78 Publications (Page 2 of 4)
1997
Assembly and full functionality of recombinantly expressed dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex.
Yang, Da Qing⋅Song, J⋅Wagenknecht, T and Roche, Thomas E
The Journal of biological chemistry, vol. 272, (no. 10), pp. 6361-9, 1997/Mar/7. | Journal Article
1996
Activated function of the pyruvate dehydrogenase phosphatase through Ca2+-facilitated binding to the inner lipoyl domain of the dihydrolipoyl acetyltransferase.
Chen, G⋅Wang, L⋅Liu, S⋅Chuang, Cynthia F and Roche, Thomas E
The Journal of biological chemistry, vol. 271, (no. 45), pp. 28064-70, 1996/Nov/8. | Journal Article
 
Lipoyl domain-based mechanism for the integrated feedback control of the pyruvate dehydrogenase complex by enhancement of pyruvate dehydrogenase kinase activity.
Ravindran, S⋅Radke, G A⋅Guest, J R and Roche, Thomas E
The Journal of biological chemistry, vol. 271, (no. 2), pp. 653-62, 1996/Jan/12. | Journal Article
1995
Arginine-239 in the beta subunit is at or near the active site of bovine pyruvate dehydrogenase.
Eswaran, D⋅Ali, M S⋅Shenoy, B C⋅Korotchkina, L G⋅Roche, Thomas E and Patel, M S
Biochimica et biophysica acta, vol. 1252, (no. 2), pp. 203-8, 1995/Oct/25. | Journal Article
 
Binding of the pyruvate dehydrogenase kinase to recombinant constructs containing the inner lipoyl domain of the dihydrolipoyl acetyltransferase component.
Liu, S⋅Baker, J C and Roche, Thomas E
The Journal of biological chemistry, vol. 270, (no. 2), pp. 793-800, 1995/Jan/13. | Journal Article
 
Heterogeneity of autoreactive T cell clones specific for the E2 component of the pyruvate dehydrogenase complex in primary biliary cirrhosis.
Van De Water, Judy⋅Ansari, Aftab A⋅Prindiville, Thomas P⋅Coppel, Ross⋅Ricalton, N⋅Kotzin, B L⋅Liu, S⋅Roche, Thomas E⋅Krams, S M⋅Munoz, S and Gershwin, M. E
The Journal of experimental medicine, vol. 181, (no. 2), pp. 723-33, 1995/Feb/1. | Journal Article
 
Identification of the tryptophan residue in the thiamin pyrophosphate binding site of mammalian pyruvate dehydrogenase.
Ali, M S⋅Shenoy, B C⋅Eswaran, D⋅Andersson, L A⋅Roche, Thomas E and Patel, M S
The Journal of biological chemistry, vol. 270, (no. 9), pp. 4570-4, 1995/Mar/3. | Journal Article
 
Recombinant expression and evaluation of the lipoyl domains of the dihydrolipoyl acetyltransferase component of the human pyruvate dehydrogenase complex.
Liu, S⋅Baker, J C⋅Andrews, P C and Roche, Thomas E
Archives of biochemistry and biophysics, vol. 316, (no. 2), pp. 926-40, 1995/Feb/1. | Journal Article
1993
Critical role of a lipoyl cofactor of the dihydrolipoyl acetyltransferase in the binding and enhanced function of the pyruvate dehydrogenase kinase.
Radke, G A⋅Ono, K⋅Ravindran, S and Roche, Thomas E
Biochemical and biophysical research communications, vol. 190, (no. 3), pp. 982-91, 1993/Feb/15. | Journal Article
 
Identification of the essential cysteine residue in the active site of bovine pyruvate dehydrogenase.
Ali, M S⋅Roche, Thomas E and Patel, Mulchand S
The Journal of biological chemistry, vol. 268, (no. 30), pp. 22353-6, 1993/Oct/25. | Journal Article
 
Partial activation of the pyruvate dehydrogenase kinase by the lipoyl domain region of E2 and interchange of the kinase between lipoyl domain regions.
Ono, K⋅Radke, G A⋅Roche, Thomas E and Rahmatullah, M
The Journal of biological chemistry, vol. 268, (no. 35), pp. 26135-43, 1993/Dec/15. | Journal Article
 
Sizing of bovine heart and kidney pyruvate dehydrogenase complex and dihydrolipoyl transacetylase core by quasielastic light scattering.
Roche, Thomas E⋅Powers-Greenwood, S L⋅Shi, W F⋅Zhang, W B⋅Ren, S Z⋅Roche, E D⋅Cox, D J and Sorensen, C M
Biochemistry, vol. 32, (no. 21), pp. 5629-37, 1993/Jun/1. | Journal Article
1992
Additional binding sites for the pyruvate dehydrogenase kinase but not for protein X in the assembled core of the mammalian pyruvate dehydrogenase complex: binding region for the kinase.
Li, L⋅Radke, G A⋅Ono, K and Roche, Thomas E
Archives of biochemistry and biophysics, vol. 296, (no. 2), pp. 497-504, 1992/Aug/1. | Journal Article
1991
Cryoelectron microscopy of mammalian pyruvate dehydrogenase complex.
Wagenknecht, T⋅Grassucci, R⋅Radke, G A and Roche, Thomas E
The Journal of biological chemistry, vol. 266, (no. 36), pp. 24650-6, 1991/Dec/25. | Journal Article
 
Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis.
Van De Water, Judy⋅Ansari, Aftab A⋅Surh, C D⋅Coppel, Ross⋅Roche, Thomas E⋅Bonkovsky, H⋅Kaplan, Marshall M and Gershwin, M. E
Journal of immunology (Baltimore, Md. : 1950), vol. 146, (no. 1), pp. 89-94, 1991/Jan/1. | Journal Article
 
Specific reactivity of recombinant human PDC-E1 alpha in primary biliary cirrhosis.
Iwayama, T⋅Leung, Patrick S⋅Coppel, Ross⋅Roche, Thomas E⋅Patel, Mulchand S⋅Mizushima, Y⋅Nakagawa, T⋅Dickson, R and Gershwin, M. E
Journal of autoimmunity, vol. 4, (no. 5), pp. 769-78, 1991/Oct. | Journal Article
1990
Changes in the core of the mammalian-pyruvate dehydrogenase complex upon selective removal of the lipoyl domain from the transacetylase component but not from the protein X component.
Rahmatullah, M⋅Radke, G A⋅Andrews, P C and Roche, Thomas E
The Journal of biological chemistry, vol. 265, (no. 24), pp. 14512-7, 1990/Aug/25. | Journal Article
 
Molecular biology and biochemistry of pyruvate dehydrogenase complexes.
Patel, Mulchand S and Roche, Thomas E
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, vol. 4, (no. 14), pp. 3224-33, 1990/Nov. | Journal Article
 
Primary biliary cirrhosis. Inhibition of pyruvate dehydrogenase complex activity by autoantibodies specific for E1 alpha, a non-lipoic acid containing mitochondrial enzyme.
Fregeau, D R⋅Roche, Thomas E⋅Davis, Paul A⋅Coppel, Ross and Gershwin, M. E
Journal of immunology (Baltimore, Md. : 1950), vol. 144, (no. 5), pp. 1671-6, 1990/Mar/1. | Journal Article
1989
Domain structures of the dihydrolipoyl transacetylase and the protein X components of mammalian pyruvate dehydrogenase complex. Selective cleavage by protease Arg C.
Rahmatullah, M⋅Gopalakrishnan, S⋅Radke, G A and Roche, Thomas E
The Journal of biological chemistry, vol. 264, (no. 2), pp. 1245-51, 1989/Jan/15. | Journal Article
 
Lipoyl-containing components of the pyruvate dehydrogenase complex: roles in modulating and anchoring the PDH kinase and the PDH phosphatase.
Roche, Thomas E⋅Rahmatullah, M⋅Li, L⋅Radke, G A⋅Chang, C L and Powers-Greenwood, S L
Annals of the New York Academy of Sciences, vol. 573, pp. 168-74, 1989. | Journal Article
 
Role of protein X in the function of the mammalian pyruvate dehydrogenase complex.
Gopalakrishnan, S⋅Rahmatullah, M⋅Radke, G A⋅Powers-Greenwood, S and Roche, Thomas E
Biochemical and biophysical research communications, vol. 160, (no. 2), pp. 715-21, 1989/Apr/28. | Journal Article
 
Subunit associations in the mammalian pyruvate dehydrogenase complex. Structure and role of protein X and the pyruvate dehydrogenase component binding domain of the dihydrolipoyl transacetylase component.
Rahmatullah, M⋅Gopalakrishnan, S⋅Andrews, P C⋅Chang, C L⋅Radke, G A and Roche, Thomas E
The Journal of biological chemistry, vol. 264, (no. 4), pp. 2221-7, 1989/Feb/5. | Journal Article
 
The lipoyl-containing components of the mammalian pyruvate dehydrogenase complex: structural comparison and subdomain roles.
Roche, Thomas E⋅Rahmatullah, M⋅Powers-Greenwood, S L⋅Radke, G A⋅Gopalakrishnan, S and Chang, C L
Annals of the New York Academy of Sciences, vol. 573, pp. 66-75, 1989. | Journal Article
1987
The catalytic requirements for reduction and acetylation of protein X and the related regulation of various forms of resolved pyruvate dehydrogenase kinase.
Rahmatullah, M and Roche, Thomas E
The Journal of biological chemistry, vol. 262, (no. 21), pp. 10265-71, 1987/Jul/25. | Journal Article