133 Publications (Page 2 of 6)
2010
Structural relationship between the active sites of [beta]-lactam-recognizing and amidase signature enzymes: convergent evolution?
Pratt, R.F and Mc Leish, Michael
Biochemistry, vol. 49, (no. 45), pp. 9688, 20101116. | Journal Article
 
Structural relationship between the active sites of β-lactam-recognizing and amidase signature enzymes: convergent evolution?
Pratt, Rex F and Mc Leish, Michael J
Biochemistry, vol. 49, (no. 45), pp. 9688-97, 2010/Nov/16. | Journal Article
2009
Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase.
Chakraborty, Sumit⋅Nemeria, Natalia S⋅Balakrishnan, Anand⋅Brandt, Gabriel S⋅Kneen, Malea M⋅Yep, Alejandra⋅Mc Leish, Michael J⋅Kenyon, George L⋅Petsko, Greg⋅Ringe, Dagmar and Jordan, Frank
Biochemistry, vol. 48, (no. 5), pp. 981-94, 2009/Feb/10. | Journal Article
 
Engineering the substrate binding site of benzoylformate decarboxylase
Yep, A. and Mc Leish, M.J.
Biochemistry, vol. 48, pp. 8387-8395. | Journal Article
 
Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.
Drinkwater, Nyssa⋅Gee, Christine L⋅Puri, Munish⋅Criscione, Kevin R⋅Mc Leish, Michael J⋅Grunewald, Gary L and Martin, Jennifer L
The Biochemical journal, vol. 422, (no. 3), pp. 463-71, 2009/Sep/15. | Journal Article
 
Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor.
Brandt, Gabriel S⋅Kneen, Malea M⋅Chakraborty, Sumit⋅Baykal, Ahmet T⋅Nemeria, Natalia⋅Yep, Alejandra⋅Ruby, David I⋅Petsko, Greg⋅Kenyon, George L⋅Mc Leish, Michael J⋅Jordan, Frank and Ringe, Dagmar
Biochemistry, vol. 48, (no. 15), pp. 3247-57, 2009/Apr/21. | Journal Article
 
The reaction mechanism of phenylethanolamine N-methyltransferase: a density functional theory study.
Georgieva, Polina⋅Wu, Qian⋅Mc Leish, Michael J and Himo, Fahmi
Biochimica et biophysica acta, vol. 1794, (no. 12), pp. 1831-7, 2009/Dec. | Journal Article
 
Time-dependent inactivation of human phenylethanolamine N-methyltransferase by 7-isothiocyanatotetrahydroisoquinoline
Wu, Qian⋅Caine, Joanne M⋅Thomson, Stuart A⋅Slavica, Meri⋅Grunewald, Gary L and Mc Leish, Michael J
Bioorganic and Medicinal Chemistry Letters, vol. 19, (no. 4), pp. 1071-1074, 2009. | Journal Article
 
Using directed evolution to probe the substrate specificity of mandelamide hydrolase.
Wang, Pan-Fen⋅Yep, Alejandra⋅Kenyon, George L and Mc Leish, Michael J
Protein engineering, design & selection : PEDS, vol. 22, (no. 2), pp. 103-10, 2009/Feb. | Journal Article
2008
Mechanism of benzaldehyde lyase studied via thiamin diphosphate-bound intermediates and kinetic isotope effects.
Chakraborty, Sumit⋅Nemeria, Natalia⋅Yep, Alejandra⋅Mc Leish, Michael J⋅Kenyon, George L and Jordan, Frank
Biochemistry, vol. 47, (no. 12), pp. 3800-9, 2008/Mar/25. | Journal Article
 
Physical, kinetic and spectrophotometric studies of a NAD(P)-dependent benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633
Yeung, Catherine K⋅Yep, Alejandra⋅Kenyon, George L and Mc Leish, Michael J
Biochimica et Biophysica Acta: Proteins and Proteomics, vol. 1784, (no. 9), pp. 1248-1255, 2008. | Journal Article
 
Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester.
Brandt, Gabriel S⋅Nemeria, Natalia⋅Chakraborty, Sumit⋅Mc Leish, Michael J⋅Yep, Alejandra⋅Kenyon, George L⋅Petsko, Greg⋅Jordan, Frank and Ringe, Dagmar
Biochemistry, vol. 47, (no. 29), pp. 7734-43, 2008/Jul/22. | Journal Article
 
Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism
Yep, Alejandra⋅Kenyon, George L and Mc Leish, Michael J
Proceedings of the National Academy of Sciences of the United States of America, vol. 105, (no. 15), Apr 15, 2008. | Journal Article
2007
Elucidation of the chemistry of enzyme-bound thiamin diphosphate prior to substrate binding: defining internal equilibria among tautomeric and ionization states.
Nemeria, Natalia⋅Korotchkina, Lioubov G⋅Mc Leish, Michael J⋅Kenyon, George L⋅Patel, Mulchand S and Jordan, Frank
Biochemistry, vol. 46, (no. 37), pp. 10739-44, 2007/Sep/18. | Journal Article
 
Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.
Gee, Christine L⋅Drinkwater, Nyssa⋅Tyndall, Joel D⋅Grunewald, Gary L⋅Wu, Qian⋅Mc Leish, Michael J and Martin, Jennifer L
Journal of medicinal chemistry, vol. 50, (no. 20), pp. 4845-53, 2007/Oct/4. | Journal Article
 
Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in PhenylethanolamineN-Methyltransferase
Gee, Christine L⋅Drinkwater, Nyssa⋅Tyndall, Joel D. A⋅Grunewald, Gary L⋅Wu, Qian⋅Mc Leish, Michael J and Martin, Jennifer L
Journal of Medicinal Chemistry, vol. 50, (no. 25), pp. 6441, 2007-12-00. | Journal Article
 
Isolation and characterization of a benzoylformate decarboxylase and a NAD+/NADP+-dependent benzaldehyde dehydrogenase involved in D-phenylglycine metabolism in Pseudomonas stutzeri ST-201.
Saehuan, Choedchai⋅Rojanarata, Theerasak⋅Wiyakrutta, Suthep⋅Mc Leish, Michael J and Meevootisom, Vithaya
Biochimica et biophysica acta, vol. 1770, (no. 11), pp. 1585-92, 2007/Nov. | Journal Article
 
Mechanism-based inactivation of benzoylformate decarboxylase, a thiamin diphosphate-dependent enzyme.
Bera, Asim K⋅Polovnikova, Lena S⋅Roestamadji, Juliatek⋅Widlanski, Theodore S⋅Kenyon, George L⋅Mc Leish, Michael J and Hasson, Miriam S
Journal of the American Chemical Society, vol. 129, (no. 14), pp. 4120-1, 2007/Apr/11. | Journal Article
2006
Characterization of benzaldehyde lyase from Pseudomonas fluorescens: A versatile enzyme for asymmetric C-C bond formation
Janzen, Elena⋅Mueller, Michael⋅Kolter-Jung, Doris⋅Kneen, Malea M⋅Mc Leish, Michael J and Pohl, Martina
Bioorganic Chemistry, vol. 34, (no. 6), pp. 345-361, 2006. | Journal Article
 
Determinants of substrate specificity in KdcA, a thiamin diphosphate- dependent decarboxylase
Yep, Alejandra⋅Kenyon, George L and Mc Leish, Michael J
Bioorganic Chemistry, vol. 34, (no. 6), pp. 325-336, 2006. | Journal Article
 
Exploring the role of the active site cysteine in human muscle creatine kinase.
Wang, Pan-Fen⋅Flynn, Allen J⋅Naor, Mor M⋅Jensen, Jan H⋅Cui, Guanglei⋅Merz, Kenneth M⋅Kenyon, George L and Mc Leish, Michael J
Biochemistry, vol. 45, (no. 38), pp. 11464-72, 2006/Sep/26. | Journal Article
 
Heterogeneity of Escherichia coli-expressed human muscle creatine kinase.
Wang, Pan-Fen⋅Kenyon, George L and Mc Leish, Michael J
IUBMB life, vol. 58, (no. 7), pp. 421-8, 2006/Jul. | Journal Article
 
Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents.
Andricopulo, Adriano D⋅Akoachere, M B⋅Krogh, R⋅Nickel, C⋅Mc Leish, Michael J⋅Kenyon, George L⋅Arscott, L D⋅Williams, Charles H⋅Davioud-Charvet, E and Becker, K
Bioorganic & medicinal chemistry letters, vol. 16, (no. 8), pp. 2283-92, 2006/Apr/15. | Journal Article
2005
Disulfide-linked dimers of human adrenaline synthesizing enzyme PNMT are catalytically active.
Gee, Christine L⋅Nourse, Amanda⋅Hsin, A-Yen⋅Wu, Qian⋅Tyndall, Joel D⋅Grunewald, Gary L⋅Mc Leish, Michael J and Martin, Jennifer L
Biochimica et biophysica acta, vol. 1750, (no. 1), pp. 82-92, 2005/Jun/15. | Journal Article
 
Exchanging the substrate specificities of pyruvate decarboxylase from Zymomonas mobilis and benzoylformate decarboxylase from Pseudomonas putida
Siegert, Petra⋅Mc Leish, Michael J⋅Baumann, Martin⋅Iding, Hans⋅Kneen, Malea M⋅Kenyon, George L and Pohl, Martina
Protein Engineering, Design & Selection, vol. 18, (no. 7), pp. 345-57, Jul 2005. | Journal Article