138 Publications (Page 1 of 6)
2020
Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo
Miyagawa, KazuakiMiyagawa, KazuakiOhata, YasuhisaOhata, YasuhisaDelgado-Calle, JesusDelgado-Calle, JesusTeramachi, JumpeiTeramachi, JumpeiZhou, HuaZhou, HuaDempster, David DDempster, David DSubler, Mark ASubler, Mark AWindle, Jolene JWindle, Jolene JChirgwin, John MChirgwin, John MRoodman, G DavidRoodman, G DavidKurihara, Noriyoshi and Kurihara, Noriyoshi
JCI insight, vol. 5, (no. 6), 2020-Mar-26. | Journal Article
2019
Anti-Cancer Agents in Medicinal Chemistry: Meet Our Editorial Board Member
Chirgwin, John
Anti-Cancer Agents in Medicinal Chemistry, vol. 19, (no. 2), pp. 145, 20190000. | Journal Article
 
Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors
Marino, SilviaMarino, SilviaMarino, SilviaPetrusca, Daniela NicoletaPetrusca, Daniela NicoletaPetrusca, Daniela NicoletaSimpson, EdwardSimpson, EdwardSimpson, EdwardAnderson, Judith LAnderson, Judith LAnderson, Judith LXie, Xiang-QunXie, Xiang-QunXie, Xiang-QunLiu, YunlongLiu, YunlongLiu, YunlongChirgwin, JohnChirgwin, JohnChirgwin, JohnRoodman, G. DavidRoodman, G. David and Roodman, G. David
Blood, vol. 134, (no. Supplement_1), pp. 4391, 2019-11-13. | Journal Article
2018
PTHrP May Contribute to Cachexia Accompanying Multiple Myeloma Bone Disease
Suvannasankha, AttayaSuvannasankha, AttayaCrean, ColinCrean, ColinOchoa, Isaac CarreraOchoa, Isaac CarreraRoodman, G DavidRoodman, G DavidChirgwin, John and Chirgwin, John
Blood, vol. 132, (no. Supplement 1), pp. 4450, 2018-11-29. | Journal Article
 
Small molecules inhibit ex vivo tumor growth in bone.
Zhou, DonghuiZhou, DonghuiBum-Erdene, KhuchtumurBum-Erdene, KhuchtumurXu, DavidXu, DavidLiu, DegangLiu, DegangTompkins, DougTompkins, DougSulaiman, Rania SSulaiman, Rania SCorson, Timothy WCorson, Timothy WChirgwin, John MChirgwin, John MMeroueh, Samy O and Meroueh, Samy O
Bioorganic & medicinal chemistry, November 16, 2018. | Journal Article
 
The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis.
Lontos, KonstantinosLontos, KonstantinosAdamik, JurajAdamik, JurajTsagianni, AnastasiaTsagianni, AnastasiaGalson, Deborah LGalson, Deborah LChirgwin, John MChirgwin, John MSuvannasankha, Attaya and Suvannasankha, Attaya
Frontiers in endocrinology, vol. 9, pp. 322, 2018. | Journal Article
2017
Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis
Juárez, PatriciaJuárez, PatriciaJuárez, PatriciaFournier, Pierrick G JFournier, Pierrick G JFournier, Pierrick G JMohammad, Khalid SMohammad, Khalid SMohammad, Khalid SMcKenna, Ryan CMcKenna, Ryan CMcKenna, Ryan CDavis, Holly WDavis, Holly WDavis, Holly WPeng, Xiang HPeng, Xiang HPeng, Xiang HNiewolna, MariaNiewolna, MariaNiewolna, MariaMauviel, AlainMauviel, AlainMauviel, AlainChirgwin, John MChirgwin, John MChirgwin, John MGuise, Theresa AGuise, Theresa A and Guise, Theresa A
Oncotarget, vol. 8, (no. 49), pp. 86462, 2017-Oct-17. | Journal Article
2016
Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma.
Delgado Calle, JesusDelgado-Calle, JesusDelgado-Calle, JesusDelgado-Calle, JesusAnderson, JudithAnderson, JudithAnderson, JudithAnderson, JudithCregor, Meloney DCregor, Meloney DCregor, Meloney DCregor, Meloney DHiasa, MasahiroHiasa, MasahiroHiasa, MasahiroHiasa, MasahiroChirgwin, John MChirgwin, John MChirgwin, John MChirgwin, John MCarlesso, NadiaCarlesso, NadiaCarlesso, NadiaCarlesso, NadiaYoneda, ToshiyukiYoneda, ToshiyukiYoneda, ToshiyukiYoneda, ToshiyukiMohammad, Khalid SMohammad, Khalid SMohammad, Khalid SMohammad, Khalid SPlotkin, Lilian IPlotkin, Lilian IPlotkin, Lilian IPlotkin, Lilian IRoodman, G DavidRoodman, G DavidRoodman, G DavidRoodman, G DavidBellido, TeresitaBellido, TeresitaBellido, Teresita and Bellido, Teresita
Cancer research, vol. 76, (no. 5), pp. 1089-1100, March 1, 2016. | Journal Article
 
Cell adhesion molecule CD166 drives malignant progression and osteolytic disease in multiple myeloma.
Xu, LinlinXu, LinlinMohammad, Khalid SMohammad, Khalid SWu, HaoWu, HaoCrean, ColinCrean, ColinPoteat, BradleyPoteat, BradleyCheng, YinghuaCheng, YinghuaCardoso, Angelo ACardoso, Angelo AMarchal, Christophe CMachal, ChristopheHanenberg, HelmutHanenberg, HelmutAbonour, RafatAbonour, RafatKacena, Melissa AKacena, Melissa AChirgwin, John MChirgwin, JohnSuvannasankha, AttayaSuvannasankha, AttayaSrour, Edward F and Srour, Edward F
Cancer research, September 7, 2016. | Journal Article
 
Myeloma Cells Induce High Level of TAF12 Expression in Bone Marrow Stromal Cells, Resulting in Increased Osteoclastogenesis and Myeloma Cell Growth in Response to 1,25(OH)2D3
Ohata, YasuhisaOhata, YasuhisaChirgwin, John MChirgwin, John MWindle, Jolene JWindle, Jolene JRoodman, G. DavidRoodman, G. DavidKurihara, Noriyoshi and Kurihara, Noriyoshi
Blood, vol. 128, (no. 22), pp. 4421, 2016-12-02. | Journal Article
 
Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D
Suvannasankha, AttayaSuvannasankha, AttayaSuvannasankha, AttayaSuvannasankha, AttayaCrean, Colin DCrean, Colin DCrean, Colin DCrean, Colin DTompkins, Douglas RTompkins, Douglas RTompkins, Douglas RTompkins, Douglas RDelgado-Calle, JesusDelgado-Calle, JesusDelgado Calle, JesusDelgado-Calle, JesusBellido, Teresita MBellido, Teresita MBellido, Teresita MBellido, Teresita MRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidRoodman, G. DavidChirgwin, John MChirgwin, John MChirgwin, John M and Chirgwin, John M
Blood, vol. 128, (no. 22), pp. 4439, 2016-12-02. | Journal Article
2015
FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells.
Suvannasankha, AttayaTompkins, Douglas REdwards, Daniel FPetyaykina, Katarina VCrean, Colin DFournier, Pierrick GParker, Jamie MSandusky, George EIchikawa, ShojiImel, Erik A and Chirgwin, John M
Oncotarget, vol. 6, (no. 23), pp. 19647-19660, August 14, 2015. | Journal Article
 
The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone.
Fournier, Pierrick G JJuárez, PatriciaJiang, GuanglongClines, Gregory ANiewolna, MariaKim, Hun SooWalton, Holly WPeng, Xiang HongLiu, YunlongMohammad, Khalid SWells, Clark DChirgwin, John M and Guise, Theresa A
Cancer cell, vol. 27, (no. 6), pp. 809-821, June 8, 2015. | Journal Article
2014
Role of bone-anabolic agents in the treatment of breast cancer bone metastases.
Suvannasankha, Attaya and Chirgwin, John M
Breast cancer research : BCR, vol. 16, (no. 6), pp. 484, 2014. | Journal Article
 
TAF12 Enhances the Biological Reponses of Myeloma Cells to Low Concentrations of 1,25-(OH)2dvitamin D3
Kurihara, NoriyoshiKurihara, NoriyoshiKitagawa, YukikoKitagawa, YukikoInagaki, YujiInagaki, YujiWindle, Jolene JWindle, Jolene JChirgwin, John MChirgwin, John MRoodman, G. David and Roodman, G. David
Blood, vol. 124, (no. 21), pp. 2066, 2014-12-06. | Journal Article
 
Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis.
Siclari, Valerie AMohammad, Khalid STompkins, Douglas RDavis, HollyMcKenna, C RyanPeng, XianghongWessner, Lisa LNiewolna, MariaGuise, Theresa ASuvannasankha, Attaya and Chirgwin, John M
Breast cancer research : BCR, vol. 16, (no. 6), pp. 458, December 2, 2014. | Journal Article
2013
Neonatal Mouse Bone Supports Growth Of Primary Myeloma Cells Ex Vivo and Assessment Of Responses To Antimyeloma Drugs
Suvannasankha, AttayaSuvannasankha, AttayaSuvannasankha, AttayaTompkins, Douglas RTompkins, Douglas RTompkins, Douglas RPetyaykina, KaterynaPetyaykina, KaterynaPetyaykina, KaterynaCrean, Colin DCrean, Colin DCrean, Colin DCondon, Keith WCondon, Keith WCondon, Keith WDavid Roodman, G. DavidDavid Roodman, G. DavidDavid Roodman, G. DavidChirgwin, John MChirgwin, John M and Chirgwin, John M
Blood, vol. 122, (no. 21), pp. 1893, 2013-11-15. | Journal Article
 
Role Of CD166 In Multiple Myeloma Cell Homing To The Bone Marrow Microenvironment and Disease Progression
Xu, LinlinXu, LinlinXu, LinlinXu, LinlinXu, LinlinMachal, ChristopheMachal, ChristopheMachal, ChristopheMachal, ChristopheMachal, ChristopheWu, HaoWu, HaoWu, HaoWu, HaoWu, HaoPoteat, BradleyPoteat, BradleyPoteat, BradleyPoteat, BradleyPoteat, BradleyCrean, Colin DCrean, Colin DCrean, Colin DCrean, Colin DCrean, Colin DCardoso, Angelo ACardoso, Angelo ACardoso, Angelo ACardoso, Angelo ACardoso, Angelo AChirgwin, John MChirgwin, John MChirgwin, John MChirgwin, John MChirgwin, John MHanenberg, HelmutHanenberg, HelmutHanenberg, HelmutHanenberg, HelmutHanenberg, HelmutMohammad, Khalid SMohammad, Khalid SMohammad, Khalid SMohammad, Khalid SMohammad, Khalid SSuvannasankha, AttayaSuvannasankha, AttayaSuvannasankha, AttayaSuvannasankha, AttayaSuvannasankha, AttayaSrour, Edward FSrour, Edward FSrour, Edward FSrour, Edward F and Srour, Edward F
Blood, vol. 122, (no. 21), pp. 3102, 2013-11-15. | Journal Article
2012
Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Juárez, PatriciaMohammad, Khalid SYin, Juan JFournier, Pierrick GMcKenna, Ryan CDavis, Holly WPeng, Xiang HNiewolna, MariaJavelaud, DelphineChirgwin, John CMauviel, Alain and Guise, Theresa A
Cancer research, vol. 72, (no. 23), pp. 6247-56, 2012/Dec/1. | Journal Article
 
The Increased 1,25-(OH)2D3 Sensitivity of Myeloma Cells and Marrow Stromal Cells Enhances RANKL Production and Tumor Cell Growth
Teramachi, JumpeiTeramachi, JumpeiKurihara, NoriyoshiKurihara, NoriyoshiChirgwin, John MChirgwin, John MRoodman, G David and Roodman, G David
Blood, vol. 120, (no. 21), pp. 3946, 2012-11-16. | Journal Article
 
The stem cell niche as a pharmaceutical target for prevention of skeletal metastases.
Chirgwin, John C
Anti-cancer agents in medicinal chemistry, vol. 12, (no. 3), pp. 187-93, 2012/Mar. | Journal Article
2011
Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor.
Clines, GregoryMohammad, Khalid SGrunda, Jessica MClines, Katrina LNiewolna, MariaMcKenna, C RMcKibbin, Christopher RYanagisawa, MasashiSuva, Larry JChirgwin, John C and Guise, Theresa A
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 26, (no. 10), pp. 2523-36, 2011/Oct. | Journal Article
2010
Meeting report from the IX international meeting on cancer induced bone disease
Chirgwin, John MEdwards, Claire MPedersen, Elisabeth AShiozawa, YusukeTaichman, Russell SPark, Serk InMcCauley, Laurie KMatsumoto, Toshio and Abe, Masahiro
IBMS BoneKEy, vol. 7, (no. 1), pp. 46, 2010-01-00. | Journal Article
2009
Agents targeting prostate cancer bone metastasis.
Mohammad, Khalid SFournier, Pierrick GGuise, Theresa A and Chirgwin, John C
Anti-cancer agents in medicinal chemistry, vol. 9, (no. 10), pp. 1079-88, 2009/Dec. | Journal Article
 
Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.
Dunn, Lauren KMohammad, Khalid SFournier, Pierrick GMcKenna, C RDavis, Holly WNiewolna, MariaPeng, Xiang HChirgwin, John C and Guise, Theresa A
PloS one, vol. 4, (no. 9), pp. e6896, 2009. | Journal Article