78 Publications (Page 1 of 4)
2008
Critical role of specific ions for ligand-induced changes regulating pyruvate dehydrogenase kinase isoform 2.
Hiromasa, Yasuaki and Roche, Thomas E
Biochemistry, vol. 47, (no. 8), pp. 2298-311, 2008/Feb/26. | Journal Article
 
Specific ion influences on self-association of pyruvate dehydrogenase kinase isoform 2 (PDHK2), binding of PDHK2 to the L2 lipoyl domain, and effects of the lipoyl group-binding site inhibitor, Nov3r.
Hiromasa, Yasuaki⋅Yan, Xiaohua and Roche, Thomas E
Biochemistry, vol. 47, (no. 8), pp. 2312-24, 2008/Feb/26. | Journal Article
 
Structures of the human pyruvate dehydrogenase complex cores: a highly conserved catalytic center with flexible N-terminal domains.
Yu, Xuekui⋅Hiromasa, Yasuaki⋅Tsen, Hua⋅Stoops, James K⋅Roche, Thomas E and Zhou, Z. H
Structure (London, England : 1993), vol. 16, (no. 1), pp. 104-14, 2008/Jan. | Journal Article
2007
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer
Roche, Thomas E and Hiromasa, Yasuaki
Cellular and molecular life sciences CMLS., vol. 64, (no. 7-8), pp. 830-849, 2007. | Journal Article
2006
Ligand-induced Effects on Pyruvate Dehydrogenase Kinase Isoform 2
Hiromasa, Yasuaki⋅Hu, Liangyan and Roche, Thomas E
Journal of Biological Chemistry, vol. 281, (no. 18), pp. 12568-12579, 2006. | Journal Article
 
Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands.
Knoechel, Thorsten R⋅Tucker, Alec D⋅Robinson, Colin M⋅Phillips, Chris⋅Taylor, Wendy⋅Bungay, Peter J⋅Kasten, Shane A⋅Roche, Thomas E and Brown, David G
Biochemistry, vol. 45, (no. 2), pp. 402-15, 2006/Jan/17. | Journal Article
2004
Formation of a complex of the catalytic subunit of pyruvate dehydrogenase phosphatase isoform 1 (PDP1c) and the L2 domain forms a Ca2+ binding site and captures PDP1c as a monomer.
Turkan, Ali⋅Hiromasa, Yasuaki and Roche, Thomas E
Biochemistry, vol. 43, (no. 47), pp. 15073-85, 2004/Nov/30. | Journal Article
 
Organization of the cores of the mammalian pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and their capacities to bind the E1 and E3 components.
Hiromasa, Yasuaki⋅Fujisawa, Tetsuro⋅Aso, Yoichi and Roche, Thomas E
The Journal of biological chemistry, vol. 279, (no. 8), pp. 6921-33, 2004/Feb/20. | Journal Article
 
Pyruvate dehydrogenase kinase isoform 2 activity limited and further inhibited by slowing down the rate of dissociation of ADP.
Bao, Haiying⋅Kasten, Shane A⋅Yan, Xiaohua and Roche, Thomas E
Biochemistry, vol. 43, (no. 42), pp. 13432-41, 2004/Oct/26. | Journal Article
 
Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.
Bao, Haiying⋅Kasten, Shane A⋅Yan, Xiaohua⋅Hiromasa, Yasuaki and Roche, Thomas E
Biochemistry, vol. 43, (no. 42), pp. 13442-51, 2004/Oct/26. | Journal Article
2003
AZD7545 is a selective inhibitor of pyruvate dehydrogenase kinase 2.
Morrell, J A⋅Orme, J⋅Butlin, R J⋅Roche, Thomas E⋅Mayers, R M and Kilgour, E
Biochemical Society transactions, vol. 31, (no. Pt 6), pp. 1168-70, 2003/Dec. | Journal Article
 
Essential roles of lipoyl domains in the activated function and control of pyruvate dehydrogenase kinases and phosphatase isoform 1.
Roche, Thomas E⋅Hiromasa, Yasuaki⋅Turkan, Ali⋅Gong, Xiaoming⋅Peng, Tao⋅Yan, Xiaohua⋅Kasten, Shane A⋅Bao, Haiying and Dong, Jianchun
European journal of biochemistry / FEBS. , vol. 270, (no. 6), pp. 1050-6, 2003/Mar. | Journal Article
 
Facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase.
Hiromasa, Yasuaki and Roche, Thomas E
The Journal of biological chemistry, vol. 278, (no. 36), pp. 33681-93, 2003/Sep/5. | Journal Article
2002
Structural requirements within the lipoyl domain for the Ca2+-dependent binding and activation of pyruvate dehydrogenase phosphatase isoform 1 or its catalytic subunit.
Turkan, Ali⋅Gong, Xiaoming⋅Peng, Tao and Roche, Thomas E
The Journal of biological chemistry, vol. 277, (no. 17), pp. 14976-85, 2002/Apr/26. | Journal Article
 
Structural Requirements within the Lipoyl Domain for the Ca super(2+)-dependent Binding and Activation of Pyruvate Dehydrogenase Phosphatase Isoform 1 or Its Catalytic Subunit
Turkan, A.⋅Gong, X.⋅Peng, T. and Roche, Thomas E
Journal of Biological Chemistry, vol. 277, (no. 17), pp. 14976-14985, 2002. | Journal Article
2001
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms
Roche, Thomas E⋅Baker, JC⋅Yan, X.⋅Hiromasa, Y.⋅Gong, X.⋅Peng, T.⋅Dong, J.⋅Turkan, A. and Kasten, SA
Progress in Nucleic Acid Research and Molecular Biology, vol. 70, pp. 33-54, 2001. | Journal Article
 
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.
Roche, Thomas E⋅Baker, J.C.⋅Yan, X.⋅Hiromasa, Y.⋅Gong, X.⋅Peng, T.⋅Dong, J.⋅Turkan, A. and Kasten, S.A.
Progress in nucleic acid research and molecular biology., pp. 33-75, 2001. | Journal Article
 
Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.
Roche, Thomas E⋅Baker, J C⋅Yan, X⋅Hiromasa, Y⋅Gong, X⋅Peng, T⋅Dong, J⋅Turkan, A and Kasten, S A
Progress in nucleic acid research and molecular biology, vol. 70, pp. 33-75, 2001. | Journal Article
 
Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.
Liu, S⋅Gong, X⋅Yan, X⋅Peng, T⋅Baker, J C⋅Li, L⋅Robben, P M⋅Ravindran, S⋅Andersson, L A⋅Cole, A B and Roche, Thomas E
Archives of biochemistry and biophysics, vol. 386, (no. 2), pp. 123-35, 2001/Feb/15. | Journal Article
2000
Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic.
Sasaki, M⋅Ansari, Aftab A⋅Pumford, N⋅Van De Water, Judy⋅Leung, Patrick S⋅Humphries, K M⋅Szweda, L I⋅Nakanuma, Y⋅Roche, Thomas E⋅Coppel, Ross⋅Bach, J F and Gershwin, M. E
Journal of autoimmunity, vol. 15, (no. 1), pp. 51-60, 2000/Aug. | Journal Article
 
Marked differences between two isoforms of human pyruvate dehydrogenase kinase.
Baker, J C⋅Yan, X⋅Peng, T⋅Kasten, S and Roche, Thomas E
The Journal of biological chemistry, vol. 275, (no. 21), pp. 15773-81, 2000/May/26. | Journal Article
 
Specificity determinants for the pyruvate dehydrogenase component reaction mapped with mutated and prosthetic group modified lipoyl domains.
Gong, X⋅Peng, T⋅Yakhnin, A⋅Zolkiewski, M⋅Quinn, J⋅Yeaman, Steve J and Roche, Thomas E
The Journal of biological chemistry, vol. 275, (no. 18), pp. 13645-53, 2000/May/5. | Journal Article
1999
Autoepitope mapping and reactivity of autoantibodies to the dihydrolipoamide dehydrogenase-binding protein (E3BP) and the glycine cleavage proteins in primary biliary cirrhosis.
Dubel, L⋅Tanaka, A⋅Leung, Patrick S⋅Van de Water, J⋅Coppel, R⋅Roche, Thomas E⋅Johanet, C⋅Motokawa, Y⋅Ansari, Aftab A and Gershwin, M E
Hepatology (Baltimore, Md.), vol. 29, (no. 4), pp. 1013-8, 1999/Apr. | Journal Article
1998
Identification and precursor frequency analysis of a common T cell epitope motif in mitochondrial autoantigens in primary biliary cirrhosis.
SHIMODA, S⋅Shimoda, Shinji⋅VAN DE WATER, J⋅Van de Water, J⋅Ansari, Aftab A⋅ANSARI, A⋅Nakamura, Mary C⋅al.⋅Ishibashi, H⋅Coppel, R L⋅Lake, J⋅Keeffe, E B⋅Roche, Thomas E and Gershwin, M. E
The Journal of clinical investigation, vol. 102, (no. 10), pp. 1831-40, 1998/Nov/15. | Journal Article
 
Requirements for the adaptor protein role of dihydrolipoyl acetyltransferase in the up-regulated function of the pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase.
Yang, Da Qing⋅Gong, X⋅Yakhnin, A and Roche, Thomas E
The Journal of biological chemistry, vol. 273, (no. 23), pp. 14130-7, 1998/Jun/5. | Journal Article