95 Publications (Page 1 of 4)
2019
Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration
Hartman, Jessica H⋅Hartman, Jessica H⋅Hartman, Jessica H⋅Hartman, Jessica H.⋅Gonzalez Hunt, Claudia⋅Gonzalez-Hunt, Claudia⋅Gonzalez-Hunt, Claudia⋅Gonzalez-Hunt, Claudia⋅Hall, Samantha M.⋅Hall, Samantha M⋅Hall, Samantha M⋅Hall, Samantha M⋅Ryde, Ian T⋅Ryde, Ian T⋅Ryde, Ian T.⋅Ryde, Ian T⋅Caldwell, Kim A⋅Caldwell, Kim A⋅Caldwell, Kim A⋅Caldwell, Kim A.⋅Caldwell, Guy A⋅Caldwell, Guy A⋅Caldwell, Guy A.⋅Caldwell, Guy A⋅Meyer, Joel N⋅Meyer, Joel N⋅Meyer, Joel N. and Meyer, Joel N
International Journal of Molecular Sciences, vol. 20, (no. 13), 2019. | Journal Article
2018
Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.
Griffin, Edward F⋅Yan, Xiaohui⋅Caldwell, Kim A and Caldwell, Guy A
Human molecular genetics, vol. 27, (no. 24), pp. 4176-4193, December 15, 2018. | Journal Article
 
Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson's models.
Kim, Hanna⋅Perentis, Rylee J⋅Caldwell, Guy A and Caldwell, Kim A
Cell death & disease, vol. 9, (no. 5), pp. 555, May 10, 2018. | Journal Article
 
No Country for Old Worms: A Systematic Review of the Application of C. elegans to Investigate a Bacterial Source of Environmental Neurotoxicity in Parkinson's Disease.
Caldwell, Kim A⋅Thies, Jennifer L and Caldwell, Guy A
Metabolites, vol. 8, (no. 4), October 29, 2018. | Journal Article
2017
C. elegans as a model system to accelerate discovery for Parkinson disease.
Martinez, Bryan A⋅Caldwell, Kim A and Caldwell, Guy A
Current opinion in genetics & development, vol. 44, pp. 102-109, June 2017. | Journal Article
 
Dopamine induces soluble [alpha]-synuclein oligomers and nigrostriatal degeneration
Mor, Danielle⋅Mor, Danielle E⋅Tsika, Elpida⋅Tsika, Elpida⋅Mazzulli, Joseph R⋅Mazzulli, Joseph⋅Gould, Neal⋅Gould, Neal S⋅Kim, Hanna⋅Kim, Hanna⋅Daniels, Malcolm J⋅Daniels, Malcolm⋅Doshi, Shachee⋅Doshi, Shachee⋅Gupta, Preetika⋅Gupta, Preetika⋅Grossman, Jennifer⋅Grossman, Jennifer L⋅Tan, Victor⋅Tan, Victor X⋅Kalb, Robert G⋅Kalb, Robert⋅Caldwell, Kim A⋅Caldwell, Kim⋅Caldwell, Guy⋅Caldwell, Guy A⋅Wolfe, John H⋅Wolfe, John⋅Ischiropoulos, Harry and Ischiropoulos, Harry
Nature Neuroscience, vol. 20, (no. 11), pp. 1560-1568, Nov 2017. | Journal Article
 
Dopamine induces soluble α-synuclein oligomers and nigrostriatal degeneration.
Mor, Danielle E⋅Tsika, Elpida⋅Mazzulli, Joseph R⋅Gould, Neal S⋅Kim, Hanna⋅Daniels, Malcolm J⋅Doshi, Shachee⋅Gupta, Preetika⋅Grossman, Jennifer L⋅Tan, Victor X⋅Kalb, Robert G⋅Caldwell, Kim A⋅Caldwell, Guy A⋅Wolfe, John H and Ischiropoulos, Harry
Nature neuroscience, September 18, 2017. | Journal Article
 
Dysregulation of the mitochondrial unfolded protein response induces non-apoptotic dopaminergic neurodegeneration in C. elegans models of Parkinson's disease.
Martinez, Bryan A⋅Petersen, Daniel A⋅Gaeta, Anthony L⋅Stanley, Samuel P⋅Caldwell, Guy A and Caldwell, Kim A
The Journal of neuroscience : the official journal of the Society for Neuroscience, October 13, 2017. | Journal Article
 
Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans.
Griffin, Edward F⋅Caldwell, Kim A and Caldwell, Guy A
ACS chemical neuroscience, October 25, 2017. | Journal Article
 
NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.
Zhang, Siyuan⋅Glukhova, Samantha A⋅Caldwell, Kim A and Caldwell, Guy A
Human molecular genetics, vol. 26, (no. 19), pp. 3823-3836, October 1, 2017. | Journal Article
2016
Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson's Disease.
Wang, Shaoxiao⋅Zhang, Siyuan⋅Xu, Chuan⋅Barron, Addie⋅Galiano, Floyd⋅Patel, Dhaval⋅Lee, Yong Joo⋅Caldwell, Guy A⋅Caldwell, Kim A and Witt, Stephan N
PloS one, vol. 11, (no. 10), pp. e0164465, 2016. | Journal Article
2014
Calcineurin determines toxic versus beneficial responses to [alpha]-synuclein
Caraveo, Gabriela⋅Auluck, Pavan K⋅Whitesell, Luke⋅Chung, Chee Y⋅Baru, Valeriya⋅Mosharov, Eugene V⋅Yan, Xiaohui⋅Ben-Johny, Manu⋅Soste, Martin⋅Picotti, Paola⋅Kim, Hanna⋅Caldwell, Kim A⋅Caldwell, Guy⋅Sulzer, David⋅Yue, David T and Lindquist, Susan
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 34), Aug 26, 2014. | Journal Article
 
Calcineurin determines toxic versus beneficial responses to α-synuclein.
Caraveo, Gabriela⋅Auluck, Pavan K⋅Whitesell, Luke⋅Chung, Chee Yeun⋅Baru, Valeriya⋅Mosharov, Eugene V⋅Yan, Xiaohui⋅Ben-Johny, Manu⋅Soste, Martin⋅Picotti, Paola⋅Kim, Hanna⋅Caldwell, Kim A⋅Caldwell, Guy A⋅Sulzer, David⋅Yue, David T and Lindquist, Susan
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 34), pp. E3544-E3552, August 26, 2014. | Journal Article
 
Clioquinol promotes the degradation of metal-dependent amyloid-[Beta] (A[Beta]) oligomers to restore endocytosis and ameliorate A[Beta] toxicity
Matlack, Kent E⋅Tardiff, Daniel F⋅Narayan, Priyanka⋅Hamamichi, Shusei⋅Caldwell, Kim A⋅Caldwell, Guy and Lindquist, Susan L
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 11), Mar 18, 2014. | Journal Article
 
Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity.
Matlack, Kent E⋅Tardiff, Daniel F⋅Narayan, Priyanka⋅Hamamichi, Shusei⋅Caldwell, Kim A⋅Caldwell, Guy and Lindquist, Susan
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 11), pp. 4013-8, 2014/Mar/18. | Journal Article
 
Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model.
Ray, A⋅Martinez, B A⋅Berkowitz, Laura A⋅Caldwell, Guy and Caldwell, Kim A
Cell death & disease, vol. 5, pp. e984, 2014. | Journal Article
 
Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.
Wang, Shaoxiao⋅Zhang, Siyuan⋅Liou, Liang-Chun⋅Ren, Qun⋅Zhang, Zhaojie⋅Caldwell, Guy A⋅Caldwell, Kim A and Witt, Stephan N
Proceedings of the National Academy of Sciences of the United States of America, vol. 111, (no. 38), pp. E3976-E3985, September 23, 2014. | Journal Article
 
Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.
Jackrel, Meredith E⋅Desantis, Morgan E⋅Martinez, Bryan A⋅Castellano, Laura M⋅Stewart, Rachel M⋅Caldwell, Kim A⋅Caldwell, Guy and Shorter, James
Cell, vol. 156, (no. 1-2), pp. 170-82, 2014/Jan/16. | Journal Article
 
Protective role of DNJ-27/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases.
Muñoz-Lobato, Fernando⋅Muñoz-Lobato, F.⋅Rodríguez-Palero, M.J.⋅Rodríguez-Palero, María J⋅Naranjo-Galindo, F.J.⋅Naranjo-Galindo, Francisco J⋅Shephard, Freya⋅Shephard, F.⋅Gaffney, Christopher J⋅Gaffney, C.J.⋅Szewczyk, N.J.⋅Szewczyk, Nathaniel J⋅Hamamichi, Shusei⋅Hamamichi, S.⋅Caldwell, K.A.⋅Caldwell, Kim A⋅Caldwell, G.A.⋅Caldwell, Guy⋅Link, Chris D⋅Link, C.D.⋅Miranda-Vizuete, A. and Miranda-Vizuete, Antonio
Antioxidants & redox signaling, vol. 20, (no. 2), pp. 217-35, 2014/Jan/10. | Journal Article
 
RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.
Ray, Arpita⋅Zhang, Siyuan⋅Rentas, Courtney⋅Caldwell, Kim A and Caldwell, Guy A
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 34, (no. 48), pp. 16076-16085, November 26, 2014. | Journal Article
 
The effects of pdr1, djr1.1 and pink1 loss in manganese-induced toxicity and the role of α-synuclein in C. elegans.
Bornhorst, Julia⋅Bornhorst, Julia⋅Chakraborty, Sudipta⋅Chakraborty, Sudipta⋅Meyer, Sören⋅Meyer, Sören⋅Lohren, Hanna⋅Lohren, Hanna⋅Brinkhaus, Sigrid G⋅Große Brinkhaus, Sigrid⋅Knight, Adam L⋅Knight, Adam L⋅Caldwell, Kim A⋅Caldwell, Kim A⋅Caldwell, Guy A⋅Caldwell, Guy⋅Karst, Uwe⋅Karst, Uwe⋅Schwerdtle, Tanja⋅Schwerdtle, Tanja⋅Bowman, Aaron⋅Bowman, Aaron⋅Aschner, Michael and Aschner, Michael
Metallomics : integrated biometal science, vol. 6, (no. 3), pp. 476-90, 2014/Mar. | Journal Article
 
The glycolytic enzyme, GPI, is a functionally conserved modifier of dopaminergic neurodegeneration in Parkinson's models.
Knight, Adam L⋅Yan, Xiaohui⋅Hamamichi, Shusei⋅Ajjuri, Rami R⋅Mazzulli, Joseph R⋅Zhang, Mike W⋅Daigle, J Gavin⋅Zhang, Siyuan⋅Borom, Akeem R⋅Roberts, Lindsay R⋅Lee, S Kyle⋅DeLeon, Susan M⋅Viollet-Djelassi, Coralie⋅Krainc, Dimitri⋅O'Donnell, Janis M⋅Caldwell, Kim A and Caldwell, Guy A
Cell metabolism, vol. 20, (no. 1), pp. 145-157, July 1, 2014. | Journal Article
 
TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS.
Thompson, Michelle L⋅Chen, Pan⋅Yan, Xiaohui⋅Kim, Hanna⋅Borom, Akeem R⋅Roberts, Nathan B⋅Caldwell, Kim A and Caldwell, Guy
Disease models & mechanisms, vol. 7, (no. 2), pp. 233-43, 2014/Feb. | Journal Article
2013
Invertebrate models of dystonia.
Caldwell, Kim A⋅Shu, Yilong⋅Roberts, Nathan B⋅Caldwell, Guy and O'donnell, Janis M
Current neuropharmacology, vol. 11, (no. 1), pp. 16-29, 2013/Jan. | Journal Article
 
Lysosomal impairment in Parkinson's disease.
Dehay, Benjamin⋅Martinez-Vicente, Marta⋅Caldwell, Guy⋅Caldwell, Kim A⋅Yue, Zhenyue⋅Cookson, Mark R⋅Klein, Christine⋅Vila, Miquel and Bezard, Erwan
Movement disorders : official journal of the Movement Disorder Society, vol. 28, (no. 6), pp. 725-32, 2013/Jun. | Journal Article