133 Publications (Page 1 of 6)
2021
Enzymatic Stetter Reaction: Computational Study of the Reaction Mechanism of MenD
ACS Catalysis. | Journal Article
2020
Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1
Journal of Medicinal Chemistry. | Journal Article
2019
Computational characterization of enzyme-bound thiamin diphosphate reveals a surprisingly stable tricyclic state: implications for catalysis
Planas, Ferran⋅Mc Leish, Michael J and Himo, Fahmi
Beilstein Journal of Organic Chemistry, vol. 15, pp. 145–159. | Journal Article
 
Computational Study of Enantioselective Carboligation Catalyzed by Benzoylformate Decarboxylase
Planas, Ferran⋅Mc Leish, Michael J. and Himo, Fahmi
ACS Catalysis, pp. 5657–5667. | Journal Article
2018
A Theoretical Study of the Benzoylformate Decarboxylase Reaction Mechanism
Planas, Ferran⋅Sheng, Xiang⋅Mc Leish, Michael J and Himo, Fahmi
Frontiers in chemistry, vol. 6, pp. 205, 2018-00-00. | Journal Article
2017
Environmental heterogeneity and the evolution of plant-virus interactions: Viruses in wild pepper populations
Fraile, Aurora⋅Mc Leish, Michael J⋅Pagán, Israel⋅González-Jara, Pablo⋅Piñero, Daniel and García-Arenal, Fernando
Virus Research, vol. 241, pp. 76, 2017-09-15. | Journal Article
 
Phosphonodifluoropyruvate is a mechanism-based inhibitor of phosphonopyruvate decarboxylase from Bacteroides fragilis.
Bioorganic & medicinal chemistry. | Journal Article
 
Spatial correspondence between the specialist galling insect genus Kladothrips (Thysanoptera: Tubulifera: Phlaeothripidae) and its Acacia host: ecological and evolutionary constraints on host use
Mc Leish, Michael J⋅González‐Orozco, Carlos E and Miller, Joe T
Austral Entomology, vol. 56, (no. 4), pp. 423, November 2017. | Journal Article
 
Specificity and mechanism of mandelamide hydrolase catalysis.
Adediran, S A⋅Wang, Pan-Fen⋅Shilabin, Abbas G⋅Baron, Charles A and Mc Leish, Michael J
Archives of biochemistry and biophysics, January 24, 2017. | Journal Article
 
Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily.
Protein engineering, design & selection : PEDS. | Journal Article
2016
Mechanistic and Structural Insight to an Evolved Benzoylformate Decarboxylase with Enhanced Pyruvate Decarboxylase Activity
Catalysts. | Journal Article
2015
Crystal Structure of Benzoylformate Decarboxylase Mutant H281Y/T377P/F397T/A460I
Andrews, F.H. and Mc Leish, M.J.
Protein Data Bank, Rutgers University
 
The kinetic characterization and X-ray structure of a putative benzoylformate decarboxylase from M. smegmatis highlights the difficulties in the functional annotation of ThDP-dependent enzymes
Andrews, F.H.⋅Horton, J.D.⋅Shin, D.⋅Yoon, H.-J.⋅Logsdon, M.G.⋅Malik, A.M.⋅Rogers, M.P.⋅Kneen, M.M.⋅Suh, S.W. and Mc Leish, M.J.
Biochimica et Biophysica Acta - Proteins and Proteomics, vol. 1854, pp. 1001-1009. | Journal Article
2014
Crystal Structure of Benzoylformate Decarboxylase Mutant A306F
Andrews, F.H. and Mc Leish, M.J.
Protein Data Bank, Rutgers University
 
Extended reaction scope of thiamine diphosphate dependent cyclohexane-1,2-dione hydrolase: From C-C bond cleavage to C-C bond ligation
Loschonsky, S.⋅Wacker, T.⋅Waltzer, S.⋅Giovannini, P.P.⋅Mc Leish, M.J.⋅Andrade, S.L.A. and Müller, M.
Angewandte Chemie - International Edition, vol. 53, pp. 14402-14406. | Journal Article
 
Identification of charge transfer transitions related to thiamin-bound intermediates on enzymes provides a plethora of signatures useful in mechanistic studies.
Patel, Hetalben⋅Nemeria, Natalia S⋅Andrews, Forest H⋅Mc Leish, Michael J and Jordan, Frank
Biochemistry, vol. 53, (no. 13), pp. 2145-52, 2014/Apr/8. | Journal Article
 
Perturbation of the monomer-monomer interfaces of the benzoylformate decarboxylase tetramer
Andrews, F.H.⋅Rogers, M.P.⋅Paul, L.N. and Mc Leish, M.J.
Biochemistry, vol. 53, pp. 4358-4367. | Journal Article
2013
A bulky hydrophobic residue is not required to maintain the V-conformation of enzyme-bound thiamin diphosphate.
Andrews, Forest H⋅Andrews, F.H.⋅Tom, Alan R⋅Tom, A.R.⋅Gunderman, P.R.⋅Gunderman, Peter R⋅Novak, W.R.P.⋅Novak, Walter R⋅Mc Leish, Michael J and McLeish, M.J.
Biochemistry, vol. 52, (no. 18), pp. 3028-30, 2013/May/7. | Journal Article
 
Kinetic and pH studies on human phenylethanolamine N-methyltransferase
Wu, Q. and Mc Leish, M.J.
Archives of Biochemistry and Biophysics, vol. 539, pp. 1-8. | Journal Article
 
Using site-saturation mutagenesis to explore mechanism and substrate specificity in thiamin diphosphate-dependent enzymes.
Andrews, Forest H and Mc Leish, Michael J
The FEBS journal, vol. 280, (no. 24), pp. 6395-6411, December 2013. | Journal Article
2012
Substrate specificity in thiamin diphosphate-dependent decarboxylases.
Andrews, Forest H and Mc Leish, Michael J
Bioorganic chemistry, vol. 43, pp. 26-36, 2012/Aug. | Journal Article
2011
Characterization of a thiamin diphosphate-dependent phenylpyruvate decarboxylase from Saccharomycescerevisiae
Kneen, Malea M⋅Stan, Razvan⋅Yep, Alejandra⋅Tyler, Ryan P⋅Saehuan, Choedchai and Mc Leish, Michael J
The FEBS Journal, vol. 278, (no. 11), pp. 1842-1853, Jun 2011. | Journal Article
 
Characterization of a thiamin diphosphate-dependent phenylpyruvate decarboxylase from Saccharomyces cerevisiae.
Kneen, Malea M⋅Stan, Razvan⋅Yep, Alejandra⋅Tyler, Ryan P⋅Saehuan, Choedchai and Mc Leish, Michael J
The FEBS journal, vol. 278, (no. 11), pp. 1842-53, 2011/Jun. | Journal Article
2010
Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition.
Brandt, Gabriel S⋅Kneen, Malea M⋅Petsko, Greg⋅Ringe, Dagmar and Mc Leish, Michael J
Journal of the American Chemical Society, vol. 132, (no. 2), pp. 438-9, 2010/Jan/20. | Journal Article
 
Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.
Drinkwater, Nyssa⋅Drinkwater, Nyssa⋅Vu, Hoan⋅Vu, Hoan⋅Lovell, Kimberly M⋅Lovell, Kimberly M.⋅Criscione, Kevin R⋅Criscione, Kevin R.⋅Collins, Brett M.⋅Collins, Brett M⋅Prisinzano, Thomas E⋅Prisinzano, Thomas E.⋅Poulsen, Sally-Ann⋅Poulsen, Sally-Ann⋅Mc Leish, Michael J⋅McLeish, Michael J.⋅Grunewald, Gary L.⋅Grunewald, Gary L⋅Martin, Jennifer L. and Martin, Jennifer L
The Biochemical journal, vol. 431, (no. 1), pp. 51-61, 2010/Oct/1. | Journal Article