128 Publications (Page 1 of 6)
2021
Treadmilling FtsZ polymers drive the directional movement of sPG-synthesis enzymes via a Brownian ratchet mechanism
McCausland, Joshua W⋅McCausland, Joshua W⋅McCausland, Joshua W⋅Mc Causland, Joshua W⋅Yang, Xinxing⋅⋅⋅⋅Squyres, Georgia R⋅Squyres, Georgia R⋅Squyres, Georgia R⋅Squyres, Georgia R⋅⋅Lyu, Zhixin⋅⋅⋅Bruce, Kevin E⋅Bruce, Kevin E⋅Bruce, Kevin E⋅Bruce, Kevin E⋅Lamanna, Melissa M⋅Lamanna, Melissa M⋅Lamanna, Melissa M⋅Lamanna, Melissa M⋅⋅⋅Söderström, Bill⋅⋅Garner, Ethan C⋅Garner, Ethan C⋅Garner, Ethan C⋅Garner, Ethan C⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Xiao, Jie⋅Xiao, Jie⋅Xiao, Jie⋅Xiao, Jie⋅Liu, Jian⋅Liu, Jian⋅Liu, Jian and Liu, Jian
Nature Communications, vol. 12, (no. 1), 2021. | Journal Article
 
Undermodification cues division
Winkler, Malcolm E
Nature Chemical Biology, vol. 17, (no. 8), pp. 841-843, Aug 2021. | Journal Article
2020
Chemical tools for selective activity profiling of bacterial penicillin-binding proteins
Sharifzadeh, Shabnam⋅Brown, Nathaniel W⋅Shirley, Joshua D⋅Bruce, Kevin E⋅Winkler, Malcolm E and Carlson, Erin E
Methods in enzymology, vol. 638, pp. 27, 2020-00-00. | Journal Article
2019
Competence beyond Genes: Filling in the Details of the Pneumococcal Competence Transcriptome by a Systems Approach
Winkler, Malcolm E and Morrison, Donald A
Journal of bacteriology, vol. 201, (no. 13), pp. 1, 2019-Jul-01. | Journal Article
 
Movement dynamics of divisome proteins and PBP2x:FtsW in cells of Streptococcus pneumoniae
Perez, Amilcar J⋅Perez, Amilcar J⋅Perez, Amilcar J⋅Cesbron, Yann⋅Cesbron, Yann⋅Cesbron, Yann⋅Shaw, Sidney L⋅Shaw, Sidney L⋅Shaw, Sidney L⋅Bazan Villicana, Jesus⋅Bazan Villicana, Jesus⋅Bazan Villicana, Jesus⋅Tsui, Ho-Ching T⋅Tsui, Ho-Ching T⋅Tsui, Ho-Ching T⋅Boersma, Michael J⋅Boersma, Michael J⋅Boersma, Michael J⋅Ye, Ziyun A⋅Ye, Ziyun A⋅Ye, Ziyun A⋅Tovpeko, Yanina⋅Tovpeko, Yanina⋅Tovpeko, Yanina⋅Dekker, Cees⋅Dekker, Cees⋅Dekker, Cees⋅Holden, Seamus⋅Holden, Seamus⋅Holden, Seamus⋅Winkler, Malcolm E⋅Winkler, Malcolm E and Winkler, Malcolm E
Proceedings of the National Academy of Sciences of the United States of America, vol. 116, (no. 8), pp. 3220, 2019-02-19. | Journal Article
 
Redefining the Small Regulatory RNA Transcriptome in Streptococcus pneumoniae Serotype 2 Strain D39
Sinha, Dhriti⋅Zimmer, Kurt⋅Cameron, Todd A⋅Rusch, Douglas B⋅Winkler, Malcolm E and De Lay, Nicholas R
Journal of bacteriology, vol. 201, (no. 14), pp. 1, 2019-Jul-15. | Journal Article
 
Redefining the sRNA Transcriptome in Streptococcus pneumoniae Serotype 2 Strain D39
Sinha, Dhriti⋅Zimmer, Kurt⋅Cameron, Todd A⋅Rusch, Douglas B⋅Winkler, Malcolm E and De Lay, Nicholas R
Journal of bacteriology, 2019-Mar-04. | Journal Article
 
Selective Penicillin-Binding Protein Imaging Probes Reveal Substructure in Bacterial Cell Division
Kocaoglu, Ozden⋅Kocaoglu, Ozden⋅Calvo, Rebecca A⋅Calvo, Rebecca A⋅Sham, Lok-To⋅Sham, Lok-To⋅Cozy, Loralyn M⋅Cozy, Loralyn M⋅Lanning, Bryan R⋅Lanning, Bryan R⋅Francis, Samson⋅Francis, Samson⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Kearns, Daniel B⋅Kearns, Daniel B⋅Carlson, Erin E and Carlson, Erin E
ACS Chemical Biology, vol. 14, (no. 7), pp. 1672, 2019-07-19. | Journal Article
 
Structure of the Large Extracellular Loop of FtsX and Its Interaction with the Essential Peptidoglycan Hydrolase PcsB in Streptococcus pneumoniae
Rued, Britta E⋅Rued, Britta E⋅Rued, Britta E⋅Alcorlo, Martín⋅Alcorlo, Martín⋅Alcorlo, Martín⋅Edmonds, Katherine A⋅Edmonds, Katherine A⋅Edmonds, Katherine A⋅Martínez-Caballero, Siseth⋅Martínez-Caballero, Siseth⋅Martínez-Caballero, Siseth⋅Straume, Daniel⋅Straume, Daniel⋅Straume, Daniel⋅Fu, Yue⋅Fu, Yue⋅Fu, Yue⋅Bruce, Kevin E⋅Bruce, Kevin E⋅Bruce, Kevin E⋅Wu, Hongwei⋅Wu, Hongwei⋅Wu, Hongwei⋅Håvarstein, Leiv S⋅Håvarstein, Leiv S⋅Håvarstein, Leiv S⋅Hermoso, Juan A⋅Hermoso, Juan A⋅Hermoso, Juan A⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Giedroc, David P⋅Giedroc, David P and Giedroc, David P
mBio, vol. 10, (no. 1), pp. e02622-18, 2019-01-29. | Journal Article
 
The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes
Cleverley, Robert M⋅Rutter, Zoe J⋅Rismondo, Jeanine⋅Corona, Federico⋅Tsui, Ho-Ching Tiffany⋅Alatawi, Fuad A⋅Daniel, Richard A⋅Halbedel, Sven⋅Massidda, Orietta⋅Winkler, Malcolm E and Lewis, Richard J
Nature communications, vol. 10, (no. 1), pp. 17, 2019-01-16. | Journal Article
2018
The Opp (AmiACDEF) Oligopeptide Transporter Mediates Resistance of Serotype 2 Streptococcus pneumoniae D39 to Killing by Chemokine CXCL10 and Other Antimicrobial Peptides
Bruce, Kevin E⋅Rued, Britta E⋅Tsui, Ho-Ching Tiffany and Winkler, Malcolm E
Journal of bacteriology, vol. 200, (no. 11), 2018-Jun-01. | Journal Article
2017
Absence of the KhpA and KhpB (JAG/EloR) RNA-binding proteins suppresses the requirement for PBP2b by overproduction of FtsA in Streptococcus pneumoniae D39
Zheng, Jiaqi J⋅Perez, Amilcar J⋅Tsui, Ho-Ching Tiffany⋅Massidda, Orietta and Winkler, Malcolm E
Molecular Microbiology, vol. 106, (no. 5), pp. 814, 2017-12-00. | Journal Article
 
Biological and Chemical Adaptation to Endogenous Hydrogen Peroxide Production in Streptococcus pneumoniae D39.
Lisher, John P⋅Lisher, John P⋅Tsui, Ho-Ching Tiffany⋅Tsui, Ho-Ching Tiffany⋅Ramos-Montañez, Smirla⋅Ramos-Montañez, Smirla⋅Hentchel, Kristy L⋅Hentchel, Kristy L⋅Martin, Julia E⋅Martin, Julia E⋅Trinidad, Jonathan C⋅Trinidad, Jonathan C⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Giedroc, David P and Giedroc, David P
mSphere, vol. 2, (no. 1). | Journal Article
 
Novel Electrophilic Scaffold for Imaging of Essential Penicillin-Binding Proteins in Streptococcus pneumoniae
Sharifzadeh, Shabnam⋅Boersma, Michael J⋅Kocaoglu, Ozden⋅Shokri, Alireza⋅Brown, Clayton L⋅Shirley, Joshua D⋅Winkler, Malcolm E and Carlson, Erin E
ACS chemical biology, vol. 12, (no. 11), pp. 2857, 2017-11-17. | Journal Article
 
Perturbation of manganese metabolism disrupts cell division inStreptococcus pneumoniae
Martin, Julia E⋅Martin, Julia E⋅Lisher, John P⋅Lisher, John P⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Giedroc, David P and Giedroc, David P
Molecular Microbiology, vol. 104, (no. 2), pp. 348, 2017-04-00. | Journal Article
 
Roles of the Essential Protein FtsA in Cell Growth and Division in Streptococcus pneumoniae
Mura, Andrea⋅Fadda, Daniela⋅Perez, Amilcar J⋅Danforth, Madeline L⋅Musu, Daniela⋅Rico, Ana Isabel⋅Krupka, Marcin⋅Denapaite, Dalia⋅Tsui, Ho-Ching T⋅Winkler, Malcolm E⋅Branny, Pavel⋅Vicente, Miguel⋅Margolin, William and Massidda, Orietta
Journal of bacteriology, vol. 199, (no. 3), pp. E00608, 2017-Feb-01. | Journal Article
 
The zinc efflux activator SczA protects S treptococcus pneumoniae serotype 2 D39 from intracellular zinc toxicity
Martin, Julia E⋅Martin, J.E.⋅Martin, Julia E⋅Edmonds, Katherine A⋅Edmonds, K.A.⋅Edmonds, Katherine A⋅Bruce, K.E.⋅Bruce, Kevin E⋅Bruce, Kevin E⋅Campanello, Gregory C⋅Campanello, Gregory C⋅Campanello, G.C.⋅Eijkelkamp, B.A.⋅Eijkelkamp, Bart A⋅Eijkelkamp, Bart A⋅Brazel, Erin B⋅Brazel, Erin B⋅Brazel, E.B.⋅McDevitt, Christopher A⋅McDevitt, Christopher A⋅Mc Devitt, C.A.⋅Winkler, Malcolm E⋅Winkler, M.E.⋅Winkler, Malcolm E⋅Giedroc, David P⋅Giedroc, D.P. and Giedroc, David P
Molecular Microbiology, vol. 104, (no. 4), pp. 651, 2017-05-00. | Journal Article
2016
1H, 13C, 15N resonance assignments of the extracellular loop 1 domain (ECL1) of Streptococcus pneumoniae D39 FtsX, an essential cell division protein.
Fu, Yue⋅Bruce, Kevin E⋅Rued, Britta⋅Winkler, Malcolm E and Giedroc, David P
Biomolecular NMR assignments, vol. 10, (no. 1), pp. 89-92, April 2016. | Journal Article
 
Biochemical characterization of essential cell division proteins FtsX and FtsE that mediate peptidoglycan hydrolysis by PcsB in Streptococcus pneumoniae.
Bajaj, Ruchika⋅Bajaj, Ruchika⋅Bruce, Kevin E.⋅Bruce, Kevin E⋅Davidson, Amy L⋅Davidson, Amy L.⋅Rued, Britta E.⋅Rued, Britta E⋅Stauffacher, Cynthia V⋅Stauffacher, Cynthia V.⋅Winkler, Malcolm E. and Winkler, Malcolm E
MicrobiologyOpen, May 10, 2016. | Journal Article
 
Physiological Roles of the Dual Phosphate Transporter Systems in Low and High Phosphate Conditions and in Capsule Maintenance of Streptococcus pneumoniae D39.
Zheng, Jiaqi J⋅Sinha, Dhriti⋅Wayne, Kyle J and Winkler, Malcolm E
Frontiers in cellular and infection microbiology, vol. 6, pp. 63, 2016. | Journal Article
 
Roles of the essential protein FtsA in cell growth and division in Streptococcus pneumoniae.
Mura, Andrea⋅Fadda, Daniela⋅Perez, Amilcar J⋅Danforth, Madeline L⋅Musu, Daniela⋅Rico, Ana Isabel⋅Krupka, Marcin⋅Denapaite, Dalia⋅Tsui, Ho-Ching T⋅Winkler, Malcolm E⋅Branny, Pavel⋅Vicente, Miguel⋅Margolin, William and Massidda, Orietta
Journal of bacteriology, November 21, 2016. | Journal Article
 
Suppression and Synthetic-Lethal Genetic Relationships of ΔgpsB Mutations Indicate That GpsB Mediates Protein Phosphorylation and Penicillin-Binding Protein Interactions in Streptococcus pneumoniae D39.
Rued, Britta E⋅Zheng, Jiaqi J⋅Mura, Andrea⋅Tsui, Ho-Ching T⋅Boersma, Michael J⋅Mazny, Jeffrey L⋅Corona, Federico⋅Perez, Amilcar J⋅Fadda, Daniela⋅Doubravová, Linda⋅Buriánková, Karolína⋅Branny, Pavel⋅Massidda, Orietta and Winkler, Malcolm E
Molecular microbiology, December 23, 2016. | Journal Article
 
Suppression of a deletion mutation in the gene encoding essential PBP2b reveals a new lytic transglycosylase involved in peripheral peptidoglycan synthesis in Streptococcus pneumoniae D39.
Tsui, Ho-Ching Tiffany⋅Zheng, Jiaqi J⋅Magallon, Ariel N⋅Ryan, John D⋅Yunck, Rachel⋅Rued, Britta E⋅Bernhardt, Thomas G and Winkler, Malcolm E
Molecular microbiology, vol. 100, (no. 6), pp. 1039-1065, June 2016. | Journal Article
2015
A new quorum-sensing system (TprA/PhrA) for Streptococcus pneumoniae D39 that regulates a lantibiotic biosynthesis gene cluster.
Hoover, Sharon E⋅Hoover, Sharon E⋅Hoover, Sharon E⋅Perez, Amilcar J⋅Perez, Amilcar J⋅Perez, Amilcar J⋅Tsui, Ho‐Ching T⋅Tsui, Ho-Ching T⋅Tsui, Ho-Ching T⋅Sinha, Dhriti⋅Sinha, Dhriti⋅Sinha, Dhriti⋅Smiley, David L⋅Smiley, David L⋅Smiley, David L⋅DiMarchi, Richard D⋅Di Marchi, Richard D⋅DiMarchi, Richard D⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Winkler, Malcolm E⋅Lazazzera, Beth A⋅Lazazzera, Beth A and Lazazzera, Beth A
Molecular microbiology, vol. 97, (no. 2), pp. 229-243, July 2015. | Journal Article
 
Minimal Peptidoglycan (PG) Turnover in Wild-Type and PG Hydrolase and Cell Division Mutants of Streptococcus pneumoniae D39 Growing Planktonically and in Host-Relevant Biofilms.
Boersma, Michael J⋅Boersma, Michael J⋅Kuru, Erkin⋅Kuru, Erkin⋅Rittichier, Jonathan T⋅Rittichier, Jonathan T⋅VanNieuwenhze, Michael S⋅Van Nieuwenhze, Michael S⋅Brun, Yves V⋅Brun, Yves V⋅Winkler, Malcolm E and Winkler, Malcolm E
Journal of bacteriology, vol. 197, (no. 21), pp. 3472-3485, November 2015. | Journal Article