131 Publications (Page 2 of 6)
2017
Abstract LB-119: Targeting DNA-PK via small molecule inhibitors of the Ku-DNA interaction
Turchi, John J⋅Gavande, Navnath⋅VanderVere-Carozza, Pamela⋅Vernon, Tyler and Pawelczak, Katherine
Cancer Research, vol. 77, (no. 13 Supplement), pp. LB-119, 2017-07-01. | Journal Article
 
Design and Structure-Guided Development of Novel Inhibitors of the Xeroderma Pigmentosum Group A (XPA) Protein–DNA Interaction
Gavande, Navnath S⋅VanderVere-Carozza, Pamela⋅Mishra, Akaash K⋅Vernon, Tyler L⋅Pawelczak, Katherine S and Turchi, John J
Journal of Medicinal Chemistry, vol. 60, (no. 19), pp. 8070, 20171012. | Journal Article
 
Modulating DNA repair pathways to improve precision genome engineering.
Pawelczak, Katherine S⋅Gavande, Navnath S⋅VanderVere-Carozza, Pamela S and Turchi, John J
ACS chemical biology, December 6, 2017. | Journal Article
2016
DNA damage response (DDR) pathway engagement in cisplatin radiosensitization of non-small cell lung cancer.
Sears, Catherine R⋅Sears, Catherine R⋅Cooney, Sean A⋅Cooney, Sean A⋅Chin-Sinex, Helen⋅Chin-Sinex, Helen⋅Mendonca, Marc S⋅Mendonca, Marc S⋅Turchi, John J and Turchi, John J
DNA repair, vol. 40, pp. 35-46, April 2016. | Journal Article
 
DNA repair targeted therapy: The past or future of cancer treatment?
Gavande, Navnath S⋅VanderVere-Carozza, Pamela S⋅Hinshaw, Hilary D⋅Jalal, Shadia I⋅Sears, Catherine R⋅Pawelczak, Katherine S and Turchi, John J
Pharmacology & therapeutics, vol. 160, pp. 65-83, April 2016. | Journal Article
2015
Abstract C57: Discovery and development of replication protein A (RPA)-DNA interaction inhibitors for cancer chemotherapy
Gavande, Navnath⋅VanderVere-Carozza, Pamela S⋅Mishra, Akaash and Turchi, John J
Molecular Cancer Therapeutics, vol. 14, (no. 12 Supplement 2), pp. C57, 2015-12-00. | Journal Article
 
Abstract C58: Small molecule inhibitors targeting the interaction of xeroderma pigmentosum group A protein with cisplatin-damaged DNA
VanderVere-Carozza, Pamela S⋅Gavande, Navnath⋅Mishra, Akaash and Turchi, John J
Molecular Cancer Therapeutics, vol. 14, (no. 12 Supplement 2), pp. C58, 2015-12-00. | Journal Article
 
Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer.
Mishra, Akaash K⋅Dormi, Silvana S⋅Turchi, Alaina M⋅Woods, Derek S and Turchi, John J
Biochemical pharmacology, vol. 93, (no. 1), pp. 25-33, January 1, 2015. | Journal Article
 
Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit.
Woods, Derek S⋅Sears, Catherine R and Turchi, John J
PloS one, vol. 10, (no. 5), pp. e0127321, 2015. | Journal Article
2014
Exploring a structural protein-drug interactome for new therapeutics in lung cancer.
Peng, Xiaodong⋅Peng, Xiaodong⋅Peng, Xiaodong⋅Wang, Fang⋅Wang, Fang⋅Wang, Fang⋅Li, Liwei⋅Li, Liwei⋅Li, Liwei⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Xu, David⋅Xu, David⋅Xu, David⋅Wang, Bo⋅Wang, Bo⋅Wang, Bo⋅Sinn, Anthony A⋅Sinn, Anthony A⋅Sinn, Anthony A⋅Pollok, Karen E⋅Pollok, Karen E⋅Pollok, Karen E⋅Sandusky, George E⋅Sandusky, George E⋅Sandusky, George E⋅Li, Lang⋅Li, Lang⋅Li, Lang⋅Turchi, John J⋅Turchi, John J⋅Turchi, John J⋅Jalal, Shadia I⋅Jalal, Shadia I⋅Jalal, Shadia I⋅Meroueh, Samy O⋅Meroueh, Samy O and Meroueh, Samy
Molecular bioSystems, vol. 10, (no. 3), pp. 581-91, 2014/Mar/4. | Journal Article
 
Testing the metal of ERCC2 in predicting the response to platinum-based therapy.
Turchi, John J⋅Woods, Derek S and VanderVere-Carozza, Pamela
Cancer discovery, vol. 4, (no. 10), pp. 1118-1119, October 2014. | Journal Article
 
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer.
Fang, Fang⋅Munck, Joanne⋅Tang, Jessica⋅Taverna, Pietro⋅Wang, Yinu⋅Miller, David F B⋅Pilrose, Jay⋅Choy, Gavin⋅Azab, Mohammad⋅Pawelczak, Katherine S⋅VanderVere-Carozza, Pamela⋅Wagner, Michael⋅Lyons, John⋅Matei, Daniela⋅Turchi, John J and Nephew, Kenneth P
Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 20, (no. 24), pp. 6504-6516, December 15, 2014. | Journal Article
 
Unraveling the complexities of DNA-dependent protein kinase autophosphorylation.
Neal, Jessica A⋅Sugiman-Marangos, Seiji⋅VanderVere-Carozza, Pamela⋅Wagner, Mike⋅Turchi, John⋅Lees Miller, Susan P⋅Junop, Murray S and Meek, Katheryn
Molecular and cellular biology, vol. 34, (no. 12), pp. 2162-75, 2014/Jun. | Journal Article
2013
Abstract 4623: The novel, small molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer
Tang, Jessica⋅Tang, Jessica⋅Fang, Fang⋅Fang, Fang⋅Wang, Yinu⋅Wang, Yinu⋅Taverna, Pietro⋅Taverna, Pietro⋅Miller, David F.B⋅Miller, David F.B⋅Choy, Gavin⋅Choy, Gavin⋅Azab, Mohammad⋅Azab, Mohammad⋅Matei, Daniela⋅Matei, Daniela⋅Pawelczak, Katherine S⋅Pawelczak, Katherine S⋅VanderVere-Carozza, Pamela⋅VanderVere-Carozza, Pamela⋅Wagner, Michael⋅Wagner, Michael⋅Turchi, John J⋅Turchi, John J⋅Nephew, Kenneth P and Nephew, Kenneth P
Cancer Research, vol. 73, (no. 8 Supplement), pp. 4623, 2013-04-15. | Journal Article
 
Chemotherapy induced DNA damage response: convergence of drugs and pathways.
Woods, Derek and Turchi, John J
Cancer biology & therapy, vol. 14, (no. 5), pp. 379-89, 2013/May. | Journal Article
 
Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer.
Yakubov, Bakhtiyor⋅Yakubov, Bakhtiyor⋅Chelladurai, Bhadrani⋅Chelladurai, Bhadrani⋅Schmitt, Jordan⋅Schmitt, Jordan⋅Emerson, Robert⋅Emerson, Robert⋅Turchi, John J⋅Turchi, John⋅Matei, Daniela and Matei, Daniela
Neoplasia (New York, N.Y.), vol. 15, (no. 6), pp. 609-19, 2013/Jun. | Journal Article
 
Extracellular Tissue Transglutaminase Activates Noncanonical NF-κB Signaling and Promotes Metastasis in Ovarian Cancer12
Yakubov, Bakhtiyor⋅Yakubov, Bakhtiyor⋅Chelladurai, Bhadrani⋅Chelladurai, Bhadrani⋅Schmitt, Jordan⋅Schmitt, Jordan⋅Emerson, Robert⋅Emerson, Robert⋅Turchi, John J⋅Turchi, John J⋅Matei, Daniela and Matei, Daniela
Neoplasia (New York, N.Y.), vol. 15, (no. 6), pp. 619, 2013-06-01. | Journal Article
 
Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma.
Xu, Jie⋅Zeng, Li-Fan⋅Shen, Weihua⋅Turchi, John J and Zhang, Z. F
Biochemical and biophysical research communications, vol. 439, (no. 4), pp. 586-90, 2013/Oct/4. | Journal Article
2012
Abstract 4753: Targeting nucleotide excision repair: Chemical synthetic lethality and biology-based combination therapy
Turchi, John J⋅Lee, Jiyoon⋅Hendricks, Jeremiah⋅Neher, Tracy M and Fitch, Richard W
Cancer Research, vol. 72, (no. 8 Supplement), pp. 4753, 2012-04-15. | Journal Article
 
Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways.
Sears, Catherine R and Turchi, John J
The Journal of biological chemistry, vol. 287, (no. 29), pp. 24263-72, 2012/Jul/13. | Journal Article
 
Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80.
Bennett, Sara M⋅Woods, Derek S⋅Pawelczak, Katherine S and Turchi, John J
International journal of biochemistry and molecular biology, vol. 3, (no. 1), pp. 36-45, 2012. | Journal Article
2011
Abstract 1551: Soluble tissue transglutaminase modulates cellular adhesion to matrix and peritoneal metastasis in ovarian cancer
Yakubov, Bakhtiyor⋅Yakubov, Bakhtiyor⋅Chelladurai, Bhadrani⋅Chelladurai, Bhadrani⋅Turchi, John⋅Turchi, John⋅Matei, Daniela E and Matei, Daniela E
Cancer Research, vol. 71, (no. 8 Supplement), pp. 1551, 2011-04-15. | Journal Article
 
Abstract 2320: In vivo characterization of small molecule inhibitors of replication protein A: Implications for cancer therapy
Neher, Tracy M⋅Neher, Tracy M⋅Bodenmiller, Diane M⋅Bodenmiller, Diane M⋅Turchi, John J⋅Turchi, John J⋅Jalal, Shadia I and Jalal, Shadia I
Cancer Research, vol. 71, (no. 8 Supplement), pp. 2320, 2011-04-15. | Journal Article
 
Coordination of DNA-PK Activation and Nuclease Processing of DNA Termini in NHEJ
Pawelczak, KS⋅Bennett, SM and Turchi, John J
Antioxidants and Redox Signaling, vol. 14, (no. 12), pp. 2531-2543, 2011. | Journal Article
 
Current advances in DNA repair: regulation of enzymes and pathways involved in maintaining genomic stability.
Neher, Tracy M and Turchi, John J
Antioxidants & redox signaling, vol. 14, (no. 12), pp. 2461-4, 2011/Jun/15. | Journal Article