19 Publications
2014
Soypeptide lunasin in cytokine immunotherapy for lymphoma.
Chang, Hua-ChenChang, Hua-ChenChang, Hua-ChenLewis, DavidLewis, DavidLewis, DavidTung, Chun-YuTung, Chun-YuTung, Chun-YuHan, LingHan, LingHan, LingHenriquez, SarahHenriquez, SarahHenriquez, Sarah MVoiles, LarryVoiles, LarryVoiles, LarryLupov, Ivan PLupov, IvanLupov, IvanPelloso, DavidPelloso, DavidPelloso, DavidSinn, AnthonySinn, Anthony LSinn, AnthonyPollok, Karen EPollok, KarenPollok, Karende Lumen, Bende Lumen, Ben Ode Lumen, BenLi, FangLi, FangLi, FangBlum, Janice SBlum, JaniceBlum, JaniceSrivastava, ShivaniSrivastava, ShivaniSrivastava, ShivaniRobertson, Michael JRobertson, Michael and Robertson, Michael
Cancer immunology, immunotherapy : CII, vol. 63, (no. 3), pp. 283-95, 2014/Mar. | Journal Article
2011
The transcription factor PU.1 regulates γδ T cell homeostasis.
Jabeen, RukhsanaChang, Hua-ChenGoswami, RitobrataNutt, Stephen L and Kaplan, Mark H
PloS one, vol. 6, (no. 7), pp. e22189, 2011. | Journal Article
2010
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.
Chang, Hua-ChenChang, Hua-ChenSehra, SaritaSehra, SaritaGoswami, RitobrataGoswami, RitobrataYao, WeiguoYao, WeiguoYu, QingYu, QingStritesky, Gretta LStritesky, Gretta LJabeen, RukhsanaJabeen, RukhsanaMcKinley, CarlMcKinley, CarlAhyi, Ayele-NatiAhyi, Ayele-NatiHan, LingHan, LingNguyen, Evelyn TNguyen, Evelyn TRobertson, Michael JRobertson, Michael JPerumal, Narayanan BPerumal, Narayanan BTepper, Robert STepper, Robert SNutt, Stephen LNutt, Stephen LKaplan, Mark H and Kaplan, Mark H
Nature immunology, vol. 11, (no. 6), pp. 527-34, 2010/Jun. | Journal Article
2009
IFN regulatory factor 4 regulates the expression of a subset of Th2 cytokines.
Ahyi, Ayele-Nati NChang, Hua-ChenDent, Alexander LNutt, Stephen L and Kaplan, Mark H
Journal of immunology (Baltimore, Md. : 1950), vol. 183, (no. 3), pp. 1598-606, 2009/Aug/1. | Journal Article
 
Impaired development of human Th1 cells in patients with deficient expression of STAT4.
Chang, Hua-ChenHan, LingGoswami, RitobrataNguyen, Evelyn TPelloso, DavidRobertson, Michael J and Kaplan, Mark H
Blood, vol. 113, (no. 23), pp. 5887-90, 2009/Jun/4. | Journal Article
 
PU.1 regulates TCR expression by modulating GATA-3 activity.
Chang, Hua-ChenHan, LingJabeen, RukhsanaCarotta, SebastianNutt, Stephen L and Kaplan, Mark H
Journal of immunology (Baltimore, Md. : 1950), vol. 183, (no. 8), pp. 4887-94, 2009/Oct/15. | Journal Article
 
Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells
O'Malley, John TSehra, SaritaThieu, Vivian TYu, QingChang, Hua-ChenStritesky, Gretta LNguyen, Evelyn TMathur, Anubhav NLevy, David E and Kaplan, Mark H
Immunology, vol. 127, (no. 4), pp. 587-595, 2009. | Journal Article
2008
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination.
Thieu, Vivian TThieu, Vivian TYu, QingYu, QingChang, Hua-ChenChang, Hua-ChenYeh, NormanYeh, NormanNguyen, Evelyn TNguyen, Evelyn TSehra, SaritaSehra, SaritaKaplan, Mark H and Kaplan, Mark H
Immunity, vol. 29, (no. 5), pp. 679-90, 2008/Nov/14. | Journal Article
 
STAT4 isoforms differentially regulate Th1 cytokine production and the severity of inflammatory bowel disease.
O'Malley, John TEri, Rajaraman DStritesky, Gretta LMathur, Anubhav NChang, Hua-ChenHogenesch, HarmHogen Esch, HarmSrinivasan, Mythily and Kaplan, Mark H
Journal of immunology (Baltimore, Md. : 1950), vol. 181, (no. 7), pp. 5062-70, 2008/Oct/1. | Journal Article
 
Transcription factor-dependent chromatin remodeling of Il18r1 during Th1 and Th2 differentiation.
Yu, QingChang, Hua-ChenAhyi, Ayele-Nati N and Kaplan, Mark H
Journal of immunology (Baltimore, Md. : 1950), vol. 181, (no. 5), pp. 3346-52, 2008/Sep/1. | Journal Article
 
Vaccinia virus blocks Stat1-dependent and Stat1-independent gene expression induced by type I and type II interferons.
Mann, Brandon AHuang, Julia HLi, PingChang, Hua-ChenSlee, Roger BO'Sullivan, AudreyAnita, MathurYeh, NormanKlemsz, Michael JBrutkiewicz, Randy RBlum, Janice S and Kaplan, Mark H
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, vol. 28, (no. 6), pp. 367-80, 2008/Jun. | Journal Article
2007
Rap1a Null Mice Have Altered Myeloid Cell Functions Suggesting Distinct Roles for the Closely Related Rap1a and 1b Proteins
Li, YuLi, YuLi, YuYan, JingliangYan, JingliangYan, JingliangDe, PradipDe, PradipDe, PradipChang, Hua-ChenChang, Hua-ChenChang, Hua-ChenYamauchi, AkiraYamauchi, AkiraYamauchi, AkiraChristopherson, KentChristopherson, Kent WChristopherson, KentParanavitana, NivankaParanavitana, Nivanka CParanavitana, NivankaPeng, XiaodongPeng, XiaodongPeng, XiaodongKim, ChaekyunKim, ChaekyunKim, ChaekyunMunugulavadla, VeerendraMunugulavadla, VeerendraMunugulavadla, VeerendraKapur, ReubenKapur, ReubenKapur, ReubenChen, HanyingChen, HanyingChen, HanyingShou, WeinianShou, WeinianShou, WeinianStone, James CStone, JamesStone, JamesKaplan, MarkKaplan, Mark HKaplan, MarkDinauer, Mary CDinauer, MaryDinauer, MaryDurden, DonaldDurden, DonaldDurden, Donald LQuilliam, LawrenceQuilliam, Lawrence A and Quilliam, Lawrence
Journal of Immunology, vol. 179, (no. 12), pp. 8322-8331, 2007. | Journal Article
 
Stat3 and Stat4 direct development of IL-17-secreting Th cells.
Mathur, Anubhav NChang, Hua-ChenZisoulis, Dimitrios GStritesky, Gretta LYu, QingO'Malley, John TKapur, ReubenLevy, David EKansas, Geoffrey S and Kaplan, Mark H
Journal of immunology (Baltimore, Md. : 1950), vol. 178, (no. 8), pp. 4901-7, 2007/Apr/15. | Journal Article
2006
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.
Mathur, Anubhav NChang, Hua-ChenZisoulis, Dimitrios GKapur, ReubenBelladonna, Maria LKansas, Geoffrey S and Kaplan, Mark H
Blood, vol. 108, (no. 5), pp. 1595-601, 2006/Sep/1. | Journal Article
2005
PU.1 expression delineates heterogeneity in primary Th2 cells.
Chang, Hua-ChenZhang, ShangmingThieu, Vivian TSlee, Roger BBruns, Heather ALaribee, R NKlemsz, Michael J and Kaplan, Mark H
Immunity, vol. 22, (no. 6), pp. 693-703, 2005/Jun. | Journal Article
2004
STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus.
O'Sullivan, AudreyChang, Hua-ChenYu, Qing and Kaplan, Mark H
The Journal of biological chemistry, vol. 279, (no. 8), pp. 7339-45, 2004/Feb/20. | Journal Article
2003
Distinct requirements for Stat4 and Stat6 in hematopoietic progenitor cell responses to growth factors and chemokines.
Kaplan, Mark HChang, Hua-ChenCooper, ScottLee, Younghee and Broxmeyer, Hal E
Journal of hematotherapy & stem cell research. , vol. 12, (no. 4), pp. 401-8, 2003/Aug. | Journal Article
 
STAT4 requires the N-terminal domain for efficient phosphorylation.
Chang, Hua-ChenZhang, ShangmingOldham, IndiaNaeger, LisaHoey, Timothy and Kaplan, Mark H
The Journal of biological chemistry, vol. 278, (no. 34), pp. 32471-7, 2003/Aug/22. | Journal Article
2002
Neonatal tolerance in the absence of Stat4- and Stat6- dependent Th cell differentiation.
Chang, Hua-ChenZhang, Shangming and Kaplan, Mark H
Journal of immunology (Baltimore, Md. : 1950), vol. 169, (no. 8), pp. 4124-8, 2002/Oct/15. | Journal Article