The primary interest of my laboratory is structure and function investigations of enzymes involved in peptidoglycan metabolism in bacteria.
Our investigations have included PBPs from E. coli, M. tuberculosis, P. aeruginosa and N. gonorrhoeae. A major focus at present is to understand the impact of mutations in penicillin-binding protein 2 (PBP2) derived from cephalosporin-resistant strains of N. gonorrhoeae (including H041, identified in Japan, and F89, identified in France).
