267 Publications (Page 4 of 11)
2006
Reducing infarct size in the setting of acute myocardial infarction.
Downey, James M and Cohen, Michael V
Progress in cardiovascular diseases, vol. 48, (no. 5), pp. 363-71, 2006 Mar-Apr. | Journal Article
2005
Cardioprotection with adenosine A2 receptor activation at reperfusion.
Xu, Zhelong⋅Mueller, Robert A⋅Park, Sung-Sik⋅Boysen, Philip G⋅Cohen, Michael V and Downey, James M
Journal of cardiovascular pharmacology, vol. 46, (no. 6), pp. 794-802, 2005/Dec. | Journal Article
 
Mechanisms of acetylcholine- and bradykinin-induced preconditioning.
Critz, Stuart D⋅Cohen, Michael V and Downey, James M
Vascular pharmacology, vol. 42, (no. 5-6), pp. 201-9, 2005 Apr-May. | Journal Article
 
Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart.
Krieg, Thomas⋅Philipp, Sebastian⋅Cui, Lin⋅Dostmann, Wolfgang R⋅Downey, James M and Cohen, Michael V
American journal of physiology. Heart and circulatory physiology, vol. 288, (no. 4), pp. H1976-81, 2005/Apr. | Journal Article
 
Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation.
Yang, Xi-Ming⋅Philipp, Sebastian⋅Downey, James M and Cohen, Michael V
Basic research in cardiology, vol. 100, (no. 1), pp. 57-63, 2005/Jan. | Journal Article
 
Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria.
Costa, Alexandre⋅Costa, Alexandre D⋅Garlid, Keith⋅Garlid, Keith D⋅West, Ian⋅West, Ian C⋅Lincoln, Thomas M⋅Lincoln, Thomas⋅Downey, James M⋅Downey, James⋅Cohen, Michael V⋅Cohen, Michael⋅Critz, Stuart D and Critz, Stuart
Circulation research, vol. 97, (no. 4), pp. 329-36, 2005/Aug/19. | Journal Article
 
Unraveling the mysteries of classical preconditioning.
Downey, James M and Cohen, Michael V
Journal of molecular and cellular cardiology. , vol. 39, (no. 6), pp. 845-8, 2005/Dec. | Journal Article
 
We think we see a pattern emerging here.
Downey, James M and Cohen, Michael V
Circulation, vol. 111, (no. 2), pp. 120-1, 2005/Jan/18. | Journal Article
2004
Acetylcholine and bradykinin trigger preconditioning in the heart through a pathway that includes Akt and NOS.
Krieg, Thomas⋅Qin, Qining⋅Philipp, Sebastian⋅Alexeyev, Mikhail F⋅Cohen, Michael V and Downey, James M
American journal of physiology. Heart and circulatory physiology, vol. 287, (no. 6), pp. H2606-11, 2004/Dec. | Journal Article
 
Augmented taurine release is not the mechanism of ischemic preconditioning's cardioprotection
Krieg, Thomas⋅Yang, X-M⋅Downey, James M⋅Schaffer, Stephen W and Cohen, MV
Amino Acids, vol. 26, (no. 3), pp. 263-266, 2004. | Journal Article
 
Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection.
Oldenburg, Olaf⋅Qin, Qining⋅Krieg, Thomas⋅Yang, Xi-Ming⋅Philipp, Sebastian⋅Critz, Stuart D⋅Cohen, Michael V and Downey, James M
American journal of physiology. Heart and circulatory physiology, vol. 286, (no. 1), pp. H468-76, 2004/Jan. | Journal Article
 
Exogenous NO triggers preconditioning via a cGMP- and mitoKATP-dependent mechanism.
Qin, Qining⋅Yang, Xi-Ming⋅Cui, Lin⋅Critz, Stuart D⋅Cohen, Michael V⋅Browner, Natasha C⋅Lincoln, Thomas M and Downey, James M
American journal of physiology. Heart and circulatory physiology, vol. 287, (no. 2), pp. H712-8, 2004/Aug. | Journal Article
 
Mitochondrial ROS generation following acetylcholine-induced EGF receptor transactivation requires metalloproteinase cleavage of proHB-EGF.
Krieg, Thomas⋅Cui, Lin⋅Qin, Qining⋅Cohen, Michael V and Downey, James M
Journal of molecular and cellular cardiology, vol. 36, (no. 3), pp. 435-43, 2004/Mar. | Journal Article
 
Multiple, brief coronary occlusions during early reperfusion protect rabbit hearts by targeting cell signaling pathways.
Yang, Xi-Ming⋅Yang, Xi-Ming⋅Proctor, J. Bradley⋅Proctor, J B⋅Cui, Lin⋅Cui, Lin⋅Krieg, Thomas⋅Krieg, Thomas⋅Downey, James M⋅Downey, James M⋅Cohen, Michael V and Cohen, Michael V
Journal of the American College of Cardiology, vol. 44, (no. 5), pp. 1103-10, 2004/Sep/1. | Journal Article
 
NECA and bradykinin at reperfusion reduce infarction in rabbit hearts by signaling through PI3K, ERK, and NO.
Yang, Xi-Ming⋅Krieg, Thomas⋅Cui, Lin⋅Downey, James M and Cohen, Michael V
Journal of molecular and cellular cardiology, vol. 36, (no. 3), pp. 411-21, 2004/Mar. | Journal Article
 
Protective and anti-protective effects of acute ethanol exposure in myocardial ischemia/reperfusion.
Krenz, Maike⋅Cohen, Michael V and Downey, James M
Pathophysiology : the official journal of the International Society for Pathophysiology / ISP, vol. 10, (no. 2), pp. 113-9, 2004/Apr. | Journal Article
2003
Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase
Qin, Qining⋅Downey, James M and Cohen, Michael
American Journal of Physiology, vol. 53, (no. 2), pp. H727-H734, Feb 2003. | Journal Article
 
Acetylcholine but not adenosine triggers preconditioning through PI3-kinase and a tyrosine kinase.
Qin, Qining⋅Downey, James M and Cohen, Michael V
American journal of physiology. Heart and circulatory physiology, vol. 284, (no. 2), pp. H727-34, 2003/Feb. | Journal Article
 
Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening.
Oldenburg, Olaf⋅Critz, Stuart D⋅Cohen, Michael V and Downey, James M
Journal of molecular and cellular cardiology, vol. 35, (no. 6), pp. 653-60, 2003/Jun. | Journal Article
 
Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals.
Krieg, Thomas⋅Landsberger, Martin⋅Alexeyev, Mikhail F⋅Felix, Stephan B⋅Cohen, Michael V and Downey, James M
Cardiovascular research, vol. 58, (no. 1), pp. 196-202, 2003/Apr/1. | Journal Article
 
CGX-1051, a peptide from Conus snail venom, attenuates infarction in rabbit hearts when administered at reperfusion.
Zhang, Shi J⋅Yang, Xi-Ming⋅Liu, Guang S⋅Cohen, Michael V⋅Pemberton, Karen and Downey, James M
Journal of cardiovascular pharmacology, vol. 42, (no. 6), pp. 764-71, 2003/Dec. | Journal Article
 
Mitochondria and their role in preconditioning's trigger phase
Krieg, Thomas⋅Cohen, Michael and Downey, James M
Basic Research in Cardiology, vol. 98, (no. 4), pp. 228-234, Jul 2003. | Journal Article
 
Mitochondrial K(ATP) channels in preconditioning.
Oldenburg, Olaf⋅Cohen, Michael V and Downey, James M
Journal of molecular and cellular cardiology, vol. 35, (no. 6), pp. 569-75, 2003/Jun. | Journal Article
 
P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.
Oldenburg, Olaf⋅Yang, Xi-Ming⋅Krieg, Thomas⋅Garlid, Keith D⋅Cohen, Michael V⋅Grover, Gary J and Downey, James M
Journal of molecular and cellular cardiology, vol. 35, (no. 9), pp. 1035-42, 2003/Sep. | Journal Article
 
Preconditioning the myocardium: from cellular physiology to clinical cardiology.
Yellon, Derek and Downey, James M
Physiological reviews, vol. 83, (no. 4), pp. 1113-51, 2003/Oct. | Journal Article