21 Publications
2017
Impact of a novel phosphoinositol-3 kinase inhibitor in preventing mitochondrial DNA damage and damage-associated molecular pattern accumulation: Results from the Biochronicity Project.
Black, George Edward⋅Sokol, Kyle K⋅Moe, Donald M⋅Simmons, Jon D⋅Muscat, David⋅Pastukh, Victor⋅Capley, Gina⋅Gorodnya, Olena⋅Ruchko, Mykhaylo⋅Roth, Mark B⋅Gillespie, Mark and Martin, Matthew J
The journal of trauma and acute care surgery, vol. 83, (no. 4), pp. 683-689, October 2017. | Journal Article
2014
Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.
Hashizume, Masahiro⋅Mouner, Marc⋅Chouteau, Joshua M⋅Gorodnya, Olena M⋅Ruchko, Mykhaylo V⋅Wilson, Glenn L⋅Gillespie, Mark N and Parker, James C
Pharmaceuticals (Basel, Switzerland), vol. 7, (no. 8), pp. 894-912, 2014. | Journal Article
2013
Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice.
Hashizume, Masahiro⋅Mouner, Marc⋅Chouteau, Joshua M⋅Gorodnya, Olena M⋅Ruchko, Mykhaylo V⋅Potter, Barry J⋅Wilson, Glenn L⋅Gillespie, Mark and Parker, James C
American journal of physiology. Lung cellular and molecular physiology, vol. 304, (no. 4), pp. L287-97, 2013/Feb/15. | Journal Article
2011
Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs
Chouteau, Joshua M⋅Obiako, Boniface⋅Gorodnya, Olena M⋅Pastukh, Viktor⋅Ruchko, Mykhaylo V⋅Wright, Anthony J⋅Wilson, Glenn L and Gillespie, Mark
American Journal of Physiology, vol. 301, (no. 6), Dec 2011. | Journal Article
 
Oxidative DNA damage in lung tissue from patients with COPD is clustered in functionally significant sequences.
Pastukh, Viktor⋅Zhang, Li⋅Ruchko, Mykhaylo V⋅Gorodnya, Olena⋅Bardwell, Gina C⋅Tuder, Rubin M and Gillespie, Mark
International journal of chronic obstructive pulmonary disease, vol. 6, pp. 209-17, 2011. | Journal Article
 
The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells
Ruchko, Mykhaylo V⋅Gorodnya, Olena M⋅Zuleta, Andres⋅Pastukh, Viktor and Gillespie, Mark
Free Radical Biology and Medicine, vol. 50, (no. 9), pp. 1107-1113, 2011. | Journal Article
2010
Controlled DNA damage and repair in hypoxic signaling
Gillespie, Mark⋅Pastukh, Viktor and Ruchko, Mykhaylo V
Respiratory Physiology & Neurobiology, vol. 174, (no. 3), pp. 244-251, 2010. | Journal Article
2009
Hypoxia-induced oxidative base modifications in the VEGF hypoxia-response element are associated with transcriptionally active nucleosomes
Ruchko, Mykhaylo V⋅Gorodnya, Olena M⋅Pastukh, Viktor⋅Swiger, Brad M⋅Middleton, Natavia S⋅Wilson, Glenn L and Gillespie, Mark
Free Radical Biology and Medicine, vol. 46, (no. 3), pp. 352-359, 2009. | Journal Article
 
Oxidative DNA modifications in hypoxic signaling.
Gillespie, Mark⋅Pastukh, Viktor and Ruchko, Mykhaylo V
Annals of the New York Academy of Sciences, vol. 1177, pp. 140-50, 2009/Oct. | Journal Article
 
Oxidative DNA Modifications in Hypoxic Signaling
Gillespie, Mark⋅Pastukh, Viktor and Ruchko, Mykhaylo V
Annals of the New York Academy of Sciences, vol. 1177, (no. 1), pp. 140-150, 2009. | Journal Article
2007
Sequence-specific oxidative base modifications in hypoxia-inducible genes
Pastukh, Viktor⋅Ruchko, Mykhaylo V⋅Gorodnya, Olena⋅Wilson, Glenn L and Gillespie, Mark
Free Radical Biology and Medicine, vol. 43, (no. 12), pp. 1616-1626, 2007. | Journal Article
2005
Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells
Ruchko, Mykhaylo V⋅Gorodnya, Olena⋅Le Doux, Susan P⋅Alexeyev, Mikhail F and al, et
American Journal of Physiology, vol. 32, (no. 3), pp. L530-L535, Mar 2005. | Journal Article
 
Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells.
Ruchko, Mykhaylo V⋅Gorodnya, Olena⋅Le Doux, Susan P⋅Alexeyev, Mikhail F⋅Al Mehdi, Abu Bakr and Gillespie, Mark
American journal of physiology. Lung cellular and molecular physiology, vol. 288, (no. 3), pp. L530-5, 2005/Mar. | Journal Article
2003
Putrescine transport in hypoxic rat main PASMCs is required for p38 MAP kinase activation
Ruchko, Mykhaylo V⋅Gillespie, Mark⋅Weeks, Reitha S⋅Olson, Jack W and Babal, Pavel
American Journal of Physiology, vol. 28, (no. 1), pp. L179-L186, Jan 2003. | Journal Article
 
Putrescine transport in hypoxic rat main PASMCs is required for p38 MAP kinase activation.
Ruchko, Mykhaylo V⋅Gillespie, Mark⋅Weeks, Reitha S⋅Olson, Jack W and Babal, Pavel
American journal of physiology. Lung cellular and molecular physiology, vol. 284, (no. 1), pp. L179-86, 2003/Jan. | Journal Article
2002
Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells
Babel, Pavel⋅Ruchko, Mykhaylo V⋅Ault-Ziel, Kathryn⋅Cronenberg, Lauren and al, et
American Journal of Physiology, vol. 26, (no. 4), pp. L840-L846, Apr 2002. | Journal Article
 
Regulation of ornithine decarboxylase and polyamine import by hypoxia in pulmonary artery endothelial cells.
Babal, Pavel⋅Ruchko, Mykhaylo V⋅Ault-Ziel, Kathryn⋅Cronenberg, Lauren⋅Olson, Jack W and Gillespie, Mark N
American journal of physiology. Lung cellular and molecular physiology, vol. 282, (no. 4), pp. L840-6, 2002/Apr. | Journal Article
2001
Regulation of ornithine decarboxylase activity and polyamine transport by agmatine in rat pulmonary artery endothelial cells.
Babál, P⋅Ruchko, Mykhaylo V⋅Campbell, C C⋅Gilmour, S P⋅Mitchell, John L⋅Olson, J W and Gillespie, Mark
The Journal of pharmacology and experimental therapeutics, vol. 296, (no. 2), pp. 372-7, 2001/Feb. | Journal Article
2000
Interactions between agmatine and polyamine uptake pathways in rat pulmonary artery endothelial cells.
Babál, P⋅Ruchko, Mykhaylo V⋅Olson, Jack W and Gillespie, Mark
General pharmacology, vol. 34, (no. 4), pp. 255-61, 2000/Apr. | Journal Article
1999
Phytoremediation of Radiocesium-Contaminated Soil in the Vicinity of Chernobyl, Ukraine
Dushenkov, S.⋅Mikheev, A.⋅Prokhnevsky, A.⋅Ruchko, Mykhaylo V and Sorochinsky, B.
Environmental Science & Technology, vol. 33, (no. 3), pp. 469-475, 1999. | Journal Article
1990
[Increase in free Ca2+ level determined by quin-2 in spleen lymphocytes from irradiated rats].
Ruchko, Mykhaylo V⋅Slatvinskaia, E A⋅Matyshevskaia, O P and Kucherenko, N E
Ukrainskiĭ biokhimicheskiĭ zhurnal, vol. 62, (no. 4), pp. 110-3, 1990 Jul-Aug. | Journal Article