95 Publications (Page 3 of 4)
2009
[alpha]-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicityGitler, Aaron⋅Chesi, Alessandra⋅Geddie, Melissa L⋅Strathearn, Katherine E⋅Hamamichi, Shusei⋅Hill, Kathryn J⋅Caldwell, Kim A⋅Caldwell, Guy⋅Cooper, Antony A⋅Rochet, Jean Christophe and Lindquist, Susan LNature Genetics, vol. 41, (no. 3), pp. 308-315, 2009.
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Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.Gitler, Aaron D⋅Chesi, Alessandra⋅Geddie, Melissa L⋅Strathearn, Katherine E⋅Hamamichi, Shusei⋅Hill, Kathryn J⋅Caldwell, Kim A⋅Caldwell, Guy A⋅Cooper, Antony A⋅Rochet, Jean Christophe and Lindquist, SusanNature genetics, vol. 41, (no. 3), pp. 308-315, March 2009.
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Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.Caldwell, Kim A⋅Caldwell, Kim A⋅Tucci, Michelle L⋅Tucci, Michelle L⋅Armagost, Jafa⋅Hodges, Tyler W⋅Hodges, Tyler W⋅Chen, Jue⋅Chen, Jue⋅Memon, Shermeen B⋅Memon, Shermeen B ...more » ⋅Blalock, Jeana E⋅Blalock, Jeana E⋅DeLeon, Susan M⋅DeLeon, Susan M⋅Findlay, Robert H⋅Findlay, Robert H⋅Ruan, Qingmin⋅Ruan, Qingmin⋅Webber, Philip J⋅Webber, Philip J⋅Standaert, David G⋅Standaert, David G⋅Olson, Julie B⋅Olson, Julie B⋅Caldwell, Guy and Caldwell, Guy A « lessPloS one, vol. 4, (no. 10), pp. e7227, 2009.
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Pharmacogenetic Analysis Reveals a Post-Developmental Role for Rac GTPases in Caenorhabditis elegans GABAergic NeurotransmissionLocke, Cody J⋅Kautu, Bwarenaba B⋅Berry, Kalen P⋅Lee, S. K⋅Caldwell, Kim A and Caldwell, GuyGenetics, vol. 183, (no. 4), pp. 1357-72, Dec 2009.
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Rapid selection of cyclic peptides that reduce alpha -synuclein toxicity in yeast and animal modelsKritzer, Joshua A⋅Kritzer, Joshua A⋅Hamamichi, Shusei⋅Hamamichi, Shusei⋅Mccaffery, J M⋅McCaffery, J. M⋅Santagata, Sandro⋅Santagata, Sandro⋅Naumann, Todd A⋅Naumann, Todd A⋅Caldwell, Kim A ...more » ⋅Caldwell, Kim A⋅Caldwell, Guy A⋅Caldwell, Guy⋅Lindquist, Susan L and Lindquist, Susan « lessNature Chemical Biology, vol. 5, (no. 9), pp. 655-663, 2009.
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Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.Kritzer, Joshua A⋅Hamamichi, Shusei⋅McCaffery, J Michael⋅Santagata, Sandro⋅Naumann, Todd A⋅Caldwell, Kim A⋅Caldwell, Guy A and Lindquist, SusanNature chemical biology, vol. 5, (no. 9), pp. 655-663, September 2009.
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The microtubule-associated protein, NUD-1, exhibits chaperone activity in vitro.Faircloth, Lindsay M⋅Churchill, Perry F⋅Caldwell, Guy and Caldwell, Kim ACell stress & chaperones, vol. 14, (no. 1), pp. 95-103, 2009/Jan.
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2008
Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's diseaseLocke, Cody J⋅Fox, Stacey A⋅Caldwell, Guy and Caldwell, Kim ANeuroscience Letters, vol. 439, (no. 2), pp. 129-133, 2008.
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Animal models for drug discovery in dystoniaJinnah, Hyder A⋅Richter, Angelika⋅Mink, Jonathon W⋅Caldwell, Guy⋅Caldwell, Kim A⋅Gonzalez Alegre, Pedro⋅Cookson, Mark R⋅Breakefield, Xandra O⋅De Long, Mahlon R and Hess, Ellen JExpert Opinion on Drug Discovery, vol. 3, (no. 1), pp. 83-97, 2008.
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Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.Berkowitz, Laura A⋅Hamamichi, Shusei⋅Knight, Adam L⋅Harrington, Adam J⋅Caldwell, Guy and Caldwell, Kim AJournal of visualized experiments : JoVE, (no. 17), 2008.
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Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease modelHamamichi, Shusei⋅Rivas, Renee N⋅Knight, Adam L⋅Cao, Songsong⋅Caldwell, Kim A and Caldwell, GuyProceedings of the National Academy of Sciences of the United States of America, vol. 105, (no. 2), Jan 15, 2008.
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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity.Qiao, Liyan⋅Hamamichi, Shusei⋅Caldwell, Kim A⋅Caldwell, Guy⋅Yacoubian, Talene⋅Wilson, Scott⋅Xie, Zuo-Lei⋅Speake, Lisa D⋅Parks, Rachael⋅Crabtree, Donna⋅Liang, Qiuli ...more » ⋅Crimmins, Stephen⋅Schneider, Lonnie⋅Uchiyama, Yasuo⋅Iwatsubo, Takeshi⋅Zhou, Yi⋅Peng, Lisheng⋅Lu, Youming⋅Standaert, David G⋅Walls, Ken C⋅Shacka, John J⋅Roth, Kevin A and Zhang, Jianhua M « lessMolecular brain, vol. 1, (no. 1), pp. 17, 2008.
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The Parkinson's disease protein alpha -synuclein disrupts cellular Rab homeostasisGitler, Aaron⋅Bevis, Brooke J⋅Shorter, James⋅Strathearn, Katherine E⋅Hamamichi, Shusei⋅Su, Linhui J⋅Caldwell, Kim A⋅Caldwell, Guy⋅Rochet, Jean Christophe⋅McCaffery, JMichael⋅Barlowe, Charles K and Lindquist, Susan LProceedings of the National Academy of Sciences, USA, vol. 105, (no. 1), pp. 145-150, 2008.
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The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis.Gitler, Aaron D⋅Bevis, Brooke J⋅Shorter, James⋅Strathearn, Katherine E⋅Hamamichi, Shusei⋅Su, Linhui Julie⋅Caldwell, Kim A⋅Caldwell, Guy A⋅Rochet, Jean Christophe⋅McCaffery, J Michael⋅Barlowe, Charles and Lindquist, SusanProceedings of the National Academy of Sciences of the United States of America, vol. 105, (no. 1), pp. 145-150, January 8, 2008.
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The Parkinson's disease protein ¿-synuclein disrupts cellular Rab homeostasisGitler, Aaron⋅Bevis, Brooke J⋅Shorter, James⋅Strathearn, Katherine E⋅Hamamichi, Shusei⋅Su, Linhui J⋅Caldwell, Kim A⋅Caldwell, Guy⋅Rochet, Jean Christophe⋅McCaffery, J M⋅Barlowe, Charles K and Lindquist, Susan LProceedings of the National Academy of Sciences of the United States of America, vol. 105, (no. 1), Jan 8, 2008.
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The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis.Gitler, Aaron⋅Bevis, Brooke J⋅Shorter, James⋅Strathearn, Katherine E⋅Hamamichi, Shusei⋅Su, Linhui J⋅Caldwell, Kim A⋅Caldwell, Guy⋅Rochet, Jean Christophe⋅McCaffery, J. M⋅Barlowe, Charles and Lindquist, Susan LProceedings of the National Academy of Sciences of the United States of America., vol. 105, (no. 1), pp. 145-150, 2008.
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Traversing a wormhole to combat Parkinson's disease.Caldwell, Guy and Caldwell, Kim ADisease models & mechanisms, vol. 1, (no. 1), pp. 32-6, 2008 Jul-Aug.
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2007
Ubiquitin conjugating enzymes participate in polyglutamine protein aggregationHoward, Rebecca A⋅Sharma, Pratima⋅Hajjar, Connie⋅Caldwell, Kim A⋅Caldwell, Guy⋅du Breuil, Rusla⋅Moore, Rhonda and Boyd, LynnBMC Cell Biology, vol. 8, pp. 32-32, 2007.
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Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation.Howard, Rebecca A⋅Sharma, Pratima⋅Hajjar, Connie⋅Caldwell, Kim A⋅Caldwell, Guy⋅du Breuil, Rusla⋅Moore, Rhonda and Boyd, LynnBMC cell biology, vol. 8, pp. 32, 2007.
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2006
{alpha}-Synuclein Blocks ER-Golgi Traffic and Rab1 Rescues Neuron Loss in Parkinson's ModelsCooper, Antony A⋅Gitler, Aaron⋅Cashikar, Anil G⋅Haynes, Cole⋅Hill, Kathryn J⋅Bhullar, Bhupinder⋅Liu, Kangning⋅Xu, Kexiang⋅Strathearn, Katherine E⋅Liu, Fang⋅Cao, Songsong ...more » ⋅Caldwell, Kim A⋅Caldwell, Guy⋅Marsischky, Gerald⋅Kolodner, Richard D⋅Labaer, Joshua⋅Rochet, Jean Christophe⋅Bonini, Nancy M and Lindquist, Susan L « lessScience (Washington), vol. 313, (no. 5785), pp. 324-328, 2006.
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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.Cooper, Antony A⋅Gitler, Aaron D⋅Cashikar, Anil⋅Haynes, Cole M⋅Hill, Kathryn J⋅Bhullar, Bhupinder⋅Liu, Kangning⋅Xu, Kexiang⋅Strathearn, Katherine E⋅Liu, Fang⋅Cao, Songsong ...more » ⋅Caldwell, Kim A⋅Caldwell, Guy A⋅Marsischky, Gerald⋅Kolodner, Richard D⋅Labaer, Joshua⋅Rochet, Jean Christophe⋅Bonini, Nancy M and Lindquist, Susan « lessScience (New York, N.Y.), vol. 313, (no. 5785), pp. 324-328, July 21, 2006.
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Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species.Dickey, Chad A⋅Yue, Mei⋅Lin, Wen-Lang⋅Dickson, Dennis W⋅Dunmore, Judith H⋅Lee, Wing C⋅Zehr, Cynthia⋅West, Gemma⋅Cao, Songsong⋅Clark, Amber M K⋅Caldwell, Guy A ...more » ⋅Caldwell, Kim A⋅Eckman, Christopher⋅Patterson, Cam⋅Hutton, Michael and Petrucelli, Leonard « lessThe Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 26, (no. 26), pp. 6985-6996, June 28, 2006.
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Deletion of the Ubiquitin Ligase CHIP Leads to the Accumulation, But Not the Aggregation, of Both Endogenous Phospho- and Caspase-3-Cleaved Tau SpeciesDickey, Chad⋅Yue, Mei⋅Lin, Wen-Lang⋅Dickson, Dennis W⋅Dunmore, Judith H⋅Lee, Wing C⋅Zehr, Cynthia⋅West, Gemma⋅Cao, Songsong⋅Clark, Amber M⋅Caldwell, Guy ...more » ⋅Caldwell, Kim A⋅Eckman, Christopher⋅Patterson, Cam⋅Hutton, Michael L and Petrucelli, Leonard « lessJournal of Neuroscience, vol. 26, (no. 26), pp. 6985-6996, 2006.
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Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans.Locke, Cody J⋅Williams, Shelli N⋅Schwarz, Erich M⋅Caldwell, Guy and Caldwell, Kim ABrain research, vol. 1120, (no. 1), pp. 23-34, 2006/Nov/20.
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