebecca⋅Savage, Julie⋅Wildsmith, Kristin⋅Holley, Monica and Landreth, Gary
Alzheimer's Research & Therapy, vol. 5, (no. 33), 20130712. | Journal Article
 
Evidence for impaired amyloid β clearance in Alzheimer's disease
Wildsmith, Kristin R⋅Wildsmith, Kristin R⋅Holley, Monica⋅Holley, Monica⋅Savage, Julie C⋅Savage, Julie C⋅Skerrett, Rebecca⋅Skerrett, Rebecca⋅Landreth, Gary E and Landreth, Gary E
Alzheimer's research & therapy, vol. 5, (no. 4), pp. 33, 2013-00-00. | Journal Article
 
In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis
Ulrich, Jason D⋅Ulrich, Jason D⋅Burchett, Jack M⋅Burchett, Jack M⋅Restivo, Jessica L⋅Restivo, Jessica L⋅Schuler, Dorothy R⋅Schuler, Dorothy R⋅Verghese, Philip B⋅Verghese, Philip B⋅Mahan, Thomas E⋅Mahan, Thomas E⋅Landreth, Gary E⋅Landreth, Gary E⋅Castellano, Joseph M⋅Castellano, Joseph M⋅Jiang, Hong⋅Jiang, Hong⋅Cirrito, John R⋅Cirrito, John R⋅Holtzman, David M and Holtzman, David M
Molecular neurodegeneration, vol. 8, (no. 1), pp. 13, 2013-Apr-19. | Journal Article
 
Response to comments on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models"
Landreth, Gary E⋅Landreth, Gary E⋅Cramer, Paige E⋅Cramer, Paige E⋅Lakner, Mitchell M⋅Lakner, Mitchell M⋅Cirrito, John R⋅Cirrito, John R⋅Wesson, Daniel W⋅Wesson, Daniel W⋅Brunden, Kurt R⋅Brunden, Kurt R⋅Wilson, Donald A and Wilson, Donald A
Science (New York, N.Y.), vol. 340, (no. 6135), pp. g, 2013-May-24. | Journal Article
 
The PPARγ agonist pioglitazone crosses the blood–brain barrier and reduces tumor growth in a human xenograft model
Grommes, Christian⋅Grommes, Christian⋅Karlo, J C⋅Karlo, J⋅Caprariello, Andrew⋅Caprariello, Andrew⋅Blankenship, D'Arbra⋅Blankenship, D’Arbra⋅Dechant, Anne⋅DeChant, Anne⋅Landreth, Gary E and Landreth, Gary
Cancer Chemotherapy and Pharmacology, vol. 71, (no. 4), pp. 936, 20130400. | Journal Article
2012
44 ApoE-directed therapeutics for the treatment of Alzheimer's disease
Landreth, Gary⋅Cramer, P⋅Wesson, D⋅Cirrito, J⋅Brunden, K and Wilson, D
Neurobiology of Aging, vol. 33, pp. S19, 2012. | Journal Article
 
ApoE-Directed Therapeutics Rapidly Clear ß-Amyloid and Reverse Deficits in AD Mouse Models
Cramer, Paige⋅Cirrito, John⋅Wesson, Daniel⋅Lee, C.⋅Karlo, J.⋅Zinn, Adriana⋅Casali, Brad⋅Restivo, Jessica⋅Goebel, Whitney⋅James, Michael⋅Brunden, Kurt⋅Wilson, Donald and Landreth, Gary
Science, vol. 335, (no. 6075), pp. 1506, 20120323. | Journal Article
 
ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models
Cramer, Paige E⋅Cramer, Paige E⋅Cirrito, John R⋅Cirrito, John R⋅Wesson, Daniel W⋅Wesson, Daniel W⋅Lee, C Y⋅Lee, C Y Daniel⋅Karlo, J Colleen⋅Karlo, J C⋅Zinn, Adriana E⋅Zinn, Adriana E⋅Casali, Brad T⋅Casali, Brad T⋅Restivo, Jessica L⋅Restivo, Jessica L⋅Goebel, Whitney D⋅Goebel, Whitney D⋅James, Michael J⋅James, Michael J⋅Brunden, Kurt R⋅Brunden, Kurt R⋅Wilson, Donald A⋅Wilson, Donald A⋅Landreth, Gary E and Landreth, Gary E
Science (New York, N.Y.), vol. 335, (no. 6075), pp. 1506, 2012-Mar-23. | Journal Article