133 Publications (Page 3 of 6)
2005
Exploring the active site of benzaldehyde lyase by modeling and mutagenesis.
Kneen, Malea M⋅Pogozheva, Irina D⋅Kenyon, George L and Mc Leish, Michael J
Biochimica et biophysica acta, vol. 1753, (no. 2), pp. 263-71, 2005/Dec/1. | Journal Article
 
Loop movement and catalysis in creatine kinase.
Wang, Pan-Fen⋅Flynn, Allen J⋅Mc Leish, Michael J and Kenyon, George L
IUBMB life, vol. 57, (no. 4-5), pp. 355-62, 2005 Apr-May. | Journal Article
 
Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.
Gee, Christine L⋅Tyndall, Joel D⋅Grunewald, Gary L⋅Wu, Qian⋅Mc Leish, Michael J and Martin, Jennifer L
Biochemistry, vol. 44, (no. 51), pp. 16875-85, 2005/Dec/27. | Journal Article
 
Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenyl ethanolamine N-methyltransferase: Implications for catalysis
Gee, Christine⋅Tyndall, Joel⋅Grunewald, Gary⋅Wu, Qian⋅Mc Leish, Michael and Martin, Jennifer
Biochemistry, vol. 44, (no. 51), pp. 16875, 20051227. | Journal Article
 
Relating Structure to Mechanism in Creatine Kinase
Mc Leish, Michael J and Kenyon, George L
Critical Reviews in Biochemistry and Molecular Biology, vol. 40, (no. 1), pp. 1-20, 2005. | Journal Article
 
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.
Wu, Qian⋅Gee, Christine L⋅Lin, Frank⋅Tyndall, Joel D⋅Martin, Jennifer L⋅Grunewald, Gary L and Mc Leish, Michael J
Journal of medicinal chemistry, vol. 48, (no. 23), pp. 7243-52, 2005/Nov/17. | Journal Article
2004
Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor.
Romero, F A⋅Vodonick, Steven M⋅Criscione, Kevin R⋅Mc Leish, Michael J and Grunewald, Gary L
Journal of medicinal chemistry, vol. 47, (no. 18), pp. 4483-93, 2004/Aug/26. | Journal Article
 
Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: Design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the α2-adrenoceptor
Romero, F.A.⋅Vodonick, S.M.⋅Criscione, K.R.⋅Mc Leish, M.J. and Grunewald, G.L.
Journal of Medicinal Chemistry, vol. 47, pp. 4483-4493. | Journal Article
 
Isoleucine 69 and valine 325 form a specificity pocket in human muscle creatine kinase.
Novak, Walter R⋅Wang, Pan-Fen⋅Mc Leish, Michael J⋅Kenyon, George L and Babbitt, Patsy C
Biochemistry, vol. 43, (no. 43), pp. 13766-74, 2004/Nov/2. | Journal Article
 
Mandelamide Hydrolase from Pseudomonas putida: Characterization of a New Member of the Amidase Signature Family
Gopalakrishna, Kota⋅Stewart, BH⋅Kneen, MM⋅Andricopulo, Adriano D⋅Kenyon, George L and Mc Leish, Michael J
Biochemistry (Washington), vol. 43, (no. 24), pp. 7725-7735, 2004. | Journal Article
 
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
McMillan, Fiona M⋅Archbold, Julia⋅Mc Leish, Michael J⋅Caine, Joanne M⋅Criscione, Kevin R⋅Grunewald, Gary L and Martin, Jennifer L
Journal of medicinal chemistry, vol. 47, (no. 1), pp. 37-44, 2004/Jan/1. | Journal Article
 
Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data.
Wu, Qian⋅Criscione, Kevin R⋅Grunewald, Gary L and Mc Leish, Michael J
Bioorganic & medicinal chemistry letters, vol. 14, (no. 16), pp. 4217-20, 2004/Aug/16. | Journal Article
2003
Approaches to the Rational Design of Enzyme Inhibitors. Burger s Medicinal Chemistry and Drug Discovery
 
Benzoylformate Decarboxylase
Mc Leish, Michael⋅Kenyon, George⋅Polovnikova, Elena⋅Bera, Asim⋅Anderson, Natalie and Hasson, Miriam
CRC Press
 
Identification and characterization of a mandelamide hydrolase and an NAD(P)+-dependent benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633.
Mc Leish, Michael J⋅Kneen, Malea M⋅Gopalakrishna, Kota⋅Koo, Carolyn W⋅Babbitt, Patsy C⋅Gerlt, John A and Kenyon, George L
Journal of bacteriology, vol. 185, (no. 8), pp. 2451-6, 2003/Apr. | Journal Article
 
Identification and Characterization of a Mandelamide Hydrolase and an NAD(P) super(+)-Dependent Benzaldehyde Dehydrogenase from Pseudomonas putida ATCC 12633
Mc Leish, Michael J⋅Kneen, MM⋅Gopalakrishna, KN⋅Koo, CW⋅Babbitt, PC⋅Gerlt, JA and Kenyon, GL
Journal of Bacteriology, vol. 185, (no. 8), pp. 2451-2456, 2003. | Journal Article
 
Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity.
Davioud-Charvet, Elisabeth⋅Mc Leish, Michael J⋅Veine, Donna M⋅Giegel, David⋅Arscott, L D⋅Andricopulo, Adriano D⋅Becker, Katja⋅Muller, Sylke⋅Schirmer, R H⋅Williams, Charles H and Kenyon, George L
Biochemistry, vol. 42, (no. 45), pp. 13319-30, 2003/Nov/18. | Journal Article
 
Structural and kinetic analysis of catalysis by a thiamin diphosphate-dependent enzyme, benzoylformate decarboxylase.
Polovnikova, Elena S⋅Mc Leish, Michael J⋅Sergienko, Eduard A⋅Burgner, John T⋅Anderson, Natalie L⋅Bera, Asim K⋅Jordan, Frank⋅Kenyon, George L and Hasson, Miriam S
Biochemistry, vol. 42, (no. 7), pp. 1820-30, 2003/Feb/25. | Journal Article
2002
Creatine Kinase. Wiley Encyclopedia of Molecular Medicine
 
Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration.
Begun, Jake⋅Mc Leish, Michael J⋅Caine, Joanne M⋅Palant, Elka⋅Grunewald, Gary L and Martin, Jennifer L
Acta crystallographica. Section D, Biological crystallography, vol. 58, (no. Pt 2), pp. 314-5, 2002/Feb. | Journal Article
 
Expression of Torpedo californica creatine kinase in Escherichia coli and purification from inclusion bodies.
Wang, Pan-Fen⋅Novak, Walter R⋅Cantwell, John S⋅Babbitt, Patsy C⋅Mc Leish, Michael J and Kenyon, George L
Protein expression and purification, vol. 26, (no. 1), pp. 89-95, 2002/Oct. | Journal Article
 
The 2.1 Angstrom structure of Torpedo californica creatine kinase complexed with the ADP-Mg - -creatine transition-state analogue complex
Lahiri, Sushmita⋅Lahiri, Sushmita⋅Wang, Pan-Fen⋅Wang, Pan-Fen⋅Babbitt, Patricia⋅Babbitt, Patricia⋅Mc Leish, Michael⋅McLeish, Michael⋅Kenyon, George⋅Kenyon, George⋅Allen, Karen and Allen, Karen
Biochemistry, vol. 41, (no. 47), pp. 13861, 20021126. | Journal Article
 
The 2.1 A structure of Torpedo californica creatine kinase complexed with the ADP-Mg(2+)-NO(3)(-)-creatine transition-state analogue complex.
Lahiri, Sushmita D⋅Wang, Pan-Fen⋅Babbitt, Patsy C⋅Mc Leish, Michael J⋅Kenyon, George L and Allen, Karen N
Biochemistry, vol. 41, (no. 47), pp. 13861-7, 2002/Nov/26. | Journal Article
 
The 2.1 Å structure of Torpedo californica creatine kinase complexed with the ADP-Mg2+-NO3 –creatine transition-state analogue complex
Lahiri, Sushmita D⋅Lahiri, S.D.⋅Wang, P.-F.⋅Wang, Pan-Fen⋅Babbitt, Patricia C⋅Babbitt, P.C.⋅McLeish, Michael J⋅Mc Leish, M.J.⋅Kenyon, G.L.⋅Kenyon, George L⋅Allen, Karen N and Allen, K.N.
Biochemistry, vol. 41, pp. 13861-13867. | Journal Article
2001
An unusually low pKa for Cys282 in the active site of human muscle creatine kinase
Wang, P.-F.⋅Mc Leish, M.J.⋅Kneen, M.M.⋅Lee, G. and Kenyon, G.L.
Biochemistry, vol. 40, pp. 11698-11705. | Journal Article