He became interested in genes involved in alcohol metabolism, and cloned several alcohol dehydrogenase genes (ADHs).

This led to an interest in alcoholism and other complex genetic diseases, and in applying genomics to understand them

My research focuses on the genetics and genomics of complex genetic disorders, especially alcohol and other substance use disorders. It spans interrelated areas that extend from genome-wide searches for genes affecting the risk for disease to molecular studies of the mechanisms by which associated variants affect gene expression, and from studies of the regulation of individual genes to genome-wide studies of expression using RNAseq and ATAC-seq, and includes the development of high throughput assays to identify functional elements in the genome

Biochemistry, Molecular Biology, Cellular Biochemistry, Molecular Biochemistry
PhD, Stanford University, 1973
AM, Stanford University, 1970
MS, Stanford University, 1970
AB, Queens College, The City University of New York, 1968
BS, Queens College, The City University of New York, 1968
africa asia europe alcohol or alcoholism biotechnology drug metabolism biomedical research training alcoholism prevention alcoholism treatment gene cloning biochemical markers enzymes gene products gene regulation gene expression cell lines biochemistry & molecular biology biochemistry, proteins