246 Publications (Page 1 of 10)
2024
Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes. Chemico-Biological Interactions
. | Journal Article
 
Impaired malin expression and interaction with partner proteins in Lafora disease. Journal of Biological Chemistry
. | Journal Article
 
Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and other glycogen storage disorders
Ullman, J.C.⋅Mellem, K.T.⋅Xi, Y.⋅Ramanan, V.⋅Merritt, H.⋅Choy, R.⋅Gujral, T.⋅Young, L.E.A.⋅Blake, K.⋅Tep, S.⋅Homburger, J.R.⋅O?Regan, A.⋅Ganesh, S.⋅Wong, P.⋅Satterfield, T.F.⋅Lin, B.⋅Situ, E.⋅Yu, C.⋅Espanol, B.⋅Sarwaikar, R.⋅Fastman, N.⋅Tzitzilonis, C.⋅Lee, P.⋅Reiton, D.⋅Morton, V.⋅Santiago, P.⋅Won, W.⋅Powers, H.⋅Cummings, B.B.⋅Hoek, M.⋅Graham, R.R.⋅Chandriani, S.J.⋅Bainer, R.⋅DePaoli-Roach, A.A.⋅Roach, P.J.⋅Hurley, T.D.⋅Sun, R.C.⋅Gentry, M.S.⋅Sinz, C.⋅Dick, R.A.⋅Noonberg, S.B.⋅Beattie, D.T.⋅Morgans, D.J. and Green, E.M.
Science Translational Medicine, vol. 16. | Journal Article
2022
A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer
 
A Novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer. Cancers
 
The structural mechanism of human glycogen synthesis by the GYS1-GYG1 complex. Cell reports
. | Journal Article
2021
Brain glycogen serves as a critical glucosamine cache required for protein glycosylation
Sun, R.C.⋅Young, L.E.A.⋅Bruntz, R.C.⋅Markussen, K.H.⋅Zhou, Z.⋅Conroy, L.R.⋅Hawkinson, T.R.⋅Clarke, H.A.⋅Stanback, A.E.⋅Macedo, J.K.A.⋅Emanuelle, S.⋅Brewer, M.K.⋅Rondon, A.L.⋅Mestas, A.⋅Sanders, W.C.⋅Mahalingan, K.K.⋅Tang, B.⋅Chikwana, V.M.⋅Segvich, D.M.⋅Contreras, C.J.⋅Allenger, E.J.⋅Brainson, C.F.⋅Johnson, L.A.⋅Taylor, R.E.⋅Armstrong, D.D.⋅Shaffer, R.⋅Waechter, C.J.⋅Vander Kooi, C.W.⋅DePaoli-Roach, A.A.⋅Roach, P.J.⋅Hurley, T.D.⋅Drake, R.R. and Gentry, M.S.
Cell Metabolism, vol. 33, pp. 1404-1417.e9. | Journal Article
 
Development of 2,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of aldehyde dehydrogenase 1A (ALDH1A) as potential adjuncts to ovarian cancer chemotherapy. European Journal of Medicinal Chemistry
. | Journal Article
2020
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
B, Tang⋅MS, Frasinyuk⋅VM, Chikwana⋅KK, Mahalingan⋅CA, Morgan⋅DM, Segvich⋅SP, Bondarenko⋅GP, Mrug⋅P, Wyrebek⋅DS, Watt⋅AA, DePaoli-Roach⋅PJ, Roach and TD, Hurley
Journal of medicinal chemistry. | Journal Article
 
Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase.
B, Tang⋅MS, Frasinyuk⋅VM, Chikwana⋅KK, Mahalingan⋅CA, Morgan⋅DM, Segvich⋅SP, Bondarenko⋅GP, Mrug⋅P, Wyrebek⋅DS, Watt⋅AA, DePaoli-Roach⋅PJ, Roach and TD, Hurley
 
Targeting Aldehyde Dehydrogenases to Eliminate Cancer Stem Cells in Gynecologic Malignancies
Muralikrishnan, Vaishnavi⋅Hurley, Thomas D and Nephew, Kenneth P
Cancers. | Journal Article
 
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
MS, Gentry⋅Z, Afawi⋅DD, Armstrong⋅A, Delgado-Escueta⋅YP, Goldberg⋅TR, Grossman⋅JJ, Guinovart⋅F, Harris⋅TD, Hurley⋅R, Michelucci⋅BA, Minassian⋅P, Sanz and JM, Serratosa
Epilepsy & behavior : E&B. | Journal Article
 
The 5th International Lafora Epilepsy Workshop: Basic science elucidating therapeutic options and preparing for therapies in the clinic.
MS, Gentry⋅Z, Afawi⋅DD, Armstrong⋅A, Delgado-Escueta⋅YP, Goldberg⋅TR, Grossman⋅JJ, Guinovart⋅F, Harris⋅TD, Hurley⋅R, Michelucci⋅BA, Minassian⋅P, Sanz and JM, Serratosa
2019
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
I, Chefetz⋅E, Grimley⋅K, Yang⋅L, Hong⋅EV, Vinogradova⋅R, Suciu⋅I, Kovalenko⋅D, Karnak⋅CA, Morgan⋅M, Chtcherbinine⋅C, Buchman⋅B, Huddle⋅S, Barraza and RJ, Buckanovich
 
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Chefetz, Ilana⋅I, Chefetz⋅Chefetz, Ilana⋅Chefetz, Ilana⋅Grimley, Edward⋅Grimley, Edward⋅E, Grimley⋅Grimley, Edward⋅Yang, Kun⋅Yang, Kun⋅K, Yang⋅Yang, Kun⋅Hong, Linda⋅L, Hong⋅Hong, Linda⋅Hong, Linda⋅Vinogradova, Ekaterina V⋅Vinogradova, Ekaterina V⋅Vinogradova, Ekaterina V⋅EV, Vinogradova⋅R, Suciu⋅Suciu, Radu⋅Suciu, Radu⋅Suciu, Radu⋅Kovalenko, Ilya⋅Kovalenko, Ilya⋅I, Kovalenko⋅Kovalenko, Ilya⋅Karnak, David⋅Karnak, David⋅Karnak, David⋅D, Karnak⋅Morgan, Cynthia A⋅Morgan, Cynthia A⋅CA, Morgan⋅Morgan, Cynthia A⋅Chtcherbinine, Mikhail⋅M, Chtcherbinine⋅Chtcherbinine, Mikhail⋅Chtcherbinine, Mikhail⋅Buchman, Cameron⋅Buchman, Cameron⋅Buchman, Cameron⋅C, Buchman⋅B, Huddle⋅Huddle, Brandt⋅Huddle, Brandt⋅Huddle, Brandt⋅Barraza, Scott⋅Barraza, Scott⋅S, Barraza⋅Barraza, Scott⋅Morgan, Meredith⋅Morgan, Meredith⋅Morgan, Meredith⋅RJ, Buckanovich⋅Bernstein, Kara A⋅Bernstein, Kara A⋅Bernstein, Kara A⋅Yoon, Euisik⋅Yoon, Euisik⋅Yoon, Euisik⋅Lombard, David B⋅Lombard, David B⋅Lombard, David B⋅Bild, Andrea⋅Bild, Andrea⋅Bild, Andrea⋅Mehta, Geeta⋅Mehta, Geeta⋅Mehta, Geeta⋅Romero, Iris⋅Romero, Iris⋅Romero, Iris⋅Chiang, Chun-Yi⋅Chiang, Chun-Yi⋅Chiang, Chun-Yi⋅Landen, Charles⋅Landen, Charles⋅Landen, Charles⋅Cravatt, Benjamin⋅Cravatt, Benjamin⋅Cravatt, Benjamin⋅Hurley, Thomas D⋅Hurley, Thomas D⋅Hurley, Thomas D⋅Larsen, Scott D⋅Larsen, Scott D⋅Larsen, Scott D⋅Buckanovich, Ronald J⋅Buckanovich, Ronald J and Buckanovich, Ronald J
Cell reports. | Journal Article
2018
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDH High Melanoma-Initiating Cells
Sarvi, Sana⋅Crispin, Richard⋅Lu, Yuting⋅Zeng, Lifan⋅Hurley, Thomas D⋅Houston, Douglas R⋅von Kriegsheim, Alex⋅Chen, Che-Hong⋅Mochly-Rosen, Daria⋅Ranzani, Marco⋅Mathers, Marie E⋅Xu, Xiaowei⋅Xu, Wei⋅Adams, David J⋅Carragher, Neil O⋅Fujita, Mayumi⋅Schuchter, Lynn⋅Unciti-Broceta, Asier⋅Brunton, Valerie G and Patton, E Elizabeth
Cell chemical biology, vol. 25, (no. 12), pp. 1456, 2018-12-20. | Journal Article
 
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
Sarvi, Sana⋅Sarvi, Sana⋅Crispin, Richard⋅Crispin, Richard⋅Lu, Yuting⋅Lu, Yuting⋅Zeng, Lifan⋅Zeng, Lifan⋅Hurley, Thomas D⋅Hurley, Thomas D.⋅Houston, Douglas R.⋅Houston, Douglas R⋅von Kriegsheim, Alex⋅Kriegsheim, Alex⋅Chen, Che-Hong⋅Chen, Che-Hong⋅Mochly-Rosen, Daria⋅Mochly Rosen, Daria⋅Ranzani, Marco⋅Ranzani, Marco⋅al.⋅Mathers, Marie E⋅Xu, Xiaowei⋅Xu, Wei⋅Adams, David J⋅Carragher, Neil O⋅Fujita, Mayumi⋅Schuchter, Lynn⋅Unciti-Broceta, Asier⋅Brunton, Valerie G and Patton, E Elizabeth
Cell chemical biology, September 25, 2018. | Journal Article
 
ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells.
S, Sarvi⋅R, Crispin⋅Y, Lu⋅L, Zeng⋅TD, Hurley⋅DR, Houston⋅Kriegsheim A⋅CH, Chen⋅D, Mochly-Rosen⋅M, Ranzani⋅ME, Mathers⋅X, Xu⋅W, Xu⋅DJ, Adams and EE, Patton
 
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
Huddle, Brandt C⋅BC, Huddle⋅E, Grimley⋅Grimley, Edward⋅CD, Buchman⋅Buchman, Cameron D⋅Chtcherbinine, Mikhail⋅M, Chtcherbinine⋅Debnath, Bikash⋅B, Debnath⋅P, Mehta⋅Mehta, Pooja⋅K, Yang⋅Yang, Kun⋅CA, Morgan⋅Morgan, Cynthia A⋅Li, Siwei⋅S, Li⋅Felton, Jeremy Antonio⋅J, Felton⋅D, Sun⋅Sun, Duxin⋅G, Mehta⋅Metha, Geeta⋅Neamati, Nouri⋅N, Neamati⋅RJ, Buckanovich⋅Buckanovich, Ronald J⋅Hurley, Thomas D⋅SD, Larsen and Larsen, Scott D
Journal of medicinal chemistry. | Journal Article
 
Structure-Based Optimization of a Novel Class of Aldehyde Dehydrogenase 1A (ALDH1A) Subfamily-Selective Inhibitors as Potential Adjuncts to Ovarian Cancer Chemotherapy.
BC, Huddle⋅E, Grimley⋅CD, Buchman⋅M, Chtcherbinine⋅B, Debnath⋅P, Mehta⋅K, Yang⋅CA, Morgan⋅S, Li⋅J, Felton⋅D, Sun⋅G, Mehta⋅N, Neamati⋅RJ, Buckanovich and SD, Larsen
2017
Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
CD, Buchman and TD, Hurley
Journal of medicinal chemistry. | Journal Article
 
Inhibition of the Aldehyde Dehydrogenase 1/2 Family by Psoralen and Coumarin Derivatives.
CD, Buchman and TD, Hurley
2016
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.
CA, Maile⋅JR, Hingst⋅KK, Mahalingan⋅AO, O’Reilly⋅ME, Cleasby⋅JR, Mickelson⋅ME, McCue⋅SM, Anderson⋅TD, Hurley⋅JFP, Wojtaszewski and RJ, Piercy
 
A highly prevalent equine glycogen storage disease is explained by constitutive activation of a mutant glycogen synthase.
Maile, C A⋅Maile, C. A.⋅CA, Maile⋅JR, Hingst⋅Hingst, J. R.⋅Hingst, J R⋅KK, Mahalingan⋅Mahalingan, K. K.⋅Mahalingan, K K⋅O’Reilly, A. O.⋅O'Reilly, A O⋅AO, O’Reilly⋅Cleasby, M. E.⋅Cleasby, M E⋅ME, Cleasby⋅Mickelson, J. R.⋅JR, Mickelson⋅Mickelson, J R⋅Mc Cue, M. E.⋅McCue, M E⋅ME, McCue⋅Anderson, S M⋅SM, Anderson⋅Anderson, S. M.⋅TD, Hurley⋅Hurley, T. D.⋅Hurley, T D⋅JFP, Wojtaszewski⋅Wojtaszewski, J. F.P.⋅Wojtaszewski, J F P⋅RJ, Piercy⋅Piercy, R. J. and Piercy, R J
Biochimica et biophysica acta. General subjects. | Journal Article
 
Incorporation of phosphate into glycogen by glycogen synthase.
Contreras, Christopher J⋅Contreras, Christopher J⋅Segvich, Dyann M⋅Segvich, Dyann M⋅Mahalingan, Krishna⋅Mahalingan, Krishna⋅Chikwana, Vimbai M⋅Chikwana, Vimbai M⋅Kirley, Terence L⋅Kirley, Terence L⋅Hurley, Thomas D⋅Hurley, Thomas D⋅DePaoli-Roach, Anna A⋅DePaoli-Roach, Anna A⋅Roach, Peter J and Roach, Peter J
Archives of biochemistry and biophysics, vol. 597, pp. 21-29, May 1, 2016. | Journal Article