138 Publications (Page 1 of 6)
2020
Osteoclast-derived IGF1 is required for pagetic lesion formation in vivo
Miyagawa, Kazuaki⋅Miyagawa, Kazuaki⋅Ohata, Yasuhisa⋅Ohata, Yasuhisa⋅Delgado-Calle, Jesus⋅Delgado-Calle, Jesus⋅Teramachi, Jumpei⋅Teramachi, Jumpei⋅Zhou, Hua⋅Zhou, Hua⋅Dempster, David D⋅Dempster, David D⋅Subler, Mark A⋅Subler, Mark A⋅Windle, Jolene J⋅Windle, Jolene J⋅Chirgwin, John M⋅Chirgwin, John M⋅Roodman, G David⋅Roodman, G David⋅Kurihara, Noriyoshi and Kurihara, Noriyoshi
JCI insight, vol. 5, (no. 6), 2020-Mar-26. | Journal Article
2019
Anti-Cancer Agents in Medicinal Chemistry: Meet Our Editorial Board Member
Chirgwin, John
Anti-Cancer Agents in Medicinal Chemistry, vol. 19, (no. 2), pp. 145, 20190000. | Journal Article
 
Targeting the p62-ZZ/N-End Rule Pathway in Multiple Myeloma Overcomes Proteasome Inhibitor-Resistance Via Induction of Necroptosis and Enhances the Bone Anabolic Effects of Proteasome Inhibitors
Marino, Silvia⋅Marino, Silvia⋅Marino, Silvia⋅Petrusca, Daniela Nicoleta⋅Petrusca, Daniela Nicoleta⋅Petrusca, Daniela Nicoleta⋅Simpson, Edward⋅Simpson, Edward⋅Simpson, Edward⋅Anderson, Judith L⋅Anderson, Judith L⋅Anderson, Judith L⋅Xie, Xiang-Qun⋅Xie, Xiang-Qun⋅Xie, Xiang-Qun⋅Liu, Yunlong⋅Liu, Yunlong⋅Liu, Yunlong⋅Chirgwin, John⋅Chirgwin, John⋅Chirgwin, John⋅Roodman, G. David⋅Roodman, G. David and Roodman, G. David
Blood, vol. 134, (no. Supplement_1), pp. 4391, 2019-11-13. | Journal Article
2018
PTHrP May Contribute to Cachexia Accompanying Multiple Myeloma Bone Disease
Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Crean, Colin⋅Crean, Colin⋅Ochoa, Isaac Carrera⋅Ochoa, Isaac Carrera⋅Roodman, G David⋅Roodman, G David⋅Chirgwin, John and Chirgwin, John
Blood, vol. 132, (no. Supplement 1), pp. 4450, 2018-11-29. | Journal Article
 
Small molecules inhibit ex vivo tumor growth in bone.
Zhou, Donghui⋅Zhou, Donghui⋅Bum-Erdene, Khuchtumur⋅Bum-Erdene, Khuchtumur⋅Xu, David⋅Xu, David⋅Liu, Degang⋅Liu, Degang⋅Tompkins, Doug⋅Tompkins, Doug⋅Sulaiman, Rania S⋅Sulaiman, Rania S⋅Corson, Timothy W⋅Corson, Timothy W⋅Chirgwin, John M⋅Chirgwin, John M⋅Meroueh, Samy O and Meroueh, Samy O
Bioorganic & medicinal chemistry, November 16, 2018. | Journal Article
 
The Role of Semaphorin 4D in Bone Remodeling and Cancer Metastasis.
Lontos, Konstantinos⋅Lontos, Konstantinos⋅Adamik, Juraj⋅Adamik, Juraj⋅Tsagianni, Anastasia⋅Tsagianni, Anastasia⋅Galson, Deborah L⋅Galson, Deborah L⋅Chirgwin, John M⋅Chirgwin, John M⋅Suvannasankha, Attaya and Suvannasankha, Attaya
Frontiers in endocrinology, vol. 9, pp. 322, 2018. | Journal Article
2017
Halofuginone inhibits TGF-β/BMP signaling and in combination with zoledronic acid enhances inhibition of breast cancer bone metastasis
Juárez, Patricia⋅Juárez, Patricia⋅Juárez, Patricia⋅Fournier, Pierrick G J⋅Fournier, Pierrick G J⋅Fournier, Pierrick G J⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅McKenna, Ryan C⋅McKenna, Ryan C⋅McKenna, Ryan C⋅Davis, Holly W⋅Davis, Holly W⋅Davis, Holly W⋅Peng, Xiang H⋅Peng, Xiang H⋅Peng, Xiang H⋅Niewolna, Maria⋅Niewolna, Maria⋅Niewolna, Maria⋅Mauviel, Alain⋅Mauviel, Alain⋅Mauviel, Alain⋅Chirgwin, John M⋅Chirgwin, John M⋅Chirgwin, John M⋅Guise, Theresa A⋅Guise, Theresa A and Guise, Theresa A
Oncotarget, vol. 8, (no. 49), pp. 86462, 2017-Oct-17. | Journal Article
2016
Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma.
Delgado-Calle, Jesus⋅Delgado-Calle, Jesus⋅Delgado Calle, Jesus⋅Delgado-Calle, Jesus⋅Anderson, Judith⋅Anderson, Judith⋅Anderson, Judith⋅Anderson, Judith⋅Cregor, Meloney D⋅Cregor, Meloney D⋅Cregor, Meloney D⋅Cregor, Meloney D⋅Hiasa, Masahiro⋅Hiasa, Masahiro⋅Hiasa, Masahiro⋅Hiasa, Masahiro⋅Chirgwin, John M⋅Chirgwin, John M⋅Chirgwin, John M⋅Chirgwin, John M⋅Carlesso, Nadia⋅Carlesso, Nadia⋅Carlesso, Nadia⋅Carlesso, Nadia⋅Yoneda, Toshiyuki⋅Yoneda, Toshiyuki⋅Yoneda, Toshiyuki⋅Yoneda, Toshiyuki⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅Plotkin, Lilian I⋅Roodman, G David⋅Roodman, G David⋅Roodman, G David⋅Roodman, G David⋅Bellido, Teresita⋅Bellido, Teresita⋅Bellido, Teresita and Bellido, Teresita
Cancer research, vol. 76, (no. 5), pp. 1089-1100, March 1, 2016. | Journal Article
 
Cell adhesion molecule CD166 drives malignant progression and osteolytic disease in multiple myeloma.
Xu, Linlin⋅Xu, Linlin⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Wu, Hao⋅Wu, Hao⋅Crean, Colin⋅Crean, Colin⋅Poteat, Bradley⋅Poteat, Bradley⋅Cheng, Yinghua⋅Cheng, Yinghua⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Machal, Christophe⋅Marchal, Christophe C⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Abonour, Rafat⋅Abonour, Rafat⋅Kacena, Melissa A⋅Kacena, Melissa A⋅Chirgwin, John M⋅Chirgwin, John⋅Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Srour, Edward F and Srour, Edward F
Cancer research, September 7, 2016. | Journal Article
 
Myeloma Cells Induce High Level of TAF12 Expression in Bone Marrow Stromal Cells, Resulting in Increased Osteoclastogenesis and Myeloma Cell Growth in Response to 1,25(OH)2D3
Ohata, Yasuhisa⋅Ohata, Yasuhisa⋅Chirgwin, John M⋅Chirgwin, John M⋅Windle, Jolene J⋅Windle, Jolene J⋅Roodman, G. David⋅Roodman, G. David⋅Kurihara, Noriyoshi and Kurihara, Noriyoshi
Blood, vol. 128, (no. 22), pp. 4421, 2016-12-02. | Journal Article
 
Regulation of Osteoblast Function in Myeloma Bone Disease By Semaphorin 4D
Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Crean, Colin D⋅Crean, Colin D⋅Crean, Colin D⋅Crean, Colin D⋅Tompkins, Douglas R⋅Tompkins, Douglas R⋅Tompkins, Douglas R⋅Tompkins, Douglas R⋅Delgado Calle, Jesus⋅Delgado-Calle, Jesus⋅Delgado-Calle, Jesus⋅Delgado-Calle, Jesus⋅Bellido, Teresita M⋅Bellido, Teresita M⋅Bellido, Teresita M⋅Bellido, Teresita M⋅Roodman, G. David⋅Roodman, G. David⋅Roodman, G. David⋅Roodman, G. David⋅Chirgwin, John M⋅Chirgwin, John M⋅Chirgwin, John M and Chirgwin, John M
Blood, vol. 128, (no. 22), pp. 4439, 2016-12-02. | Journal Article
2015
FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells.
Suvannasankha, Attaya⋅Tompkins, Douglas R⋅Edwards, Daniel F⋅Petyaykina, Katarina V⋅Crean, Colin D⋅Fournier, Pierrick G⋅Parker, Jamie M⋅Sandusky, George E⋅Ichikawa, Shoji⋅Imel, Erik A and Chirgwin, John M
Oncotarget, vol. 6, (no. 23), pp. 19647-19660, August 14, 2015. | Journal Article
 
The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone.
Fournier, Pierrick G J⋅Juárez, Patricia⋅Jiang, Guanglong⋅Clines, Gregory A⋅Niewolna, Maria⋅Kim, Hun Soo⋅Walton, Holly W⋅Peng, Xiang Hong⋅Liu, Yunlong⋅Mohammad, Khalid S⋅Wells, Clark D⋅Chirgwin, John M and Guise, Theresa A
Cancer cell, vol. 27, (no. 6), pp. 809-821, June 8, 2015. | Journal Article
2014
Role of bone-anabolic agents in the treatment of breast cancer bone metastases.
Suvannasankha, Attaya and Chirgwin, John M
Breast cancer research : BCR, vol. 16, (no. 6), pp. 484, 2014. | Journal Article
 
TAF12 Enhances the Biological Reponses of Myeloma Cells to Low Concentrations of 1,25-(OH)2dvitamin D3
Kurihara, Noriyoshi⋅Kurihara, Noriyoshi⋅Kitagawa, Yukiko⋅Kitagawa, Yukiko⋅Inagaki, Yuji⋅Inagaki, Yuji⋅Windle, Jolene J⋅Windle, Jolene J⋅Chirgwin, John M⋅Chirgwin, John M⋅Roodman, G. David and Roodman, G. David
Blood, vol. 124, (no. 21), pp. 2066, 2014-12-06. | Journal Article
 
Tumor-expressed adrenomedullin accelerates breast cancer bone metastasis.
Siclari, Valerie A⋅Mohammad, Khalid S⋅Tompkins, Douglas R⋅Davis, Holly⋅McKenna, C Ryan⋅Peng, Xianghong⋅Wessner, Lisa L⋅Niewolna, Maria⋅Guise, Theresa A⋅Suvannasankha, Attaya and Chirgwin, John M
Breast cancer research : BCR, vol. 16, (no. 6), pp. 458, December 2, 2014. | Journal Article
2013
Neonatal Mouse Bone Supports Growth Of Primary Myeloma Cells Ex Vivo and Assessment Of Responses To Antimyeloma Drugs
Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Tompkins, Douglas R⋅Tompkins, Douglas R⋅Tompkins, Douglas R⋅Petyaykina, Kateryna⋅Petyaykina, Kateryna⋅Petyaykina, Kateryna⋅Crean, Colin D⋅Crean, Colin D⋅Crean, Colin D⋅Condon, Keith W⋅Condon, Keith W⋅Condon, Keith W⋅David Roodman, G. David⋅David Roodman, G. David⋅David Roodman, G. David⋅Chirgwin, John M⋅Chirgwin, John M and Chirgwin, John M
Blood, vol. 122, (no. 21), pp. 1893, 2013-11-15. | Journal Article
 
Role Of CD166 In Multiple Myeloma Cell Homing To The Bone Marrow Microenvironment and Disease Progression
Xu, Linlin⋅Xu, Linlin⋅Xu, Linlin⋅Xu, Linlin⋅Xu, Linlin⋅Machal, Christophe⋅Machal, Christophe⋅Machal, Christophe⋅Machal, Christophe⋅Machal, Christophe⋅Wu, Hao⋅Wu, Hao⋅Wu, Hao⋅Wu, Hao⋅Wu, Hao⋅Poteat, Bradley⋅Poteat, Bradley⋅Poteat, Bradley⋅Poteat, Bradley⋅Poteat, Bradley⋅Crean, Colin D⋅Crean, Colin D⋅Crean, Colin D⋅Crean, Colin D⋅Crean, Colin D⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Cardoso, Angelo A⋅Chirgwin, John M⋅Chirgwin, John M⋅Chirgwin, John M⋅Chirgwin, John M⋅Chirgwin, John M⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Hanenberg, Helmut⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Mohammad, Khalid S⋅Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Suvannasankha, Attaya⋅Srour, Edward F⋅Srour, Edward F⋅Srour, Edward F⋅Srour, Edward F and Srour, Edward F
Blood, vol. 122, (no. 21), pp. 3102, 2013-11-15. | Journal Article
2012
Halofuginone inhibits the establishment and progression of melanoma bone metastases.
Juárez, Patricia⋅Mohammad, Khalid S⋅Yin, Juan J⋅Fournier, Pierrick G⋅McKenna, Ryan C⋅Davis, Holly W⋅Peng, Xiang H⋅Niewolna, Maria⋅Javelaud, Delphine⋅Chirgwin, John C⋅Mauviel, Alain and Guise, Theresa A
Cancer research, vol. 72, (no. 23), pp. 6247-56, 2012/Dec/1. | Journal Article
 
The Increased 1,25-(OH)2D3 Sensitivity of Myeloma Cells and Marrow Stromal Cells Enhances RANKL Production and Tumor Cell Growth
Teramachi, Jumpei⋅Teramachi, Jumpei⋅Kurihara, Noriyoshi⋅Kurihara, Noriyoshi⋅Chirgwin, John M⋅Chirgwin, John M⋅Roodman, G David and Roodman, G David
Blood, vol. 120, (no. 21), pp. 3946, 2012-11-16. | Journal Article
 
The stem cell niche as a pharmaceutical target for prevention of skeletal metastases.
Chirgwin, John C
Anti-cancer agents in medicinal chemistry, vol. 12, (no. 3), pp. 187-93, 2012/Mar. | Journal Article
2011
Regulation of postnatal trabecular bone formation by the osteoblast endothelin A receptor.
Clines, G.A.⋅Clines, Gregory⋅Mohammad, K.S.⋅Mohammad, Khalid S⋅Grunda, J.M.⋅Grunda, Jessica M⋅Clines, K.L.⋅Clines, Katrina L⋅Niewolna, Maria⋅Niewolna, M.⋅McKenna, C.R.⋅McKenna, C R⋅McKibbin, C.R.⋅McKibbin, Christopher R⋅Yanagisawa, Masashi⋅Yanagisawa, M.⋅Suva, L.J.⋅Suva, Larry J⋅Chirgwin, John C⋅Chirgwin, J.M.⋅Guise, Theresa A and Guise, T.A.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, vol. 26, (no. 10), pp. 2523-36, 2011/Oct. | Journal Article
2010
Meeting report from the IX international meeting on cancer induced bone disease
Chirgwin, John M⋅Edwards, Claire M⋅Pedersen, Elisabeth A⋅Shiozawa, Yusuke⋅Taichman, Russell S⋅Park, Serk In⋅McCauley, Laurie K⋅Matsumoto, Toshio and Abe, Masahiro
IBMS BoneKEy, vol. 7, (no. 1), pp. 46, 2010-01-00. | Journal Article
2009
Agents targeting prostate cancer bone metastasis.
Mohammad, Khalid S⋅Fournier, Pierrick G⋅Guise, Theresa A and Chirgwin, John C
Anti-cancer agents in medicinal chemistry, vol. 9, (no. 10), pp. 1079-88, 2009/Dec. | Journal Article
 
Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.
Dunn, Lauren K⋅Mohammad, Khalid S⋅Fournier, Pierrick G⋅McKenna, C R⋅Davis, Holly W⋅Niewolna, Maria⋅Peng, Xiang H⋅Chirgwin, John C and Guise, Theresa A
PloS one, vol. 4, (no. 9), pp. e6896, 2009. | Journal Article