Pharmacologic targets and pathobiology of pulmonary arterial hypertension.
Research Interests
The primary focus of my laboratory's research is the regulation of pulmonary vascular tone and structure and the pathogenesis of pulmonary arterial hypertension, with an emphasis on the interactive roles of vasoactive factors such as nitric oxide, endothelin-1, thromboxane, serotonin, and sphingosine-1-phosphate.
Current focus is on the role of Rho GTPases, such as RhoA and Rac1, and their downstream effectors in mediating the cellular effects of vasoactive factors.
