95 Publications (Page 2 of 4)
2013
Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling.
Kautu, Bwarenaba B⋅Carrasquilla, Alejandro⋅Hicks, Matthew L⋅Caldwell, Kim A and Caldwell, Guy
Neuroscience letters, vol. 541, pp. 116-9, 2013/Apr/29. | Journal Article
 
Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates [alpha]-Synuclein Toxicity in Neurons
Tardiff, Daniel F⋅Jui, Nathan T⋅Khurana, Vikram⋅Tambe, Mitali A⋅Thompson, Michelle L⋅Chung, Chee Y⋅Kamadurai, Hari B⋅Kim, Hyoung T⋅Lancaster, Alex K⋅Caldwell, Kim A⋅Caldwell, Guy⋅Rochet, Jean-Christophe⋅Buchwald, Stephen L and Lindquist, Susan L
Science, vol. 342, (no. 6161), pp. 979-983, Nov 22, 2013. | Journal Article
 
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.
Tardiff, Daniel F⋅Jui, Nathan T⋅Khurana, Vikram⋅Tambe, Mitali A⋅Thompson, Michelle L⋅Chung, Chee Y⋅Kamadurai, Hari B⋅Kim, Hyoung T⋅Lancaster, Alex⋅Caldwell, Kim A⋅Caldwell, Guy⋅Rochet, Jean Christophe⋅Buchwald, Stephen L and Lindquist, Susan
Science (New York, N.Y.), vol. 342, (no. 6161), pp. 979-83, 2013/Nov/22. | Journal Article
2012
A predictable worm: application of Caenorhabditis elegans for mechanistic investigation of movement disorders.
Dexter, Paige M⋅Caldwell, Kim A and Caldwell, Guy A
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, vol. 9, (no. 2), pp. 393-404, April 2012. | Journal Article
 
Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.
Tardiff, Daniel F⋅Tucci, Michelle L⋅Caldwell, Kim A⋅Caldwell, Guy and Lindquist, Susan L
The Journal of biological chemistry, vol. 287, (no. 6), pp. 4107-20, 2012/Feb/3. | Journal Article
 
Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.
Harrington, Adam J⋅Yacoubian, Talene⋅Slone, Sunny R⋅Caldwell, Kim A and Caldwell, Guy
The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 32, (no. 6), pp. 2142-53, 2012/Feb/8. | Journal Article
 
Identification of novel ATP13A2 interactors and their role in [alpha]-synuclein misfolding and toxicity
Usenovic, Marija⋅Knight, Adam L⋅Ray, Arpita⋅Wong, Victoria⋅Brown, Kevin R⋅Caldwell, Guy⋅Caldwell, Kim A⋅Stagljar, Igor and Krainc, Dimitri
Human Molecular Genetics, vol. 21, (no. 17), pp. 3785-3794, 2012. | Journal Article
 
Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.
Usenovic, Marija⋅Knight, Adam L⋅Ray, Arpita⋅Wong, Victoria⋅Brown, Kevin R⋅Caldwell, Guy⋅Caldwell, Kim A⋅Stagljar, Igor and Krainc, Dimitri
Human molecular genetics, vol. 21, (no. 17), pp. 3785-94, 2012/Sep/1. | Journal Article
2011
Caenorhabditis elegans as a model system for identifying effectors of alpha -synuclein misfolding and dopaminergic cell death associated with Parkinson's disease
Harrington, Adam J⋅Knight, Adam L⋅Caldwell, Guy and Caldwell, Kim A
Methods, vol. 53, (no. 3), pp. 220-225, 2011. | Journal Article
 
Caenorhabditis elegans as a model system for identifying effectors of α-synuclein misfolding and dopaminergic cell death associated with Parkinson's disease.
Harrington, Adam J⋅Knight, Adam L⋅Caldwell, Guy and Caldwell, Kim A
Methods (San Diego, Calif.), vol. 53, (no. 3), pp. 220-5, 2011/Mar. | Journal Article
 
Functional Links Between A beta Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
Treusch, Sebastian⋅Hamamichi, Shusei⋅Goodman, Jessica L⋅Matlack, Kent E⋅Chung, Chee Y⋅Baru, Valeriya⋅Shulman, Joshua M⋅Parrado, Antonio⋅Bevis, Brooke J⋅Valastyan, Julie S⋅Han, Haesun⋅Lindhagen-Persson, Malin⋅Reiman, Eric M⋅Evans, Denis A⋅Bennett, David A⋅Olofsson, Anders⋅DeJager, Philip L⋅Tanzi, Rudy E⋅Caldwell, Kim A⋅Caldwell, Guy and Lindquist, Susan L
Science (Washington), vol. 334, (no. 6060), pp. 1241-1245, 2011. | Journal Article
 
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast.
Treusch, Sebastian⋅Treusch, Sebastian⋅Hamamichi, Shusei⋅Hamamichi, Shusei⋅Goodman, Jessica L.⋅Goodman, Jessica L⋅Matlack, Kent E. S.⋅Matlack, Kent E⋅Chung, Chee Y⋅Chung, Chee Yeun⋅Baru, Valeriya⋅Baru, Valeriya⋅Shulman, Joshua M.⋅Shulman, Joshua M⋅Parrado, Antonio⋅Parrado, Antonio⋅Bevis, Brooke J.⋅Bevis, Brooke J⋅Valastyan, Julie S⋅Valastyan, Julie S.⋅Han, Haesun⋅Han, Haesun⋅Lindhagen-Persson, Malin⋅Lindhagen-Persson, Malin⋅Reiman, Eric M⋅Reiman, Eric M.⋅Evans, Denis A.⋅Evans, Denis A⋅Bennett, David A.⋅Bennett, David A⋅Olofsson, Anders⋅Olofsson, Anders⋅Dejager, Philip L.⋅Dejager, Philip L⋅Tanzi, Rudy E⋅Tanzi, Rudolph E.⋅Caldwell, Kim A.⋅Caldwell, Kim A⋅Caldwell, Guy⋅Caldwell, Guy A.⋅Lindquist, Susan and Lindquist, Susan L
Science (New York, N.Y.), vol. 334, (no. 6060), pp. 1241-5, 2011/Dec/2. | Journal Article
 
Gaucher Disease Glucocerebrosidase and alpha -Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies
Mazzulli, Joseph R⋅Xu, You Hai⋅Sun, Ying⋅Knight, Adam L⋅McLean, Pamela J⋅Caldwell, Guy⋅Sidransky, Ellen⋅Grabowski, Gregory A and Krainc, Dimitri
Cell, vol. 146, (no. 1), pp. 37-52, 2011. | Journal Article
 
Gaucher disease glucocerebrosidase and α-synuclein form a bidirectional pathogenic loop in synucleinopathies.
Mazzulli, Joseph R⋅Xu, You Hai⋅Sun, Ying⋅Knight, Adam L⋅McLean, Pamela J⋅Caldwell, Guy⋅Sidransky, Ellen⋅Grabowski, Gregory A and Krainc, Dimitri
Cell, vol. 146, (no. 1), pp. 37-52, 2011/Jul/8. | Journal Article
 
Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
Liu, Zhaohui⋅Hamamichi, Shusei⋅Dae Lee, Byoung⋅Yang, Dejun⋅Ray, Arpita⋅Caldwell, Guy⋅Caldwell, Kim A⋅Dawson, Ted M⋅Smith, Wanli and Dawson, Valina L
Human Molecular Genetics, vol. 20, (no. 20), pp. 3933-3942, 2011. | Journal Article
 
Modeling dopamine neuron degeneration in Caenorhabditis elegans.
Tucci, Michelle L⋅Harrington, Adam J⋅Caldwell, Guy and Caldwell, Kim A
Methods in molecular biology (Clifton, N.J.), vol. 793, pp. 129-48, 2011. | Journal Article
 
TorsinA participates in endoplasmic reticulum-associated degradation.
Nery, Flavia C⋅Armata, Ioanna A⋅Farley, Jonathan E⋅Cho, Jin A⋅Yaqub, Uzma⋅Chen, Pan⋅da Hora, Cintia C⋅Da Hora, Cintia⋅Wang, Qiuyan⋅Tagaya, Mitsuo⋅Klein, Christine⋅Tannous, Bakhos A⋅Caldwell, Kim A⋅Caldwell, Guy⋅Lencer, Wayne I⋅Ye, Yihong and Breakefield, Xandra O
Nature communications, vol. 2, pp. 393, 2011. | Journal Article
2010
C. elegans as a model organism to investigate molecular pathways involved with Parkinson's disease.
Harrington, Adam J⋅Hamamichi, Shusei⋅Caldwell, Guy and Caldwell, Kim A
Developmental dynamics : an official publication of the American Association of Anatomists, vol. 239, (no. 5), pp. 1282-95, 2010/May. | Journal Article
 
Chemical enhancement of torsinA function in cell and animal models of torsion dystonia.
Cao, Songsong⋅Hewett, Jeffrey W⋅Yokoi, Fumiaki⋅Lu, Jun⋅Buckley, Amber C⋅Burdette, Alexander J⋅Chen, Pan⋅Nery, Flavia C⋅Li, Yuqing⋅Breakefield, Xandra O⋅Caldwell, Guy and Caldwell, Kim A
Disease models & mechanisms, vol. 3, (no. 5-6), pp. 386-96, 2010 May-Jun. | Journal Article
 
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models.
Su, Linhui Julie⋅Su, Linhui J⋅Auluck, Pavan K⋅Auluck, Pavan K⋅Outeiro, Tiago F⋅Outeiro, Tiago Fleming⋅Yeger-Lotem, Esti⋅Yeger-Lotem, Esti⋅Kritzer, Joshua A⋅Kritzer, Joshua A⋅Tardiff, Daniel F⋅Tardiff, Daniel F⋅Strathearn, Katherine E⋅Strathearn, Katherine E⋅Liu, Fang⋅Liu, Fang⋅Cao, Songsong⋅Cao, Songsong⋅Hamamichi, Shusei⋅Hamamichi, Shusei⋅Hill, Kathryn J⋅Hill, Kathryn J⋅Caldwell, Kim A⋅Caldwell, Kim A⋅Bell, George W⋅Bell, George W⋅Fraenkel, Ernest⋅Fraenkel, Ernest⋅Cooper, Antony A⋅Cooper, Antony A⋅Caldwell, Guy A⋅Caldwell, Guy⋅McCaffery, J M⋅McCaffery, J Michael⋅Rochet, Jean-Christophe⋅Rochet, Jean Christophe⋅Lindquist, Susan and Lindquist, Susan L
Disease models & mechanisms, vol. 3, (no. 3-4), pp. 194-208, 2010 Mar-Apr. | Journal Article
 
Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease.
Yacoubian, Talene⋅Slone, S R⋅Harrington, A J⋅Hamamichi, S⋅Schieltz, J M⋅Caldwell, Kim A⋅Caldwell, Guy and Standaert, David G
Cell death & disease, vol. 1, (no. 1), pp. e2, 2010. | Journal Article
 
Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction
Pivtoraiko, Violetta N⋅Harrington, Adam J⋅Mader, Burton J⋅Luker, Austin M⋅Caldwell, Guy⋅Caldwell, Kim A⋅Roth, Kevin and Shacka, John
Journal of Neurochemistry, vol. 114, (no. 4), pp. 1193-1204, 2010. | Journal Article
 
The early-onset torsion dystonia-associated protein, torsinA, displays molecular chaperone activity in vitro.
Burdette, Alexander J⋅Churchill, Perry F⋅Caldwell, Guy and Caldwell, Kim A
Cell stress & chaperones, vol. 15, (no. 5), pp. 605-17, 2010/Sep. | Journal Article
 
The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response.
Chen, Pan⋅Burdette, Alexander J⋅Porter, J C⋅Ricketts, John C⋅Fox, Stacey A⋅Nery, Flavia C⋅Hewett, Jeffrey W⋅Berkowitz, Laura A⋅Breakefield, Xandra O⋅Caldwell, Kim A and Caldwell, Guy
Human molecular genetics, vol. 19, (no. 18), pp. 3502-15, 2010/Sep/15. | Journal Article
 
VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease
Ruan, Qingmin⋅Harrington, Adam J⋅Caldwell, Kim A⋅Caldwell, Guy and Standaert, David G
Neurobiology of Disease, vol. 37, (no. 2), pp. 330-338, 2010. | Journal Article