68 Publications (Page 2 of 3)
2011
Medical genetics and epigenetics of telomerase.
Koziel, Jillian E⋅Fox, Melanie J⋅Steding, Catherine E⋅Sprouse, Alyssa A and Herbert, Brittney Shea
Journal of cellular and molecular medicine, vol. 15, (no. 3), pp. 457-67, 2011/Mar. | Journal Article
 
The impact of telomeres and telomerase in cellular biology and medicine: it's not the end of the story
Herbert, Brittney Shea
Journal of cellular and molecular medicine, vol. 15, (no. 1), pp. 2, 2011-Jan. | Journal Article
2010
Abstract 4291: Imetelstat, a telomerase inhibitor in phase I trials in solid tumor and hematological malignancies, has broad activity against multiple types of cancer stem cells
Joseph, Immanual⋅Matsui, William⋅LaPorta, Caterina A M⋅Tabori, Uri⋅Kornblum, Harley⋅Herbert, Brittney Shea⋅Harley, Calvin and Tressler, Robert J
Cancer Research, vol. 70, (no. 8 Supplement), pp. 4291, 2010-04-15. | Journal Article
 
Abstract 683: Evaluating the therapeutic potential of a peptide derivative of cancer-associated PCNA in DNA repair deficient breast cancers
Phipps, Elizabeth A⋅Dobrolecki, Lacey E⋅Hickey, Robert J⋅Sledge, George W⋅Herbert, Brittney Shea and Malkas, Linda H
Cancer Research, vol. 70, (no. 8 Supplement), pp. 683, 2010-04-15. | Journal Article
 
A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers.
Herbert, Brittney Shea⋅Chanoux, Rebecca A⋅Liu, Yunlong⋅Baenziger, Peter H⋅Goswami, Chirayu P⋅Mc Clintick, Jeanette⋅Edenberg, Howard J⋅Pennington, Robert E⋅Lipkin, Steven Monroe and Kopelovich, Levy
Oncotarget, vol. 1, (no. 6), pp. 405-22, 2010/Oct. | Journal Article
2009
Chapter 10: Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors
Herbert, Brittney Shea⋅Hiyama, Keiko and Goldblatt, EM
Cancer Drug Discovery and Development, pp. 225-249, 2009. | Journal Article
 
Lipid-conjugated telomerase template antagonists sensitize resistant HER2-positive breast cancer cells to trastuzumab
Goldblatt, Erin M⋅Erickson, Priscilla A⋅Gentry, Erin R⋅Gryaznov, Sergei M and Herbert, Brittney Shea
Breast Cancer Research and Treatment, vol. 118, (no. 1), pp. 21-32, Nov 2009. | Journal Article
 
Meeting report: Second international meeting on quadruplex DNA
Herbert, Brittney Shea⋅Huppert, Julian L⋅Johnson, FBrad⋅Lane, Andrew N and Phan, Anh T
Biochimie, vol. 91, (no. 9), pp. 1059-1065, 2009. | Journal Article
 
Premature senescence of highly proliferative endothelial progenitor cells is induced by tumor necrosis factor-{alpha} via the p38 mitogen-activated protein kinase pathway
Zhang, Yanmin⋅Zhang, Yanmin⋅Herbert, Brittney-Shea⋅Herbert, Brittney Shea⋅Rajashekhar, Gangaraju⋅Rajashekhar, Gangaraju⋅Ingram, David⋅Ingram, David A⋅Yoder, Mervin⋅Yoder, Mervin C⋅Clauss, Matthias⋅Clauss, Matthias⋅Rehman, Jalees and Rehman, Jalees
The FASEB Journal, vol. 23, (no. 5), pp. 1358, 20090501. | Journal Article
 
Targeting critical steps of cancer metastasis and recurrence using telomerase template antagonists
Dikmen, Z. Gunnur⋅Ozgurtas, Taner⋅Gryaznov, Sergei M and Herbert, Brittney Shea
BBA - Molecular Basis of Disease, vol. 1792, (no. 4), pp. 247, April 2009. | Journal Article
 
Targeting critical steps of cancer metastasis and recurrence using telomerase template antagonists
Dikmen, Z Gunnur⋅Ozgurtas, Taner⋅Gryaznov, Sergei M and Herbert, Brittney Shea
Biochimica et biophysica acta, vol. 1792, (no. 4), pp. 240, 2009-Apr. | Journal Article
 
The telomerase template antagonist GRN163L alters MDA-MB-231 breast cancer cell morphology, inhibits growth, and augments the effects of paclitaxel
Goldblatt, Erin M⋅Goldblatt, Erin⋅Gentry, Erin R⋅Gentry, Erin⋅Fox, Melanie J⋅Fox, Melanie⋅Gryaznov, Sergei M⋅Gryaznov, Sergei⋅Shen, Changyu⋅Shen, Changyu⋅Herbert, Brittney-Shea and Herbert, Brittney Shea
Molecular Cancer Therapeutics, vol. 8, (no. 7), pp. 2035, 20090701. | Journal Article
2008
Factors impacting human telomere homeostasis and age-related disease
Gilley, David⋅Gilley, David⋅Gilley, David⋅Gilley, David P⋅Herbert, Brittney-Shea⋅Herbert, Brittney-Shea⋅Herbert, Brittney-Shea⋅Herbert, Brittney Shea⋅Huda, Nazmul⋅Huda, Nazmul⋅Huda, Nazmul⋅Huda, Nazmul⋅Tanaka, Hiromi⋅Tanaka, Hiromi⋅Tanaka, Hiromi⋅Tanaka, Hiromi⋅Reed, Terry⋅Reed, Terry⋅Reed, Terry and Reed, Terry
Mechanisms of Ageing and Development, vol. 129, (no. 1), pp. 34, 2008. | Journal Article
2007
Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent.
Gryaznov, Sergei M⋅Jackson, Shalmica⋅Dikmen, Gunnur⋅Harley, Calvin⋅Herbert, Brittney Shea⋅Wright, Woodring E and Shay, Jerry W
Nucleosides, nucleotides & nucleic acids, vol. 26, (no. 10-12), pp. 1577-9, 2007. | Journal Article
 
Shared environmental factors associated with telomere length maintenance in elderly male twins.
Huda, Nazmul⋅Tanaka, Hiromi⋅Herbert, Brittney Shea⋅Reed, Terry and Gilley, David P
Aging cell, vol. 6, (no. 5), pp. 709-13, 2007/Oct. | Journal Article
 
Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells
Gomez-Millan, Jaime⋅Goldblatt, Erin M⋅Gryaznov, Sergei M⋅Mendonca, Marc S and Herbert, Brittney Shea
International Journal of Radiation Oncology, Biology, & Physics, vol. 67, (no. 3), pp. 897-905, 2007. | Journal Article
2006
A cancer-associated PCNA expressed in breast cancer has implications as a potential biomarker
Malkas, Linda H⋅Malkas, Linda⋅Herbert, Brittney Shea⋅Herbert, Brittney⋅Abdel-Aziz, Waleed⋅Abdel-Aziz, Waleed⋅Dobrolecki, Lacey E⋅Dobrolecki, Lacey⋅Liu, Yang⋅Liu, Yang⋅Agarwal, Beamon⋅Agarwal, Beamon⋅Hoelz, Derek J⋅Hoelz, Derek⋅Badve, Sunil S⋅Badve, Sunil⋅Schnaper, Lauren⋅Schnaper, Lauren⋅Arnold, Randy⋅Arnold, Randy J⋅Mechref, Yehia⋅Mechref, Yehia⋅Novotny, Milos⋅Novotny, Milos V⋅Loehrer, Patrick⋅Loehrer, Patrick⋅Goulet, Robert J⋅Goulet, Robert⋅Hickey, Robert and Hickey, Robert J
Proceedings of the National Academy of Sciences, USA, vol. 103, (no. 51), pp. 19472-19477, 2006. | Journal Article
 
Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol
Herbert, Brittney Shea⋅Hochreiter, Amelia E⋅Wright, Woodring E and Shay, Jerry W
Nature Protocols, vol. 1, (no. 3), pp. 1583-1590, 2006. | Journal Article
 
Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model.
Canales, Benjamin K⋅Li, Yingming⋅Thompson, Melissa G⋅Gleason, Joseph M⋅Chen, Zhi⋅Malaeb, Bahaa S⋅Corey, David R⋅Herbert, Brittney Shea⋅Shay, Jerry W and Koeneman, Kenneth S
Urologic oncology, vol. 24, (no. 2), pp. 141-51, 2006 Mar-Apr. | Journal Article
 
Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier
Lewis, Cheryl M⋅Lewis, Cheryl M⋅Herbert, Brittney Shea⋅Bu, Dawei⋅Bu, Dawei⋅Halloway, Shane⋅Halloway, Shane⋅Beck, Adam⋅Beck, Adam W⋅Shadeo, Ashleen⋅Shadeo, Ashleen⋅Zhang, Cindy⋅Zhang, Cindy⋅Ashfaq, Raheela⋅Ashfaq, Raheela⋅Shay, Jerry W⋅Shay, Jerry W⋅Euhus, David M and Euhus, David M
Breast Cancer Research and Treatment, vol. 99, (no. 1), pp. 103-115, 2006. | Journal Article
 
Telomerase Template Antagonist GRN163L Disrupts Telomere Maintenance, Tumor Growth, and Metastasis of Breast Cancer
Hochreiter, Amelia E⋅Xiao, Hongling⋅Goldblatt, Erin M⋅Gryaznov, Sergei M⋅Miller, Kathy D⋅Badve, Sunil S⋅Sledge, George W and Herbert, Brittney Shea
Clinical Cancer Research, vol. 12, (no. 10), pp. 3184-3192, 2006. | Journal Article
2005
Lipid modification of GRN163, an N3' arrow right P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
Herbert, Brittney Shea⋅Gellert, GC⋅Hochreiter, A.⋅Pongracz, K.⋅Wright, Woodring E⋅Zielinska, D.⋅Chin, AC⋅Harley, CB⋅Shay, Jerry W and Gryaznov, SM
Oncogene, vol. 24, (no. 33), pp. 5262-5268, 2005. | Journal Article
 
Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition.
Herbert, Brittney Shea⋅Gellert, Ginelle C⋅Hochreiter, Amelia⋅Pongracz, Krisztina⋅Wright, Woodring E⋅Zielinska, Daria⋅Chin, Allison C⋅Harley, Calvin B⋅Shay, Jerry W and Gryaznov, Sergei M
Oncogene. , vol. 24, (no. 33), pp. 5262-8, 2005/Aug/4. | Journal Article
 
Lipid modification of GRN163, an N3[variant prime] [arrow right] P5[variant prime] thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition
Herbert, Brittney Shea⋅Gellert, Ginelle C⋅Hochreiter, Amelia⋅Pongracz, Krisztina⋅Wright, Woodring E⋅Zielinska, Daria⋅Chin, Allison C⋅Harley, Calvin B⋅Shay, Jerry W and Gryaznov, Sergei M
Oncogene, vol. 24, (no. 33), pp. 5262-8, Aug 4, 2005. | Journal Article
 
Telomere dysfunction in aging and cancer.
Gilley, David P⋅Tanaka, Hiromi and Herbert, Brittney Shea
The international journal of biochemistry & cell biology, vol. 37, (no. 5), pp. 1000-13, 2005/May. | Journal Article